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    South Carolina Medical Centers for Lease

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    Greenville, SC Columbia, SC Charleston, SC Myrtle Beach, SC North Charleston, SC Spartanburg, SC Rock Hill, SC Mount Pleasant, SC
    6 properties
    Renovated Medical Office Suite
    Updated: Jun 18
    Renovated Medical Office Suite

    4310 Highway 17 Business, Murrells Inlet, SC 29576

    $8,000/Mo
    3,557 sqft 3.00 AC lot
    3,557‑square‑foot Suite 103 in a recently renovated Class A medical building
    GC zoning with a Tenant Improvement Allowance available
    Utilities, trash service, and janitorial service included in the rent
    Approximately 160 parking spaces plus dedicated patient and service elevators
    New surgery center under construction with nine pre‑operative beds, nine post‑operative beds, and three operating rooms
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    Second-Generation Medical Office
    Updated: May 22
    Second-Generation Medical Office

    100 Jimmy Love Ln, Columbia, SC 29212

    Contact for pricing
    9,668 sqft
    Well‑maintained second‑generation medical/office space
    Strategically located between St. Andrews Road and Harbison Boulevard with quick access to Interstate 26
    Surrounded by established residential neighborhoods
    Suited for owner‑users, investors, or medical/office tenants such as a medical practice, urgent care, specialty clinic, outpatient providers, med spa, or professional services
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    Medical Office Suite
    Medical Office Suite

    3210 Landmark Drive, North Charleston, SC 29418

    Contact for pricing
    1,880 sqft

    Move-in ready OB-GYN medical space with strong visibility, signage, and ample parking for healthcare practices.

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    Hospital-Anchored Medical Office Building
    Hospital-Anchored Medical Office Building

    986 Wellness Way, Fort Mill, SC 29715

    $33 SF/Yr

    Three-story medical outpatient building with an enclosed walkway connection to Fort Mill Hospital–Piedmont Medical Center.

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    Medical Office Space with 11 Treatment Rooms
    Medical Office Space with 11 Treatment Rooms

    1334 Ebenezer Rd, Rock Hill, SC 29732

    Contact for pricing
    4,135 sqft

    Free-standing medical office with 11 treatment rooms, training room, and parking for 24 plus two handicap spaces.

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    New Retail/Office/Medical Space
    New Retail/Office/Medical Space

    565 Spears Creek Church Rd, Elgin, SC 29045

    Contact for pricing

    Newly constructed space on rapidly growing Spears Creek Church Road.

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    Based on your search, we've compiled 20 Potential Opportunities for your consideration. Besides 6 Active listings in South Carolina, we suggest exploring alternatives. Similar 14 Properties for Sales.

    Similar Spaces for Sale in South Carolina

    Consider Similar Space for Sale. We found 14 Spaces matching your search parameters.

    Medical Office with Dental Buildout
    Medical Office with Dental Buildout

    1466 Columbia Highway, Aiken, SC 29801

    $1,200,000
    4,044 sqft 0.82 AC lot

    Brick facility includes plumbed exam rooms, executive offices, reception, lab, kitchen, and multiple restrooms.

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    Medical Campus with Auditorium
    Medical Campus with Auditorium

    1608 Main St., Conway, SC 29526

    $3,950,000
    23,777 sqft 0.77 AC lot

    Two buildings bring together clinical, administrative, and multipurpose areas for medical and professional operations.

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    New Medical Office Space
    New Medical Office Space

    116 Professional Park Dr., Conway, SC 29526

    $1,899,000
    3,988 sqft 0.78 AC lot

    Purpose-built medical space with exam rooms, private offices, laboratory facilities, and dedicated HVAC for the computer room.

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    Two-Unit Medical Office Building
    Two-Unit Medical Office Building

    110 E Main St, Kingstree, SC 29556

    $715,000
    7,076 sqft 0.29 AC lot

    Two-unit, brick commercial building with 100% occupancy, zoned CC, and included supplemental parking.

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    West Columbia Medical Office Opportunity
    West Columbia Medical Office Opportunity

    110 Medical Cir, West Columbia, SC 29169

    $4,000,000
    10,840 sqft

    Medical office building for sale in West Columbia, SC.

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    Two-Location Medical Office Campus
    Two-Location Medical Office Campus

    1608 Main St. 1708 Oak St, Conway, SC 29526

    $3,950,000
    2.91 AC lot

    Medical and professional facilities offer exam rooms, offices, administrative areas, pharmacy space, and a multipurpose auditorium.

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    Medical Office with Dental Equipment
    Medical Office with Dental Equipment

    104 W Oak Highway, Westminster, SC 29693

    $374,000
    0.29 AC lot

    Existing clinical and office improvements support continued medical use or conversion to professional office space.

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    Three-Suite Medical Office
    Three-Suite Medical Office

    85 Springview Lane, Summerville, SC 29485

    $2,010,000

    Configured for an owner-user with rental income from two additional suites.

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    Ambulatory Surgery Center and Medical Office
    Ambulatory Surgery Center and Medical Office

    457 E Bypass 123 Building D, Seneca, SC 29678

    Contact for pricing
    10,421 sqft

    Medicare-certified ambulatory surgery center with two laminar flow operating rooms and shared campus medical office building.

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    Urgent Care Medical Center
    Urgent Care Medical Center

    447 N HWY 52, Moncks Corner, SC 29461

    $3,256,000

    The property carries a brand-new 12-year lease with 10% rent bumps every 5 years.

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    Net Leased Urgent Care Facility
    Net Leased Urgent Care Facility

    140 Saint James Avenue, Goose Creek, SC 29445

    $2,990,500

    A modified NNN urgent care investment in Goose Creek featuring a long-term lease with extension options.

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    Two-Building Medical and Religious Facility
    Two-Building Medical and Religious Facility

    2799 Whiskey Rd, Aiken, SC 29803

    $1,300,000
    10,001 sqft

    Two buildings totaling 10,000+ square feet on 4.7 acres with ample parking and adaptable medical or religious use.

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    Integrated Heart Center Medical Facility
    Integrated Heart Center Medical Facility

    8 Richland Medical Park Dr, Columbia, SC 29203

    Contact for pricing
    96,190 sqft

    Advanced heart center integrated into Prisma Health Heart Hospital; new roof installed in Q1 2026.

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    Medical Office Suites For Sale
    Medical Office Suites For Sale

    25 Hospital Center Boulevard, Hilton Head Island, SC 29926

    Contact for pricing

    Medical office suites available in prestigious Hilton Head medical complex.

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    South Carolina Medical centers Market Trends and Statistics

    Explore Medical centers leasing options in South Carolina with 6 listings featured on our commercial real estate exchange. The current inventory includes 19,240 square feet of properties with an estimated lease value of $59.99.

    Estimated lease rates for Medical centers in South Carolina begin at $26.99 SF/Yr, with an average of $29.99 SF/Yr and extend to $33 SF/Yr.
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