Chillicothe, OH Commercial real estate for sale

Updated: Oct 22

Commercial Land with Road Frontage

13223 Pleasant Valley Road, Chillicothe, OH 45601

$800,000

40.00 AC lot

40 acres
Road frontage and easement access
Septic system and electric service
Water tap, county water, and Pleasant Valley Sewer

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Updated: Oct 9

Brick Storefront with Drive-Through

486 S Paint St, Chillicothe, OH 45601

$539,900

1,800 sqft

1,800‑square‑foot brick retail building with a drive‑through
Land extends to the edge of Paint Creek
Paint St transitions into St Rt 772 at the property
On‑site parking
Equipment available for separate purchase

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Three-Unit Mixed-Use Building

22-26 W Main St, Chillicothe, OH 45601

$475,000

11,698 sqft

An occupied restaurant unit anchors two additional spaces with flexible commercial layouts.

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Historic Four-Level Mixed-Use Building

63 N Paint St, Chillicothe, OH 45601

$535,000

14,000 sqft

Downtown property combines street-facing storefronts with adaptable space for residential or commercial uses.

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Corner Automotive Property

1987 Western Ave., Chillicothe, OH 45601

$399,000

1,456 sqft 1.00 AC lot

Commercial zoning and on-site vehicle parking support automotive or related business use.

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Commercial Space on US Route 50

1075 Western Ave, Chillicothe, OH 45601

$895,000

7,524 sqft 2.10 AC lot

Commercial space suitable for retail, nursery, or creative event purposes.

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Corner Office Building with Parking

553 W 4th St, Chillicothe, OH 45601

$475,000

3,850 sqft

Brick office property with flexible room configuration, accessible entry, and on-site surface parking near the OU campus.

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Renovated Mixed-Use Building For Sale

7 Saint Andrews Blvd, Chillicothe, OH 45601

$650,000

4,832 sqft

Renovated mixed-use building with high visibility and ample parking.

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Commercial Space on US Route 50

1075 Western Ave, Chillicothe, OH 45601

$1,295,000

10,668 sqft 2.54 AC lot

Commercial property with multiple buildings, ample parking, and redevelopment potential.

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Mixed-Use Storefront Building

20 E Main St, Chillicothe, OH 45601

$250,000

1,482 sqft

Downtown property offers storefront exposure, commercial use flexibility, and potential for apartments on the upper level.

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Established Tire Business For Sale

394 N High St, Chillicothe, OH 45601

$350,000

2,020 sqft

Well-respected tire business on a highly visible corner lot.

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Leased Mixed-Use Building

43-49 Paint St, Chillicothe, OH 45601

$795,000

19,233 sqft

Historic property combines occupied commercial suites with leased residential apartments in a diversified downtown configuration.

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Historic Office Unit with Private Offices

147 W Water St, Chillicothe, OH 45601

Contact for pricing

1,704 sqft

Flexible layout combines reception, shared workspace, private offices, and support areas.

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Flex Space with Overhead Doors

19475 US Highway 50, Chillicothe, OH 45601

Contact for pricing

3,232 sqft 2.00 AC lot

Functional facility combines separated work areas, office space, employee amenities, and substantial gravel parking.

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Retail Showroom With Office

304 E Main St, Chillicothe, OH 45601

Contact for pricing

1,203 sqft

Updated showroom includes a private office, additional room, and two storage spaces.

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Pizza Restaurant with Drive-Through

490 W 5th St, Chillicothe, OH 45601

$500,000

Established dine-in and carryout operation with a to-go liquor license and included equipment.

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Commercial and Agricultural Land

13223 Pleasant Valley Road, Chillicothe, OH 45601

$1,250,000

61.40 AC lot

Road-fronted land with septic, electric, and a water tap, offering flexible options for commercial or agricultural use.

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Office Buildings with Private Parking

166 W Main St, Chillicothe, OH 45601

$159,000

1,516 sqft

Two income-producing buildings occupy a downtown commercial setting with on-site parking.

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Midas NNN Property

785 North Bridge Street, Chillicothe, OH 45601

Contact for pricing

3,096 sqft

The property is subject to a 20-year NNN lease beginning September 1, 2026.

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Prime Retail Site on Western

1318 Western Ave, Chillicothe, OH 45601

$439,000

0.71 AC lot

0.71-acre retail site with high traffic and visibility.

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For Sale Restaurant Property

820 N. Bridge Street, Chillicothe, OH 45601

$1,730,000

Restaurant property offered for sale at 820 N. Bridge Street in Chillicothe, Ohio.

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Specialty Property with Loft

1110 Spud Run Road, Chillicothe, OH 45601

$65,000

0.25 AC lot

An open ground-floor layout is paired with a two-room loft and two half-baths.

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Multi-Use Main Street Building

83-85 W Main Street, Chillicothe, OH 45601

Contact for pricing

4,125 sqft

Versatile commercial building with 20 on-site parking spaces, suited for retail or office use.

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Commercial Development Land with Bridge Frontage

1555 N Bridge St Lot 1, Chillicothe, OH 45601

$1,115,000

Land parcel with Bridge Street frontage and currently not zoned, positioned north of Chillicothe’s main retail stretch.

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Chillicothe, OH Commercial Real Estate Market Trends and Statistics

Explore 72 commercial real estate for sale in Chillicothe, OH, showcased through 27 active listings on our real estate platform. These investment opportunities span a total of 95,287 square feet of properties for sale, with an estimated market value of $12,716,900.

Sale prices for business properties in Chillicothe, OH start at $65,000, averaging $669,310, and reaching up to $1,730,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

Chillicothe, OH CRE market trends — vacancy, lease rates and price per SF, updated monthly

Neighborhood	Average Price
45601	$554K

Neighborhood

Average Price

45601

$554K