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    Pickens County, SC Commercial Real Estate for Lease

    26 results
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    Downtown Clemson Retail Space Available
    $2,800 / Mo

    Downtown Clemson Retail Space Available

    382 College Ave Unit, Clemson, SC 29631

    Retail space in downtown Clemson, formerly a coffee shop.

    • Prime downtown Clemson location.
    • Approximately 2100 sqf. of finished space.
    • Accessible from Kieth St.
    • Central heating and cooling.
    • Durable brick construction.
    Updated: Dec 30, 2025
    View details
    Easley Retail Leasing Opportunity
    $10 SF/Yr
    16,528 SF

    Easley Retail Leasing Opportunity

    1943 East Main St, Easley, SC 29640

    Turnkey retail space with high visibility and ample parking.

    • Turnkey retail space ready for immediate occupancy.
    • High‑visibility location at the gateway to Downtown Easley with ± 15,300 VPD.
    • Abundant on‑site parking available.
    • Open, spacious floor plan with high ceilings and ample lighting.
    • Multiple signage opportunities available.
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    Retail Space Near Clemson University
    Contact for pricing
    1,233 SF

    Retail Space Near Clemson University

    Publix-anchored retail space with high visibility near Clemson University.

    1390 Tiger Blvd, Clemson, SC 29631
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    Commercial Land Near Walmart
    Contact for pricing

    Commercial Land Near Walmart

    0.93 acre commercial land for rent, anchored by Walmart.

    2641 Gentry Memorial Hwy, Pickens, SC 29671
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    Land Parcels Near Future C-Store
    Contact for pricing

    Land Parcels Near Future C-Store

    Land parcels available for rent near future C-Store.

    4314 Calhoun Memorial Hwy, Easley, SC 29640
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    Easley Land for Lease
    Contact for pricing
    251,100 SF

    Easley Land for Lease

    Large commercial land parcel available for ground lease or build-to-suit.

    3800 Calhoun Memorial Hwy, Easley, SC 29640
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    Remodeled Retail Building on Acreage
    Contact for pricing
    1,000 SF

    Remodeled Retail Building on Acreage

    Remodeled 1,000 SF retail building on 0.45 acres.

    5536 Calhoun Memorial Hwy, Easley, SC 29640
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    Medical Office Near Prisma Health
    Contact for pricing
    4,038 SF

    Medical Office Near Prisma Health

    4,038 SF available near Prisma Health Baptist Easley Hospital.

    201 Richard St, Easley, SC 29640
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    Freestanding Restaurant Space Available
    Contact for pricing
    4,029 SF

    Freestanding Restaurant Space Available

    4,029 SF freestanding restaurant with drive-thru in Clemson, SC.

    1071 Tiger Blvd, Clemson, SC 29631
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    Retail Space on Highway 123
    Contact for pricing
    1,200 SF

    Retail Space on Highway 123

    Retail space in Easley's trade area with high visibility.

    6811 Calhoun Memorial Hwy, Easley, SC 29640
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    Retail/Restaurant Space Near Clemson University
    Contact for pricing
    3,500 SF

    Retail/Restaurant Space Near Clemson University

    Retail/restaurant space with dedicated parking and lake access.

    894 Tiger Blvd, Clemson, SC 29631
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    Retail Space in High-Traffic Area
    Contact for pricing
    1,396 SF

    Retail Space in High-Traffic Area

    Retail space with strong tenant mix and high visibility.

    6101 Calhoun Memorial Hwy, Easley, SC 29640
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    Easley Office Space Available
    Contact for pricing
    2,100 SF

    Easley Office Space Available

    Office space available for lease in Easley, South Carolina.

    836 Powdersville Rd, Easley, SC 29642
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    Office Space in Easley, SC
    Contact for pricing
    2,589 SF

    Office Space in Easley, SC

    Office space available for lease in Easley, South Carolina.

    810 Powdersville Rd, Easley, SC 29642
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    Easley Office Space Available
    Contact for pricing
    3,422 SF

    Easley Office Space Available

    Office space available for rent in Easley, South Carolina.

    109 Fleetwood Dr, Easley, SC 29640
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    Mixed-Use Property Near Clemson Campus
    Contact for pricing

    Mixed-Use Property Near Clemson Campus

    Mixed-use property with residential and retail components near Clemson University.

    111 Earle St, Clemson, SC 29631
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    Easley Land for Lease
    Contact for pricing
    337,500 SF

    Easley Land for Lease

    Large industrial land parcel available for ground lease or build-to-suit.

    Calhoun Memorial Hwy, Easley, SC 29640
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    Retail/Restaurant Space Near Clemson University
    Contact for pricing
    1,401 SF

    Retail/Restaurant Space Near Clemson University

    Retail/restaurant spaces available in mixed-use student housing project.

    114 Earle St, Clemson, SC 29631
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    Easley Retail Center - 2,400 SF Available
    $16 SF/Yr
    4,800 SF

    Easley Retail Center - 2,400 SF Available

    High-traffic retail space, Easley, SC.

    5156 Calhoun Memorial Hwy, Easley, SC 29640
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    Calhoun Hwy Retail Space
    $22 SF/Yr

    Calhoun Hwy Retail Space

    1660 sq ft Retail Suite Available

    5115-5119 Calhoun Memorial Hwy, Easley, SC 29640
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    Prime Retail Space, Pickens County
    Contact for pricing
    76,566 SF

    Prime Retail Space, Pickens County

    High-traffic location, multiple units available

    500 Old Greenville Hwy, Clemson, SC 29631
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    Cedar Square Retail Center
    $5 SF/Yr
    64,880 SF

    Cedar Square Retail Center

    Pickens Retail Space Available Now

    2700 Gentry Memorial Hwy, Pickens, SC 29671
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    Easley Retail Center - Main St.
    $10 SF/Yr
    38,878 SF

    Easley Retail Center - Main St.

    High-traffic retail space, Easley, SC.

    504 Main St, Easley, SC 29640
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    Clemson Retail Space: 15,214 SF Available
    Contact for pricing
    44,128 SF

    Clemson Retail Space: 15,214 SF Available

    High-traffic Clemson retail space, ideal for multiple tenants.

    107 Canoy Ln, Clemson, SC 29631
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    Pickens County, SC Commercial real estate Leasing Opportunities Market Analysis

    Explore Commercial real estate leasing options in Pickens County, SC with 125 listings featured on our commercial real estate exchange. The current inventory includes 5,505,374,160 square feet of properties with an estimated lease value of $63 SF/Yr.

    Estimated lease rates for Commercial real estate in Pickens County, SC begin at $5 SF/Yr, with an average of $12 SF/Yr and extend to $22 SF/Yr.
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