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    Port St Lucie, FL
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    Port St Lucie, FL Office Buildings for Lease

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    Port Saint Lucie, FL Vero Beach, FL Jensen Beach, FL
    6 results
    Fort Pierce Freestanding Office Space
    $6,000/Mo
    4,805 SF

    Fort Pierce Freestanding Office Space

    706 N 7th Street, Fort Pierce, FL 34950

    Freestanding office space in Fort Pierce, ideal for diverse businesses.

    • 4,691 SQFT Freestanding Office Space
    • Ideal Location Minutes from Intracoastal and Downtown Fort Pierce
    • Suitable for Medical, Insurance, and Government Agencies
    • 20 Private Offices (6 with Sinks and Exterior Doors)
    • 5 Bathrooms, 2 Reception Areas, and 1 Kitchen
    Updated: Apr 9
    View details
    Landmark Office Building in Fort Pierce
    $17 SF/Yr
    5,400 SF

    Landmark Office Building in Fort Pierce

    2222 Colonial Road, Fort Pierce, FL 34950

    5,400 sq ft office space available for lease.

    • 5,400 sq ft of office space available.
    • Prime location near US #1 and Virginia Ave.
    • Includes 15 offices, waiting room, receptionist office, kitchen/break room, 2 conference rooms, and file room.
    • Reasonable lease rates starting at $16.50 per sq ft.
    • Join established tenants like DiBartolomeo, McBee, Hartley & Barnes CPA Firm and Endeavors.
    Updated: Nov 14, 2025
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    Professional Office Suites For Rent
    Contact for pricing

    Professional Office Suites For Rent

    Flexible, furnished office spaces in a prime Port St. Lucie location.

    Port St Lucie, FL 34952
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    Class A Office Space Available
    $22 SF/Yr
    3,207 SF

    Class A Office Space Available

    Professional office building with flexible spaces and modern amenities.

    Fort Pierce, FL 34986
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    Class A Office Space Available
    $22 SF/Yr
    15,000 SF

    Class A Office Space Available

    Professional office building with flexible spaces and modern amenities.

    Port St Lucie, FL 34986
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    New Class A Office Building
    $23 SF/Yr

    New Class A Office Building

    Newly constructed Class A commercial building available for rent.

    Port St Lucie, FL 34952
    View details
    Based on your search, we've compiled 21 Potential Opportunities for your consideration. Besides 6 Active listings in Port St Lucie, FL, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 7 Properties for Sales.

    Office buildings for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Jupiter Office Building For Rent
    Contact for pricing
    3,300 SF

    Jupiter Office Building For Rent

    Renovated office suites available on Indiantown Road in Jupiter.

    675 West Indiantown Road, Jupiter, FL 33458
    View details
    Class A Office Buildings
    $29 SF/Yr

    Class A Office Buildings

    Premier office buildings in Stuart, Florida, with excellent access.

    729-819 SW Federal Hwy, Stuart, FL 34994
    View details
    Premier Jupiter Office Space Available
    $30 SF/Yr

    Premier Jupiter Office Space Available

    Class-A office space with monument signage and private terraces.

    1061 E Indiantown Rd, Jupiter, FL 33477
    View details
    Stuart Office Campus for Lease
    $22 SF/Yr

    Stuart Office Campus for Lease

    Mediterranean-style office buildings in Stuart's business corridor.

    1000 SE Monterey Commons Blvd, Stuart, FL 34996
    View details

    Similar Spaces for Sale in Port St Lucie, FL

    Consider Similar Space for Sale. We found 7 Spaces matching your search parameters.

    Port St. Lucie Professional Building
    $799,000
    3,404 SF
    Port St. Lucie Professional Building

    High-visibility building suitable for professional offices or medical use.

    756 SE, Port St Lucie, FL

    View details
    Freestanding Office Space in Fort Pierce
    $550,000
    4,805 SF
    Freestanding Office Space in Fort Pierce

    4,691 SF+/- freestanding office building suitable for diverse businesses.

    706 N 7th Street, Fort Pierce, FL

    View details
    Freestanding Office Space in Fort Pierce
    $550,000
    4,691 SF
    Freestanding Office Space in Fort Pierce

    4,691 SF freestanding office building suitable for diverse businesses.

    706 N 7th St, Fort Pierce, FL 34950

    View details
    Downtown Fort Pierce Office Building
    $900,000
    Downtown Fort Pierce Office Building

    Versatile office building in thriving downtown Fort Pierce.

    321 S 2nd St, Fort Pierce, FL 34950

    View details
    Waterfront Property with Development Potential
    $1,850,000
    5,660 SF
    Waterfront Property with Development Potential

    Unique waterfront property with hospitality, office, and development potential.

    515 S Indian River Dr, Fort Pierce, FL 34950

    View details
    Fort Pierce Industrial Opportunity
    $8,500,000
    141,894 SF
    Fort Pierce Industrial Opportunity

    140,000 SF industrial property on 12 acres.

    4204 Okeechobee Rd, Fort Pierce, FL 34947

    View details
    Development Powerhouse Near Airport
    $4,300,000
    11,476 SF
    Development Powerhouse Near Airport

    43.59 acres near Treasure Coast International Airport.

    3032 N 25th St, Fort Pierce, FL 34946

    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Melbourne Land for Ground Lease
    Contact for pricing

    Melbourne Land for Ground Lease

    1.2-acre development site in Viera/Suntree area available for lease.

    6365 N. Wickham Road, Melbourne, FL 32940
    View details
    Downtown Winter Haven Commercial Land
    $29,940 SF/Yr

    Downtown Winter Haven Commercial Land

    City-approved commercial land in a growing business district.

    511 AVENUE G NW, Winter Haven, FL 33881
    View details
    Cleared Lot in Williston
    $20,000/Mo

    Cleared Lot in Williston

    C2-zoned lot in Williston's central business area for rent.

    33 NW 3RD St, Williston, FL 32696
    View details
    Prime Commercial Lot For Lease
    $7,500/Mo

    Prime Commercial Lot For Lease

    0.66 acre commercial lot in high-traffic area.

    Tift Avenue N, Tifton, GA 31794
    View details

    Port St Lucie, FL Office buildings Leasing Opportunities Market Analysis

    Explore Office buildings leasing options in Port St Lucie, FL with 6 listings featured on our commercial real estate exchange. The current inventory includes 28,412 square feet of properties with an estimated lease value of $75 SF/Yr.

    Estimated lease rates for Office buildings in Port St Lucie, FL begin at $14 SF/Yr, with an average of $18 SF/Yr and extend to $22 SF/Yr.
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    Most Searched ZIP Codes in Port St Lucie, FL

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    • 34952
    • 34986

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