Office Building

Waltham, MA Office Buildings for Lease

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Class A Life Science Office Building
Updated: Jul 25
Class A Life Science Office Building

21 Hickory Drive, Waltham, MA 02451

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6,183 sqft
Recently converted office‑to‑life‑science property
Conversion included main infrastructure upgrades
Located in Waltham’s established life science corridor
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Cafe with Shared Conference Space
Updated: Jul 24
Cafe with Shared Conference Space

1440 Main St, Waltham, MA 02451

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7,484 sqft
Cafe suite with full food service access
Access to shared conference space
On‑site fitness center
Abundant parking with 205 spaces
Convenient access to Route 117, I‑95, Route 128, and I‑90
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Multi-Suite Office Property
Multi-Suite Office Property

1400 Main St, Waltham, MA 02451

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5,354 sqft

Office space is available for lease in a range of configurations within a substantial commercial property.

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Class A Office and Lab Space
Class A Office and Lab Space

225 Wyman St, Waltham, MA 02451

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14,602 sqft

Existing Class A office and lab space with in-building amenities including fitness, café, and conference facilities.

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Office Building with Three-Story Atrium
Office Building with Three-Story Atrium

333 Wyman Street, Waltham, MA 02451

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54,621 sqft

Contemporary office building features a three-story atrium and landscaped front entrance, with surface parking and onsite amenities.

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LEED Gold Laboratory Office Building
LEED Gold Laboratory Office Building

300 Third Avenue, Waltham, MA 02451

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106,422 sqft

Class A lab and office space with LEED Gold certification, high floor-to-floor clearances, and ready infrastructure for tenant build-out.

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Office Building with Conference Center
Office Building with Conference Center

245 Winter Street, Waltham, MA 02451

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61,085 sqft

Efficient office layout with large windows, ample parking, and on-site amenities including a conference center.

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Renovated Brick-and-Beam Flex Space
Renovated Brick-and-Beam Flex Space

224 Calvary St, Waltham, MA 02453

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16,768 sqft 2.15 AC lot

Updated commercial space supports office, R&D, and light lab uses in a connected urban setting.

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Six-Story Office Building with Parking
Six-Story Office Building with Parking

95 Sawyer Rd, Waltham, MA 02453

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3,463 sqft

Six-story office building with covered parking, dining amenities, and on-site commuter rail access.

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Flex Space with Drive-In Door
Flex Space with Drive-In Door

62 4th Ave, Waltham, MA 02451

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30,000 sqft

Flex/R&D sublease offers a 50/50 office and R&D layout, with loading dock and 80 parking spaces.

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Waltham Freestanding Commercial Building
Waltham Freestanding Commercial Building

1273-1275 Main Street, Waltham, MA 02451

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11,416 sqft 0.82 AC lot

Versatile 11,416 SF building suitable for office, retail, industrial.

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Six-Story Office Building
Six-Story Office Building

95 Sawyer Rd, Waltham, MA 02453

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6,801 sqft

Six-story office building with covered parking and an on-site MBTA commuter rail station.

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Class A Office Building in Courtyard
Class A Office Building in Courtyard

281 Winter St, Waltham, MA 02451

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6,173 sqft

Three-story, multi-tenant Class A office building with highly visible access to major regional routes.

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Class A Multi-Tenant Office Building
Class A Multi-Tenant Office Building

281 Winter St, Waltham, MA 02451

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2,774 sqft

Three-story Class A office building totaling 67,000 SF with immediate access to major regional roadways.

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Four-Story Class B Office Building
Four-Story Class B Office Building

307 Waverley Oaks Road, Waltham, MA 02452

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51,787 sqft

Four-story office building in Waverley Oaks Office Park offering Class B office space.

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Six-Story Office Building with Covered Parking
Six-Story Office Building with Covered Parking

95 Sawyer Rd, Waltham, MA 02453

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21,783 sqft

Six-story office building with covered parking, cafe and fitness center, plus an on-site MBTA commuter rail station.

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Four-Story Class A Office Building
Four-Story Class A Office Building

307 Waverley Oaks Rd, Waltham, MA 02452

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16,058 sqft

Four-story Class A office space in the Waverley Oaks Office Park, about six miles east of Route 128.

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Amenity-Rich Office Campus in Waltham
Amenity-Rich Office Campus in Waltham

910 Winter Street, Waltham, MA 02451

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150,000 sqft

Vibrant corporate campus near high-tech hub with shuttle service.

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Class A Office Building
Class A Office Building

230 3rd Ave, Waltham, MA 02451

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43,184 sqft

Class A, six-story office building with upgraded amenities, abundant natural light, and LEED Gold sustainability credentials.

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Lab and Office Build-to-Suit
Lab and Office Build-to-Suit

225 Wyman St, Waltham, MA 02451

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72,691 sqft

Shell-condition space offers flexibility, with 30,000 SF of lab and office delivery planned for Q3 2026.

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Class A Office and Lab Space
Class A Office and Lab Space

225 Wyman St, Waltham, MA 02451

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24,386 sqft

Class A office and lab space with in-building fitness, café, conference facilities, outdoor space, and bike room access.

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Waltham Office Space Available
Waltham Office Space Available

400 Totten Pond Road, Waltham, MA 02451

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26,318 sqft

Office building with 26,318 square feet available for rent.

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Waltham Life Science Conversion Project
Waltham Life Science Conversion Project

21 Hickory Drive, Waltham, MA 02451

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24,057 sqft

Class A life science space for rent in Waltham, MA.

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Corporate Campus in Waltham, MA
Corporate Campus in Waltham, MA

10 Sylvan Road, Waltham, MA 02451

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440,000 sqft

Vibrant corporate campus with amenities and highway access.

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Waltham, MA Office buildings Lease Rates & Market Statistics

Explore 74 Office buildings for lease in Waltham, MA on Realmo, a commercial real estate exchange covering the Waltham area. The current inventory totals 2,348,779 square feet of properties — an average of ~31,750 SF per listing.

Asking lease rates for Office buildings in Waltham start at $37 SF/Yr, average $37 SF/Yr, and reach $37 SF/Yr at the top of the market. Pricing across the market is relatively uniform, which simplifies like-for-like comparison between listings. The local average of $37 SF/Yr is 62% above the Massachusetts state average of $22.85 SF/Yr.

Waltham accounts for 20% of the 373 office buildings currently available across Middlesex County, where nearby markets include Cambridge and Burlington. Office buildings make up 59% of the 126 Office Spaces currently for lease in Waltham, with asking rates averaging $37 SF/Yr — 43% above the citywide Office Spaces average of $25.91 SF/Yr. Also worth a look for tenants weighing alternatives: Office Units (49 listings) and Medical Office Space (6 listings) elsewhere in the Waltham market.

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