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    Port St Lucie, FL Office Buildings for Lease

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    Port Saint Lucie, FL Vero Beach, FL Jensen Beach, FL Stuart, FL Palm City, FL Sebastian, FL Hobe Sound, FL
    11 properties
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    Freestanding Office Building
    Updated: Apr 9
    Freestanding Office Building

    706 N 7th Street, Fort Pierce, FL 34950

    $6,000/Mo
    4,805 sqft $14.98 SF/Yr
    Free‑standing office space with 4,691 +/- SF available for lease
    Includes 20 private offices; 6 offices have sinks and many feature exterior doors
    5 bathrooms plus 2 reception areas and 1 kitchen
    Central heating and central A/C; concrete construction materials
    Served by public water and public sewer
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    Office Suite with Multiple Private Offices
    Updated: Nov 14, 2025
    Office Suite with Multiple Private Offices

    2222 Colonial Road, Fort Pierce, FL 34950

    $17/Mo
    5,400 sqft $0.04 SF/Yr
    5,400 SF available in a landmark office building built in 1989
    Layout includes 15 offices plus waiting room, receptionist office, kitchen/break room, file room, and 2 conference rooms
    Gross rent rates: $16.50/SF first year and $17.50/SF second year, with CPI increases thereafter
    3‑year minimum lease term
    Tenant pays a prorata share of increases in property taxes (in addition to gross rates)
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    Updated Free-Standing Office Building
    Updated Free-Standing Office Building

    2210 S 40th Street, Fort Pierce, FL 34947

    $1,700/Mo
    792 sqft $25.76 SF/Yr

    Completely updated office with impact windows, a private office, ADA-compliant restroom, and multi-use work area.

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    Office Suite for Lease
    Office Suite for Lease

    240 NW Peacock Blvd 104, Port St Lucie, FL 34986

    $4,477/Mo

    Available for rent at 240 NW Peacock Blvd, Unit 104, within a commercial office setting in St. Lucie County.

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    Freestanding Office Building
    Freestanding Office Building

    Port St Lucie, FL 34952

    $21/Mo

    Freestanding office with high visibility on Port Saint Lucie Boulevard, ideal for tenants customizing their layout.

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    Professional Office Building with Parking
    Professional Office Building with Parking

    4609 North US Highway 1, Fort Pierce, FL 34946

    Contact for pricing
    1,144 sqft

    Turnkey office building with six private offices and large on-site parking on high-visibility US Highway 1.

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    Professional Office and Medical Building
    Professional Office and Medical Building

    1945 SE Port St Lucie Blvd, Port St Lucie, FL 34952

    Contact for pricing
    2,430 sqft

    Well-maintained medical and office building on busy Port St. Lucie Boulevard near US 1 for convenient access.

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    Class A Office Space Available
    Class A Office Space Available

    Fort Pierce, FL 34986

    $22 SF/Yr
    3,207 sqft $5,879/Mo

    Professional office building with flexible spaces and modern amenities.

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    New Construction Office Building
    New Construction Office Building

    Port St Lucie, FL 34953

    $25 SF/Yr

    Three-story office building under construction, delivery in late Spring/early Summer.

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    Class A Office Space Available
    Class A Office Space Available

    Port St Lucie, FL 34986

    $22 SF/Yr
    15,000 sqft $27,500/Mo

    Professional office building with flexible spaces and modern amenities.

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    New Class A Office Building
    New Class A Office Building

    Port St Lucie, FL 34952

    $23 SF/Yr

    Newly constructed Class A commercial building available for rent.

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    Based on your search, we've compiled 24 Potential Opportunities for your consideration. Besides 11 Active listings in Port St Lucie, FL, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 5 Properties for Sales.

    Office buildings for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Well-Maintained Property For Sale
    Well-Maintained Property For Sale

    7430-7448 S Federal Hwy, Port Saint Lucie, FL

    $2,550/Mo
    13,129 sqft $2.33 SF/Yr

    Well-maintained property with long-term occupants and upside potential.

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    Modernized Office Space in Stuart
    Modernized Office Space in Stuart

    2100 SE Ocean Blvd, Stuart, FL 34996

    $18 SF/Yr

    Prestigious Stuart property with renovated office space and competitive rates.

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    Single-Story Office Building For Rent
    Single-Story Office Building For Rent

    120-128 SW Chamber Ct, Port Saint Lucie, FL

    $22 SF/Yr
    4,020 sqft $7,370/Mo

    Single-story office building with immediate availability and hurricane impact glass.

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    Class A Office Buildings
    Class A Office Buildings

    729-819 SW Federal Hwy, Stuart, FL 34994

    $29.50 SF/Yr

    Premier office buildings in Stuart, Florida, with excellent access.

    View details

    Similar Spaces for Sale in Port St Lucie, FL

    Consider Similar Space for Sale. We found 5 Spaces matching your search parameters.

    Freestanding Office/Medical Building
    Freestanding Office/Medical Building

    3651 Virginia Avenue, Fort Pierce, FL

    $1,695,000
    9,255 sqft 0.69 AC lot

    Freestanding office and medical facility with classroom-style rooms and private offices, built in 2006 on general commercial zoning.

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    Freestanding Office Building with Private Offices
    Freestanding Office Building with Private Offices

    706 N 7th Street, Fort Pierce, FL

    $550,000
    4,805 sqft 0.28 AC lot

    Freestanding office building with exterior access, multiple reception areas, and 20 private offices suited for professional and medical uses.

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    Freestanding Office Medical Building
    Freestanding Office Medical Building

    3651 Virginia Avenue, Fort Pierce, FL 34981

    $1,695,000
    9,255 sqft 0.69 AC lot

    Well-maintained freestanding building on Virginia Avenue, designed for office and healthcare-related uses.

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    Development Powerhouse Near Airport
    Development Powerhouse Near Airport

    3032 N 25th St, Fort Pierce, FL 34946

    $4,300,000
    11,476 sqft 43.59 AC lot

    43.59 acres near Treasure Coast International Airport.

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    Mixed-Use Office and Apartment Building
    Mixed-Use Office and Apartment Building

    117 N 5th Street, Fort Pierce, FL 34950

    $1,595,000

    Turnkey building with renovated second-floor apartments and 14 office suites below, plus a separate parking-lot parcel.

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    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Melbourne Land for Ground Lease
    Melbourne Land for Ground Lease

    6365 N. Wickham Road, Melbourne, FL 32940

    $36 SF/Yr

    1.2-acre development site in Viera/Suntree area available for lease.

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    Cleared Lot in Williston
    Cleared Lot in Williston

    33 NW 3RD St, Williston, FL 32696

    $20,000/Mo

    C2-zoned lot in Williston's central business area for rent.

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    Prime Commercial Lot For Lease
    Prime Commercial Lot For Lease

    Tift Avenue N, Tifton, GA 31794

    $7,500/Mo

    0.66 acre commercial lot in high-traffic area.

    View details
    Prime Development Opportunity in Greenville
    Prime Development Opportunity in Greenville

    39 Airpark Ct, Greenville, SC 29607

    Contact for pricing

    1.27 acre interstate-visible land for ground lease or build-to-suit.

    View details

    Port St Lucie, FL Office buildings Market Trends and Statistics

    Explore Office buildings leasing options in Port St Lucie, FL with 11 listings featured on our commercial real estate exchange. The current inventory includes 23,804 square feet of properties with an estimated lease value of $84.74 SF/Yr.

    Estimated lease rates for Office buildings in Port St Lucie, FL begin at $14.98 SF/Yr, with an average of $21.18 SF/Yr and extend to $25.76 SF/Yr.
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    Most Searched ZIP Codes in Port St Lucie, FL

    • 34952
    • 34986
    • 34950
    • 34946
    • 34947
    • 34953

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