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    San Diego, CA Office Spaces for Lease

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    Found 558 office space listings for lease in San Diego, CA, averaging $21/SF/YR. Use lease type data to compare options faster.
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    Flexible Two-Story Office Building
    Flexible Two-Story Office Building

    5893 Oberlin Dr, San Diego, CA 92121

    Sorrento Valley
    Contact for pricing
    120–200 people  30,000 sqft

    Flexible office building with high-volume two-story interiors and skylights, plus parking for about 3.9 per 1,000 SF.

    View details
    Office Space for Sublease
    Office Space for Sublease

    12790 El Camino Real, San Diego, CA 92130

    Torrey Preserve
    Contact for pricing
    141–236 people  35,482 sqft
    29 private offices  5 meeting rooms

    Sublease office with 63 workstations, 29 private offices, and five conference rooms plus a break room.

    Break Room
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    Renovated San Diego Amenity-Rich Space
    Renovated San Diego Amenity-Rich Space

    8145-8245 Ronson Rd., San Diego, CA 92111

    Coworking Kearny Mesa
    Contact for pricing
    3 spaces  Built 2026

    Recently renovated office and fitness spaces with extensive amenity center.

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    Renovated Office Building For Lease
    Renovated Office Building For Lease

    9320 Chesapeake Dr, San Diego, CA

    Kearny Mesa
    Contact for pricing
    5–9 people  2 spaces  1,472 sqft  1.11 acres

    Recently renovated office building with central San Diego location.

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    Office Building with Ocean Views
    Office Building with Ocean Views

    10188 Telesis Ct, San Diego, CA 92121

    Sorrento Valley
    Contact for pricing
    43–73 people  10,982 sqft
    Public transit

    Office building featuring monument and building signage, an on-site café, and outdoor patio event space with ocean and canyon views.

    Monument and building signage  On-site gourmet café  Fitness center  Lap pool
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    Creative Office Suite with Conference Room
    Creative Office Suite with Conference Room

    2251 San Diego Ave, San Diego, CA 92110

    Full service Old Town
    Contact for pricing
    1 person  1 space  293 sqft  modern Spanish style
    Highway access

    Renovated office suite featuring six private offices and a conference room with exposed wood beams and vaulted ceilings.

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    Office Building Converted to Lab
    Office Building Converted to Lab

    10201 Wateridge Cir, San Diego, CA 92121

    Sorrento Valley
    Contact for pricing
    77–128 people  19,273 sqft

    Office building now available for lease, converted to lab use in Q2 2023.

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    ABC-Licensed Nightclub and Office
    ABC-Licensed Nightclub and Office

    500-502 Fourth Ave, San Diego, CA 92101

    Triple net (NNN) Marina
    Contact for pricing
    11,000 sqft  2-story

    Includes an ABC-licensed 11,000 SF nightclub plus 2,000 SF second-floor office.

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    Office Building Converted to Lab Space
    Office Building Converted to Lab Space

    10201 Wateridge Cir, San Diego, CA 92121

    Sorrento Valley
    Contact for pricing
    81–136 people  20,482 sqft

    Office building now available for lease, converted to lab space, offering a flexible suite size range.

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    Move-In Ready Office Suites Available
    Move-In Ready Office Suites Available

    8755-8775 Aero Dr, San Diego, CA

    Modified gross Serra Mesa
    Contact for pricing
    9–16 people  2 spaces  2,496 sqft  3.93 acres

    Office suites available for rent with flexible lease terms.

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    Office Building with EV Parking
    Office Building with EV Parking

    550 W C St, San Diego, CA 92101

    Core-Columbia
    Contact for pricing
    75–125 people  18,872 sqft

    Office building with enhanced lobby, fully equipped conference room, gym, and EV-charging parking for tenants.

    Enhanced lobby  Dining and outdoor amenities  EV charging stations  Panoramic views
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    Office Space with Exterior Patios
    Office Space with Exterior Patios

    6160 Cornerstone Ct E, San Diego, CA 92121

    Sorrento Valley
    Contact for pricing
    67–113 people  1 space  16,956 sqft
    Highway access

    Office space features operable windows, exterior patios, and in-building Wi-Fi with convenient on-site parking options.

    3.8/1,000 SF parking  Wi-Fi in common area courtyard  Exterior patios  Operable windows
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    Office Space For Lease
    Office Space For Lease

    17190 Bernardo Center Dr, San Diego, CA 92128

    Rancho Bernardo
    Contact for pricing
    10–18 people  2,707 sqft

    Office space is available for lease at 17190 Bernardo Center Dr, with suites ranging in size.

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    Office Building with Bay Views
    Office Building with Bay Views

    550 W C St, San Diego, CA 92101

    Core-Columbia
    Contact for pricing
    9–16 people  2,488 sqft
    Public transit

    Office building with panoramic San Diego Bay views, EV-charging parking, gym, and a fully equipped conference room.

    2.0/1,000 SF parking  Enhanced lobby  Dining  Outdoor amenities
    View details
    Office Space in Secure Location
    Office Space in Secure Location

    16705 Via Del Campo Ct, San Diego, CA

    Rancho Bernardo
    Contact for pricing
    113–188 people  28,313 sqft  11.72 acres

    Office space with high-quality construction and lab-ready features.

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    Creative Office Space with Balconies
    Creative Office Space with Balconies

    185 W F St, San Diego, CA 92101

    Full service Horton Plaza
    Contact for pricing
    4–8 people  1 space  1,207 sqft

    Renovated building offers 9,000 SF floor plates and direct subterranean parking access into a lobby.

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    Contiguous Office Suites
    Contiguous Office Suites

    600 B St, San Diego, CA 92101

    Core-Columbia
    Contact for pricing
    5–9 people  1,446 sqft

    Contiguous office suites with double-door entry off the elevator lobby.

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    Office Building with Vaulted Lobby
    Office Building with Vaulted Lobby

    16745 W Bernardo Dr, San Diego, CA 92127

    Rancho Bernardo
    Contact for pricing
    13–21 people  3,267 sqft
    Public transit

    Office building with panoramic views, vaulted lobby, and on-site showers and locker facilities.

    Signage opportunities  Panoramic views  Future development opportunities  Showers and locker facilities
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    Renovated San Diego Office Space
    Renovated San Diego Office Space

    8250-8380 Vickers St., San Diego, CA 92111

    Kearny Mesa
    Contact for pricing
    4 spaces  Built 2026

    Recently renovated office space with modern amenities in San Diego.

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    Mesa Rim Road Office Space
    Mesa Rim Road Office Space

    9955 Mesa Rim Rd, San Diego, CA

    Sorrento Valley
    Contact for pricing
    63–105 people  15,853 sqft  5.46 acres

    Office space with private offices, conference rooms, and clean rooms.

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    Rancho Bernardo Office Space Available
    Rancho Bernardo Office Space Available

    16745 W Bernardo Dr, San Diego, CA

    Rancho Bernardo
    Contact for pricing
    52–88 people  13,232 sqft  5.31 acres

    Office space with signage and transit access in San Diego.

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    Life Science Development in San Diego
    Life Science Development in San Diego

    4242 Campus Point Court, San Diego, CA 92121

    Torrey Pines
    Contact for pricing

    High-amenity life science development in University Towne Centre.

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    Office Space For Rent
    Office Space For Rent

    5675 Ruffin Rd, San Diego, CA 92123

    Kearny Mesa
    Contact for pricing
    11–18 people  2,830 sqft

    Office space available for rent in San Diego, CA.

    View details
    High-Image Office Space Available
    High-Image Office Space Available

    10180 Telesis Ct, San Diego, CA

    Sorrento Valley
    Contact for pricing
    19–33 people  1 space  4,964 sqft  16.98 acres

    Office space with amenities, ocean views, and convenient location.

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    Most Searched ZIP Codes in San Diego, CA

    • 92121
    • 92101
    • 92123
    • 92130
    • 92108
    • 92128
    • 92037
    • 92127
    • 92131
    • 92110
    • 92111
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