Office Building

Waltham, MA Office Buildings for Lease

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Class A Life Science Office Building
Updated: Jul 25
Class A Life Science Office Building

21 Hickory Drive, Waltham, MA 02451

Contact for pricing
6,183 sqft
Recently converted office‑to‑life‑science property
Conversion included main infrastructure upgrades
Located in Waltham’s established life science corridor
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Cafe with Shared Conference Space
Updated: Jul 24
Cafe with Shared Conference Space

1440 Main St, Waltham, MA 02451

Contact for pricing
7,484 sqft
Cafe suite with full food service access
Access to shared conference space
On‑site fitness center
Abundant parking with 205 spaces
Convenient access to Route 117, I‑95, Route 128, and I‑90
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Multi-Suite Office Property
Multi-Suite Office Property

1400 Main St, Waltham, MA 02451

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5,354 sqft

Office space is available for lease in a range of configurations within a substantial commercial property.

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Class A Office and Lab Space
Class A Office and Lab Space

225 Wyman St, Waltham, MA 02451

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14,602 sqft

Existing Class A office and lab space with in-building amenities including fitness, café, and conference facilities.

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Renovated Brick-and-Beam Flex Space
Renovated Brick-and-Beam Flex Space

224 Calvary St, Waltham, MA 02453

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5,267 sqft 2.15 AC lot

Updated commercial space supports office, R&D, and light lab uses in a connected urban setting.

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Office Building with Three-Story Atrium
Office Building with Three-Story Atrium

333 Wyman Street, Waltham, MA 02451

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54,621 sqft

Contemporary office building features a three-story atrium and landscaped front entrance, with surface parking and onsite amenities.

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LEED Gold Laboratory Office Building
LEED Gold Laboratory Office Building

300 Third Avenue, Waltham, MA 02451

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106,422 sqft

Class A lab and office space with LEED Gold certification, high floor-to-floor clearances, and ready infrastructure for tenant build-out.

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Office Building with Conference Center
Office Building with Conference Center

245 Winter Street, Waltham, MA 02451

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61,085 sqft

Efficient office layout with large windows, ample parking, and on-site amenities including a conference center.

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Flex Space with Drive-In Door
Flex Space with Drive-In Door

62 4th Ave, Waltham, MA 02451

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30,000 sqft

Flex/R&D sublease offers a 50/50 office and R&D layout, with loading dock and 80 parking spaces.

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Class A Office Building in Courtyard
Class A Office Building in Courtyard

281 Winter St, Waltham, MA 02451

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6,173 sqft

Three-story, multi-tenant Class A office building with highly visible access to major regional routes.

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Class A Multi-Tenant Office Building
Class A Multi-Tenant Office Building

281 Winter St, Waltham, MA 02451

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2,774 sqft

Three-story Class A office building totaling 67,000 SF with immediate access to major regional roadways.

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Four-Story Class B Office Building
Four-Story Class B Office Building

307 Waverley Oaks Road, Waltham, MA 02452

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51,787 sqft

Four-story office building in Waverley Oaks Office Park offering Class B office space.

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Amenity-Rich Office Campus in Waltham
Amenity-Rich Office Campus in Waltham

910 Winter Street, Waltham, MA 02451

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150,000 sqft

Vibrant corporate campus near high-tech hub with shuttle service.

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Class A Office Building
Class A Office Building

230 3rd Ave, Waltham, MA 02451

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43,184 sqft

Class A, six-story office building with upgraded amenities, abundant natural light, and LEED Gold sustainability credentials.

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Four-Story Class A Office Building
Four-Story Class A Office Building

307 Waverley Oaks Rd, Waltham, MA 02452

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16,058 sqft

Four-story Class A office space in the Waverley Oaks Office Park, about six miles east of Route 128.

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Waltham Office Space Available
Waltham Office Space Available

400 Totten Pond Road, Waltham, MA 02451

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26,318 sqft

Office building with 26,318 square feet available for rent.

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Waltham Life Science Conversion Project
Waltham Life Science Conversion Project

21 Hickory Drive, Waltham, MA 02451

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24,057 sqft

Class A life science space for rent in Waltham, MA.

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Corporate Campus in Waltham, MA
Corporate Campus in Waltham, MA

10 Sylvan Road, Waltham, MA 02451

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440,000 sqft

Vibrant corporate campus with amenities and highway access.

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Corporate Campus in Waltham, MA
Corporate Campus in Waltham, MA

940 Winter Street, Waltham, MA 02451

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115,000 sqft

Vibrant corporate campus with amenities and highway access.

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Waltham Office Building For Lease
Waltham Office Building For Lease

245 Winter Street, Waltham, MA 02451

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61,085 sqft

Office building with ample parking and convenient highway access.

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Contemporary Office Building with Atrium
Contemporary Office Building with Atrium

404 Wyman Street, Waltham, MA 02451

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50,861 sqft

Newly designed office building with a stunning three-story atrium.

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Waltham Office Space Available
Waltham Office Space Available

460 Totten Pond Road, Waltham, MA 02451

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87,438 sqft

87,438 sqft office space for rent in Waltham, MA.

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Office Suite for Lease
Office Suite for Lease

800 South Street, Waltham, MA 02453

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Office suite leasing opportunity at 800 South Street in Waltham, MA for businesses seeking professional workspace.

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Freestanding Flex Space Building
Freestanding Flex Space Building

1273-1275 Main St, Waltham, MA 02451

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11,416 sqft 0.81 AC lot

Freestanding flex space on a large lot with a flexible interior layout for office, retail, or light industrial use.

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Waltham, MA Office buildings Lease Rates & Market Statistics

Explore 40 Office buildings for lease in Waltham, MA on Realmo, a commercial real estate exchange covering the Waltham area. The current inventory totals 1,780,943 square feet of properties — an average of ~44,500 SF per listing.

Asking lease rates for Office buildings in Waltham start at $37 SF/Yr, average $37 SF/Yr, and reach $37 SF/Yr at the top of the market. Pricing across the market is relatively uniform, which simplifies like-for-like comparison between listings. The local average of $37 SF/Yr is 62% above the Massachusetts state average of $22.78 SF/Yr.

Waltham accounts for 18% of the 222 office buildings currently available across Middlesex County, where nearby markets include Burlington and Cambridge. Office buildings make up 43% of the 93 Office Spaces currently for lease in Waltham, with asking rates averaging $37 SF/Yr — 53% above the citywide Office Spaces average of $24.16 SF/Yr. Also worth a look for tenants weighing alternatives: Office Units (52 listings) and Medical Office Space (4 listings) elsewhere in the Waltham market.

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