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Port St Lucie, FL Office Buildings for Lease

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Port Saint Lucie, FL Vero Beach, FL Jensen Beach, FL Stuart, FL Palm City, FL Sebastian, FL Hobe Sound, FL
12 properties
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Freestanding Live-Work Space
Updated: Aug 12
Freestanding Live-Work Space

Port St Lucie, FL 34952

$4,216/Mo
1,865 sqft 0.27 AC lot
Freestanding live‑work property with professional office configuration
Reception and waiting area plus multiple private offices or treatment rooms
Two restrooms, kitchen, storage, and flexible workspace
Monument signage with on‑site and covered parking
Concrete construction with terrazzo flooring and metal roof
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Freestanding Office Building
Updated: Apr 9
Freestanding Office Building

706 N 7th Street, Fort Pierce, FL 34950

$6,000/Mo
4,805 sqft 0.28 AC lot
Free‑standing office space with 4,691 +/- SF available for lease
Includes 20 private offices; 6 offices have sinks and many feature exterior doors
5 bathrooms plus 2 reception areas and 1 kitchen
Central heating and central A/C; concrete construction materials
Served by public water and public sewer
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Freestanding Medical Office Space
Freestanding Medical Office Space

761 E PRIMA VISTA Boulevard, Port St Lucie, FL 34952

$4,216/Mo
1,865 sqft

Flexible layout includes private rooms, reception, kitchen, storage, and two restrooms.

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Freestanding Medical Office Building
Freestanding Medical Office Building

1215 S 25th Street S, Fort Pierce, FL 34947

$6,600/Mo
2,416 sqft

Configured with private rooms, reception, support areas, and three restrooms.

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Multi-Tenant Office Buildings
Multi-Tenant Office Buildings

805 Virginia Ave, Fort Pierce, FL 34982

$18 SF/Yr
27,000 sqft 2.55 AC lot

Single-story office buildings offer leasing options along Virginia Avenue.

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Professional Office Building with Parking
Professional Office Building with Parking

4609 North US Highway 1, Fort Pierce, FL 34946

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1,144 sqft 1.04 AC lot

Turnkey office building with six private offices and large on-site parking on high-visibility US Highway 1.

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Professional Office and Medical Building
Professional Office and Medical Building

1945 SE Port St Lucie Blvd, Port St Lucie, FL 34952

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2,430 sqft

Well-maintained medical and office building on busy Port St. Lucie Boulevard near US 1 for convenient access.

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New Class A Office Building
New Class A Office Building

Port St Lucie, FL 34952

$23 SF/Yr

Newly constructed Class A commercial building available for rent.

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Freestanding Corner Office & Retail Building
Freestanding Corner Office & Retail Building

300 S 6th Street, Fort Pierce, FL 34950

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27,500 sqft 1.90 AC lot

Two-story freestanding corner building with 91 dedicated parking spaces and flexible leasing from 1,000 SF to the full building.

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Freestanding Mixed-Use Building
Freestanding Mixed-Use Building

129 North 5th Street, Fort Pierce, FL 34950

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Two-story property combines climate-controlled office areas with an upper-level work-and-living layout.

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New Construction Office Building
New Construction Office Building

Port St Lucie, FL 34953

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Three-story office building under construction, delivery in late Spring/early Summer.

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Class A Office Space Available
Class A Office Space Available

Port St Lucie, FL 34986

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15,000 sqft

Professional office building with flexible spaces and modern amenities.

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Based on your search, we've compiled 35 Potential Opportunities for your consideration. Besides 12 Active listings in Port St Lucie, FL, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 19 Properties for Sales.

Office buildings for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

Freestanding Medical Office Space
Freestanding Medical Office Space

761 E Prima Vista Blvd, Port Saint Lucie, FL 34952

Contact for pricing
1,425 sqft 0.27 AC lot

Standalone facility includes reception, private rooms, kitchen, storage, and two restrooms.

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Flexible Floor Plan Office Building
Flexible Floor Plan Office Building

215 SW Federal Hwy, Stuart, FL 34994

Contact for pricing
3,800 sqft

Office building with flexible floor plans and abundant natural light, plus convenient parking for tenants and visitors.

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Well-Maintained Property For Sale
Well-Maintained Property For Sale

7430-7448 S Federal Hwy, Port Saint Lucie, FL

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13,129 sqft 1.09 AC lot

Well-maintained property with long-term occupants and upside potential.

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Contemporary Office Building
Contemporary Office Building

215 SW Federal Hwy, Stuart, FL 34994

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1,974 sqft

Contemporary office building with flexible floor plans, abundant natural light, and convenient parking for tenants and visitors.

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Similar Spaces for Sale in Port St Lucie, FL

Consider Similar Space for Sale. We found 19 Spaces matching your search parameters.

Freestanding Medical Office Building
Freestanding Medical Office Building

Port St Lucie, FL

$3,300,000
11,187 sqft 1.02 AC lot

Vacant, five-suite professional facility with dedicated on-site parking near an established hospital campus.

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Freestanding Office Building with Private Offices
Freestanding Office Building with Private Offices

706 N 7th Street, Fort Pierce, FL

$550,000
4,805 sqft 0.28 AC lot

Freestanding office building with exterior access, multiple reception areas, and 20 private offices suited for professional and medical uses.

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Medical Office Space with Two Buildings
Medical Office Space with Two Buildings

1803 & 1805 S 25th Street, Fort Pierce, FL

$1,900,000
9,560 sqft 0.96 AC lot

Fully occupied medical and office property with central climate control, public utilities, and guest parking.

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Freestanding Medical Office Building
Freestanding Medical Office Building

Port St Lucie, FL 34952

$3,300,000
11,187 sqft

Vacant professional facility with multiple medical suites beside HCA Florida St. Lucie Hospital in an established medical corridor.

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Freestanding Medical Office Building
Freestanding Medical Office Building

3651 Virginia Avenue, Fort Pierce, FL

$1,695,000
9,255 sqft 0.69 AC lot

The property combines private offices, classrooms, and a kitchen with dining space in a dedicated commercial facility.

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Professional Office Building
Professional Office Building

756 SE, Port St Lucie, FL

$799,000
3,404 sqft 0.50 AC lot

Professional-zoned office property with flexible space for up to four separate units and central air conditioning.

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Freestanding Medical Office
Freestanding Medical Office

1900 Nebraska Avenue, Fort Pierce, FL 34950

$699,500
2,100 sqft

Purpose-built clinical layout with exam rooms, patient reception, private offices, and dedicated parking.

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Freestanding Office Building
Freestanding Office Building

3651 Virginia Avenue, Fort Pierce, FL 34981

Contact for pricing
9,255 sqft 0.69 AC lot

Adaptable commercial facility with classrooms, private offices, and a kitchen adjoining a dining area.

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Freestanding Medical Office Building
Freestanding Medical Office Building

1215 S 25th Street S, Fort Pierce, FL 34947

Contact for pricing
2,400 sqft

Flexible professional layout with private rooms, reception areas, kitchenette, storage, restrooms, and natural light.

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Freestanding Medical Office Building
Freestanding Medical Office Building

Port St Lucie, FL 34952

Contact for pricing
1,865 sqft

Flexible interior includes reception, private rooms, support areas, and two restrooms.

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Single-Story Medical Office Building
Single-Story Medical Office Building

Port St Lucie, FL 34952

Contact for pricing
8,873 sqft

Single-story layout configured for medical office operations, with on-site parking and nearby civic, governmental, and healthcare facilities.

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Renovated Office Campus with Child Care Plans
Renovated Office Campus with Child Care Plans

Port St Lucie, FL 34986

Contact for pricing

Three renovated office buildings on an established campus, with additional proposed space for academic child care and education.

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Port St Lucie, FL Office buildings Lease Rates & Market Statistics

Browse 12 Office buildings for lease in Port St Lucie, FL on Realmo, a commercial real estate marketplace serving the Port St Lucie area. The current inventory totals 84,025 square feet of properties — an average of ~7,000 SF per listing.

Office buildings lease rates in Port St Lucie range from $14.98 SF/Yr at the entry level to $32.78 SF/Yr at the top of the market, averaging $23.18 SF/Yr. Pricing across the market is relatively uniform, which simplifies like-for-like comparison between listings. At $23.18 SF/Yr, the local average runs 11% below Florida's state average of $26.17 SF/Yr.

Port St Lucie accounts for 80% of the 15 office buildings currently available across St. Lucie County, where nearby markets include Fort Pierce and Port Saint Lucie. Office buildings make up 11% of the 112 Office Spaces currently for lease in Port St Lucie, with asking rates averaging $23.18 SF/Yr — 12% below the citywide Office Spaces average of $26.21 SF/Yr. Tenants comparing options may also consider Office Units (72 listings) and Medical Office Space (39 listings) elsewhere in the Port St Lucie market.

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