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    Hillsboro, MO Office Spaces for Sale

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    Dittmer, MO De Soto, MO Cedar Hill, MO Mapaville, MO House Springs, MO Grubville, MO Richwoods, MO Festus, MO
    Brick Office Building
    Updated: Jul 28
    Brick Office Building

    405 Main Street, Hillsboro, MO 63050

    $795,000
    0.66 AC lot
    Almost 10,000SF of finished office space
    0.6554‑acre property
    Across the street from the County Courthouse
    Original building constructed in 1951; additional section built in 1967
    Brick and brick veneer construction
    View details
    Office Building with Kitchen Area
    Updated: Nov 11, 2025
    Office Building with Kitchen Area

    114 Main Street, Hillsboro, MO 63050

    $426,900
    2,772 sqft 0.51 AC lot
    2,772‑square‑foot office building on a 0.51‑acre lot
    Across from City Hall and one block from the courthouse
    Recently updated interior with functional kitchen area
    Brick construction with flat roof
    Forced‑air natural gas heat and central air conditioning
    View details
    Brick Storefront Building
    Brick Storefront Building

    10550 Business 21, Hillsboro, MO 63050

    $299,000
    0.27 AC lot

    Corner commercial property with office accommodations, customer reception, kitchenette, and highway frontage in Hillsboro.

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    Turn a Listing Into an Investment Snapshot Cap Rate, Potential NOI, Demand score for every listing. Go To Analytics Center
    Commercial Property Near City Hall
    Commercial Property Near City Hall

    114 Main St, Hillsboro, MO 63050

    $426,900
    2,772 sqft 0.50 AC lot

    Updated commercial property with large lot near government buildings.

    View details
    Based on your search, we've compiled 51 Potential Opportunities for your consideration. Besides 4 Active listings in Hillsboro, MO, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 39 Off-Market properties to explore as potential leads, plus 4 Land Listings that present a potential for development.

    Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    Two-Story Flex Office/Warehouse
    Two-Story Flex Office/Warehouse

    622 Collins Drive, Festus, MO 63028

    $875,000
    0.74 AC lot

    CT1-zoned property combines climate-controlled offices with warehouse space, loading access, paved parking, and established utility infrastructure.

    View details
    Professional Office Building
    Professional Office Building

    3601 Commerce Drive, Arnold, MO 63010

    $950,000
    0.75 AC lot

    Flexible office property with central air and convenient access just off Interstate 55.

    View details
    Mixed-Use Building with Garage
    Mixed-Use Building with Garage

    11 S 2nd Street, Festus, MO 63028

    $269,999
    0.16 AC lot

    Flexible commercial layout with unfinished second-floor space, off-street parking, and an attached garage.

    View details
    Office Building with Highway Access
    Office Building with Highway Access

    3675 W Outer Road, Arnold, MO 63010

    Contact for pricing
    25,558 sqft

    Office building offering strong visibility and convenient access supported by high daily vehicle counts on nearby roadways.

    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Commercial Land with Highway Access
    Commercial Land with Highway Access

    3 Cedric Station, Cedar Hill, MO 63016

    $349,620
    0.99 AC lot

    Commercial parcel with public water and sewer access, plus cable availability.

    View details
    Commercial Land Near Highway Access
    Commercial Land Near Highway Access

    2 Cedric Station, Cedar Hill, MO 63016

    $291,740
    0.80 AC lot

    Commercial-zoned development site with public water, public sewer, and cable availability.

    View details
    Commercial Land with Dual Frontage
    Commercial Land with Dual Frontage

    6250 Upper Byrnes Mill Road, Byrnes Mill, MO 63051

    $600,000
    3.35 AC lot

    Commercially zoned acreage with access from two roadways and cable availability.

    View details
    Commercial Land with Alley Access
    Commercial Land with Alley Access

    306 N State Street, Desloge, MO 63601

    $175,000
    0.86 AC lot

    Commercial parcel with street frontage, rear alley access, and public water and sewer.

    View details

    Off-Market Properties in Hillsboro, MO

    Consider similar Off-Market properties in Hillsboro, MO. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    304 Locust St
    OFFICE (GENERAL)

    304 Locust St, Hillsboro, MO 63050-4346

    Estimated value:
    $270,000
    0.25 AC lot
    View details
    535 Elm St
    OFFICE (GENERAL)

    535 Elm St, Hillsboro, MO 63050-4322

    Estimated value:
    $310,000
    980 sqft 1.41 AC lot
    View details
    10770 Business 21
    OFFICE (GENERAL)

    10770 Business 21, Hillsboro, MO 63050-5075

    Estimated value:
    $250,000
    1,708 sqft 0.30 AC lot
    View details
    638 1st St
    OFFICE (GENERAL)

    638 1st St, Hillsboro, MO 63050-4306

    Estimated value:
    $250,000
    960 sqft 0.42 AC lot
    View details
    10940 State Rte 21
    OFFICE (GENERAL)

    10940 State Rte 21, Hillsboro, MO 63050-5003

    Estimated value:
    $270,000
    1,456 sqft 1.32 AC lot
    View details
    114 Main St
    OFFICE (GENERAL)

    114 Main St, Hillsboro, MO 63050-5081

    Estimated value:
    $260,000
    2,772 sqft 0.51 AC lot
    View details
    102 4th St
    OFFICE (GENERAL)

    102 4th St, Hillsboro, MO 63050-5043

    Estimated value:
    $290,000
    5,411 sqft 0.49 AC lot
    View details
    428 Vreeland Rd
    OFFICE (GENERAL)

    428 Vreeland Rd, Hillsboro, MO 63050-5091

    Estimated value:
    $260,000
    2,586 sqft 1.16 AC lot
    View details
    10626 Business 21
    OFFICE (GENERAL)

    10626 Business 21, Hillsboro, MO 63050-4939

    Estimated value:
    $260,000
    1,920 sqft 0.20 AC lot
    View details
    5998 State Rd B B
    OFFICE (GENERAL)

    5998 State Rd B B, Hillsboro, MO 63050-3046

    Estimated value:
    $265,000
    2,920 sqft 1.14 AC lot
    View details
    415 Vreeland Rd
    OFFICE (GENERAL)

    415 Vreeland Rd, Hillsboro, MO 63050-5087

    Estimated value:
    $255,000
    1,350 sqft 0.31 AC lot
    View details
    10570 Business 21
    OFFICE (GENERAL)

    10570 Business 21, Hillsboro, MO 63050-5088

    Estimated value:
    $445,000
    3,480 sqft 0.69 AC lot
    View details
    10752 Business 21
    OFFICE (GENERAL)

    10752 Business 21, Hillsboro, MO 63050-5075

    Estimated value:
    $260,000
    2,632 sqft 0.26 AC lot
    View details
    10632 Business 21
    OFFICE (GENERAL)

    10632 Business 21, Hillsboro, MO 63050-5039

    Estimated value:
    $280,000
    0.79 AC lot
    View details
    411 Maple Ln
    OFFICE (GENERAL)

    411 Maple Ln, Hillsboro, MO 63050-4363

    Estimated value:
    $275,000
    3,100 sqft 0.30 AC lot
    View details
    401 1st St
    OFFICE (GENERAL)

    401 1st St, Hillsboro, MO 63050-4374

    Estimated value:
    $270,000
    2,668 sqft 0.10 AC lot
    View details
    10450 Business 21
    OFFICE (GENERAL)

    10450 Business 21, Hillsboro, MO 63050-5809

    Estimated value:
    $350,000
    5,828 sqft 0.78 AC lot
    View details
    349 Main St
    OFFICE (GENERAL)

    349 Main St, Hillsboro, MO 63050-4371

    Estimated value:
    $280,000
    0.46 AC lot
    View details
    10550 Business 21
    OFFICE (GENERAL)

    10550 Business 21, Hillsboro, MO 63050-5088

    Estimated value:
    $270,000
    0.27 AC lot
    View details
    10890 Business 21
    OFFICE (GENERAL)

    10890 Business 21, Hillsboro, MO 63050-5002

    Estimated value:
    $275,000
    4,403 sqft 0.54 AC lot
    View details

    Hillsboro, MO Office Spaces Market Trends and Statistics

    Explore 43 office spaces for sale in Hillsboro, MO, showcased through 4 active listings on our real estate platform. These investment opportunities span a total of 5,544 square feet of properties for sale, with an estimated market value of $1,947,800.

    Sale prices for office spaces in Hillsboro, MO start at $299,000, averaging $486,950, and reaching up to $795,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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    Top Commercial Asset Segments

    Commercial property segments ranked by active listings on the market

    Office Units 5
    Office buildings 2
    Medical Office Space 1

    Demographics Overview

    Population 18K
    Population Growth (5Y) +10.9%
    Median Household Income $79,462
    College Educated 26.8%

    High-Yield Neighborhoods for Investment

    Identify Hillsboro submarkets with the highest inventory density on the market and evaluate the average listing prices of real estate assets

    Neighborhood Average Price
    63050 $487K

    Taxes & Financing

    Average Loan-to-Value 65.0%

    Listings Trend

    New vs delisted commercial listings in Jefferson County

    New Delisted

    Total CRE Inventory on Market (SF)

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