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    Waltham, MA Office Spaces for Lease

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    Second-Floor Office Suite For Rent
    Updated: Apr 25
    Second-Floor Office Suite For Rent

    49 River St, Waltham, MA 02453

    $25 SF/Yr
    3,400 sqft
    ±3,400 SF office suite ideal for professional, medical, or service‑based users.
    Flexible layout with a mix of private offices, open work areas, and conference space.
    Option to remove the demising wall for a fully connected floor plan.
    Includes two restrooms and dedicated storage.
    Previously operated as a single unit, indicating a proven functional layout.
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    Waltham Medical Commercial Condo Unit
    Updated: May 19
    Waltham Medical Commercial Condo Unit

    20 Hope Avenue #208, Waltham, MA 02452

    $3,500/Mo
    1,156 sqft
    Recently renovated and updated medical commercial condo unit.
    Prime, convenient location just off major highways and routes in Waltham.
    Ideal for medical or medical‑like use with check‑in area, waiting room, private office, two treatment rooms, two exam rooms, and large restroom.
    Handicap and elevator access.
    Excellent rental history.
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    Downtown Main Street Medical Office
    Downtown Main Street Medical Office

    649 Main Street, Waltham, MA 02451

    $27 SF/Yr
    3,890 sqft

    Renovated two-story suite with ADA-compliant restrooms, private treatment/offices, and separate rear access for flexible healthcare use.

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    Freestanding Retail/Office Flex Building
    Freestanding Retail/Office Flex Building

    305 2nd Ave 1, Waltham, MA 02452

    $38 SF/Yr
    8,000 sqft

    Standalone flex layout supports a mix of retail, office, medical, or service uses with major highway access.

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    Renovated Office Space on Moody
    Renovated Office Space on Moody

    280 Moody St, Waltham, MA 02453

    $25 SF/Yr
    5,500 sqft

    Renovated office space for lease on vibrant Moody Street.

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    Waltham Office Building For Rent
    Waltham Office Building For Rent

    296 Newton St, Waltham, MA 02453

    $23 SF/Yr
    13,000 sqft

    Full building or individual suites available near Moody Street.

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    Waltham Office Suite For Rent
    Waltham Office Suite For Rent

    440 Totten Pond Rd, Waltham, MA 02451

    $2,500/Mo
    1,547 sqft

    1547 SF office suite in Waltham, ample parking.

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    Waltham Freestanding Commercial Building
    Waltham Freestanding Commercial Building

    1273-1275 Main Street, Waltham, MA 02451

    Contact for pricing
    11,416 sqft

    Versatile 11,416 SF building suitable for office, retail, industrial.

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    Office Suite with Kitchenette
    Office Suite with Kitchenette

    400 5th Ave, Waltham, MA 02451

    $34.50 SF/Yr
    5,317 sqft

    Suite offers private offices, conference space, and a dedicated break area with kitchenette in a commuter-accessible setting.

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    Office Suite with Private Offices
    Office Suite with Private Offices

    400 5th Ave, Waltham, MA 02451

    $34 SF/Yr
    5,317 sqft

    Office suite includes private offices, open work areas, conference rooms, and a kitchenette break area.

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    Flex Office Suite with 12-Foot Ceilings
    Flex Office Suite with 12-Foot Ceilings

    25 Fox Rd, Waltham, MA 02451

    Contact for pricing
    4,000 sqft

    Flex office space with 12-foot ceiling heights and parking, suited for light industrial and office use.

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    LEED Gold Laboratory Office Building
    LEED Gold Laboratory Office Building

    300 Third Avenue, Waltham, MA 02451

    Contact for pricing
    106,422 sqft

    Class A lab and office space with LEED Gold certification, high floor-to-floor clearances, and ready infrastructure for tenant build-out.

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    Office Flex and R&D Space
    Office Flex and R&D Space

    187 Lexington St, Waltham, MA 02452

    Contact for pricing
    18,154 sqft

    Sublease offering warehouse space with high ceilings, drive-in access, and second-floor offices with dedicated kitchen amenities.

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    Waltham Office Suite For Rent
    Waltham Office Suite For Rent

    85 River Street, Waltham, MA 02453

    $25 SF/Yr

    Office suite available at Colonial Shopping Center in Waltham.

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    Flex/R&D Sublease with Loading
    Flex/R&D Sublease with Loading

    62 4th Ave, Waltham, MA 02451

    Contact for pricing
    30,000 sqft

    Flexible space blends offices and R&D, with drive-in and dock loading plus substantial power and backup generation.

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    Turnkey Office Suite
    Turnkey Office Suite

    103-740 Main St, Waltham, MA 02453

    $1,350/Mo

    Light-filled second-floor suite with private offices and turnkey setup in a professionally managed building.

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    Waltham Office Building For Rent
    Waltham Office Building For Rent

    1100 Winter St, Waltham, MA

    $25 SF/Yr
    31,040 sqft

    Four-story office building in Waltham, overlooking the Cambridge Reservoir.

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    Waltham Office Suite For Rent
    Waltham Office Suite For Rent

    740 Main St #103, Waltham, MA 02451

    $1,350/Mo

    Centrally located, light-filled office suite with off-street parking.

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    Modern Office Space Available
    Modern Office Space Available

    1601 Trapelo Road, Waltham, MA 02451

    Contact for pricing
    8,539 sqft

    Furnished office space with amenities, convenient location, and discounted rate.

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    4th-Floor Office Suite
    4th-Floor Office Suite

    480 Totten Pond Rd, Waltham, MA 02451

    Contact for pricing
    14,552 sqft

    Flexible office suite with direct elevator access in a highly amenitized building near major expressways.

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    Amenity-Rich Office Campus in Waltham
    Amenity-Rich Office Campus in Waltham

    910 Winter Street, Waltham, MA 02451

    Contact for pricing
    150,000 sqft

    Vibrant corporate campus near high-tech hub with shuttle service.

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    Versatile Retail/Warehouse/Office Space
    Versatile Retail/Warehouse/Office Space

    1256 Main St #L, Waltham, MA 02451

    $17 SF/Yr
    3,000 sqft

    Adaptable commercial space with retail, warehouse, and office potential.

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    Waltham Office Sublease Opportunity
    Waltham Office Sublease Opportunity

    300 5th Ave, Waltham, MA 02451

    Contact for pricing
    4,800 sqft

    4,800 SF office space available for sublease in Waltham.

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    Waltham Office Sublease Opportunity
    Waltham Office Sublease Opportunity

    230 3rd Ave, Waltham, MA 02451

    Contact for pricing
    7,394 sqft

    7,394 SF office space available for sublease in Waltham.

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    Waltham, MA Office Spaces Market Trends and Statistics

    Explore Office Spaces leasing options in Waltham, MA with 75 listings featured on our commercial real estate exchange. The current inventory includes 319,707 square feet of properties with an estimated lease value of $729.45 /Mo.

    Estimated lease rates for Office Spaces in Waltham, MA begin at $17 SF/Yr, with an average of $34.74 SF/Yr and extend to $140.73 SF/Yr.
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    Most Searched ZIP Codes in Waltham, MA

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    • 02453
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