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    Port St Lucie, FL Mixed-use Properties for Lease

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    Port Saint Lucie, FL Vero Beach, FL Jensen Beach, FL
    Renovated Mixed-Use Professional Office Space
    $48,000 SF/Yr
    1,911 SF

    Renovated Mixed-Use Professional Office Space

    Port St Lucie, FL 34986

    Turnkey, renovated office space in St. Lucie West.

    • Turnkey, fully renovated 1,911 sq ft professional office space.
    • Prime location in the heart of St. Lucie West with convenient I‑95 access.
    • Ideal for medical, wellness, or professional office use.
    • Features five private exam rooms, three restrooms, a private office, and a staff breakroom.
    • Separate rear entrance for staff convenience and privacy.
    Updated: May 12
    View details
    Based on your search, we've compiled 33 Potential Opportunities for your consideration. Besides 1 Active listings in Port St Lucie, FL, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 24 Properties for Sales.

    Mixed-use properties for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Salerno Road Commercial Space Available
    $3,500/Mo
    1,800 SF

    Salerno Road Commercial Space Available

    Prime location with high visibility and flexible layout.

    4149 SE Salerno Road, Stuart, FL 34997
    View details
    Lake Park Innovation Center Units
    $36 SF/Yr

    Lake Park Innovation Center Units

    Modern units for small businesses in a growing area.

    230 N Congress Avenue, Lake Park, FL 33403
    View details
    Retail Building with Office, Warehouse
    $222 SF/Yr
    18,486 SF

    Retail Building with Office, Warehouse

    Freestanding retail building with office, warehouse, and yard space.

    4461 SE Federal Hwy, Stuart, FL 34997
    View details
    Prime Commercial Space Available
    $23 SF/Yr

    Prime Commercial Space Available

    Commercial space in a rapidly developing area, minutes from US 1.

    801 Park Ave, Lake Park, FL 33403
    View details

    Similar Spaces for Sale in Port St Lucie, FL

    Consider Similar Space for Sale. We found 24 Spaces matching your search parameters.

    Port St. Lucie Commercial Opportunity
    $1,300,000
    2,573 SF

    Port St. Lucie Commercial Opportunity

    Commercial property with outdoor storage and income potential.

    Port St Lucie, FL
    View details
    Fort Pierce Mixed-Use Portfolio
    $2,599,000
    0.16 Acres

    Fort Pierce Mixed-Use Portfolio

    Mixed-use portfolio with development potential in Fort Pierce, Florida.

    2402 S US Highway 1, Fort Pierce, FL 34982
    View details
    Reimagined Flex Building on US-1
    $308,000
    900 SF

    Reimagined Flex Building on US-1

    Adaptable flex building in growing Fort Pierce market.

    2997 US-1, Fort Pierce, FL 34946
    View details
    Mixed-Use Investment Opportunity
    $450,000

    Mixed-Use Investment Opportunity

    Mixed-use property with commercial and residential income potential.

    1712 Ave E, Fort Pierce, FL 34950
    View details
    Mixed-Use Investment Opportunity
    $2,900,000
    9,060 SF

    Mixed-Use Investment Opportunity

    Stabilized mixed-use property in Fort Pierce with diversified income.

    3901 Orange Ave, Fort Pierce, FL 34947
    View details
    Mixed-Use Investment Opportunity
    $450,000

    Mixed-Use Investment Opportunity

    Mixed-use property with commercial storefronts and residential units.

    1710 Ave E, Fort Pierce, FL 34950
    View details
    Port St. Lucie Commercial Land
    $1,300,000
    2,573 SF

    Port St. Lucie Commercial Land

    0.58 acres in fast-growing commercial corridor, Port St. Lucie.

    Port St Lucie, FL 34984
    View details
    Mixed-Use Commercial Building For Sale
    $990,000
    3,810 SF

    Mixed-Use Commercial Building For Sale

    3,810 SF mixed-use building with established tenants and high visibility.

    Port St Lucie, FL 34983
    View details
    Downtown Fort Pierce Corner Building
    $4,995,000
    25,000 SF

    Downtown Fort Pierce Corner Building

    Two-story, 25,000 SF building on 1.9 acres with parking.

    300 S 6th Street, Fort Pierce, FL 34950
    View details
    Versatile Commercial Space on US1
    $1,960,000
    11,661 SF

    Versatile Commercial Space on US1

    High-traffic location with income potential and flexible commercial space.

    621 S US Hwy 1, Fort Pierce, FL 34950
    View details
    Freestanding Building With Lot
    $950,000
    620 SF

    Freestanding Building With Lot

    Retail | Port St Lucie, Florida

    Fort Pierce, FL 34952
    View details
    Freestanding Building With Lot
    $950,000
    620 SF

    Freestanding Building With Lot

    Retail | Port St Lucie, Florida

    Fort Pierce, FL 34952
    View details
    Freestanding Building with Drive-Thru
    $2,500,000
    3,367 SF

    Freestanding Building with Drive-Thru

    Retail | Fort Pierce, Florida

    2716 S US Highway 1, Fort Pierce, Florida 34982, Fort Pierce, FL 34982
    View details
    Freestanding Building with Drive-Thru
    $2,500,000
    3,367 SF

    Freestanding Building with Drive-Thru

    Retail | Fort Pierce, Florida

    2716 S US Highway 1, Fort Pierce, Florida 34982, Fort Pierce, FL 34982
    View details
    Multi-Tenant Investment Opportunity
    $1,499,999
    5,520 SF

    Multi-Tenant Investment Opportunity

    Industrial warehouse and office building on 0.92 acres.

    3802 OLEANDER AVENUE, Fort Pierce, FL 34982
    View details
    Downtown Fort Pierce Office Space
    Contact for pricing

    Downtown Fort Pierce Office Space

    Professional office space in downtown Fort Pierce's Renaissance Business Center.

    130 S Indian River Dr., Suite 403, Fort Pierce, FL 34950
    View details
    ±12,350 SF Warehouse
    $2,550,000
    12,350 SF

    ±12,350 SF Warehouse

    12,350-square-foot warehouse on a 1.014-acre lot in Port St. Lucie

    Fort Pierce, FL 34953
    View details
    ±12,350 SF Warehouse
    $2,550,000
    12,350 SF

    ±12,350 SF Warehouse

    12,350-square-foot warehouse on a 1.014-acre lot in Port St. Lucie

    Fort Pierce, FL 34953
    View details
    Large Mixed-Use Development Opportunity
    $35,000,000
    256.00 Acres

    Large Mixed-Use Development Opportunity

    256 acres for mixed-use development in Port St. Lucie.

    Port St Lucie, FL 34987
    View details
    Runway's End Commerce Center
    $8,200,000
    25,000 SF

    Runway's End Commerce Center

    Runway’s End Commerce Center | Industrial property

    3250 Saint Lucie Blvd, Fort Pierce, FL 34946, Fort Pierce, FL 34946
    View details
    Runway's End Commerce Center
    $8,200,000
    25,000 SF

    Runway's End Commerce Center

    Runway’s End Commerce Center | Industrial property

    3250 Saint Lucie Blvd, Fort Pierce, FL 34946, Fort Pierce, FL 34946
    View details
    Multi-Tenant Investment Opportunity
    $1,299,000
    5,520 SF

    Multi-Tenant Investment Opportunity

    Multi-tenant industrial and office buildings on .92 acres.

    3802 Oleander Avenue, Fort Pierce, FL 34982
    View details
    Lakefront Property with Commercial Zoning
    $2,500,000
    1,600 SF

    Lakefront Property with Commercial Zoning

    Remodeled home and shop with commercial zoning near US1.

    5379 N Us Highway 1, Fort Pierce, FL 34946
    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Miami Development Opportunity on NW 27th
    Contact for pricing

    Miami Development Opportunity on NW 27th

    33,600 SF vacant land near transit with development potential.

    6611 NW 27 Avenue, Miami, FL 33147
    View details
    Atlanta Land for Lease
    $1,850/Mo

    Atlanta Land for Lease

    3-acre commercial land available for lease in Atlanta, GA.

    1057 Constitution Road SW, Atlanta, GA 30315
    View details
    Prime Commercial Acres For Lease
    $6,000/Mo

    Prime Commercial Acres For Lease

    4.12 acres of commercial land for lease in Rainsville, AL.

    4.12 Acres Al Highway 35, Rainsville, AL 35986
    View details
    Baton Rouge Commercial Parcel For Rent
    Contact for pricing

    Baton Rouge Commercial Parcel For Rent

    1.33-acre commercial parcel in a prime Baton Rouge location.

    7597 Jefferson Hwy, Baton Rouge, LA 70806
    View details

    Port St Lucie, FL Mixed-use properties Leasing Opportunities Market Analysis

    Explore Mixed-use properties leasing options in Port St Lucie, FL with 1 listings featured on our commercial real estate exchange. The current inventory includes 1,911 square feet of properties with an estimated lease value of $48,000.

    Estimated lease rates for Mixed-use properties in Port St Lucie, FL begin at $48,000, with an average of $48,000 and extend to $48,000.
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