Onondaga County, NY Office Spaces for Rent & Lease

Updated: Aug 10

Retail Space with Central Air

4455A E Genesee Street, Syracuse, NY 13214

$1,300/Mo

14,760 sqft 0.86 AC lot

14,760‑square‑foot retail property on a 0.86‑acre parcel
Multiple listed use options, including retail, office, service, gallery, studio, and take‑out food service
Central air conditioning and natural gas forced‑air heating
Public water and public sewer
Built in 1963 with a flat roof

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Updated: Jul 15

Class A Office Suite

5710 Commons Park, East Syracuse, NY 13057

$1,850/Mo

950 sqft 2.04 AC lot

950 SF Suite 103 in a one‑story Class A professional building
2.04‑acre property near Widewaters Parkway and the Erie Canal trail
Gross lease with landlord‑paid heat, air conditioning, and electricity
Shared restrooms, conference room access, remodeled kitchen, and outdoor patio
Approximately four minutes from major highways

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Office Suite with Elevator

5099 W GENESEE Street, Camillus, NY 13031

$25 SF/Yr

2,278 sqft 0.62 AC lot

Accessible elevator service, two bathrooms and a galley kitchen serve the office suite.

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Creative Space With Roof Access

308 W Genesee St, Syracuse, NY 13202

$10,000/Mo

11,220 sqft

Second-floor shell space offers large windows, flexible build-out potential, and access to a rooftop outdoor area.

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Mixed-Use Building with Diner

3604 Court Street, Syracuse, NY 13206

Contact for pricing

5,351 sqft 0.41 AC lot

Includes a mechanic garage and one-bedroom apartment under the same roof.

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End-Cap Office Suite

6253 Rt-31, Cicero, NY 13039

$2,275/Mo

1,300 sqft 0.95 AC lot

The layout provides four private offices, a reception area, and a dedicated restroom.

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Creative Office/Retail Space

112 Wilkinson Street, Syracuse, NY 13204

$8 SF/Yr

12,500 sqft

Second-floor creative office and retail space offers natural light and a flexible blank-canvas layout.

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Multi-Suite Retail Space

7570 Oswego Road, Clay, NY 13090

$3,052-$11,540/Mo

5,770 sqft

Three contiguous suites offer flexible retail configuration with landlord-considered combination options and on-site parking.

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Office Unit with Private Offices

8289 Loop Road, Lysander, NY 13027

$2,000/Mo

1,600 sqft

Office suite with reception, break room, storage, and accessible restroom facilities.

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Furnished Office Units with Parking

580 South Salina Street, Syracuse, NY 13202

$11.67-$14 SF/Yr

3,600 sqft

CBD-zoned office premises with optional furniture, basement storage, and exterior signage opportunities.

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Medical Office Suite with Dental Layout

5102 W Genesee St, Camillus, NY 13031

$16 SF/Yr

1,200 sqft

Existing dental configuration supports medical, professional, or general office use with build-to-suit flexibility.

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End-Cap Office Suite

6253 State Route 31, Cicero, NY 13039

$2,275/Mo

1,300 sqft

The suite pairs private offices with a reception area and private restroom.

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Flexible Office Building with Windows

6575 Kirkville Road, East Syracuse, NY 13057

$16.50 SF/Yr

3,306 sqft

A 2005-built office building with large floor-to-ceiling windows and a layout that can be modified to tenant needs.

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Office Unit with Outdoor Patio

Dewitt, NY 13057

$1,850/Mo

950 sqft

One-story professional office space with conference room access, shared restrooms, and convenient parking.

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Medical Office Space Available

792 North Main Street, North Syracuse, NY 13212

$18.50 SF/Yr

5,126 sqft

5,126 SF medical office suite for lease.

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Class A Office Suites Available

225 Greenfield Parkway, Liverpool, NY 13088

$17.95 SF/Yr

7,092 sqft

Modern office suites with ample natural light near major highways.

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Open-Plan Office Suite

36 Oswego Suite 204, Lysander, NY 13027

$900/Mo

Hardwood flooring, exposed HVAC ductwork, and overhead lighting define the interior.

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Office Suite with Exposed Ductwork

36 Oswego Suite 202, Lysander, NY 13027

$700/Mo

An open-plan layout pairs hardwood floors with overhead lighting and exposed HVAC ductwork.

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Corner Office Unit

447 East Washington Street, Syracuse, NY 13202

$3,000/Mo

Ground-level commercial space combines an adaptable open area with separate private and public restrooms.

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Office Suite with Exposed Ductwork

36 Oswego Street Suite 301, Lysander, NY 13027

$1,800/Mo

An open-plan workspace pairs hardwood floors with overhead lighting and visible HVAC ductwork.

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Office Suite with Brick Fireplace

36 Oswego Suite 207, Lysander, NY 13027

$950/Mo

An open-plan workspace pairs hardwood floors with exposed HVAC ductwork and a brick fireplace.

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Iconic Mixed-Use State Tower

109 South Warren Street, Syracuse, NY 13202

$18.50 SF/Yr

23,201 sqft

Mixed-use property with office, residential, and retail spaces available.

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Open-Plan Office Suite

36 Oswego Suite 203, Lysander, NY 13027

$950/Mo

An adaptable interior features hardwood floors, overhead lighting, and exposed HVAC ductwork.

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Class A Office Space Available

5015 Campuswood Drive, East Syracuse, NY 13057

$18.50 SF/Yr

54,392 sqft

Class A office suites for lease in Pioneer Business Park.

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Onondaga County, NY Office Spaces Market Trends and Statistics

Explore Office Spaces leasing options in Onondaga County, NY with 103 listings featured on our commercial real estate exchange. The current inventory includes 1,085,498 square feet of properties with an estimated lease value of $528.67.

Estimated lease rates for Office Spaces in Onondaga County, NY begin at $1.06 SF/Yr, with an average of $17.05 SF/Yr and extend to $25 SF/Yr.