Hillsboro, MO Office Spaces for sale

Updated: Aug 24

Brick Office Building

405 Main Street, Hillsboro, MO 63050

$699,900

0.66 AC lot

Almost 10,000SF of finished office space
0.6554‑acre property
Across the street from the County Courthouse
Original building constructed in 1951; additional section built in 1967
Brick and brick veneer construction

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Updated: Nov 11, 2025

Office Building with Kitchen Area

114 Main Street, Hillsboro, MO 63050

$426,900

2,772 sqft 0.51 AC lot

2,772‑square‑foot office building on a 0.51‑acre lot
Across from City Hall and one block from the courthouse
Recently updated interior with functional kitchen area
Brick construction with flat roof
Forced‑air natural gas heat and central air conditioning

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Brick Storefront Building

10550 Business 21, Hillsboro, MO 63050

$299,000

0.27 AC lot

Corner commercial property with office accommodations, customer reception, kitchenette, and highway frontage in Hillsboro.

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Office Building

405 Main Street, Hillsboro, MO 63050

$699,900

9,810 sqft

Finished interior space supports office occupancy, with building systems in working order.

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Commercial Property Near City Hall

114 Main St, Hillsboro, MO 63050

$426,900

2,772 sqft 0.50 AC lot

Updated commercial property with large lot near government buildings.

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5 active listings match your search: Office for sale in Hillsboro, MO. Based on your search, we've also compiled 47 Potential Opportunities for your consideration: 4 properties in nearby cities, 39 off-market properties to explore as potential leads, and 4 land listings with development potential.

Opportunities in Nearby Cities

Here are 4 Similar properties we found in Nearby Locations for your consideration.

Medical Office Building

500 Sunshine Drive, Festus, MO 63028

$365,900

4,476 sqft

A 20-room layout with five bathrooms supports a range of healthcare and wellness configurations.

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Medical Office Building

126 S Main St, De Soto, MO 63020

$325,000

0.14 AC lot

The interior combines private work areas with a large open room, lab space, and two commercial restrooms.

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Flex Office/Warehouse with Dock-High Bay

622 Collins Dr, Festus, MO 63028

Contact for pricing

10,000 sqft 0.74 AC lot

Two-story flex office/warehouse with a dock-high bay, reception area, private offices, and climate-controlled office space.

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Medical Office with Flexible Layout

126 S Main St, De Soto, MO 63020

$325,000

The interior combines reception and waiting areas with a large open room and space for as many as eight offices.

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Potential Development Sites for Consideration

Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

Commercial Land with Highway Access

3 Cedric Station, Cedar Hill, MO 63016

$349,620

0.99 AC lot

Commercial parcel with public water and sewer access, plus cable availability.

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Commercial Land Near Highway Access

2 Cedric Station, Cedar Hill, MO 63016

$291,740

0.80 AC lot

Commercial-zoned development site with public water, public sewer, and cable availability.

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Commercial Land with Dual Frontage

6250 Upper Byrnes Mill Road, Byrnes Mill, MO 63051

$600,000

3.35 AC lot

Commercially zoned acreage with access from two roadways and cable availability.

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Commercial Land with Alley Access

306 N State Street, Desloge, MO 63601

$175,000

0.86 AC lot

Commercial parcel with street frontage, rear alley access, and public water and sewer.

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Off-Market Properties in Hillsboro, MO

Consider similar Off-Market properties in Hillsboro, MO. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.