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    Cape Girardeau County, MO Commercial Real Estate for Lease

    29 results
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    Office Suite in Cape Girardeau
    $5,641 /Mo
    6,770 SF

    Office Suite in Cape Girardeau

    450 Siemers Drive, Cape Girardeau, MO 63701

    Office suite with high visibility and traffic in Cape Girardeau.

    • Turn‑key ready office suite
    • High visibility and high traffic location
    • Highway/Interstate frontage
    • Heating: Forced Air, Natural Gas, Solar
    • Cooling: Central Air, Electric
    Updated: Nov 14, 2025
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    Renovated Commercial Space For Lease
    $2,500 /Mo
    2,937 SF

    Renovated Commercial Space For Lease

    230 N Sprigg Street, Cape Girardeau, MO 63701

    Renovated commercial space with high visibility in a prime location.

    • Prime location with high traffic and road frontage on N Sprigg St, offering excellent visibility in the Business District.
    • Almost 3000 sq ft of renovated space suitable for multiple offices or service providers.
    • Completely renovated with brand new A/C, roof, gutters, flooring, fixtures, bathrooms, kitchenette, and siding.
    • Significant rental income potential.
    • Located downtown, in the midst of exciting activities.
    Updated: Jun 30, 2025
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    Historic Art Deco Landmark Space
    $2,900 /Mo

    Historic Art Deco Landmark Space

    Restored historic building in downtown Cape Girardeau's commercial district.

    824 Broadway St, Cape Girardeau, MO 63701
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    Remodeled Office Space with Amenities
    $850 /Mo
    275 SF

    Remodeled Office Space with Amenities

    Centrally located office space with modern finishes and included amenities.

    1427 Thomas Dr, Cape Girardeau, MO 63701
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    Remodeled Office Space with Amenities
    $850 /Mo
    279 SF

    Remodeled Office Space with Amenities

    Centrally located office space with modern finishes and included amenities.

    1427 Thomas Dr, Cape Girardeau, MO 63701
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    Downtown Office Building For Lease
    $8,558 /Mo
    13,694 SF

    Downtown Office Building For Lease

    13,694 SF office building in historic downtown Cape Girardeau.

    18 N. Main, Cape Girardeau, MO 63701
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    Retail Space in High Traffic Area
    $1,440 /Mo

    Retail Space in High Traffic Area

    Retail space in Jackson, MO with high visibility.

    2931 E Jackson Boulevard, Jackson, MO 63755
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    Professional Office Building For Rent
    $1,100 /Mo
    1,218 SF

    Professional Office Building For Rent

    1,218 SF professional office building in good location.

    720 Forest Ave, Cape Girardeau, MO 63701
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    Cape Girardeau Warehouse Space Available
    $3,000 /Mo
    5,100 SF

    Cape Girardeau Warehouse Space Available

    Versatile warehouse space with high ceilings and ample parking.

    45 N Broadview St - Middle, Cape Girardeau, MO 63701
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    Versatile Warehouse Space Available
    $6,000 /Mo
    9,600 SF

    Versatile Warehouse Space Available

    9600 sf warehouse with high ceilings, shared loading dock.

    45 N Broadview St - Front, Cape Girardeau, MO 63701
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    Spacious Office Space in Jackson
    $5,096 /Mo
    4,368 SF

    Spacious Office Space in Jackson

    4,368 SF office space with ample parking in Jackson.

    1600 S Hope St, Jackson, MO 63755
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    600 SF Commercial Storage Space
    $400 /Mo
    600 SF

    600 SF Commercial Storage Space

    Commercial space ideal for off-site storage with drive-in door.

    2222 Kingsway Dr, Suite C, Cape Girardeau, MO 63701
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    Spacious Office Space For Rent
    Contact for pricing
    15,100 SF

    Spacious Office Space For Rent

    15,100 SF office space near dining and shopping.

    301 South Broadview Street, Cape Girardeau, MO 63703
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    New Development Retail Space Available
    Contact for pricing
    10,000 SF

    New Development Retail Space Available

    Prime lease space with high visibility and build-out allowance.

    2510 Veterans Memorial Drive, Cape Girardeau, MO 63701
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    Prime Retail/Office Space Available
    Contact for pricing
    2,300 SF

    Prime Retail/Office Space Available

    New 2,300 SF space ideal for retail or office.

    3465 William, Cape Girardeau, MO 63703
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    Retail Storefront with Office Space
    Contact for pricing
    1,275 SF

    Retail Storefront with Office Space

    Downtown retail storefront with office space for rent.

    221 Merriwether Street, Cape Girardeau, MO 63703
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    Retail Space in High-Traffic Location
    $1,440 /Mo
    1,220 SF

    Retail Space in High-Traffic Location

    Retail space with signage, parking, and delivery entrance available for lease.

    2931 E Jackson Blvd, Jackson, MO 63755
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    Prime Commercial Land For Lease
    Contact for pricing

    Prime Commercial Land For Lease

    0.47 acre commercial land for lease in Cape Girardeau.

    2148 William St, Cape Girardeau, MO
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    Retail Space Near Interstate 55
    Contact for pricing
    10,800 SF

    Retail Space Near Interstate 55

    Retail space in regional shopping hub with interstate access.

    258 Siemers Dr, Cape Girardeau, MO
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    Remodeled Office Building For Lease
    Contact for pricing
    8,200 SF

    Remodeled Office Building For Lease

    Move-in ready, remodeled office building with modern stylish space.

    1427 Thomas Dr, Cape Girardeau, MO 63701
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    Retail Space Near St. Francis
    Contact for pricing
    3,154 SF

    Retail Space Near St. Francis

    Retail space available across from St. Francis Medical Center.

    3049 Williams St, Cape Girardeau, MO
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    Commercial Space For Lease
    Contact for pricing

    Commercial Space For Lease

    Commercial space available for lease at 3049 William St.

    3049 William St, Cape Girardeau, MO 63703
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    Regional Shopping Center Near I-55
    Contact for pricing
    9,400 SF

    Regional Shopping Center Near I-55

    Regional shopping center with easy access to Interstate 55.

    155-157 Siemers Dr, Cape Girardeau, MO
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    Retail Space Near West Park
    Contact for pricing
    7,908 SF

    Retail Space Near West Park

    Retail space in regional shopping hub with easy Interstate access.

    3047 William St, Cape Girardeau, MO
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    Cape Girardeau County, MO Commercial real estate Leasing Opportunities Market Analysis

    Explore Commercial real estate leasing options in Cape Girardeau County, MO with 29 listings featured on our commercial real estate exchange. The current inventory includes 1,937,020,805 square feet of properties with an estimated lease value of $20 SF/Yr.

    Estimated lease rates for Commercial real estate in Cape Girardeau County, MO begin at $0.50 SF/Yr, with an average of $6 SF/Yr and extend to $10 SF/Yr.
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