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    Pickens County, SC Commercial Real Estate for Lease

    23 results
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    Downtown Clemson Retail Space Available
    $2,800 / Mo

    Downtown Clemson Retail Space Available

    382 College Ave Unit, Clemson, SC 29631

    Retail space in downtown Clemson, formerly a coffee shop.

    • Prime downtown Clemson location.
    • Approximately 2100 sqf. of finished space.
    • Accessible from Kieth St.
    • Central heating and cooling.
    • Durable brick construction.
    Updated: Dec 30, 2025
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    Townhome Near Clemson Campus
    $1,200 / Mo

    Townhome Near Clemson Campus

    343 Old Greenville Hwy, Clemson, SC 29631

    Townhome near Clemson, private bedrooms, CATbus route, available August 2025.

    • Very close proximity to Clemson University campus.
    • Located on the CATbus route.
    • Private bedrooms, each with its own bathroom.
    • Rear bedroom with a large private walk‑out balcony.
    • Easy bike ride to Clemson.
    Updated: Aug 26, 2025
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    Prime Retail Space, Pickens County
    Contact for pricing
    76,566 SF

    Prime Retail Space, Pickens County

    High-traffic location, multiple units available

    500 Old Greenville Hwy, Clemson, SC 29631
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    GP Speedway Industrial Park: Easley, SC
    Contact for pricing
    2,361,660 SF

    GP Speedway Industrial Park: Easley, SC

    Prime Easley Industrial Space: Flex & Warehouse

    0 Calhoun Memorial Hwy, Easley, SC 29640
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    Cedar Square Retail Center
    $5 SF/Yr
    64,880 SF

    Cedar Square Retail Center

    Pickens Retail Space Available Now

    2700 Gentry Memorial Hwy, Pickens, SC 29671
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    Easley Retail Center - 2,400 SF Available
    $16 SF/Yr
    4,800 SF

    Easley Retail Center - 2,400 SF Available

    High-traffic retail space, Easley, SC.

    5156 Calhoun Memorial Hwy, Easley, SC 29640
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    Easley Retail Center - Main St.
    $10 SF/Yr
    38,878 SF

    Easley Retail Center - Main St.

    High-traffic retail space, Easley, SC.

    504 Main St, Easley, SC 29640
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    Clemson Retail Space - Tiger Blvd
    $22 SF/Yr
    1,300 SF

    Clemson Retail Space - Tiger Blvd

    1300 SF Restaurant Space Available Now!

    1067 Tiger Blvd, Clemson, SC 29631
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    Clemson Retail Space: 15,214 SF Available
    Contact for pricing
    44,128 SF

    Clemson Retail Space: 15,214 SF Available

    High-traffic Clemson retail space, ideal for multiple tenants.

    107 Canoy Ln, Clemson, SC 29631
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    Calhoun Hwy Retail Space
    $22 SF/Yr

    Calhoun Hwy Retail Space

    1660 sq ft Retail Suite Available

    5115-5119 Calhoun Memorial Hwy, Easley, SC 29640
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    Remodeled Retail Building on Acreage
    $34 SF/Yr
    1,000 SF

    Remodeled Retail Building on Acreage

    Remodeled 1,000 SF retail building on 0.45 acres.

    5536 Calhoun Memorial Hwy, Easley, SC 29640
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    Medical Office Near Prisma Health
    $1,500,000
    4,038 SF

    Medical Office Near Prisma Health

    4,038 SF available near Prisma Health Baptist Easley Hospital.

    201 Richard St, Easley, SC 29640
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    Easley Office Space Available
    $14 SF/Yr
    2,100 SF

    Easley Office Space Available

    Office space available for lease in Easley, South Carolina.

    836 Powdersville Rd, Easley, SC 29642
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    Retail Space in High-Traffic Area
    Contact for pricing
    1,396 SF

    Retail Space in High-Traffic Area

    Retail space with strong tenant mix and high visibility.

    6101 Calhoun Memorial Hwy, Easley, SC 29640
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    Freestanding Restaurant Space Available
    $40 SF/Yr
    4,029 SF

    Freestanding Restaurant Space Available

    4,029 SF freestanding restaurant with drive-thru in Clemson, SC.

    1071 Tiger Blvd, Clemson, SC 29631
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    Retail Space on Highway 123
    $15 SF/Yr
    1,200 SF

    Retail Space on Highway 123

    Retail space in Easley's trade area with high visibility.

    6811 Calhoun Memorial Hwy, Easley, SC 29640
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    Retail/Restaurant Space Near Clemson University
    Contact for pricing
    3,500 SF

    Retail/Restaurant Space Near Clemson University

    Retail/restaurant space with dedicated parking and lake access.

    894 Tiger Blvd, Clemson, SC 29631
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    Retail Space Near Clemson University
    Contact for pricing
    1,233 SF

    Retail Space Near Clemson University

    Publix-anchored retail space with high visibility near Clemson University.

    1390 Tiger Blvd, Clemson, SC 29631
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    Office Space in Easley, SC
    $13 SF/Yr
    2,589 SF

    Office Space in Easley, SC

    Office space available for lease in Easley, South Carolina.

    810 Powdersville Rd, Easley, SC 29642
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    Easley Office Space Available
    $11 SF/Yr
    3,422 SF

    Easley Office Space Available

    Office space available for rent in Easley, South Carolina.

    109 Fleetwood Dr, Easley, SC 29640
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    Easley Retail Leasing Opportunity
    $10 SF/Yr
    16,528 SF

    Easley Retail Leasing Opportunity

    Turnkey retail space with high visibility and ample parking.

    1943 East Main St, Easley, SC 29640
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    Retail/Restaurant Space Near Clemson University
    Contact for pricing
    1,401 SF

    Retail/Restaurant Space Near Clemson University

    Retail/restaurant spaces available in mixed-use student housing project.

    114 Earle St, Clemson, SC 29631
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    Mixed-Use Property Near Clemson Campus
    Contact for pricing

    Mixed-Use Property Near Clemson Campus

    Mixed-use property with residential and retail components near Clemson University.

    111 Earle St, Clemson, SC 29631
    View details
    Based on your search, we've compiled 67 Potential Opportunities for your consideration. Besides 23 Active listings in Pickens County, SC, we suggest exploring alternatives. Similar 44 Properties for Sales.

    Explore Similar Spaces for Sale in Pickens County, SC

    Consider Similar Space for Sale. We found 44 Spaces in Nearby Locations matching your search parameters.

    Unique Office Building Near Courthouse
    $350,000
    0.16 Acres

    Unique Office Building Near Courthouse

    Commercial office building with two units and distinctive architectural features.

    113 Court St, Pickens, SC 29671
    View details

    Pickens County, SC Commercial Real Estate Leasing Opportunities Market Analysis

    Explore Commercial Real Estate leasing options in Pickens County, SC with 67 listings featured on our commercial real estate exchange. The current inventory includes 6,130,024,560 square feet of properties with an estimated lease value of $190 SF/Yr.

    Estimated lease rates for Commercial Real Estate in Pickens County, SC begin at $5 SF/Yr, with an average of $17 SF/Yr and extend to $40 SF/Yr.

    In Pickens County, SC, current lease rates show:

    • Retail properties positioned at $19
    • Individual retail properties measuring $19
    • Office Properties & Spaces assessed at $12
    • Office space calculated at $12
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