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    Port St Lucie, FL Commercial Real Estate for Lease

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    Miami, FL Orlando, FL Jacksonville, FL
    168 results
    Quincy Professional Plaza
    $2,200/Mo
    1,440 SF

    Quincy Professional Plaza

    medical, dentist, insurance, retail

    1803 S 25Th St, Unit Suite 5, Fort Pierce, FL 34947
    View details
    Medical Building Near St. Lucie Hospital
    $24 SF/Yr
    11,187 SF

    Medical Building Near St. Lucie Hospital

    Port St Lucie, FL 34952

    Turnkey medical building for lease in prime location.

    • Turnkey & Completely Built‑out Medical Building: Ready for immediate occupancy.
    • Prime Location: Adjacent to HCA Florida St. Lucie Hospital in a prominent medical area.
    • Flexible Configuration: Option for single tenant or up to 5 suites (approx. 2,006 sqft each).
    • Ample Parking: Features 49 parking spaces.
    • High‑Traffic Accessibility: Located just off US Highway 1.
    Updated: Apr 2
    View details
    Fort Pierce Freestanding Office Space
    $6,000/Mo
    4,805 SF

    Fort Pierce Freestanding Office Space

    706 N 7th Street, Fort Pierce, FL 34950

    Freestanding office space in Fort Pierce, ideal for diverse businesses.

    • 4,691 SQFT Freestanding Office Space
    • Ideal Location Minutes from Intracoastal and Downtown Fort Pierce
    • Suitable for Medical, Insurance, and Government Agencies
    • 20 Private Offices (6 with Sinks and Exterior Doors)
    • 5 Bathrooms, 2 Reception Areas, and 1 Kitchen
    Updated: Apr 9
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    Versatile Facility in Fort Pierce
    $5,000/Mo
    4,028 SF

    Versatile Facility in Fort Pierce

    Adaptable 4,028 SF space ideal for various uses.

    2525 S 25th Street, Fort Pierce, FL 34981
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    Prime Highway Frontage Office Space
    $2,210/Mo
    4,360 SF

    Prime Highway Frontage Office Space

    Professional office space for lease on US Hwy 1.

    500 S Us Highway 1, Fort Pierce, FL 34950
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    Remodeled Commercial Building with Parking
    $4,500/Mo
    2,000 SF

    Remodeled Commercial Building with Parking

    Freestanding 2,000 sq ft building with parking in Fort Pierce.

    3801 Okeechobee Road, Fort Pierce, FL 34947
    View details
    Office/Warehouse Flex Space For Lease
    $995/Mo
    4,430 SF

    Office/Warehouse Flex Space For Lease

    980 SF office/warehouse with mezzanine and private bathroom.

    515 S 3rd Street, Fort Pierce, FL 34950
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    Professional Space on Port St. Lucie
    $2,667/Mo
    3,930 SF

    Professional Space on Port St. Lucie

    Professional space on a busy corridor with private entrance.

    501 SW, Port St Lucie, FL 34953
    View details
    Flexible Co-working Space For Rent
    $3,000/Mo

    Flexible Co-working Space For Rent

    Co-working space in St. Lucie West, flexible terms.

    Port St Lucie, FL 34986
    View details
    Retail Space in Swan Plaza
    $2,500/Mo
    3,258 SF

    Retail Space in Swan Plaza

    In-line retail space in a high-traffic commercial plaza.

    Port St Lucie, FL 34983
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    Ocean View Office Suite
    $1,100/Mo
    4,500 SF

    Ocean View Office Suite

    Second-floor office suite with ocean views available for lease.

    221 S Ocean Drive, Fort Pierce, FL 34949
    View details
    Commercial Property on US Highway 1
    $10,000/Mo
    4,648 SF

    Commercial Property on US Highway 1

    4-acre commercial property with 6,000 SF building space for lease.

    3535 Old Dixie Highway, Fort Pierce, FL 34946
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    Landmark Office Building in Fort Pierce
    $17 SF/Yr

    Landmark Office Building in Fort Pierce

    5,400 sq ft office space available for lease.

    2222 Colonial Road, Fort Pierce, FL 34950
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    Fort Pierce Commercial Rental Space
    $18 SF/Yr

    Fort Pierce Commercial Rental Space

    2,400 SF commercial space with office and warehouse.

    405 Angle Road, Fort Pierce, FL 34947
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    Office with Marina View
    $1,500/Mo

    Office with Marina View

    Office space for rent with marina view and parking.

    2010 Harbortown Drive, Fort Pierce, FL 34946
    View details
    Freestanding Building on US Highway
    $26 SF/Yr

    Freestanding Building on US Highway

    General Commercial zoning ideal for retail, medical, or restaurant.

    10244 S US Highway 1, Port St Lucie, FL 34952
    View details
    Port St. Lucie Executive Suite
    $1,527/Mo
    833 SF

    Port St. Lucie Executive Suite

    Executive office suite in Port St. Lucie medical corridor.

    Port St Lucie, FL 34952
    View details
    Office Space in Harbortown Marina
    $1,000/Mo
    8,385 SF

    Office Space in Harbortown Marina

    Office space for rent in Fort Pierce, approximately 300sqft.

    2010 Harbortown W, Fort Pierce, FL 34946
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    Class A Office Suite Available
    $2,287/Mo

    Class A Office Suite Available

    Professional office suite with private offices and open space.

    Port St Lucie, FL 34952
    View details
    5.5 Acre Commercial Lot
    $1.00 SF/Yr

    5.5 Acre Commercial Lot

    5.5 acre commercial lot for lease in Fort Pierce.

    5501 Orange Avenue, Fort Pierce, FL 34947
    View details
    Medical Office Space For Rent
    $24 SF/Yr

    Medical Office Space For Rent

    Updated medical office space available for rent in Port St. Lucie.

    1801 SE Hillmoor Drive, Port St Lucie, FL 34952
    View details
    Port St. Lucie Commercial Space
    $22 SF/Yr

    Port St. Lucie Commercial Space

    Office space with high visibility in Port St. Lucie.

    Port St Lucie, FL 34952
    View details
    Lake Whitney Business Park
    $19 SF/Yr
    1,776 SF

    Lake Whitney Business Park

    FOR LEASE 1776 Square Feet Warehouse with Office in St. Lucie West

    Fort Pierce, FL 34986
    View details

    Port St Lucie, FL Commercial real estate Leasing Opportunities Market Analysis

    Explore Commercial real estate leasing options in Port St Lucie, FL with 168 listings featured on our commercial real estate exchange. The current inventory includes 725,181 square feet of properties with an estimated lease value of $136,715.

    Estimated lease rates for Commercial real estate in Port St Lucie, FL begin at $1.43 SF/Yr, with an average of $1,667 /Mo and extend to $95,000.
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    Most Searched ZIP Codes in Port St Lucie, FL

    • 34952
    • 34986
    • 34953
    • 34982
    • 34987
    • 34950
    • 34947
    • 34946
    • 34984
    • 34945
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