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    Port St Lucie, FL Commercial Real Estate for Sale

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    Port Saint Lucie, FL Vero Beach, FL Jensen Beach, FL
    403 listings
    Port St. Lucie Professional Building
    $799,000
    3,404 SF
    Port St. Lucie Professional Building

    756 SE, Port St Lucie, FL

    High-visibility building suitable for professional offices or medical use.
    • Approx. 55,000 cars per day on SE Port St. Lucie Boulevard for high‑traffic exposure
    • Zoned Professional, offering use for professional offices, medical, shared workspace, or up to four separate units
    • Metal roof with central heating and central air, plus ceiling fans
    • Built in 1994 with block/concrete block construction with stucco
    • Public utilities: public water and public sewer; cable available
    Updated: May 29
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    Freestanding Office/Medical Building
    $1,695,000
    9,255 SF
    Freestanding Office/Medical Building

    3651 Virginia Avenue, Fort Pierce, FL

    Freestanding office and medical facility with classroom-style rooms and private offices, built in 2006 on general commercial zoning.
    • Freestanding office/medical building on highly visible Virginia Avenue in Fort Pierce
    • Built in 2006; 8,420+/- SF on approximately 0.69+/- acres
    • CG (General Commercial) zoning with permitted uses including retail, office, educational, health services, detox residential treatment, and behavioral health
    • Functional interior layout includes classrooms, private offices, and a kitchen with dining hall
    • Central heating and central air; concrete block with stucco exterior; shingle roof
    Updated: Jun 9
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    Freestanding Office Space in Fort Pierce
    $550,000
    4,805 SF
    Freestanding Office Space in Fort Pierce

    4,691 SF+/- freestanding office building suitable for diverse businesses.

    706 N 7th Street, Fort Pierce, FL

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    Fort Pierce Industrial Property
    $3,299,000
    14,224 SF
    Fort Pierce Industrial Property

    Equipped industrial property with office, warehouse, and shop space.

    16050 Orange Avenue, Fort Pierce, FL

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    Light Industrial-Commercial Multi-Unit Property
    $1,300,000
    2,573 SF
    Light Industrial-Commercial Multi-Unit Property

    Two structures with fenced outdoor storage and parking, including a learning center lease through February 2027.

    Port St Lucie, FL

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    Port St. Lucie Investment Opportunity
    $7,000,000
    6,204 SF
    Port St. Lucie Investment Opportunity

    Income-producing commercial plaza with established tenants in a growing area.

    Port St Lucie, FL

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    Light Industrial Warehouse with Yard
    $1,950,000
    8,424 SF
    Light Industrial Warehouse with Yard

    A 1958 light industrial warehouse with about 14' clear height and multiple grade-level doors, plus substantial yard on 2.64 acres.

    415 ANGLE ROAD, Fort Pierce, FL 34947

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    Fort Pierce Retail Investment Opportunity
    $1,699,000
    0.51 Acres
    Fort Pierce Retail Investment Opportunity

    Net leased retail with national tenant in prime location.

    2402 S US HWY 1, Fort Pierce, FL 34982

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    New Warehouse Near Airport
    $650,000
    3,000 SF
    New Warehouse Near Airport

    New 3,000+/- SF warehouse near Treasure Coast International Airport.

    2933 Harson Way, Fort Pierce, FL 34946

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    Hotel/Motel Property for Sale
    $5,995,000
    5,808 SF
    Hotel/Motel Property for Sale

    For sale hotel/motel on a 0.43-acre site in Fort Pierce, Florida, showings by appointment only.

    2502 TAMARIND DRIVE, Fort Pierce, FL 34949

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    General Commercial and Light Industrial Land
    $1,825,000
    5.10 Acres
    General Commercial and Light Industrial Land

    5.1-acre parcel zoned for commercial general and light industrial, positioned for development near major transportation corridors.

    5001 ORANGE AVENUE, Fort Pierce, FL 34947

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    Commercial Development Land with Road Frontage
    $1,975,000
    6.53 Acres
    Commercial Development Land with Road Frontage

    6.53-acre commercial land parcel with 510 feet of road frontage and utility access for development planning.

    5800 S US HIGHWAY 1, Fort Pierce, FL 34982

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    Renovated Duplex Near South Beach
    $995,000
    2,524 SF
    Renovated Duplex Near South Beach

    Income-generating duplex with potential for expansion or redevelopment.

    711 S Ocean Drive, Fort Pierce, FL 34949

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    Income-Producing Duplex in Fort Pierce
    $740,000
    3,480 SF
    Income-Producing Duplex in Fort Pierce

    Income-producing duplex with industrial zoning and future potential.

    2856 Harson Way, Fort Pierce, FL 34946

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    Prime Industrial Land on US1
    $1,795,000
    4.00 Acres
    Prime Industrial Land on US1

    4 acres of industrial-zoned land on US1 in Fort Pierce.

    3419 S US HWY 1, Fort Pierce, FL 34982

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    Commercial Development Land with 510' Frontage
    $1,975,000
    6.53 Acres
    Commercial Development Land with 510' Frontage

    6.53-acre US-1 frontage parcel with water, sewer, gas, and electric available, located across from a major auto dealership.

    5800 S Us Highway 1, Fort Pierce, FL 34982

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    Remodeled Beach House with Waterfront Access
    $2,950,000
    0.66 Acres
    Remodeled Beach House with Waterfront Access

    Remodeled beach house with private dock, licensed for events.

    3601 N Highway A1a, Fort Pierce, FL 34949

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    Income-Producing Corner Lot Duplex
    $445,000
    2,054 SF
    Income-Producing Corner Lot Duplex

    Half-acre commercial corner lot with duplex near US-1.

    424 N 6TH STREET, Fort Pierce, FL 34950

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    Prime Commercial/Industrial Land Opportunity
    $549,500
    1.16 Acres
    Prime Commercial/Industrial Land Opportunity

    1.16-acre site ready for commercial or industrial development.

    3112 OLEANDER AVENUE, Fort Pierce, FL 34982

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    Prime US #1 Development Site
    $1,750,000
    9.80 Acres
    Prime US #1 Development Site

    9.8 acres of commercial land on US #1 in Fort Pierce.

    5000 N US HIGHWAY 1, Fort Pierce, FL 34946

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    Golf Course View Corner Lot
    $275,000
    3,757 SF
    Golf Course View Corner Lot

    Oversized corner lot with golf course and lake views.

    426 NW Chipshot Lane, Port St Lucie, FL 34986

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    Turn-Key Jamaican Restaurant Business
    $125,000
    Turn-Key Jamaican Restaurant Business

    Well-maintained Jamaican restaurant offered turn-key, including equipment and inventory for immediate operation.

    Port St Lucie, FL 34953

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    Waterfront Development Site on Midway Road
    $549,000
    2.10 Acres
    Waterfront Development Site on Midway Road

    2.1-acre waterfront development site on the Midway Road corridor.

    2083 W MIDWAY ROAD, Fort Pierce, FL 34981

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    Renovated Office Condo Suite
    $160,000
    700 SF
    Renovated Office Condo Suite

    Second-floor professional suite with renovated finishes, a reception area, two private offices, and on-site parking availability.

    725 SE, Port St Lucie, FL

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    Port St Lucie, FL Commercial Real Estate Investment Opportunities Market Analysis

    Explore 403 commercial real estate for sale in Port St Lucie, FL, showcased through 403 active listings on our real estate platform. These investment opportunities span a total of 2,168,737 square feet of properties for sale, with an estimated market value of $277,592,901.

    Sale prices for business properties in Port St Lucie, FL start at $35,000, averaging $2,168,694, and reaching up to $16,375,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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    Demographics Overview

    Population 239K
    Population Growth (5Y) +29.5%
    Median Household Income $76,114
    College Educated 29.0%

    High-Yield Neighborhoods for Investment

    Identify Port St Lucie submarkets with the highest inventory density on the market and evaluate the average listing prices of real estate assets

    Neighborhood Average Price
    Port Saint Lucie - 34985 $90K
    Port Saint Lucie - 34986 $486.6K
    Port Saint Lucie - 34983 $503.2K
    Port Saint Lucie - 34952 $1M
    Port Saint Lucie - 34984 $1.1M

    Listings Trend

    New vs delisted commercial listings in St. Lucie County

    New Delisted

    Total CRE Inventory on Market (SF)

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