Port St Lucie, FL Medical Office Space for Sale

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21 properties

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Updated: Aug 3

Freestanding Medical Office Building

Port St Lucie, FL

$3,300,000

11,187 sqft 1.02 AC lot

Freestanding medical office building with five medical suites
Delivered vacant with a fully built‑out professional interior
49 on‑site parking spaces
1.02‑acre property directly adjacent to HCA Florida St. Lucie Hospital
8 out of 10 AC units replaced within the last 5 years

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Updated: May 4

Medical Office Space with Two Buildings

1803 & 1805 S 25th Street, Fort Pierce, FL

$1,900,000

9,560 sqft 0.96 AC lot

Two‑building medical office property with 7 leased units
9,560 square feet of leased space on 0.96 acres
Fully leased medical and office suite configuration
Located near Lawnwood Regional Medical Center and the Regional Medical Trauma Center
1980 construction with block/CBS materials and a metal roof

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4-Exam-Room Medical Office

1801 S 23rd Street, Fort Pierce, FL

$399,500

1,734 sqft

Professional-zoned medical office condo with exam, reception, lab, and private office areas.

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See what stands out in St. Lucie County

We check every for-sale listing in the county against comparable properties across the country. Most price about where you would expect. A few are worth a second look.

We check every listing here. A few are worth a second look.

Cap Rate available after sign in

NOI available after sign in

Local Demand available after sign in

Free-Standing Medical Office Building

2624 S Us Highway 1, Fort Pierce, FL 34982

$990,000

8,000 sqft 0.50 AC lot

Free-standing concrete block medical office with reception, waiting area, and eight exam rooms, updated and newly roofed.

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Freestanding Medical Office Building

1900 Nebraska Avenue, Fort Pierce, FL 34950

$625,000

2,100 sqft

Configured for clinical operations with exam rooms, private offices, reception, and patient parking.

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Freestanding Medical Office Building

3651 Virginia Avenue, Fort Pierce, FL

$1,695,000

9,255 sqft 0.69 AC lot

The property combines private offices, classrooms, and a kitchen with dining space in a dedicated commercial facility.

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Professional Office Building

756 SE, Port St Lucie, FL

$799,000

3,404 sqft 0.50 AC lot

Standalone commercial building with flexible office configuration, professional zoning, updated air conditioning, and on-site parking.

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Medical Office Condo with Sale-Leaseback

St Lucie West, FL 34986

$950,000

2,818 sqft

Turn-key medical office condo with in-place practice, structured sale-leaseback for stable, predictable investor cash flow.

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Office Unit with Flex Space

540 NW University Boulevard Unit 206, Port St Lucie, FL 34986

$365,000

968 sqft

Freshly painted office unit with reception, kitchen, private offices, and adaptable open workspace.

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Freestanding Office Building

3651 Virginia Avenue, Fort Pierce, FL 34981

$1,695,000

8,420 sqft 0.69 AC lot

Adaptable commercial facility with classrooms, private offices, and a kitchen adjoining a dining area.

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Medical Office Unit with Signage

1805 S 25th Street Unit Suite 2, Fort Pierce, FL 34947

Contact for pricing

700 sqft

Freshly updated office suite with reception, storage cabinetry, private bathroom, and on-site parking near a regional medical center.

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Freestanding Medical Office Building

1215 S 25th Street S, Fort Pierce, FL 34947

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2,400 sqft

Flexible professional layout with private rooms, reception areas, kitchenette, storage, restrooms, and natural light.

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Turn-Key Medical Office

Port St Lucie, FL 34986

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4,324 sqft

Turn-key medical office with modern interior finishes and a versatile configuration, offered as an income-producing asset.

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Freestanding Medical Office Building

Port St Lucie, FL 34952

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1,865 sqft

Flexible interior includes reception, private rooms, support areas, and two restrooms.

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Turn-Key Medical Office Suite

2506 Acorn Street Unit A-b, Fort Pierce, FL 34947

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1,800 sqft

Renovated medical/professional suite with five exam rooms, private offices, and two bathrooms plus a large on-site parking lot.

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Medical Office Suite with Signage

1805 S 25th Street Unit Suite 1, Fort Pierce, FL 34947

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9,560 sqft

Move-in ready suite offers multiple office and work areas, built-in storage, and two bathrooms with prominent roadside exposure.

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Commercial Building on High-Traffic Road

602 W Midway Road, Fort Pierce, FL 34982

$559,000

Commercial building with high-traffic road frontage, suitable for office/medical use.

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Four-Office Flex Office Unit

206-540 Nw University Blvd, Port St Lucie, FL 34986

$365,000

Freshly updated office unit with reception, kitchenette, private rooms, and adaptable workspace.

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Turn-Key Medical Office Suite

A-b-2506 Acorn St, Fort Pierce, FL 34947

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Newly renovated medical suite with five exam rooms, private offices, and a large dedicated parking lot.

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Medical Office with Exam Rooms

3e-2215 Nebraska Ave, Fort Pierce, FL 34950

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Medical office with dedicated clinical, administrative, patient waiting, storage, and front-and-back access areas.

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Medical Co-working Space Opportunity

2401 Frist Blvd 1-2, Fort Pierce, FL 34950

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Co-working space in established medical hub near major hospitals.

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Based on your search, we've compiled Potential Opportunities for your consideration. Besides 21 Active Listings in Port St Lucie, FL, we suggest to view alternatives - similar 10 Off-Market properties to explore as potential leads.

Off-Market Properties in Port St Lucie, FL

Consider similar Off-Market properties in Port St Lucie, FL. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

MEDICAL BUILDING

544 University Blvd Ste, Port St Lucie, FL 34986-2283

Unit 101

Estimated value:

$215,000

891 sqft 0.02 AC lot

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MEDICAL BUILDING

540 University Blvd Ste, Port St Lucie, FL 34986-2280

Unit 105

Estimated value:

$220,000

968 sqft 0.02 AC lot

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MEDICAL BUILDING

542 University Blvd Ste, Port St Lucie, FL 34986-2282

Unit 101

Estimated value:

$265,000

2,419 sqft 0.06 AC lot

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Port St Lucie, FL Medical Office Space Market Trends and Statistics

Explore 31 medical office space for sale in Port St Lucie, FL, showcased through 21 active listings on our real estate platform. These investment opportunities span a total of 78,095 square feet of properties for sale, with an estimated market value of $13,642,500.

Sale prices for medical spaces in Port St Lucie, FL start at $365,000, averaging $1,136,875, and reaching up to $3,300,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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Top Commercial Asset Segments

Commercial property segments ranked by active listings on the market

Demographics Overview

Population 239K

Population Growth (5Y) +29.5%

Median Household Income $76,114

College Educated 29.0%

High-Yield Neighborhoods for Investment

Identify Port St Lucie submarkets with the highest inventory density on the market and evaluate the average listing prices of real estate assets

Neighborhood	Average Price
Port Saint Lucie - 34986	$370K
Port Saint Lucie - 34952	$1.1M

Listings Trend

New vs delisted commercial listings in St. Lucie County

New Delisted

Total CRE Inventory on Market (SF)

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