Lee County, FL Hospitality properties for sale

Updated: Sep 24

Waterfront Short-Term Rental Property

12200/12210 SHOREVIEW Drive, Matlacha, FL 33993

$3,250,000

7,400 sqft 1.00 AC lot

12 furnished guest accommodations across two buildings
Approximately 7,400 square feet on about one acre
155 feet of waterfront and 5 boat slips
Renovated in 2025; includes a pool
Unit mix includes two studios, six 1‑bedroom units, three 2‑bedroom units, one 3‑bedroom unit, and a hotel‑style room used for laundry

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Updated: Sep 24

Waterfront Hospitality Property

12200/12230 Shoreview Dr, Matlacha, FL 33993

$3,250,000

7,400 sqft 1.00 AC lot

Approximately 7,400 square feet across two buildings
155 feet of waterfront with direct boating access
Five boat slips and a pool
Approximately one acre; zoned RM‑2
Renovated in 2025; built in 1999

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Historic Bed & Breakfast with Cafe

2135 McGregor Boulevard, Fort Myers, FL 33901

$1,599,999

0.22 AC lot

Licensed hospitality property with guest accommodations, an owner's suite, office space, and established cafe operations.

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Historic Bed & Breakfast with Café

2135 McGregor Blvd, Fort Myers, FL 33901

$1,599,999

4,009 sqft

Licensed hospitality property with guest suites, owner accommodations, office space, and an operating café component.

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Harborfront Five-Unit Hotel

7702 Bocilla Lane, Bokeelia, FL 33922

$3,500,000

0.27 AC lot

Waterfront lodging property with a private beach, fishing pier, and flexible daily, weekly, and monthly rental options.

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Eight-Unit Waterfront Resort

3226 Stringfellow Road, St James City, FL 33956

$1,649,900

0.44 AC lot

Renovated studio accommodations include kitchens, private baths, outdoor living areas, and direct canal access.

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Boutique Hotel with Pool

235 Mango Street, Fort Myers Beach, FL 33931

$1,650,000

0.12 AC lot

Eight furnished guest suites with updated kitchens, private baths, and on-site hospitality amenities near the Gulf of Mexico.

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Waterfront Hotel with Boat Slips

12200/12230 Shoreview Dr, Matlacha, FL 33993

$3,250,000

7,400 sqft 1.00 AC lot

Two buildings provide furnished guest accommodations, a pool, and direct boating access in Matlacha.

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Lake-View RV Resort Lot

5230 Pineland Daisy Trail, Fort Myers, FL 33905

$248,000

0.07 AC lot

Finished outdoor room with lake views, RV utility connections, and access to resort amenities.

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Oversized RV Resort Lot

10095 Parkwood Dr lot: 63, Fort Myers, FL 33905

$204,999

0.13 AC lot

Improved homesite with a permitted accessory building and established annual tenancy in a gated Southwest Florida RV community.

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Renovated Midscale Hotel Opportunity

4760 S Cleveland Ave, Fort Myers, FL 33907

$10,000,000

4 sqft

Turnkey midscale hotel with 135 operational guest rooms and updated amenities, including an outdoor pool and free breakfast.

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Land with Shed in Fort Myers

5465 Cypress Trail Resort Circle, Fort Myers, FL 33905

$200,000

0.08 AC lot

Concrete RV lot with shed and landscaping in Fort Myers.

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Recreation Land with Accessory Building

5118 Cypress Trail Resort Cir lot: 10, Fort Myers, FL 33905

$159,999

0.07 AC lot

Finished RV site with a concrete pad, shaded outdoor areas, and a private tropical setting within Cypress Trail RV Resort.

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Waterfront Resort Property

12200 /12210 Shoreview Dr, Matlacha, FL 33993

$3,250,000

7,400 sqft 1.00 AC lot

Renovated in 2025 with two buildings, boat slips, and direct waterfront positioning.

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Eight-Unit Waterfront Resort

3226 Stringfellow Rd, St James City, FL 33956

$1,649,900

3,186 sqft

Renovated studio accommodations feature kitchens, private baths, and individual balconies or patios.

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Historic Waterfront Bed & Breakfast

8241 Main Street, Bokeelia, FL 33922

Contact for pricing

320,000 sqft

Four bedrooms, five bathrooms, boat access, and upgraded systems support flexible hospitality use.

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Harborfront Five-Unit Hotel

7702 Bocilla LN, Bokeelia, FL 33922

$3,500,000

Waterfront lodging property with a private swimming beach and fishing pier.

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Commercial Land with Development Entitlements

8870 8870/8891 De Lasalle Academy Way, Fort Myers, FL 33912

$4,500,000

Improved commercial site with planned development zoning supporting hotel, office, and retail uses.

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Waterfront Eight-Unit Resort

Saint James City, FL 33956

$1,649,000

Renovated studio accommodations with direct Gulf-access canal frontage, private outdoor spaces, and on-site guest amenities.

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Eight-Suite Vacation Rental Property

235237-235 Mango St, Fort Myers Beach, FL 33931

$1,650,000

Renovated, furnished accommodations with a heated pool, guest parking, and on-site operational facilities support ongoing hospitality use.

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Hospitality Resort Property

1167 Estero Boulevard, Fort Myers Beach, FL 33931

$6,500,000

For sale hospitality property on Estero Boulevard, positioned directly across from a Margaritaville pool.

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LAND - Fort Myers, FL

11501 Ariana Dr, Fort Myers, FL 33908

$110,000

1,231 sqft 0.03 AC lot

RV lot in a desirable Fort Myers community with amenities.

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Mixed-Use Redevelopment Hotel Property

1600 Estero Blvd; 71/73 Alva Dr; 1560 Estero Blvd, Fort Myers Beach, FL 33931

$10,692,300

Large hotel building with adaptable space for mixed-use concepts including condos, restaurants, and retail.

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Resort Property

26201 Hickory Boulevard, Bonita Springs, FL 34134

$4,495,000

Hospitality property located on the bay side, just before a bridge along Hickory Blvd.

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Lee County, FL Hospitality Properties Market Trends and Statistics

Explore 72 hospitality properties for sale in Lee County, FL, showcased through 27 active listings on our real estate platform. These investment opportunities span a total of 358,030 square feet of properties for sale, with an estimated market value of $85,054,096.

Sale prices for hospitality properties in Lee County, FL start at $110,000, averaging $3,271,311, and reaching up to $10,692,300 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

Featured Lee County Real Estate Agencies

Realmo connects you with licensed Lee County CRE brokers providing property specifications, local market pricing, and commercial transaction underwriting support.

Priceless Realty

1425 Del Prado Blvd Cape Coral, FL 33990

Phone: (239) 770-7121

www.pricelessrealty.com

Marzucco Real Estate

16299 S. Tamiami Trail Fort Myers, FL

Phone: (239) 269-1584

John R. Wood Properties

26269 Tamiami Trail South Bonita Springs, FL

Phone: (239) 498-9200