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Waltham, MA Office Spaces for Lease

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132 properties
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Renovated Two-Story Storefront
Updated: Jul 12
Renovated Two-Story Storefront

649 Main St, Waltham, MA 02451

$27 SF/Yr
3,890 sqft
±3,890 sq ft commercial building arranged across two floors
Recently renovated interior with open layout and expansive storefront windows
Multiple private offices or treatment rooms
Updated ADA‑compliant restroom
Rear service area with separate rear access
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Second-Floor Office and Studio Space
Updated: Jun 12
Second-Floor Office and Studio Space

99 Cedar St, Waltham, MA 02453

$18 SF/Yr
2,500 sqft
Available for lease: +/- 2,500 SF second‑floor open‑concept suite
Suite includes dedicated bathroom and kitchen access
Two‑story commercial building with ample on‑site parking
Convenient access to routes I‑90 and 128
In close proximity to Waltham’s Moody St dining
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Flex Space with Loading Dock
Flex Space with Loading Dock

240 Bear Hill Rd, Waltham, MA 02451

$25 SF/Yr
6,754 sqft

Commercial availability combines office suites with dock access and on-site parking.

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Office Units with Covered Parking
Office Units with Covered Parking

230 2nd Ave, Waltham, MA 02451

$26 SF/Yr
5,547 sqft

Two suites may be combined, with elevator access and most operating expenses included.

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Medical Office Suites with Parking
Medical Office Suites with Parking

564 Main St, Waltham, MA 02452

$22 SF/Yr
1,400 sqft

Two elevator-served office suites offer internal rooms, reception space, and onsite parking.

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Second-Floor Office Suite For Rent
Second-Floor Office Suite For Rent

49 River St, Waltham, MA 02453

$25 SF/Yr
3,400 sqft

Office suite with flexible layout suitable for various operational needs.

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Second-Floor Office Unit
Second-Floor Office Unit

85 River St, Waltham, MA 02453

$25 SF/Yr
1,400 sqft

Turnkey commercial suite with a private bathroom and signage options for service, corporate, and professional uses.

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Waltham Office Suite for Lease
Waltham Office Suite for Lease

440 Totten Pond Rd, Waltham, MA 02451

$2,500/Mo
1,547 sqft

1547 SF office suite in Waltham, ample parking.

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Medical Office Suite with Private Offices
Medical Office Suite with Private Offices

32 South St 201-a, Waltham, MA 02453

$1,500/Mo

Reception area, multiple private offices, and open parking are provided.

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Cost-Efficient Office Space at Waltham center. Contact us today to book a tour!
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Class A Life Science Office Building
Class A Life Science Office Building

21 Hickory Drive, Waltham, MA 02451

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6,183 sqft

Recently converted office property with upgraded infrastructure for life science use in Waltham’s established corridor.

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Cafe with Shared Conference Space
Cafe with Shared Conference Space

1440 Main St, Waltham, MA 02451

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7,484 sqft

Cafe suite includes full food service access to shared conference space, with ample on-site parking.

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Multi-Suite Office Property
Multi-Suite Office Property

1400 Main St, Waltham, MA 02451

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5,354 sqft

Office space is available for lease in a range of configurations within a substantial commercial property.

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Waltham Office Suite For Rent
Waltham Office Suite For Rent

400 5th Ave, Waltham, MA 02451

$34 SF/Yr
5,317 sqft

5,317 SF office suite in accessible Route 128 location.

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Flex Office Suite with 12-Foot Ceilings
Flex Office Suite with 12-Foot Ceilings

25 Fox Rd, Waltham, MA 02451

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4,000 sqft

Flex office space with 12-foot ceiling heights and parking, suited for light industrial and office use.

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Class A Office and Lab Space
Class A Office and Lab Space

225 Wyman St, Waltham, MA 02451

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14,602 sqft

Existing Class A office and lab space with in-building amenities including fitness, café, and conference facilities.

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Office Space
Office Space

200 5th Ave, Waltham, MA 02451

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11,492 sqft

Office space is available for sublease through September 2029.

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Sublease Office Suite
Sublease Office Suite

179 Bear Hill Rd, Waltham, MA 02451

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3,171 sqft

Full office unit offers two offices, a conference room, and an in-suite kitchenette.

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Flexible Office Units with Conference Room
Flexible Office Units with Conference Room

179 Bear Hill Rd, Waltham, MA 02451

Contact for pricing
3,171 sqft

Modern office space offers call rooms, an in-suite kitchenette, and convenient access to I-95.

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Renovated Medical Office Condo
Renovated Medical Office Condo

20 Hope Avenue # 208, Waltham, MA 02452

$3,200/Mo

Configured with reception, waiting, treatment, examination, office, and restroom areas for medical-oriented occupancy.

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Office Building with Three-Story Atrium
Office Building with Three-Story Atrium

333 Wyman Street, Waltham, MA 02451

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54,621 sqft

Contemporary office building features a three-story atrium and landscaped front entrance, with surface parking and onsite amenities.

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Office Units at 870 Winter St
Office Units at 870 Winter St

870 Winter St, Waltham, MA 02451

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52,527 sqft

Office accommodation totaling 52,527 square feet is available for lease in Waltham.

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LEED Gold Laboratory Office Building
LEED Gold Laboratory Office Building

300 Third Avenue, Waltham, MA 02451

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106,422 sqft

Class A lab and office space with LEED Gold certification, high floor-to-floor clearances, and ready infrastructure for tenant build-out.

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Office Building with Conference Center
Office Building with Conference Center

245 Winter Street, Waltham, MA 02451

Contact for pricing
61,085 sqft

Efficient office layout with large windows, ample parking, and on-site amenities including a conference center.

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Waltham, MA Office Spaces Lease Rates & Market Statistics

Explore 132 Office Spaces for lease in Waltham, MA on Realmo, a commercial real estate exchange covering the Waltham area. The current inventory totals 3,477,019 square feet of properties — an average of ~26,350 SF per listing.

Asking lease rates for Office Spaces in Waltham start at $17 SF/Yr, average $25.38 SF/Yr, and reach $38 SF/Yr at the top of the market. Pricing across the market is relatively uniform, which simplifies like-for-like comparison between listings. The local average of $25.38 SF/Yr is 6% below the Massachusetts state average of $27.02 SF/Yr.

Waltham accounts for 10% of the 1,381 office spaces currently available across Middlesex County, where nearby markets include Cambridge and Burlington. By space type, the market includes 78 office buildings, 52 office units and 4 medical office space listings — medical office space options typically offer the lowest entry point, while office buildings command the highest rates.

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