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    Cape Girardeau County, MO Retail Properties & Spaces for Lease

    18 results
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    Retail Space in Jackson, MO
    $1,700 / Mo
    2,200 SF

    Retail Space in Jackson, MO

    502 W Main St, Jackson, MO 63755

    Retail property for lease in Jackson, Missouri.

    • Brick Construction ensures durability and classic appeal.
    • Central Air Conditioning keeps you cool and comfortable during warmer months.
    • Forced Air Heating provides efficient warmth throughout the property.
    • Parking Lot offers convenient parking for tenants and visitors.
    • Paved or Surfaced Parking adds to the property's professional appearance.
    Updated: Oct 30, 2025
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    Renovated Commercial Space For Lease
    $2,500 / Mo
    2,937 SF

    Renovated Commercial Space For Lease

    230 N Sprigg St, Cape Girardeau, MO 63701

    Renovated commercial space with high visibility in a prime location.

    • Prime location with high traffic and road frontage on N Sprigg St, offering excellent visibility in the Business District.
    • Almost 3000 sq ft of renovated space suitable for multiple offices or service providers.
    • Completely renovated with brand new A/C, roof, gutters, flooring, fixtures, bathrooms, kitchenette, and siding.
    • Significant rental income potential.
    • Located downtown, in the midst of exciting activities.
    Updated: Jun 30, 2025
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    Mixed-Use Commercial Space Available
    $1,900 / Mo

    Mixed-Use Commercial Space Available

    Versatile storefront and warehouse space in downtown Cape Girardeau.

    2117 Broadway St, Cape Girardeau, MO 63701
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    Historic Art Deco Landmark Space
    $2,900 / Mo

    Historic Art Deco Landmark Space

    Restored historic building in downtown Cape Girardeau's commercial district.

    824 Broadway St, Cape Girardeau, MO 63701
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    Prime Retail/Office Space Available
    Contact for pricing

    Prime Retail/Office Space Available

    New 2,300 SF space ideal for retail or office.

    3465 William St, Cape Girardeau, MO 63703
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    New Development Retail Space Available
    Contact for pricing

    New Development Retail Space Available

    Prime lease space with high visibility and build-out allowance.

    2510 Veterans Memorial Dr, Cape Girardeau, MO 63701
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    Retail Storefront with Office Space
    Contact for pricing

    Retail Storefront with Office Space

    Downtown retail storefront with office space for rent.

    221 Merriwether St, Cape Girardeau, MO 63703
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    Retail Space in High Traffic Area
    $1,440 / Mo
    34,761 SF

    Retail Space in High Traffic Area

    Retail space in Jackson, MO with high visibility.

    2931 E Jackson Blvd, Jackson, MO 63755
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    Retail Space Near West Park
    Contact for pricing
    7,908 SF

    Retail Space Near West Park

    Retail space in regional shopping hub with easy Interstate access.

    3047 William St, Cape Girardeau, MO 63703
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    Retail Space Near West Park
    Contact for pricing
    4,970 SF

    Retail Space Near West Park

    Retail space in regional shopping hub with high visibility.

    3036-3048 William St, Cape Girardeau, MO 63703
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    Retail Space Near West Park
    Contact for pricing
    1,595 SF

    Retail Space Near West Park

    Retail space available in regional shopping hub near West Park.

    240-250 S Silver Springs Rd, Cape Girardeau, MO 63703
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    Retail Space Near Interstate 55
    Contact for pricing
    10,800 SF

    Retail Space Near Interstate 55

    Retail space in regional shopping hub with interstate access.

    258 Siemers Dr, Cape Girardeau, MO 63701
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    Regional Shopping Center Near I-55
    Contact for pricing
    9,400 SF

    Regional Shopping Center Near I-55

    Regional shopping center with easy access to Interstate 55.

    155-157 Siemers Dr, Cape Girardeau, MO 63701
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    Retail Space Near St. Francis
    Contact for pricing
    3,154 SF

    Retail Space Near St. Francis

    Retail space available across from St. Francis Medical Center.

    3049 Williams St, Cape Girardeau, MO
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    Retail Space in High-Traffic Location
    $1,440 / Mo

    Retail Space in High-Traffic Location

    Retail space with signage, parking, and delivery entrance available for lease.

    2931 E Jackson Blvd, Jackson, MO 63755
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    West Park Mall Medical Office Space
    Contact for pricing
    79,122 SF

    West Park Mall Medical Office Space

    Missouri medical office suites for lease

    3049 William St, Cape Girardeau, MO 63703
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    West Park Strip Center Retail Space
    Contact for pricing
    23,464 SF

    West Park Strip Center Retail Space

    High-traffic retail center; two spaces available.

    250 Silver Springs Rd, Cape Girardeau, MO 63703
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    Lambert Plaza Retail Space
    Contact for pricing
    46,692 SF

    Lambert Plaza Retail Space

    Cape Girardeau, MO Retail Opportunity

    155 Siemers Dr, Cape Girardeau, MO 63701
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    Based on your search, we've compiled 43 Potential Opportunities for your consideration. Besides 18 Active listings in Cape Girardeau County, MO, we suggest exploring alternatives. Similar 25 Properties for Sales.

    Explore Similar Spaces for Sale in Cape Girardeau County, MO

    Consider Similar Space for Sale. We found 25 Spaces in Nearby Locations matching your search parameters.

    Mixed-Use Building in Prime Location
    $990,000
    7,000 SF

    Mixed-Use Building in Prime Location

    Turn-key mixed-use building with highway frontage and high traffic potential.

    246 W Deerwood Dr, Jackson, MO 63755
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    Unique Mixed-Use Property with Treehouse
    $962,000
    2,500 SF

    Unique Mixed-Use Property with Treehouse

    Exceptional property with residence, treehouse venue, and shop potential.

    4940 County Road 532, Jackson, MO 63755
    View details
    Versatile Riverfront Commercial Property
    Pending
    $475,000
    7,044 SF

    Versatile Riverfront Commercial Property

    Flexible commercial space with riverfront location and development potential.

    308 N Main St, Cape Girardeau, MO 63701
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    Versatile Riverfront Commercial Property
    Pending
    $400,000
    4,400 SF

    Versatile Riverfront Commercial Property

    Prime riverfront property suitable for office, restaurant, warehouse, or mixed-use.

    450 N Main St, Cape Girardeau, MO 63701
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    Versatile Commercial Space in Missouri
    $900,000
    7,396 SF

    Versatile Commercial Space in Missouri

    7,396 SF commercial building with banquet, dining, and bar areas.

    20 N Spanish St, Cape Girardeau, MO 63701
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    Cape Girardeau Flex Space Building
    $299,900
    5,000 SF

    Cape Girardeau Flex Space Building

    5,000 sq ft building with concrete floors and possibilities.

    3188 Old Route V, Cape Girardeau, MO 63701
    View details

    Cape Girardeau County, MO Retail properties & Spaces Leasing Opportunities Market Analysis

    Explore Retail properties & Spaces leasing options in Cape Girardeau County, MO with 43 listings featured on our commercial real estate exchange. The current inventory includes 1,737,951,605 square feet of properties with an estimated lease value of $19 SF/Yr.

    Estimated lease rates for Retail properties & Spaces in Cape Girardeau County, MO begin at $0.50 SF/Yr, with an average of $6 SF/Yr and extend to $10 SF/Yr.
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