Matlacha, FL Medical Office Space for sale

Updated: Sep 12, 2025

Remodeled Corner Office Building

4574 Pine Island Road NW, Matlacha, FL 33993

$1,485,000

Fully remodeled commercial office building (4574 Pine Island Rd NW), built in 2005
Highly visible corner location on Pine Island Rd with 16,100 AADT traffic count near Matlacha
Two access points for smooth ingress/egress, suited for trucks and service vehicles
Recent upgrades: new roof, new flooring, and impact‑rated hurricane doors and windows
ADA‑accessible ramp for improved access

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Based on your search, we've compiled 9 Potential Opportunities for your consideration. Besides 1 Active listings in Matlacha, FL, we suggest exploring several alternatives: 4 properties in Nearby Cities, plus 4 Land Listings that present a potential for development.

Opportunities in Nearby Cities

Here are 4 Similar properties we found in Nearby Locations for your consideration.

Remodeled Corner Office Building

164 Pondella Rd, North Fort Myers, FL 33903

$474,900

1,104 sqft

Stand-alone office building remodeled in 2020 with ADA accessibility, multiple private offices, and a conference room plus reception.

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Medical Office Building with Parking

331 Cape Coral Parkway W, Cape Coral, FL 33914

$1,350,000

0.47 AC lot

For sale office building with ample parking and original metal roof on a corner lot.

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Stand-Alone Office Building Corner

164 Pondella Rd, North Fort Myers, FL 33903

$499,000

Stand-alone, partially furnished office building on a high-visibility corner with ADA-accessible layout and private offices.

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Remodeled Office Suite with Reception

1224 Del Prado Blvd S #C, Cape Coral, FL 33990

Contact for pricing

Recently remodeled office suite with multiple entrances, glass-enclosed reception, nine designated parking spaces, and new AC.

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Potential Development Sites for Consideration

Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

Ceitus Parkway Commercial Land

2918 Ceitus Pkwy, Cape Coral, FL 33991

$425,000

Premium commercial site ideal for medical or professional use.

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Lakefront Commercial Development Land

1500 SW 5th Street, Cape Coral, FL 33991

$700,000

1.30 AC lot

C1-zoned lakefront commercial land with city sewer, water, and irrigation in place.

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Upscale Development Site Available

1500 SW 5th St, Cape Coral, FL 33991

$700,000

Prime commercial land for development in Cape Coral, Florida.

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Vacant Commercial Lot with Development Potential

1617 SW 23rd Terrace, Cape Coral, FL 33991

$200,000

0.23 AC lot

Compact vacant lot off Veterans Parkway, suited for retail, office, medical, or mixed-use development.

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Matlacha, FL Medical Office Space Market Trends and Statistics

Explore 1 medical office space for sale in Matlacha, FL on our real estate platform.

Sale prices for medical spaces in Matlacha, FL average $1,485,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

Matlacha, FL Medical Office Space for Sale

4574 Pine Island Road NW, Matlacha, FL 33993

Opportunities in Nearby Cities

164 Pondella Rd, North Fort Myers, FL 33903

331 Cape Coral Parkway W, Cape Coral, FL 33914

164 Pondella Rd, North Fort Myers, FL 33903

1224 Del Prado Blvd S #C, Cape Coral, FL 33990