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    Seneca, SC Retail Properties & Spaces for Lease

    9 results
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    Seneca Retail/Office Space Available
    $1,700 /Mo
    712 SF

    Seneca Retail/Office Space Available

    1109 Jennings Ave Unit A, Seneca, SC 29768

    Retail/office space for lease in Seneca, SC. Renovated and visible.

    • Located at one of the busiest intersections in Seneca, SC, offering incredible visibility.
    • Rent includes all utilities ($1,700/month).
    • Recently renovated with new lights, new paint, and concrete floors.
    • Ample parking available.
    • Lots of natural light.
    Updated: Mar 5
    View details
    Retail Space Near Clemson University
    $21 SF/Yr
    43,000 SF

    Retail Space Near Clemson University

    1085 Old Clemson Highway, Seneca, SC 29672

    End-cap retail space with drive-thru potential near Clemson University.

    • High Traffic Location: 29,900 Vehicles Per Day (VPD) on Hwy. 123.
    • Proximity to Clemson University: Only 5 minutes away.
    • Located Between Two Major Lakes: Lake Keowee and Lake Hartwell.
    • End Cap Unit: ±1,200 SF Available for Lease.
    • Drive‑Thru Potential: Suite A offers drive‑thru possibilities.
    Updated: Nov 26, 2025
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    Retail Opportunity Near Walmart
    Contact for pricing

    Retail Opportunity Near Walmart

    Retail space available for lease near Walmart and hospital.

    Seneca, SC 29678
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    Retail Property on Main Corridor
    $11 SF/Yr
    7,250 SF

    Retail Property on Main Corridor

    Retail property with excellent visibility and heavy traffic.

    1592 Sandifer Blvd, Seneca, SC
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    Retail Opportunity Near Walmart
    Contact for pricing

    Retail Opportunity Near Walmart

    Retail space available for lease, GL, or build-to-suit.

    1637 Sandifer Blvd, Seneca, SC
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    Seneca Office/Retail Space Available
    $15 SF/Yr
    4,800 SF

    Seneca Office/Retail Space Available

    Office and retail spaces for lease in Seneca, South Carolina.

    12019 North Radio Station Rd, Seneca, SC
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    Restaurant Space Near Oconee Medical
    Contact for pricing
    16,000 SF

    Restaurant Space Near Oconee Medical

    1,600 SF 2nd Gen Restaurant Space Available For Rent.

    201-273 Applewood Center Pl, Seneca, SC
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    Retail Space Near Oconee Medical
    Contact for pricing
    1,600 SF

    Retail Space Near Oconee Medical

    Retail space available near Oconee Medical Center and Clemson University.

    101 Applewood Center Pl, Seneca, SC
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    Dominant Power Center For Rent
    Contact for pricing
    245,000 SF

    Dominant Power Center For Rent

    245,000 SF power center anchored by Belk, Hobby Lobby, etc.

    201 Applewood Center Pl, Seneca, SC 29678
    View details
    Based on your search, we've compiled 25 Potential Opportunities for your consideration. Besides 9 Active listings in Seneca, SC, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 8 Properties for Sales.

    Explore Retail properties & Spaces for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Historic Pendleton Bank Retail Space
    $3,500 /Mo

    Historic Pendleton Bank Retail Space

    Renovated retail space in historic Pendleton Town Square.

    104 Exchange Street, Pendleton, SC 29670
    View details
    Downtown Clemson Retail Space Available
    $2,800 /Mo

    Downtown Clemson Retail Space Available

    Retail space in downtown Clemson, formerly a coffee shop.

    382 College Avenue unit: Basement Space, Clemson, SC 29631
    View details
    Retail Space with Open Layout
    Contact for pricing

    Retail Space with Open Layout

    Retail space featuring an open layout and additional storage.

    125 N Mechanic St, Pendleton, SC 29670
    View details
    Retail/Restaurant Space Near Clemson University
    Contact for pricing
    3,500 SF

    Retail/Restaurant Space Near Clemson University

    Retail/restaurant space with dedicated parking and lake access.

    894 Tiger Blvd, Clemson, SC
    View details

    Explore Similar Spaces for Sale in Seneca, SC

    Consider Similar Space for Sale. We found 8 Spaces matching your search parameters.

    Seneca Retail/Warehouse Opportunity
    $1,800,000
    1.01 Acres

    Seneca Retail/Warehouse Opportunity

    All brick/concrete building with existing tenants and expansion potential.

    518 W N 1st Street, Seneca, SC 29678
    View details
    Turn-Key Restaurant Franchise Opportunity
    $1,900,000
    0.78 Acres

    Turn-Key Restaurant Franchise Opportunity

    Turn-key national franchise restaurant with real estate for sale.

    1053 By Pass 123 Bypass, Seneca, SC 29678
    View details
    Seneca Retail Building For Sale
    $1,399,999
    12,000 SF

    Seneca Retail Building For Sale

    12,000 SF building with conversion potential in Seneca, SC.

    12020 North Radio Station Road, Seneca, SC 29678
    View details
    Seneca Automotive Service Property
    $125,000

    Seneca Automotive Service Property

    Automotive service property near downtown Seneca with four bays.

    919 E S 6th Street, Seneca, SC 29678
    View details
    Prime Commercial Acreage For Sale
    $3,500,000
    4.33 Acres

    Prime Commercial Acreage For Sale

    4.3 acres in Seneca, SC, ideal for retail or hospitality.

    1018 E. North 1st Street, Seneca, SC 29678
    View details
    Seneca Retail Building For Sale
    $1,399,999
    12,000 SF

    Seneca Retail Building For Sale

    12,000 SF building with conversion potential in Seneca, SC.

    12020 N Radio Station Rd, Seneca, SC 29678
    View details
    Established Hibachi Restaurant for Sale
    $219,000

    Established Hibachi Restaurant for Sale

    Turnkey Hibachi restaurant with existing lease and equipment included.

    1510 Blue Ridge Boulevard, Seneca, SC 29672
    View details
    Land Near Clemson University
    $350,000

    Land Near Clemson University

    Land available near Clemson University, close to lakes.

    Union Station Dr, Seneca, SC 29678
    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Land Near Oconee Medical Center
    Contact for pricing

    Land Near Oconee Medical Center

    Commercial land for rent near medical center and Clemson University.

    15516 Wells Hwy, Seneca, SC
    View details
    New Warehouse Space in Anderson
    $8 SF/Yr
    50,000 SF

    New Warehouse Space in Anderson

    New warehouse space for lease near I-85, Exit 19.

    00 Vanguard Rd, Anderson, SC 29625
    View details
    Prime Corner Lot For Lease
    $120,000

    Prime Corner Lot For Lease

    1-acre hard corner lot available for ground lease or build-to-suit.

    4640 Clemson Blvd, Anderson, SC 29621
    View details
    Waterfront Commercial Land for Lease
    $1.00 SF/Yr
    3,000 SF

    Waterfront Commercial Land for Lease

    2.2 acres of waterfront commercial land with dock.

    4400 Clemson Blvd, Anderson, SC 29621
    View details

    Seneca, SC Retail properties & Spaces Leasing Opportunities Market Analysis

    Explore Retail properties & Spaces leasing options in Seneca, SC with 9 listings featured on our commercial real estate exchange. The current inventory includes 209,088,000 square feet of properties with an estimated lease value of $15 SF/Yr.

    Estimated lease rates for Retail properties & Spaces in Seneca, SC begin at $15 SF/Yr, with an average of $15 SF/Yr and extend to $15 SF/Yr.
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    Popular Searches in Seneca, SC

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    Most Searched ZIP Codes in Seneca, SC

    • 29678
    • 29672
    • 29768

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