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    Port St Lucie, FL Office Spaces for Lease

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    Port Saint Lucie, FL Vero Beach, FL Jensen Beach, FL Stuart, FL Palm City, FL Sebastian, FL Hobe Sound, FL
    81 properties
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    Renaissance Financial
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    Office-Medical Suite with Signage
    Updated: Jul 1
    Office-Medical Suite with Signage

    1805 S 25th Street, Fort Pierce, FL 34947

    $2,300/Mo
    9,560 sqft
    Suite 1 offers approximately 1,705 SF of office/medical space near Lawnwood Regional Medical Center
    Multiple rooms, offices, and work areas with built‑in cabinets for storage plus 2 bathrooms
    Freshly painted interior with newer vinyl plank flooring
    Built in 1980 with block and concrete construction and a metal roof
    Central air conditioning and central electric heating; electric utilities available
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    General Commercial Office Suite
    Updated: Jul 10
    General Commercial Office Suite

    Port St Lucie, FL 34986

    $3,500/Mo
    1,300 sqft
    1,300+/- SF commercial suite with an open floor plan, one private office, and one restroom
    Zoned CG (General Commercial), allowing office, medical, wellness, retail, and professional service uses
    Built in 2007 with concrete construction, central heat, and central air
    Public water and public sewer, plus cable available
    Barrel roof and carpet flooring
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    Freestanding Office Building
    Freestanding Office Building

    706 N 7th Street, Fort Pierce, FL 34950

    $6,000/Mo
    4,805 sqft

    Freestanding office with 20 private offices, multiple reception areas, and dedicated bathroom and kitchen support.

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    Versatile Facility for Lease
    Versatile Facility for Lease

    2525 S 25th St, Fort Pierce, FL 34981

    $5,000/Mo
    4,028 sqft

    4,028 SF building ideal for school or office use.

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    Turn-Key Medical Office Suite
    Turn-Key Medical Office Suite

    2506 Acorn Street, Fort Pierce, FL 34947

    $3,750/Mo
    1,800 sqft

    Newly renovated medical office with 5 exam rooms, private offices, and a large on-site parking lot.

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    Industrial Flex Unit with Roll-Up Door
    Industrial Flex Unit with Roll-Up Door

    Port St Lucie, FL 34986

    $3,398/Mo
    2,232 sqft

    Industrial flex space offering air-conditioned offices, a concrete-floored mezzanine, and a ground-level roll-up door for efficient operations.

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    Versatile Commercial Retail Office Unit
    Versatile Commercial Retail Office Unit

    Port St Lucie, FL 34983

    $2,000/Mo
    900 sqft

    Lease a 900 SF commercial unit on SW Bayshore Boulevard with a flexible layout and ample on-site parking.

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    Turn-Key Medical Office Suite
    Turn-Key Medical Office Suite

    2506 Acorn St, Fort Pierce, FL 34947

    $25 SF/Yr
    1,800 sqft

    Renovated medical-professional space with five exam rooms, private offices, two bathrooms, and ample on-site parking.

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    Move-In Ready Medical Office Condo
    Move-In Ready Medical Office Condo

    1801 S 23rd Street, Fort Pierce, FL 34950

    $3,179/Mo
    1,734 sqft

    Medical office condo with four exam rooms, private offices, lab/prep area, and move-in-ready interior.

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    Versatile Facility in Fort Pierce
    Versatile Facility in Fort Pierce

    2525 S 25th Street, Fort Pierce, FL 34981

    $5,000/Mo
    4,028 sqft

    4,028 SF building suitable for various uses.

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    Landmark Office Building Space
    Landmark Office Building Space

    2222 Colonial Rd 200, Fort Pierce, FL 34950

    $16 SF/Yr
    5,400 sqft

    5,400 sq ft office space near US #1.

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    Medical Office Suite with Exam Rooms
    Medical Office Suite with Exam Rooms

    Port St Lucie, FL 34986

    $48,000/Mo
    1,911 sqft

    Fully renovated suite with five private exam rooms, multiple restrooms, reception area, and a dedicated staff breakroom.

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    Turnkey Medical Office Building
    Turnkey Medical Office Building

    Port St Lucie, FL 34952

    $20/Mo
    11,187 sqft

    Turnkey, fully built-out medical office space offering 5 suites or contiguous configuration with 49 parking spaces under NNN terms.

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    First-Floor Medical Office Suite
    First-Floor Medical Office Suite

    Port St Lucie, FL 34952

    $25 SF/Yr
    1,530 sqft

    A 1,530 SF first-floor suite with reception, four exam rooms with sinks, and two restrooms in Hillmoor Professional Plaza.

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    Updated Office Space in Marina
    Updated Office Space in Marina

    2010 Harbortown W, Fort Pierce, FL 34946

    $1,000/Mo
    8,385 sqft

    Recently updated office space in Fort Pierce's Harbortown Marina.

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    Office Suite with Multiple Private Offices
    Office Suite with Multiple Private Offices

    2222 Colonial Road, Fort Pierce, FL 34950

    $17/Mo
    5,400 sqft

    Includes 15 offices, a waiting area, two conference rooms, and kitchen/break room space in an office building.

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    Medical Office Space Available 2025
    Medical Office Space Available 2025

    Port St Lucie, FL 34952

    $24 SF/Yr
    1,530 sqft

    Medical office space near St. Lucie Medical Center available 2025.

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    Updated Free-Standing Office Building
    Updated Free-Standing Office Building

    2210 S 40th Street, Fort Pierce, FL 34947

    $1,700/Mo
    792 sqft

    Completely updated office with impact windows, a private office, ADA-compliant restroom, and multi-use work area.

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    Medical Coworking Suite
    Medical Coworking Suite

    2401 Frist Boulevard #1-2, Fort Pierce, FL 34950

    $5,416/Mo
    2,500 sqft

    Coworking space designed for medical professionals with convenient parking in an established area near major hospital facilities.

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    Class A Office Suite with Elevator
    Class A Office Suite with Elevator

    Port St Lucie, FL 34952

    $2,287/Mo
    940 sqft

    Second-floor suite includes three private offices, open work area, and elevator access for a professional setup.

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    First Floor Office Space
    First Floor Office Space

    500 S Us Highway 1, Fort Pierce, FL 34950

    $2,210/Mo
    2,084 sqft

    2,084 sq ft office space for lease on US Hwy 1.

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    Flexible Coworking Office Space
    Flexible Coworking Office Space

    Port St Lucie, FL 34986

    $3,000/Mo

    Turnkey coworking membership with flexible day schedules for professionals and service providers in a commercial corridor setting.

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    Flex Warehouse with Drive-In Door
    Flex Warehouse with Drive-In Door

    1256 SW Biltmore Street, Port St Lucie, FL 34983

    $2,350/Mo
    1,225 sqft

    Flex-use warehouse with 18-foot ceilings, drive-in access, and a separate-entry walk-in office for day-to-day operations.

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    Office Suite with Marina View
    Office Suite with Marina View

    2010 Harbortown Drive, Fort Pierce, FL 34946

    $1,500/Mo

    Office space with marina views, ample parking, and a nearby restaurant within walking distance.

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    Port St Lucie, FL Office Spaces Market Trends and Statistics

    Explore Office Spaces leasing options in Port St Lucie, FL with 81 listings featured on our commercial real estate exchange. The current inventory includes 225,623 square feet of properties with an estimated lease value of $28,040.

    Estimated lease rates for Office Spaces in Port St Lucie, FL begin at $1.43 SF/Yr, with an average of $683.91 /Mo and extend to $26,800.
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    Most Searched ZIP Codes in Port St Lucie, FL

    • 34986
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    • 34952
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