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    Port St Lucie, FL Mixed-use Properties for Lease

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    Port Saint Lucie, FL Vero Beach, FL Jensen Beach, FL Stuart, FL Palm City, FL Sebastian, FL Hobe Sound, FL
    Downtown Fort Pierce Corner Building
    Updated: Mar 10
    Downtown Fort Pierce Corner Building

    300 S 6th St, Fort Pierce, FL 34950

    Contact for pricing
    25,000 sqft 1.93 AC lot
    Prime Downtown Fort Pierce location occupying an entire city block.
    Large 1.9‑acre site with 91 dedicated parking spaces.
    Highly visible corner building with frontage on all four corners of the intersection.
    Flexible lease options available from 1,000 SF to 25,000 SF.
    Suitable for retail, office, restaurant, or mixed‑use concepts.
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    Mixed-Use Plaza with Signage
    Updated: Sep 16
    Mixed-Use Plaza with Signage

    Port St Lucie, FL 34953

    Contact for pricing
    Frontage on Southwest Port St. Lucie Boulevard with exposure to approximately 50,000 vehicles per day
    Office and retail suites suitable for medical, professional, administrative, retail, and service businesses
    On‑site parking and hurricane‑impact shutters
    Pylon and building signage opportunities
    Access to Florida’s Turnpike and I‑95
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    Downtown Fort Pierce Corner Building
    Downtown Fort Pierce Corner Building

    300 S 6th Street, Fort Pierce, FL 34950

    Contact for pricing
    27,500 sqft 1.93 AC lot

    Two-story freestanding building in thriving downtown corridor with parking.

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    Based on your search, we've compiled 26 Potential Opportunities for your consideration. Besides 3 Active listings in Port St Lucie, FL, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 19 Properties for Sales.

    Mixed-use properties for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Mixed-Use Building with Office Space
    Mixed-Use Building with Office Space

    900 US HIGHWAY 1, Lake Park, FL 33403

    $3,250/Mo
    4,174 sqft 0.17 AC lot

    C1B-zoned property combines retail and professional office configurations.

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    Hard-Corner Mixed-Use Property
    Hard-Corner Mixed-Use Property

    359 10th Street, Lake Park, FL 33403

    $5,000/Mo
    6,624 sqft

    Flexible commercial space with neighborhood-serving uses, upgraded building systems, and access near major retail and residential development.

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    Mixed-Use Retail and Office Building
    Mixed-Use Retail and Office Building

    2160 N TAMARIND Ave, West Palm Beach, FL 33407

    $2,383/Mo

    Newly built suites accommodate retail and office businesses near downtown West Palm Beach.

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    Two-Story Mixed-Use Plaza
    Two-Story Mixed-Use Plaza

    100 Century Boulevard, West Palm Beach, FL 33417

    Contact for pricing

    Five suites are available for lease within a gated, age-restricted residential community.

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    Similar Spaces for Sale in Port St Lucie, FL

    Consider Similar Space for Sale. We found 19 Spaces matching your search parameters.

    Commercially Zoned Quadplex
    Commercially Zoned Quadplex

    Fort Pierce, FL 34946

    $600,000
    2,244 sqft 0.42 AC lot

    Current multifamily use includes four apartments along with boat, RV, and warehouse storage.

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    Storage Facility with Apartment
    Storage Facility with Apartment

    2772 Harson Way, Fort Pierce, FL 34946

    $175,000
    5,025 sqft

    Built in 1925, the property includes garage and storage units alongside an apartment requiring complete renovation.

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    Mixed-Use Building with Office and Apartments
    Mixed-Use Building with Office and Apartments

    117 N 5TH STREET, Fort Pierce, FL 34950

    $1,645,990
    5,500 sqft

    Freestanding mixed-use building with 12 total units, including 6 ground-floor office suites and 6 upstairs apartments.

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    Mixed-Use Building with Office and Apartments
    Mixed-Use Building with Office and Apartments

    117 N 5TH STREET, Fort Pierce, FL 34950

    $1,695,000
    5,500 sqft

    Freestanding building with six ground-floor office suites and six second-floor apartment units plus on-site parking.

    View details
    Mixed-Use Portfolio in Fort Pierce
    Mixed-Use Portfolio in Fort Pierce

    2402 S Us Highway 1, Fort Pierce, FL 34982

    $2,599,000
    3,250 sqft 0.54 AC lot

    Mixed-use commercial portfolio with development potential in Fort Pierce, Florida.

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    Mixed-Use Commercial Portfolio
    Mixed-Use Commercial Portfolio

    2402 S US Highway 1, Fort Pierce, FL 34982

    $2,599,000
    0.16 AC lot

    Three-property portfolio combining retail, residential, and a commercial development parcel along US 1.

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    Live-Work Building with Apartment
    Live-Work Building with Apartment

    3343 S US Hwy 1, Fort Pierce, FL 34982

    $639,000

    Industrial zoning and a three-bay ground floor complement the upstairs residential space.

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    Mixed-Use Commercial Building For Sale
    Mixed-Use Commercial Building For Sale

    Port St Lucie, FL 34983

    Contact for pricing
    3,810 sqft

    3,810 SF mixed-use building with established tenants and high visibility.

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    Downtown Fort Pierce Corner Building
    Downtown Fort Pierce Corner Building

    300 S 6th St, Fort Pierce, FL 34950

    Contact for pricing
    25,000 sqft 1.93 AC lot

    Two-story building on 1.9 acres in thriving downtown corridor.

    View details
    Office/Warehouse with Roll-Up Access
    Office/Warehouse with Roll-Up Access

    Port St Lucie, FL 34953

    Contact for pricing

    Mixed-use commercial space combines office functionality with warehouse access and front-to-back airflow.

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    Office-Warehouse Unit
    Office-Warehouse Unit

    Port St Lucie, FL 34984

    Contact for pricing

    A mixed-use commercial space combines dedicated office area with warehouse space and one restroom.

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    Versatile Commercial Space on US1
    Versatile Commercial Space on US1

    621 S US Hwy 1, Fort Pierce, FL 34950

    Contact for pricing
    11,661 sqft 0.27 AC lot

    High-traffic location with income potential and flexible commercial space.

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    Freestanding Building with Drive-Thru
    Freestanding Building with Drive-Thru

    2716 S US Highway 1, Fort Pierce, Florida 34982, Fort Pierce, FL 34982

    $2,500,000
    3,367 sqft 0.80 AC lot

    Retail | Fort Pierce, Florida

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    Freestanding Building With Lot
    Freestanding Building With Lot

    Fort Pierce, FL 34952

    $950,000
    620 sqft 4.00 AC lot

    Retail | Port St Lucie, Florida

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    ±12,350 SF Warehouse
    ±12,350 SF Warehouse

    Fort Pierce, FL 34953

    $2,550,000
    12,350 sqft 1.01 AC lot

    12,350-square-foot warehouse on a 1.014-acre lot in Port St. Lucie

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    Mixed-Use Commercial Property
    Mixed-Use Commercial Property

    5300 South US Highway 1, Fort Pierce, FL 34982

    Contact for pricing

    Four parcels combine commercial land use with C-3 and CG zoning across city and county jurisdictions.

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    Runway's End Commerce Center
    Runway's End Commerce Center

    3250 Saint Lucie Blvd, Fort Pierce, FL 34946, Fort Pierce, FL 34946

    $8,200,000
    25,000 sqft

    Runway’s End Commerce Center | Industrial property

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    Development Site Near Florida Turnpike
    Development Site Near Florida Turnpike

    8101 Okeechobee Rd, Fort Pierce, FL 34945

    Contact for pricing
    2,500 sqft 10.30 AC lot

    Mixed-use development land near Florida Turnpike and Okeechobee Road.

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    Seaway Drive Mixed-Use Corner Parcel
    Seaway Drive Mixed-Use Corner Parcel

    801 Seaway Dr, Fort Pierce, FL 34949

    Contact for pricing
    0.90 AC lot

    Prime mixed-use corner parcel with high visibility and traffic.

    View details

    Port St Lucie, FL Mixed-use properties Lease Rates & Market Statistics

    Browse 3 Mixed-use properties for lease in Port St Lucie, FL on Realmo, a commercial real estate marketplace serving the Port St Lucie area. The current inventory totals 52,500 square feet of properties.

    Port St Lucie accounts for 75% of the 4 mixed-use properties currently available across St. Lucie County, where nearby markets include Fort Pierce and Port Saint Lucie.

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    Browse Mixed-use properties for Lease Near Port St Lucie, FL

    Popular Searches in Port St Lucie, FL

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    Most Searched ZIP Codes in Port St Lucie, FL

    • 34950
    • 34953

    Featured Port St Lucie Real Estate Agencies

    Realmo connects you with licensed Port St Lucie CRE brokers providing property specifications, local market pricing, and commercial transaction underwriting support.

    Keller Williams Realty of Port St Lucie
    9700 Reserve Boulevard Fort Pierce, FL 34986
    Phone: 17722365700
    Atlantic Shores Realty Executives
    201 SW Port St Lucie Blvd, Suite 104 Fort Pierce, FL 34984
    Phone: 17722282111
    www.asrefl.com
    Management Specialists
    2355 SE Seafury Lane Fort Pierce, FL 34952
    Phone: 17723809011
    www.mgtspec.com
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