Lee County, FL Hospitality properties for sale

Updated: May 11

Historic Bed & Breakfast with Cafe

2135 McGregor Boulevard, Fort Myers, FL 33901

$1,599,999

0.22 AC lot

Five guest suites with private entrances and en‑suite baths
Licensed bed‑and‑breakfast and food‑and‑beverage operations included
Cafe business, lodging business, real estate, and FF&E convey
1911 construction date
0.217 acres with fencing

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Updated: Aug 24

Eight-Unit Waterfront Resort

3226 Stringfellow Road, St James City, FL 33956

$1,649,900

0.44 AC lot

Eight studio‑style units, all renovated
Approximately 161 feet of direct, no‑bridge Gulf‑access canal frontage
Full‑length waterfront dock and expansive deck
2025 metal roof, impact‑resistant windows, and mini‑split A/C systems
Four units historically leased annually and four used as vacation rentals

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Boutique Hotel with Pool

235 Mango Street, Fort Myers Beach, FL 33931

$1,650,000

0.12 AC lot

Eight furnished guest suites with updated kitchens, private baths, and on-site hospitality amenities near the Gulf of Mexico.

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See what stands out in Lee County

We check every for-sale listing in the county against comparable properties across the country. Most price about where you would expect. A few are worth a second look.

We check every listing here. A few are worth a second look.

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NOI available after sign in

Local Demand available after sign in

Historic Bed & Breakfast with Café

2135 McGregor Blvd, Fort Myers, FL 33901

$1,599,999

4,009 sqft

Licensed hospitality property with guest suites, owner accommodations, office space, and an operating café component.

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Two-Inn Hotel Property

706 Donax Street, Sanibel, FL 33957

$5,300,000

0.50 AC lot

Nightly rentals are legally permitted, with 2024 renovations and existing management available to a new owner.

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Lake-View RV Resort Lot

5230 Pineland Daisy Trail, Fort Myers, FL 33905

$248,000

0.07 AC lot

Finished outdoor room with lake views, RV utility connections, and access to resort amenities.

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Oversized RV Resort Lot

10095 Parkwood Dr lot: 63, Fort Myers, FL 33905

$204,999

0.13 AC lot

Improved homesite with a permitted accessory building and established annual tenancy in a gated Southwest Florida RV community.

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Eight-Unit Waterfront Resort

3226 Stringfellow Rd, St James City, FL 33956

$1,649,900

3,186 sqft

Renovated studio accommodations feature kitchens, private baths, and individual balconies or patios.

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Land with Shed in Fort Myers

5465 Cypress Trail Resort Circle, Fort Myers, FL 33905

$200,000

0.08 AC lot

Concrete RV lot with shed and landscaping in Fort Myers.

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Recreation Land with Accessory Building

5118 Cypress Trail Resort Cir lot: 10, Fort Myers, FL 33905

$159,999

0.07 AC lot

Finished RV site with a concrete pad, shaded outdoor areas, and a private tropical setting within Cypress Trail RV Resort.

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Renovated Midscale Hotel Opportunity

4760 S Cleveland Ave, Fort Myers, FL 33907

$10,000,000

4 sqft

Turnkey midscale hotel with 135 operational guest rooms and updated amenities, including an outdoor pool and free breakfast.

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Waterfront Resort Property

12200 /12210 Shoreview Dr, Matlacha, FL 33993

$3,250,000

7,400 sqft 1.00 AC lot

Renovated in 2025 with two buildings, boat slips, and direct waterfront positioning.

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Historic Waterfront Bed & Breakfast

8241 Main Street, Bokeelia, FL 33922

Contact for pricing

320,000 sqft

Four bedrooms, five bathrooms, boat access, and upgraded systems support flexible hospitality use.

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I-75 Hotel Building Site

4290 Boatways Rd, Fort Myers, FL 33905

$2,500,000

2.35 AC lot

Hotel building site on I-75, near Cracker Barrel.

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Commercial Land with Development Entitlements

8870 8870/8891 De Lasalle Academy Way, Fort Myers, FL 33912

$4,500,000

Improved commercial site with planned development zoning supporting hotel, office, and retail uses.

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Eight-Suite Vacation Rental Property

235237-235 Mango St, Fort Myers Beach, FL 33931

$1,650,000

Renovated, furnished accommodations with a heated pool, guest parking, and on-site operational facilities support ongoing hospitality use.

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Hospitality Resort Property

1167 Estero Boulevard, Fort Myers Beach, FL 33931

$6,500,000

For sale hospitality property on Estero Boulevard, positioned directly across from a Margaritaville pool.

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Mixed-Use Redevelopment Hotel Property

1600 Estero Blvd; 71/73 Alva Dr; 1560 Estero Blvd, Fort Myers Beach, FL 33931

$10,692,300

Large hotel building with adaptable space for mixed-use concepts including condos, restaurants, and retail.

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LAND - Fort Myers, FL

11501 Ariana Dr, Fort Myers, FL 33908

$110,000

1,231 sqft 0.03 AC lot

RV lot in a desirable Fort Myers community with amenities.

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Hotel and Duplex Redevelopment Portfolio

4819 Tradewinds Drive, Sanibel, FL 33957

$3,000,000

Cleared Gulf-front hotel and duplex sites positioned for nightly-rental redevelopment on Sanibel Island.

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Sanibel Island Motel Opportunity

706 Donax Street, Sanibel, FL 33957

$5,300,000

Two Sanibel Island motels with strong rental income.

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Resort Property

26201 Hickory Boulevard, Bonita Springs, FL 34134

$4,495,000

Hospitality property located on the bay side, just before a bridge along Hickory Blvd.

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Furnished Vacation Rental Property

245 Mango ST, Fort Myers Beach, FL 33931

Contact for pricing

Renovated suites include kitchens, living areas, and updated baths.

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US 41 Leased Commercial Property

4805 S Cleveland Ave, Fort Myers, FL 33907

Contact for pricing

8,100 sqft

Fully leased commercial property on US 41 with billboard income.

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Lee County, FL Hospitality Properties Market Trends and Statistics

Explore 72 hospitality properties for sale in Lee County, FL, showcased through 28 active listings on our real estate platform. These investment opportunities span a total of 343,930 square feet of properties for sale, with an estimated market value of $79,755,096.

Sale prices for hospitality properties in Lee County, FL start at $110,000, averaging $3,467,612, and reaching up to $10,692,300 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

Featured Lee County Real Estate Agencies

Realmo connects you with licensed Lee County CRE brokers providing property specifications, local market pricing, and commercial transaction underwriting support.

Priceless Realty

1425 Del Prado Blvd Cape Coral, FL 33990

Phone: 12397707121

www.pricelessrealty.com

Jones & Co. Realty

9403 Cypress Lake Dr. Suite 3 Fort Myers, FL 33919

Phone: 12394155881

www.jonesandcorealty.com

Starlink Realty

1567 Hayley Lane, Suite 205 Fort Myers, FL 33907

Phone: 12396937263