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    South Carolina Office Buildings for Lease

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    Greenville, SC Columbia, SC Charleston, SC Spartanburg, SC North Charleston, SC Rock Hill, SC Summerville, SC Myrtle Beach, SC
    161 properties
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    Medical Office Space Available
    Medical Office Space Available

    3221, 3223, 3225, & 3231 Sunset Blvd., West Columbia, SC 29169

    Contact for pricing
    39,722 sqft

    Accessible medical office space in a growing Columbia corridor.

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    Renovated Office Building, High Visibility
    Renovated Office Building, High Visibility

    1001 Keys Drive, Greenville, SC 29615

    Contact for pricing
    35,500 sqft

    Office building with recent renovations and high interstate visibility.

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    Former Office Building Lease Opportunity
    Former Office Building Lease Opportunity

    118 NE Main St, Simpsonville, SC 29681

    Contact for pricing

    Lease a former office building with an 18-month short-term option on Main Street in Simpsonville.

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    Office Building Near I-77
    Office Building Near I-77

    2341 Deerfield Dr, Fort Mill, SC

    Contact for pricing
    105,844 sqft

    Two-story office building with ample parking and easy highway access.

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    Ebenezer Road Office Building
    Ebenezer Road Office Building

    1220 Ebenezer Rd, Rock Hill, SC 29732

    Contact for pricing
    1,658 sqft

    Office building near Winthrop University and regional hospital for rent.

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    Freestanding Office Building in Myrtle Beach
    Freestanding Office Building in Myrtle Beach

    1051 Shine Ave, Myrtle Beach, SC 29577

    $20 SF/Yr

    Office building in The Market Common District for rent.

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    Office Building with Major Road Visibility
    Office Building with Major Road Visibility

    4995 Lacross Road Suite 1350, North Charleston, SC 29406

    Contact for pricing

    Office space in Rivergate Center I with strong major-road visibility and ample on-site parking for tenants and visitors.

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    Downtown Office Suites with Retail Conversion
    Downtown Office Suites with Retail Conversion

    145 King Street, Charleston, SC 29401

    Contact for pricing

    Office suites in a walkable historic downtown setting, with planned renovations and convenient access plus negotiable parking.

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    Standalone Office Building
    Standalone Office Building

    3463 Maybank Highway, Johns Island, SC 29455

    Contact for pricing

    Standalone office building for lease with a reception area, private offices, and dedicated conference room plus on-site parking.

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    Office Space for Lease
    Office Space for Lease

    1140 E Butler Rd, Greenville, SC 29607

    Contact for pricing

    Flexible office space opportunity available for lease at a commercial address in Greenville, SC.

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    Office Building Near Major Interstates
    Office Building Near Major Interstates

    300 Henry Pl, Spartanburg, SC 29306

    $11.50 SF/Yr

    Built in 1990, this office building offers convenient access to I-26 and I-85 for regional connectivity.

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    Downtown Office Space
    Downtown Office Space

    14 S Main St, Greenville, SC 29601

    Contact for pricing

    For rent at 14 S Main St, offering flexible office use in a central setting.

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    Class A Office Building
    Class A Office Building

    140 Wildewood Park Dr, Columbia, SC 29223

    Contact for pricing

    Class A office space offering flexible lease terms and abundant on-site parking for day-to-day operations.

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    Freestanding Single Tenant Office Building
    Freestanding Single Tenant Office Building

    260 S Pleasantburg Dr, Greenville, SC 29607

    $10 SF/Yr

    Single tenant office building with multiple offices and storage.

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    Multi-Tenant Office Building For Rent
    Multi-Tenant Office Building For Rent

    2231 Devine Street, Columbia, SC 29205

    $17 SF/Yr

    Three-story office building in the Devine Street corridor.

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    Multi-Use Office with Warehouse Space
    Multi-Use Office with Warehouse Space

    770 Augusta Road, Edgefield, SC 29824

    Contact for pricing

    Three-floor office with wood finishes and meeting rooms, plus warehouse space and a pavilion by the pond.

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    Class A Office Suite Available
    Class A Office Suite Available

    1951 Clements Ferry Rd, Charleston, SC 29492

    $22 SF/Yr

    Freestanding Class A office building in Charleston's Clements Ferry Corridor.

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    Renovated Class A Office Building
    Renovated Class A Office Building

    4055 Faber Place Drive # 104, North Charleston, SC 29405

    $32 SF/Yr

    Three-story office building with high-end finishes, available April 2026.

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    Refreshed Office Building For Lease
    Refreshed Office Building For Lease

    620 W Evans Street, Florence, SC 29501

    $4,500/Mo
    3,000 sqft

    Standalone office building near Downtown Florence with private parking.

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    Office Building with I-95 Visibility
    Office Building with I-95 Visibility

    2240 North Douglas Street, Florence, SC 29501

    Contact for pricing

    Office building in a professional business park with visibility from I-95 and convenient access to I-20.

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    Suburban Office Park in Greenville
    Suburban Office Park in Greenville

    124 Verdae Blvd, Greenville, SC 29607

    $22.50 SF/Yr
    164,299 sqft

    Office park in prime business district near shopping and restaurants.

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    Professional Office Building
    Professional Office Building

    5 Hawthorne Park Ct, Greenville, SC 29615

    Contact for pricing

    Well-maintained office space positioned just minutes from the Patewood medical campus for professional services users.

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    Downtown Columbia Boutique Office Space
    Downtown Columbia Boutique Office Space

    1527 Blanding St, Columbia, SC 29201

    Contact for pricing

    Second floor office space for lease in downtown Columbia.

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    Office Suite with Atrium Lobby
    Office Suite with Atrium Lobby

    220 North Main Street, Suite 500, Greenville, SC 29601

    Contact for pricing

    Leasing opportunity with an impressive atrium, lounge, and videoconferencing facilities, plus an in-building restaurant.

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