Sign Up Successful!
You now have access to more from Realmo!
    For Lease
    • For Sale
    • For Lease
    • Recently Sold
    • Property Lookup
    • Brokers
    Space Uses
    • Retail
    • Restaurant
    • Office
    • Coworking
    • Medical Space
    • Automotive
    • Industrial
    • Warehouse
    • Flex
    Price
    Price range
    $
    $
    Size
    Property size / sq.ft.
    AI Search

    Cape Girardeau County, MO Commercial Real Estate for Lease

    16 results
    List
    Map
    Office Suite in Cape Girardeau
    $5,641 / Mo
    6,770 SF

    Office Suite in Cape Girardeau

    450 Siemers Dr, Cape Girardeau, MO 63701

    Office suite with high visibility and traffic in Cape Girardeau.

    • Turn‑key ready office suite
    • High visibility and high traffic location
    • Highway/Interstate frontage
    • Heating: Forced Air, Natural Gas, Solar
    • Cooling: Central Air, Electric
    Updated: Nov 14, 2025
    View details
    Retail Space in High Traffic Area
    $1,440 / Mo
    34,761 SF

    Retail Space in High Traffic Area

    2931 E Jackson Blvd, Jackson, MO 63755

    Retail space in Jackson, MO with high visibility.

    • Prime, high‑traffic location on Jackson Blvd with building signage.
    • Potential to expand into adjacent, identical unit.
    • Plenty of parking available.
    • Delivery entrance in the back of the building.
    • Trash and lot maintenance provided by the landlord.
    Updated: Jun 20, 2025
    View details
    Retail Space in Jackson, MO
    $1,700 / Mo
    2,200 SF

    Retail Space in Jackson, MO

    Retail property for lease in Jackson, Missouri.

    502 W Main St, Jackson, MO 63755
    View details
    Retail/Office Space in Jackson, MO
    $1,200 / Mo
    1,305 SF

    Retail/Office Space in Jackson, MO

    1300 SF suite suitable for office, retail, or service business.

    220 E Monroe St, Jackson, MO 63755
    View details
    Cape Girardeau Office Space Available
    Pending
    $5,500 / Mo
    7,000 SF

    Cape Girardeau Office Space Available

    Well-maintained commercial property with ample space in a convenient location.

    340 S Broadview St, Cape Girardeau, MO 63703
    View details
    Renovated Commercial Space For Lease
    $2,500 / Mo
    2,937 SF

    Renovated Commercial Space For Lease

    Renovated commercial space with high visibility in a prime location.

    230 N Sprigg St, Cape Girardeau, MO 63701
    View details
    HubCo Coworking Office Space
    $36 SF/Yr
    8,200 SF

    HubCo Coworking Office Space

    Modern Cape Girardeau Office Suites

    1427 Thomas Dr, Cape Girardeau, MO 63701
    View details
    West Park Mall Medical Office Space
    Contact for pricing
    79,122 SF

    West Park Mall Medical Office Space

    Missouri medical office suites for lease

    3049 William St, Cape Girardeau, MO 63703
    View details
    West Park Strip Center Retail Space
    Contact for pricing
    23,464 SF

    West Park Strip Center Retail Space

    High-traffic retail center; two spaces available.

    250 Silver Springs Rd, Cape Girardeau, MO 63703
    View details
    Lambert Plaza Retail Space
    Contact for pricing
    46,692 SF

    Lambert Plaza Retail Space

    Cape Girardeau, MO Retail Opportunity

    155 Siemers Dr, Cape Girardeau, MO 63701
    View details
    Retail Space Near West Park
    Contact for pricing
    7,908 SF

    Retail Space Near West Park

    Retail space in regional shopping hub with easy Interstate access.

    3047 William St, Cape Girardeau, MO 63703
    View details
    Retail Space Near Interstate 55
    Contact for pricing
    10,800 SF

    Retail Space Near Interstate 55

    Retail space in regional shopping hub with interstate access.

    258 Siemers Dr, Cape Girardeau, MO 63701
    View details
    Regional Shopping Center Near I-55
    Contact for pricing
    9,400 SF

    Regional Shopping Center Near I-55

    Regional shopping center with easy access to Interstate 55.

    155-157 Siemers Dr, Cape Girardeau, MO 63701
    View details
    Retail Space Near West Park
    Contact for pricing
    4,970 SF

    Retail Space Near West Park

    Retail space in regional shopping hub with high visibility.

    3036-3048 William St, Cape Girardeau, MO 63703
    View details
    Retail Space Near St. Francis
    Contact for pricing
    3,154 SF

    Retail Space Near St. Francis

    Retail space available across from St. Francis Medical Center.

    3049 Williams St, Cape Girardeau, MO
    View details
    Retail Space Near West Park
    Contact for pricing
    1,595 SF

    Retail Space Near West Park

    Retail space available in regional shopping hub near West Park.

    240-250 S Silver Springs Rd, Cape Girardeau, MO 63703
    View details
    Based on your search, we've compiled 49 Potential Opportunities for your consideration. Besides 16 Active listings in Cape Girardeau County, MO, we suggest exploring alternatives. Similar 31 Properties for Sales.

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Prime Commercial Land For Rent
    Contact for pricing

    Prime Commercial Land For Rent

    High-traffic commercial land available for rent near major retailers.

    210 S Silver Springs Rd, Cape Girardeau, MO 63703
    View details
    Prime Commercial Land For Lease
    Contact for pricing

    Prime Commercial Land For Lease

    0.47 acre commercial land for lease in Cape Girardeau.

    2148 William St, Cape Girardeau, MO 63703
    View details

    Explore Similar Spaces for Sale in Cape Girardeau County, MO

    Consider Similar Space for Sale. We found 31 Spaces in Nearby Locations matching your search parameters.

    Historic Landmark in Downtown Jackson
    $669,000
    10,000 SF

    Historic Landmark in Downtown Jackson

    Landmark building with potential for various commercial uses.

    101 W Main St, Jackson, MO 63755
    View details
    Versatile Commercial Building Near I-55
    Pending
    $570,000
    3,096 SF

    Versatile Commercial Building Near I-55

    High-traffic location, built in 2017, suitable for diverse businesses.

    5598 Us Highway 61 North, Jackson, MO 63755
    View details
    Cape Girardeau Commercial Property For Sale
    $599,900
    8,280 SF

    Cape Girardeau Commercial Property For Sale

    Commercial property with parking, high traffic, and recent upgrades.

    1444 Independence St, Cape Girardeau, MO 63703
    View details
    Turn-Key Restaurant Business Opportunity
    $224,000
    2,760 SF

    Turn-Key Restaurant Business Opportunity

    Fully operational restaurant business for sale in Oak Ridge, Missouri.

    4053 State Hwy E, Oak Ridge, MO 63769
    View details
    Ambulatory Surgery Center Investment Opportunity
    $8,050,000
    13,650 SF

    Ambulatory Surgery Center Investment Opportunity

    Single-tenant surgery center near St. Francis Medical Center for sale.

    3241 Percy Dr, Cape Girardeau, MO 63701
    View details
    Broadway Commercial Space with Apartment
    $280,000
    5,100 SF

    Broadway Commercial Space with Apartment

    Versatile investment opportunity with remodeled apartment and commercial space.

    520 Broadway St, Cape Girardeau, MO 63701
    View details
    Cape Girardeau Commercial Property
    Pending
    $825,000
    7,000 SF

    Cape Girardeau Commercial Property

    Well-maintained commercial property with over 7,000 square feet.

    340 S Broadview St, Cape Girardeau, MO 63703
    View details
    Commercial Building with Highway Frontage
    $1,199,000
    7,000 SF

    Commercial Building with Highway Frontage

    Turn-key commercial building with highway frontage and development potential.

    202 W Deerwood Dr, Jackson, MO 63755
    View details

    Cape Girardeau County, MO Commercial Real Estate Leasing Opportunities Market Analysis

    Explore Commercial Real Estate leasing options in Cape Girardeau County, MO with 47 listings featured on our commercial real estate exchange. The current inventory includes 2,760,522,605 square feet of properties with an estimated lease value of $125 SF/Yr.

    Estimated lease rates for Commercial Real Estate in Cape Girardeau County, MO begin at $0.50 SF/Yr, with an average of $15 SF/Yr and extend to $39 SF/Yr.

    In Cape Girardeau County, MO, current lease rates show:

    • Office Properties & Spaces positioned at $15
    • Individual retail properties measuring $7
    • Retail properties assessed at $7
    • Office space calculated at $10
    List
    Map

    Commercial real estate by market

    Browse Commercial real estate for Lease Near Cape Girardeau, MO

    Popular Searches in Cape Girardeau

    Popular Categories

    Select Neighborhood

    Google sign-in failed. Please try again or use another login method.
    Create New Password
    • At least 8 characters
    • Contains both letters and numbers
    • Contains uppercase and lowercase letters
    • At most 32 characters
    • Password required
    • Password reset link has expired. Please request a new one.