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    Onondaga County, NY Office Spaces for Sale

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    Brooklyn, NY New York, NY Bronx, NY
    44 results
    North Syracuse Medical Office Building
    $400,000
    2,244 SF
    North Syracuse Medical Office Building

    105 N Main Street, Syracuse, NY 13212

    Well-maintained medical office in a high-growth area.
    • New roof installed in 2024 significantly reduces capital expenditure risk.
    • High‑visibility location on North Main Street with 15 dedicated parking spaces.
    • Professionally designed 2,244 SF medical office layout with reception, retail, exam rooms, offices, and lab.
    • Zoned for medical and professional office use, suitable for various practices.
    • Located in the rapidly growing Central New York economic corridor, near the Micron Technology facility.
    Updated: May 19
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    Versatile Commercial/Industrial Building, Syracuse
    $379,000
    4,408 SF
    Versatile Commercial/Industrial Building, Syracuse

    6730 Townline Road, Syracuse, NY 13211

    4,408 sq ft commercial/industrial building in a busy area.
    • 4,408 sq ft commercial/industrial building in a busy commercial‑industrial area
    • Flexible layout with 6 front offices, cafeteria/break room, and large rear meeting/conference area with 2 additional bathrooms
    • 25' x 38' shop area with large compressor and air lines
    • Front and rear parking for approx. 12 vehicles with potential for additional parking
    • Multi‑zone heating and air conditioning
    Updated: Nov 21, 2025
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    Prime Commercial Land I-81 Exit
    $300,000
    1.04 Acres
    Prime Commercial Land I-81 Exit

    High-visibility commercial land parcel off I-81 exit.

    515 State Route 281, Tully, NY 13159

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    610 Oak St, Syracuse
    $425,000
    6,755 SF
    610 Oak St, Syracuse

    Historic Firehouse Converted to Office Space

    610 Oak St, Syracuse, NY 13203

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    Nedrow Office Building For Sale
    $250,000
    2,458 SF
    Nedrow Office Building For Sale

    Office building in high-traffic area with parking and storage.

    7106 S Salina Street, Nedrow, NY 13120

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    Syracuse Commercial Building For Sale
    $250,000
    1,920 SF
    Syracuse Commercial Building For Sale

    Commercial building with heated warehouse space and office, Syracuse, NY.

    401 Wolf St, Syracuse, NY 13208

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    Converted Firehouse in Syracuse, NY
    $425,000
    7,000 SF
    Converted Firehouse in Syracuse, NY

    Retail space near downtown.

    610 Oak St, Syracuse, NY 13203

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    Syracuse Flex Space Opportunity
    $89,000
    1,912 SF
    Syracuse Flex Space Opportunity

    1912 SF flex space near Syracuse and major routes.

    1455 Burnet Ave, Syracuse, NY 13206

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    Cicero Commercial Redevelopment Opportunity
    $3,500,000
    31,899 SF
    Cicero Commercial Redevelopment Opportunity

    13.37 acres with existing warehouse, flex, and office improvements.

    8574 Brewerton Rd, Cicero, NY 13039

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    Charming Cape Cod in Liverpool
    $164,900
    0.33 Acres
    Charming Cape Cod in Liverpool

    Rare B2 zoning, ample parking, ready for niche business.

    209 Hazel St, Salina, NY 13088

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    Modern Class A Office Building
    $4,500,000
    40,625 SF
    Modern Class A Office Building

    40,625 SF office building ideal for medical or conventional use.

    5062 Brittonfield Pkwy, East Syracuse, NY

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    Manlius Village Redevelopment Opportunity
    $2,450,000
    13,000 SF
    Manlius Village Redevelopment Opportunity

    Two mixed-use properties with redevelopment potential in the heart of Manlius.

    108 Washington St, Manlius, NY 13104

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    Medical Office Building For Sale
    $1,800,000
    10,000 SF
    Medical Office Building For Sale

    10,000 SF medical office building with available space.

    5639 W Genesee St, Camillus, NY 13031

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    Class A Office Building
    $13,000,000
    45,450 SF
    Class A Office Building

    Net leased office building with bank branch and lower level.

    6611 Manlius Center Road, East Syracuse, NY 13057

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    Versatile Flex Building with Storage
    $899,000
    15,800 SF
    Versatile Flex Building with Storage

    15,800± SF flex building with industrial outside storage.

    559 State Fair Blvd, Syracuse, NY 13204

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    Manufacturing Warehouse with Office Space
    $2,920,000
    30,000 SF
    Manufacturing Warehouse with Office Space

    30,000 SF manufacturing/warehouse with 8,000 SF office space.

    6250 E Molloy Rd, East Syracuse, NY

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    Fully Leased Syracuse Industrial Facility
    $1,200,000
    12,000 SF
    Fully Leased Syracuse Industrial Facility

    12,000 SF industrial facility in Syracuse's industrial corridor.

    532 State Fair Blvd, Syracuse, NY 13204

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    Turnkey Restaurant and Office Space
    $495,000
    0.17 Acres
    Turnkey Restaurant and Office Space

    4,800 SF property with restaurant and office space.

    407 Tulip St, Salina, NY 13088

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    Multi-Tenant Office Building For Sale
    $990,000
    20,808 SF
    Multi-Tenant Office Building For Sale

    Multi-tenant office building with potential sale/leaseback opportunity.

    990 James St, Syracuse, NY 13203

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    Fully Leased Syracuse Industrial Portfolio
    $2,900,000
    42,776 SF
    Fully Leased Syracuse Industrial Portfolio

    Two-building industrial investment totaling 42,776 SF on 2.64 acres.

    113 Falso Dr, Syracuse, NY 13211

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    S Salina St Office Building
    $249,900
    2,562 SF
    S Salina St Office Building

    Office building on a major commercial thoroughfare, great investment.

    4709 S Salina St, Syracuse, NY

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    Downtown Syracuse Office Building
    $3,567,324
    26,000 SF
    Downtown Syracuse Office Building

    26,000 SF office building for sale in Syracuse.

    359 S Salina St, Syracuse, NY

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    Erie Boulevard Office Space For Sale
    $1,500,000
    6,000 SF
    Erie Boulevard Office Space For Sale

    Office space for sale on a high-traffic retail corridor.

    3125 Erie Blvd E, Syracuse, NY

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    Office Buildings with Income Potential
    $2,400,000
    29,600 SF
    Office Buildings with Income Potential

    Two office buildings with anchor tenant and additional income.

    1000 & 1020 Seventh North Street, Liverpool, NY 13088

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    Onondaga County, NY Office Spaces Investment Opportunities Market Analysis

    Explore 72 office spaces for sale in Onondaga County, NY, showcased through 44 active listings on our real estate platform. These investment opportunities span a total of 731,780 square feet of properties for sale, with an estimated market value of $62,436,024.

    Sale prices for office spaces in Onondaga County, NY start at $89,000, averaging $1,643,053, and reaching up to $13,000,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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