Waltham, MA Office Spaces for Rent & Lease

Cost-Efficient Office Space at Waltham center. Contact us today to book a tour!

303 Wyman St, Unit 300, Waltham, MA 02451

16 available spaces from 11 to 1,969 sqft

$129-$40,240/Mo per office

(972) 764-8885

Flexible workspace in Waltham center. Book a tour & get info

View details

Updated: Oct 16

Multi-Suite Office Space

88A Maple St, Waltham, MA 02453

$3,200/Mo

3,200 sqft

Approximately 3,200 SF of office space
Available as individual offices or the entire premises
Adjacent public parking; public transportation and major routes are nearby
BikeScore: 56; WalkScore: 59; TransitScore: 26
Built in 1955

View details

Updated: Jul 12

Renovated Two-Story Storefront

649 Main St, Waltham, MA 02451

$27 SF/Yr

3,890 sqft

±3,890 sq ft commercial building arranged across two floors
Recently renovated interior with open layout and expansive storefront windows
Multiple private offices or treatment rooms
Updated ADA‑compliant restroom
Rear service area with separate rear access

View details

First-Floor Office Suite

77 Rumford Ave, #1st flr, Waltham, MA 02453

$25 SF/Yr

2,700 sqft

A flexible workplace combines private rooms, meeting space, support areas, and an open work area in a multi-tenant building.

View details

Second-Floor Office and Studio Space

99 Cedar St, Waltham, MA 02453

$18 SF/Yr

2,500 sqft

Second-floor suite offers approximately 2,500 SF of open layout with dedicated bathroom and kitchen access.

View details

First-Floor Office Suite

1st-flr-77 Rumford Ave, Waltham, MA 02451

$25 SF/Yr

2,700 sqft

Private offices, meeting space, and support rooms complement an open work area in this multi-tenant building.

View details

Elevator-Served Office Suite

49 River St # 1, Waltham, MA 02453

$23 SF/Yr

3,788 sqft

The second-floor space has both front and rear building access for convenient entry.

View details

Two-Story Office Suite

77 Rumford Ave, Waltham, MA 02453

$25 SF/Yr

2,685 sqft

Office space in a mill building with on-site parking and nearby transit access.

View details

Second-Floor Office Suite

49 River St # 2, Waltham, MA 02453

$23 SF/Yr

969 sqft

Elevator service and entrances at both the front and rear support access to this office space.

View details

Second-Floor Office Suite

49 River St # 4, Waltham, MA 02453

$23 SF/Yr

1,270 sqft

A flexible professional suite offers access from both the front and rear of the building, with elevator service to the second floor.

View details

Office Units with Covered Parking

230 2nd Ave, Waltham, MA 02451

$26 SF/Yr

5,547 sqft

Two suites may be combined, with elevator access and most operating expenses included.

View details

Medical Office Suites with Parking

564 Main St, Waltham, MA 02452

$22 SF/Yr

1,400 sqft

Two elevator-served office suites offer internal rooms, reception space, and onsite parking.

View details

Second-Floor Office Suite For Rent

49 River St, Waltham, MA 02453

$25 SF/Yr

3,400 sqft

Office suite with flexible layout suitable for various operational needs.

View details

Second-Floor Office Unit

85 River St, Waltham, MA 02453

$25 SF/Yr

1,400 sqft

Turnkey commercial suite with a private bathroom and signage options for service, corporate, and professional uses.

View details

Waltham Office Suite for Lease

440 Totten Pond Rd, Waltham, MA 02451

$2,500/Mo

1,547 sqft

1547 SF office suite in Waltham, ample parking.

View details

Two-Level Office Units

195 West St, Waltham, MA 02451

Contact for pricing

8,000 sqft

Office and medical space available for sublease across the first and second floors with negotiable term.

View details

Medical Office Suite with Private Offices

32 South St 201-a, Waltham, MA 02453

$1,500/Mo

Reception area, multiple private offices, and open parking are provided.

View details

Fully Furnished Office Suite Sublease

271 Waverley Oaks Rd, Waltham, MA 02452

Contact for pricing

4,729 sqft 65.00 AC lot

Sublease a fully furnished office suite within a 65-acre campus that includes athletic, dining, and fitness amenities.

View details

Class A Life Science Office Building

21 Hickory Drive, Waltham, MA 02451

Contact for pricing

6,183 sqft

Recently converted office property with upgraded infrastructure for life science use in Waltham’s established corridor.

View details

Cafe with Shared Conference Space

1440 Main St, Waltham, MA 02451

Contact for pricing

7,484 sqft

Cafe suite includes full food service access to shared conference space, with ample on-site parking.

View details

Multi-Suite Office Property

1400 Main St, Waltham, MA 02451

Contact for pricing

5,354 sqft

Office space is available for lease in a range of configurations within a substantial commercial property.

View details

Waltham Office Suite For Rent

400 5th Ave, Waltham, MA 02451

$34 SF/Yr

5,317 sqft

5,317 SF office suite in accessible Route 128 location.

View details

Flex Office Suite with 12-Foot Ceilings

25 Fox Rd, Waltham, MA 02451

Contact for pricing

4,000 sqft

Flex office space with 12-foot ceiling heights and parking, suited for light industrial and office use.

View details

Class A Office and Lab Space

225 Wyman St, Waltham, MA 02451

Contact for pricing

14,602 sqft

Existing Class A office and lab space with in-building amenities including fitness, café, and conference facilities.

View details

Renovated Brick-and-Beam Flex Space

224 Calvary St, Waltham, MA 02453

Contact for pricing

5,267 sqft 2.15 AC lot

Updated commercial space supports office, R&D, and light lab uses in a connected urban setting.

View details

Waltham, MA Office Spaces Lease Rates & Market Statistics

Explore 91 Office Spaces for lease in Waltham, MA on Realmo, a commercial real estate exchange covering the Waltham area. The current inventory totals 2,632,080 square feet of properties — an average of ~28,900 SF per listing.

Asking lease rates for Office Spaces in Waltham start at $12 SF/Yr, average $24.28 SF/Yr, and reach $38 SF/Yr at the top of the market. That's a 3x spread between entry-level and premium space, making side-by-side comparison of asking rents and lease terms essential. The local average of $24.28 SF/Yr is 14% below the Massachusetts state average of $28.35 SF/Yr.

Waltham accounts for 8% of the 1,101 office spaces currently available across Middlesex County, where nearby markets include Cambridge and Burlington. By space type, the market includes 50 office units, 40 office buildings and 4 medical office space listings — medical office space options typically offer the lowest entry point, while office buildings command the highest rates.