Cape Girardeau, MO Commercial Real Estate for Lease

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$5,641 / Mo

6,770 SF

Office Suite in Cape Girardeau

450 Siemers Dr, Cape Girardeau, MO 63701

Office suite with high visibility and traffic in Cape Girardeau.

Turn‑key ready office suite
High visibility and high traffic location
Highway/Interstate frontage
Heating: Forced Air, Natural Gas, Solar
Cooling: Central Air, Electric

Updated: Nov 14, 2025

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Pending

$5,500 / Mo

7,000 SF

Cape Girardeau Office Space Available

340 S Broadview St, Cape Girardeau, MO 63703

Well-maintained commercial property with ample space in a convenient location.

Over 7,000 square feet of usable space suitable for professional or medical use.
Highly visible and convenient location.
Ample on‑site parking for staff and visitors.
Two elevators for accessibility.
ADA compliance throughout the building.

Updated: Dec 1, 2025

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$2,500 / Mo

2,937 SF

Renovated Commercial Space For Lease

Renovated commercial space with high visibility in a prime location.

230 N Sprigg St, Cape Girardeau, MO 63701

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$36 SF/Yr

8,200 SF

HubCo Coworking Office Space

Modern Cape Girardeau Office Suites

1427 Thomas Dr, Cape Girardeau, MO 63701

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79,122 SF

West Park Mall Medical Office Space

Missouri medical office suites for lease

3049 William St, Cape Girardeau, MO 63703

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23,464 SF

West Park Strip Center Retail Space

High-traffic retail center; two spaces available.

250 Silver Springs Rd, Cape Girardeau, MO 63703

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46,692 SF

Lambert Plaza Retail Space

Cape Girardeau, MO Retail Opportunity

155 Siemers Dr, Cape Girardeau, MO 63701

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7,908 SF

Retail Space Near West Park

Retail space in regional shopping hub with easy Interstate access.

3047 William St, Cape Girardeau, MO 63703

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10,800 SF

Retail Space Near Interstate 55

Retail space in regional shopping hub with interstate access.

258 Siemers Dr, Cape Girardeau, MO 63701

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4,970 SF

Retail Space Near West Park

Retail space in regional shopping hub with high visibility.

3036-3048 William St, Cape Girardeau, MO 63703

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9,400 SF

Regional Shopping Center Near I-55

Regional shopping center with easy access to Interstate 55.

155-157 Siemers Dr, Cape Girardeau, MO 63701

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3,154 SF

Retail Space Near St. Francis

Retail space available across from St. Francis Medical Center.

3049 Williams St, Cape Girardeau, MO

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1,595 SF

Retail Space Near West Park

Retail space available in regional shopping hub near West Park.

240-250 S Silver Springs Rd, Cape Girardeau, MO 63703

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Based on your search, we've compiled 32 Potential Opportunities for your consideration. Besides 13 Active listings in Cape Girardeau, MO, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 13 Properties for Sales.

Explore Commercial Real Estate for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

$1,440 / Mo

34,761 SF

Retail Space in High Traffic Area

Retail space in Jackson, MO with high visibility.

2931 E Jackson Blvd, Jackson, MO 63755

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$1,200 / Mo

1,305 SF

Retail/Office Space in Jackson, MO

1300 SF suite suitable for office, retail, or service business.

220 E Monroe St, Jackson, MO 63755

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$13 SF/Yr

2,900 SF

Anna Commercial Flex Space

Prime Anna location, 2,900 sq ft.

1000 Leigh Ave, Anna, IL 62906

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Commercial Office Space in Anna, IL

Office space available in the Wal-Mart Plaza area.

1000 Leigh Ave, Anna, IL 62906

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Potential Development Sites for Consideration

Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

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Prime Commercial Land For Rent

High-traffic commercial land available for rent near major retailers.

210 S Silver Springs Rd, Cape Girardeau, MO 63703

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Prime Commercial Land For Lease

0.47 acre commercial land for lease in Cape Girardeau.

2148 William St, Cape Girardeau, MO 63703

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Explore Similar Spaces for Sale in Cape Girardeau, MO

Consider Similar Space for Sale. We found 13 Spaces in Nearby Locations matching your search parameters.

Cape Girardeau Commercial Property For Sale

$599,900

8,280 SF

Cape Girardeau Commercial Property For Sale

Commercial property with parking, high traffic, and recent upgrades.

1444 Independence St, Cape Girardeau, MO 63703

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Ambulatory Surgery Center Investment Opportunity

$8,050,000

13,650 SF

Ambulatory Surgery Center Investment Opportunity

Single-tenant surgery center near St. Francis Medical Center for sale.

3241 Percy Dr, Cape Girardeau, MO 63701

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Broadway Commercial Space with Apartment

$280,000

5,100 SF

Broadway Commercial Space with Apartment

Versatile investment opportunity with remodeled apartment and commercial space.

520 Broadway St, Cape Girardeau, MO 63701

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Pending

$825,000

7,000 SF

Cape Girardeau Commercial Property

Well-maintained commercial property with over 7,000 square feet.

340 S Broadview St, Cape Girardeau, MO 63703

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$500,000

7,140 SF

Leased Office Building For Sale

Two-story office building with 21 units and parking.

2711 Thomas Dr, Cape Girardeau, MO 63701

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Versatile Commercial Property in Missouri

$295,000

2,920 SF

Versatile Commercial Property in Missouri

Adaptable commercial space with retail, office, and warehouse capabilities.

225 Clark Ave, Cape Girardeau, MO 63701

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$550,000

4,548 SF

Renovated Downtown Commercial Property

Versatile, renovated 11-bedroom property in downtown Cape Girardeau, Missouri.

224 N Frederick St, Cape Girardeau, MO 63701

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Renovated Commercial Space in Cape Girardeau

$239,900

2,937 SF

Renovated Commercial Space in Cape Girardeau

Renovated commercial space with high potential in a prime location.

230 N Sprigg St, Cape Girardeau, MO 63701

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$225,000

0.57 Acres

Versatile Commercial Building in Cape

Adaptable 1800 sq ft commercial building in thriving Cape Girardeau.

2357 Rust Ave, Cape Girardeau, MO 63703

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Freestanding Restaurant in Cape Girardeau

$1,950,000

5,396 SF

Freestanding Restaurant in Cape Girardeau

Single-tenant restaurant with a new long-term lease.

202 S Broadview St, Cape Girardeau, MO 63703

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$499,900

3.90 Acres

Industrial Warehouse in Cape Girardeau

3.9 acres with 7,500 sq ft warehouse near I-55.

840 S Kings Highway St, Cape Girardeau, MO 63703

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Cape Girardeau, MO Commercial Real Estate Leasing Opportunities Market Analysis

Explore Commercial Real Estate leasing options in Cape Girardeau, MO with 26 listings featured on our commercial real estate exchange. The current inventory includes 1,093,660,920 square feet of properties with an estimated lease value of $104 SF/Yr.

Estimated lease rates for Commercial Real Estate in Cape Girardeau, MO begin at $9 SF/Yr, with an average of $20 SF/Yr and extend to $39 SF/Yr.

In Cape Girardeau, MO, current lease rates show:

Office Properties & Spaces positioned at $16
Office space measuring $10
Commercial land assessed at $39
Coworking space calculated at $36

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Cape Girardeau, MO Commercial Real Estate for Lease

Office Suite in Cape Girardeau

Office suite with high visibility and traffic in Cape Girardeau.

Cape Girardeau Office Space Available

Well-maintained commercial property with ample space in a convenient location.

Renovated Commercial Space For Lease

HubCo Coworking Office Space

West Park Mall Medical Office Space

West Park Strip Center Retail Space

Lambert Plaza Retail Space

Retail Space Near West Park

Retail Space Near Interstate 55

Retail Space Near West Park

Regional Shopping Center Near I-55

Retail Space Near St. Francis

Retail Space Near West Park

Explore Commercial Real Estate for Lease in Nearby Cities

Retail Space in High Traffic Area

Retail/Office Space in Jackson, MO

Anna Commercial Flex Space

Commercial Office Space in Anna, IL

Potential Development Sites for Consideration

Prime Commercial Land For Rent

Prime Commercial Land For Lease

Explore Similar Spaces for Sale in Cape Girardeau, MO

Cape Girardeau Commercial Property For Sale

Ambulatory Surgery Center Investment Opportunity

Broadway Commercial Space with Apartment

Cape Girardeau Commercial Property

Leased Office Building For Sale

Versatile Commercial Property in Missouri

Renovated Downtown Commercial Property

Renovated Commercial Space in Cape Girardeau

Versatile Commercial Building in Cape

Freestanding Restaurant in Cape Girardeau

Industrial Warehouse in Cape Girardeau

Cape Girardeau, MO Commercial Real Estate Leasing Opportunities Market Analysis

In Cape Girardeau, MO, current lease rates show:

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