Port St Lucie, FL Office Spaces for Lease

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Port Saint Lucie, FL Vero Beach, FL Jensen Beach, FL Stuart, FL Palm City, FL Sebastian, FL Hobe Sound, FL

100 properties

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Coworking and Private Offices with Flexible Terms at Renaissance Financial. Contact us today to book a tour!

30 Indian River Dr, Unit 202, Fort Pierce, FL 34950

16 available spaces from 11 to 2,163 sqft

$129-$17,521/Mo per office

(972) 764-8885

Flexible workspace in Renaissance Financial. Book a tour & get info

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Updated: Aug 17

Second-Floor Office Unit

2011 S 25TH Street, Fort Pierce, FL 34947

$650/Mo

13,166 sqft 0.85 AC lot

355‑square‑foot second‑floor office unit
Gross lease with electricity included
New elevator serves the building
63 parking spaces on a 0.85‑acre site
Across from the County Administrative Offices

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Updated: Aug 14

Second-Floor Office Unit

2011 S 25TH Street, Fort Pierce, FL 34947

$850/Mo

13,166 sqft 0.85 AC lot

546‑square‑foot second‑floor office unit
New elevator provides access to the second floor
Gross lease with electricity included
63 on‑site parking spaces
Zoned Office Co

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First-Floor Office Suite

600 Citrus Avenue, Fort Pierce, FL 34950

$2,700/Mo

13,284 sqft 1.00 AC lot

Newly configured professional office space within a concrete building with central HVAC and public utilities.

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Medical Office Building with Five Suites

1405 SE Goldtree Dr, Port St Lucie, FL 34952

Contact for pricing

11,187 sqft

Built-out medical space offers contiguous occupancy or multiple suite configurations near a hospital and established medical campus.

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Freestanding Medical Office

1215 S 25th Street S, Fort Pierce, FL 34947

$6,600/Mo

2,416 sqft 0.37 AC lot

Flexible interior includes exam rooms, private offices, reception, kitchenette, and storage.

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Freestanding Live-Work Space

Port St Lucie, FL 34952

$4,216/Mo

1,865 sqft 0.27 AC lot

Flexible office layout includes private rooms, reception, restrooms, kitchen, storage, and workspace.

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Renovated Medical Office with Exam Rooms

2506 Acorn Street, Fort Pierce, FL 34947

$3,750/Mo

1,800 sqft 0.90 AC lot

Configured for clinical and professional office use with reception, private offices, and patient waiting space.

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Second-Floor Office Unit

2011 S 25TH Street #207 / 209, Fort Pierce, FL 34947

$650/Mo

13,166 sqft

Gross lease includes electricity, with restroom access provided in a shared common area.

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Freestanding Office Units with Private Offices

706 N 7th Street, Fort Pierce, FL 34950

$6,000/Mo

4,805 sqft 0.28 AC lot

Concrete office property with flexible room configuration, reception areas, kitchen, and public utilities in Fort Pierce.

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Coworking Space with Marble Flooring

Port St Lucie, FL 34986

$3,000/Mo per office

2,100 sqft

Professional workspace with central HVAC and General Commercial zoning at a Port St. Lucie address.

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Second-Floor Office Unit

2011 S 25TH Street #216, Fort Pierce, FL 34947

$850/Mo

13,166 sqft

Gross-lease office space with electricity included and access to shared common-area amenities.

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Retail Suite with Open Layout

Port St Lucie, FL 34986

$3,500/Mo

1,300 sqft

CG-zoned commercial space offers a private office, restroom, and adaptable setting for office, medical, wellness, retail, or professional services.

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Turnkey Medical Office Building

Port St Lucie, FL 34952

$20 SF/Yr

11,187 sqft 1.02 AC lot

Built-out medical space with contiguous suites, public utilities, and access to guest parking near St. Lucie Medical Park.

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Second-Floor Office Unit

2011 S 25TH Street 216, Fort Pierce, FL 34947

$850/Mo

546 sqft

Gross lease includes electricity, with internet, cable, and interior maintenance handled by the tenant.

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Industrial Flex Unit with Mezzanine

Port St Lucie, FL 34986

$3,398/Mo

2,232 sqft

Air-conditioned offices complement a warehouse with high clear ceilings and ground-level roll-up loading access.

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Move-In Ready Medical Office Space

1801 S 23rd Street, Fort Pierce, FL 34950

$3,179/Mo

1,734 sqft

Configured healthcare office with exam rooms, reception, private offices, lab/prep space, and two bathrooms.

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Freestanding Medical Office Space

761 E PRIMA VISTA Boulevard, Port St Lucie, FL 34952

$4,216/Mo

1,865 sqft

Flexible layout includes private rooms, reception, kitchen, storage, and two restrooms.

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Renovated Medical Office Suite

Port St Lucie, FL 34986

$48,000/Mo

1,911 sqft

Professional suite with patient-facing areas, private workrooms, and a separate staff entrance.

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Storefront Space with Private Office

2017 Ave D, Fort Pierce, FL 34950

$1,400/Mo

1,406 sqft

Flexible interior includes a reception area, open work zone, and fenced backyard with grass and fruit trees.

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Updated Marina-View Office Unit

2010 Harbortown W, Fort Pierce, FL 34946

$1,000/Mo

8,385 sqft 1.65 AC lot

Updated vinyl-floored office unit with central HVAC, marina views, and ample parking for tenants and clients.

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Freestanding Medical Office Building

1215 S 25th Street S, Fort Pierce, FL 34947

$6,600/Mo

2,416 sqft

Configured with private rooms, reception, support areas, and three restrooms.

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Medical Office Suite with Signage

1805 S 25th Street, Fort Pierce, FL 34947

$2,300/Mo

9,560 sqft 0.96 AC lot

Fresh finishes, multiple work areas, two restrooms, and on-site parking support office or medical use.

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Second-Floor Office Unit

2011 S 25th St, Fort Pierce, FL 34947

$650/Mo

355 sqft

Compact office space with elevator access, shared common-area restroom, and electricity included under a gross lease.

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Updated Office Units with ADA Restroom

2210 S 40th Street, Fort Pierce, FL 34947

$1,700/Mo

792 sqft 0.21 AC lot

Freestanding commercial space offers flexible work areas, a private office, lounge, and employee amenities.

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Port St Lucie, FL Office Spaces Lease Rates & Market Statistics

Browse 100 Office Spaces for lease in Port St Lucie, FL on Realmo, a commercial real estate marketplace serving the Port St Lucie area. The current inventory totals 365,564 square feet of properties — an average of ~3,650 SF per listing.

Office Spaces lease rates in Port St Lucie range from $1.43 SF/Yr at the entry level to $301.41 SF/Yr at the top of the market, averaging $26.91 SF/Yr. At $26.91 SF/Yr, the local average runs 23% below Florida's state average of $35.15 SF/Yr.

Within St. Lucie County, most Port St Lucie office spaces listings are located in and around Port Saint Lucie, with additional options across the city. By space type, the market includes 65 office units, 35 medical office space listings and 11 office buildings — office buildings typically offer the lowest entry point, while medical office space commands the highest rates.

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