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    Port St Lucie, FL
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    Port St Lucie, FL Office Spaces for Lease

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    Port Saint Lucie, FL Vero Beach, FL Jensen Beach, FL
    65 results
    Renaissance Financial
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    Quincy Professional Plaza
    $2,200/Mo
    Quincy Professional Plaza

    medical, dentist, insurance, retail

    1803 S 25Th St, Unit Suite 5, Fort Pierce, FL 34947

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    Move-in Ready Medical Office Condo
    $3,352/Mo
    1,734 SF
    Move-in Ready Medical Office Condo

    1801 S 23rd Street, Fort Pierce, FL 34950

    Medical office condo for lease near Lawnwood Medical Center.
    • Move‑in ready medical office condo near Lawnwood Medical Center.
    • Equipped with 4 exam rooms, large waiting/reception area, private doctor's office, lab/prep area, break room, and 2 bathrooms.
    • Ideal for a pediatrician, previously used as a pediatrics office.
    • Lease terms: Modified gross lease at $23 per sq ft, tenant pays rent, utilities, and increases in taxes/condo fees; escalating monthly rent for years 1‑3, CPI increases for years 4 & 5.
    • Recently installed new 200 amp 3 phase break panel.
    Updated: Apr 28
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    Medical Building Near St. Lucie Hospital
    $22 SF/Yr
    11,187 SF
    Medical Building Near St. Lucie Hospital

    Port St Lucie, FL 34952

    Turnkey medical building in St. Lucie Medical Park.
    • Turnkey & Completely Built‑out: Ready for immediate occupancy as a medical building.
    • Located in a prominent medical area adjacent to HCA Florida St. Lucie Hospital.
    • 10,032 sqft available, offering flexibility for single or multiple tenants (approximately 2,006 sqft each).
    • NNN Lease at $22/sqft plus CAM $7.82/sqft.
    • 49 parking spaces available.
    Updated: Apr 2
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    Fort Pierce Freestanding Office Space
    $6,000/Mo
    4,805 SF
    Fort Pierce Freestanding Office Space

    Freestanding office space in Fort Pierce, ideal for diverse businesses.

    706 N 7th Street, Fort Pierce, FL 34950

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    Turnkey Medical Office Suite
    $48,000 SF/Yr
    1,911 SF
    Turnkey Medical Office Suite

    Fully renovated suite includes exam rooms, private office, and a rear entrance for staff convenience.

    Port St Lucie, FL 34986

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    Versatile Facility in Fort Pierce
    $5,000/Mo
    4,028 SF
    Versatile Facility in Fort Pierce

    4,028 SF building suitable for various uses.

    2525 S 25th Street, Fort Pierce, FL 34981

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    Private Entrance Professional Office Suite
    $2,667/Mo
    3,930 SF
    Private Entrance Professional Office Suite

    Professional office suite with dedicated entry, reception area, private bath, new central A/C, and five assigned parking spaces.

    501 SW, Port St Lucie, FL 34953

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    Landmark Office Building in Fort Pierce
    $17 SF/Yr
    5,400 SF
    Landmark Office Building in Fort Pierce

    5,400 sq ft office space available for lease.

    2222 Colonial Road, Fort Pierce, FL 34950

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    Flexible Co-working Space For Rent
    $3,000/Mo
    Flexible Co-working Space For Rent

    Co-working space in St. Lucie West, flexible terms.

    Port St Lucie, FL 34986

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    Fort Pierce Commercial Rental Space
    $18 SF/Yr
    Fort Pierce Commercial Rental Space

    2,400 SF commercial space with office and warehouse.

    405 Angle Road, Fort Pierce, FL 34947

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    Port St. Lucie Executive Suite
    $1,527/Mo
    833 SF
    Port St. Lucie Executive Suite

    Executive office suite in Port St. Lucie medical corridor.

    Port St Lucie, FL 34952

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    Updated Office Space in Marina
    $1,000/Mo
    8,385 SF
    Updated Office Space in Marina

    Recently updated office space in Fort Pierce's Harbortown Marina.

    2010 Harbortown W, Fort Pierce, FL 34946

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    Class A Office Suite Available
    $2,287/Mo
    Class A Office Suite Available

    Professional office suite with private offices and open space.

    Port St Lucie, FL 34952

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    Office with Marina View
    $1,500/Mo
    Office with Marina View

    Office space for rent with marina view and parking.

    2010 Harbortown Drive, Fort Pierce, FL 34946

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    Versatile Facility for Lease
    $5,000/Mo
    4,028 SF
    Versatile Facility for Lease

    4,028 SF building ideal for school or office use.

    2525 S 25th St, Fort Pierce, FL 34981

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    First Floor Office Space
    $2,210/Mo
    2,084 SF
    First Floor Office Space

    2,084 sq ft office space for lease on US Hwy 1.

    500 S Us Highway 1, Fort Pierce, FL 34950

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    Medical Co-working Space For Rent
    $5,416/Mo
    Medical Co-working Space For Rent

    Co-working space in established medical hub near major hospitals.

    2401 Frist Boulevard, Fort Pierce, FL 34950

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    Office/Warehouse Flexible Space For Lease
    $995/Mo
    980 SF
    Office/Warehouse Flexible Space For Lease

    980 SF office/warehouse with mezzanine and private bathroom.

    515 S 3rd St, Fort Pierce, FL 34950

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    Harbortown Marina Office Space
    $1,000/Mo
    300 SF
    Harbortown Marina Office Space

    Office space for rent in Harbortown Marina, Ft. Pierce.

    2010 Harbortown W, Fort Pierce, FL 34946

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    Medical Office Space For Rent
    $24 SF/Yr
    Medical Office Space For Rent

    Updated medical office space available for rent in Port St. Lucie.

    1801 SE Hillmoor Drive, Port St Lucie, FL 34952

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    Modern Flex Office Spaces
    $1,900/Mo
    1,500 SF
    Modern Flex Office Spaces

    Flexible leasing options in a busy industrial corridor.

    3801 Oleander Ave, Fort Pierce, FL 34982

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    Freestanding Office Building
    $21 SF/Yr
    Freestanding Office Building

    Freestanding office with high visibility on Port Saint Lucie Boulevard, ideal for tenants customizing their layout.

    Port St Lucie, FL 34952

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    Flex Industrial Condo Unit
    $1,750/Mo
    Flex Industrial Condo Unit

    Centralized flex unit combines office space, a restroom, and open warehouse area for versatile business operations.

    Port St Lucie, FL 34983

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    Port St Lucie, FL Office Spaces Leasing Opportunities Market Analysis

    Explore Office Spaces leasing options in Port St Lucie, FL with 65 listings featured on our commercial real estate exchange. The current inventory includes 258,436 square feet of properties with an estimated lease value of $48,842.

    Estimated lease rates for Office Spaces in Port St Lucie, FL begin at $1.43 SF/Yr, with an average of $1,285 /Mo and extend to $48,000.
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