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    Cape Girardeau, MO Commercial Real Estate for Lease

    29 results
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    Cape Girardeau Office Space Available
    Pending
    $5,500 / Mo
    7,000 SF

    Cape Girardeau Office Space Available

    340 S Broadview St, Cape Girardeau, MO 63703

    Well-maintained commercial property with ample space in a convenient location.

    • Over 7,000 square feet of usable space suitable for professional or medical use.
    • Highly visible and convenient location.
    • Ample on‑site parking for staff and visitors.
    • Two elevators for accessibility.
    • ADA compliance throughout the building.
    Updated: Dec 1, 2025
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    Office Suite in Cape Girardeau
    $5,641 / Mo
    6,770 SF

    Office Suite in Cape Girardeau

    450 Siemers Dr, Cape Girardeau, MO 63701

    Office suite with high visibility and traffic in Cape Girardeau.

    • Turn‑key ready office suite
    • High visibility and high traffic location
    • Highway/Interstate frontage
    • Heating: Forced Air, Natural Gas, Solar
    • Cooling: Central Air, Electric
    Updated: Nov 14, 2025
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    Renovated Commercial Space For Lease
    $2,500 / Mo
    2,937 SF

    Renovated Commercial Space For Lease

    Renovated commercial space with high visibility in a prime location.

    230 N Sprigg St, Cape Girardeau, MO 63701
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    600 SF Commercial Storage Space
    $400 / Mo

    600 SF Commercial Storage Space

    Commercial space ideal for off-site storage with drive-in door.

    2222 Kings Way Dr, Cape Girardeau, MO 63701
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    Remodeled Office Space with Amenities
    $850 / Mo

    Remodeled Office Space with Amenities

    Centrally located office space with modern finishes and included amenities.

    1427 Thomas Dr, Cape Girardeau, MO 63701
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    Mixed-Use Commercial Space Available
    $1,900 / Mo

    Mixed-Use Commercial Space Available

    Versatile storefront and warehouse space in downtown Cape Girardeau.

    2117 Broadway St, Cape Girardeau, MO 63701
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    Historic Art Deco Landmark Space
    $2,900 / Mo

    Historic Art Deco Landmark Space

    Restored historic building in downtown Cape Girardeau's commercial district.

    824 Broadway St, Cape Girardeau, MO 63701
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    Remodeled Office Space with Amenities
    $850 / Mo

    Remodeled Office Space with Amenities

    Centrally located office space with modern finishes and included amenities.

    1427 Thomas Dr, Cape Girardeau, MO 63701
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    Downtown Office Building For Lease
    $8,558 / Mo

    Downtown Office Building For Lease

    13,694 SF office building in historic downtown Cape Girardeau.

    18 N Main St, Cape Girardeau, MO 63701
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    Professional Office Building For Rent
    $1,100 / Mo

    Professional Office Building For Rent

    1,218 SF professional office building in good location.

    720 Forest Ave, Cape Girardeau, MO 63701
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    Prime Retail/Office Space Available
    Contact for pricing

    Prime Retail/Office Space Available

    New 2,300 SF space ideal for retail or office.

    3465 William St, Cape Girardeau, MO 63703
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    New Development Retail Space Available
    Contact for pricing

    New Development Retail Space Available

    Prime lease space with high visibility and build-out allowance.

    2510 Veterans Memorial Dr, Cape Girardeau, MO 63701
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    Spacious Office Space For Rent
    Contact for pricing

    Spacious Office Space For Rent

    15,100 SF office space near dining and shopping.

    301 South Broadview St, Cape Girardeau, MO 63703
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    Retail Storefront with Office Space
    Contact for pricing

    Retail Storefront with Office Space

    Downtown retail storefront with office space for rent.

    221 Merriwether St, Cape Girardeau, MO 63703
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    Cape Girardeau Warehouse Space Available
    $3,000 / Mo

    Cape Girardeau Warehouse Space Available

    Versatile warehouse space with high ceilings and ample parking.

    45 N Broadview St, Cape Girardeau, MO 63701
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    Versatile Warehouse Space Available
    $6,000 / Mo

    Versatile Warehouse Space Available

    9600 sf warehouse with high ceilings, shared loading dock.

    45 N Broadview St, Cape Girardeau, MO 63701
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    Versatile Warehouse Space For Lease
    Contact for pricing

    Versatile Warehouse Space For Lease

    11,000 SF warehouse space with loading dock and parking.

    500 William St, Cape Girardeau, MO 63703
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    Retail Space Near West Park
    Contact for pricing
    7,908 SF

    Retail Space Near West Park

    Retail space in regional shopping hub with easy Interstate access.

    3047 William St, Cape Girardeau, MO 63703
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    Retail Space Near West Park
    Contact for pricing
    4,970 SF

    Retail Space Near West Park

    Retail space in regional shopping hub with high visibility.

    3036-3048 William St, Cape Girardeau, MO 63703
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    Retail Space Near West Park
    Contact for pricing
    1,595 SF

    Retail Space Near West Park

    Retail space available in regional shopping hub near West Park.

    240-250 S Silver Springs Rd, Cape Girardeau, MO 63703
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    Retail Space Near Interstate 55
    Contact for pricing
    10,800 SF

    Retail Space Near Interstate 55

    Retail space in regional shopping hub with interstate access.

    258 Siemers Dr, Cape Girardeau, MO 63701
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    Regional Shopping Center Near I-55
    Contact for pricing
    9,400 SF

    Regional Shopping Center Near I-55

    Regional shopping center with easy access to Interstate 55.

    155-157 Siemers Dr, Cape Girardeau, MO 63701
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    Prime Commercial Land For Lease
    Contact for pricing

    Prime Commercial Land For Lease

    0.47 acre commercial land for lease in Cape Girardeau.

    2148 William St, Cape Girardeau, MO 63703
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    Prime Commercial Land For Rent
    Contact for pricing

    Prime Commercial Land For Rent

    High-traffic commercial land available for rent near major retailers.

    210 S Silver Springs Rd, Cape Girardeau, MO 63703
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    Cape Girardeau, MO Commercial real estate Leasing Opportunities Market Analysis

    Explore Commercial real estate leasing options in Cape Girardeau, MO with 86 listings featured on our commercial real estate exchange. The current inventory includes 1,084,948,920 square feet of properties with an estimated lease value of $65 SF/Yr.

    Estimated lease rates for Commercial real estate in Cape Girardeau, MO begin at $9 SF/Yr, with an average of $16 SF/Yr and extend to $36 SF/Yr.
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