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Chillicothe, OH Office Spaces for Lease

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Circleville, OH Piketon, OH
Historic Office Space with Private Offices
Updated: Aug 21
Historic Office Space with Private Offices

147 W Water, Chillicothe, OH 45601

$2,200/Mo
2,200 sqft
2,200 SF commercial office suite in a circa‑1900 building
Five private offices plus an open central workspace
Front entry area includes a reception desk
Original hardwood floors throughout the space
Utility and break room with two bathrooms
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Ambulatory Surgical Center and Medical Offices
Updated: Jun 17
Ambulatory Surgical Center and Medical Offices

1050 River Road, Chillicothe, OH 45601

$29 SF/Yr
Full‑service ambulatory surgical center with 4 ORs and 2 procedure rooms
Across the street from Adena Hospital
Retail visibility on SR 23 with access to patients in Central, South, and Southeast Ohio
Medical office space offered with options to lease or own
Delivery expected in early to mid‑2026
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2 active listings match your search: Office for lease in Chillicothe, OH. Based on your search, we've also compiled 10 Potential Opportunities for your consideration: 4 spaces in nearby cities and 6 properties for sale.

Office Spaces for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

Office Unit
Office Unit

1015 S Court Street A, Circleville, OH 43113

$1,500/Mo
54–90 people  13,528 sqft  Built 1978

Approximately 1,400 square feet offers a flexible commercial setting for office, retail, or professional use.

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Flex Space with Drive-In Doors
Flex Space with Drive-In Doors

665 Granite Dr, Circleville, OH 43113

Contact for pricing
6,048 sqft  Built 2003
Highway access

Three individual suites combine open work areas with front offices for industrial, contractor, or service-based operations.

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Office Creative Workspace Suite
Office Creative Workspace Suite

110 W Chestnut Street, Lancaster, OH 43130

$1,360/Mo
Built 1913

Office and creative workspace available for rent in Fairfield County.

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Fifth-Floor Office Suite
Fifth-Floor Office Suite

503-201 S Broad St, Lancaster, OH 43130

$300/Mo
Highway access

Fifth-floor private office suite with a window for natural light and elevator access, plus utilities included.

Elevator access
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Similar Spaces for Sale in Chillicothe, OH

Consider Similar Space for Sale. We found 6 Spaces matching your search parameters.

Corner Office Building with Parking
Corner Office Building with Parking

553 W 4th St, Chillicothe, OH 45601

$475,000
15–25 people  3,850 sqft  1 building  brick

Brick office property with flexible room configuration, accessible entry, and on-site surface parking near the OU campus.

37 spaces  Partially finished walkout basement  Handicap accessible
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Leased Mixed-Use Building
Leased Mixed-Use Building

43-49 Paint St, Chillicothe, OH 45601

$795,000
19,233 sqft  Built 1920

Historic property combines occupied commercial suites with leased residential apartments in a diversified downtown configuration.

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Historic Office Unit with Private Offices
Historic Office Unit with Private Offices

147 W Water St, Chillicothe, OH 45601

Contact for pricing
6–11 people  1,704 sqft  Built 1900  1 building

Flexible layout combines reception, shared workspace, private offices, and support areas.

Original hardwood floors  Front waiting room  Reception desk  Large open common space  5 private offices
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Office Buildings with Private Parking
Office Buildings with Private Parking

166 W Main St, Chillicothe, OH 45601

$159,000
6–10 people  1,516 sqft

Two income-producing buildings occupy a downtown commercial setting with on-site parking.

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Multi-Use Main Street Building
Multi-Use Main Street Building

83-85 W Main Street, Chillicothe, OH 45601

Contact for pricing
16–27 people  4,125 sqft

Versatile commercial building with 20 on-site parking spaces, suited for retail or office use.

20 spaces  Opportunity Zone
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Second-Floor Office Suites
Second-Floor Office Suites

50 W Main St, Chillicothe, OH 45601

Contact for pricing

Two second-floor office spaces are available in the historic Gazette Building with utilities included.

View details

Chillicothe, OH Office Spaces Lease Rates & Market Statistics

Explore 2 Office Spaces for lease in Chillicothe, OH on Realmo, a commercial real estate exchange covering the Chillicothe area. The current inventory totals 2,200 square feet of properties.

Asking lease rates for Office Spaces in Chillicothe start at $12 SF/Yr, average $20.50 SF/Yr, and reach $29 SF/Yr at the top of the market. Pricing across the market is relatively uniform, which simplifies like-for-like comparison between listings. At $20.50 SF/Yr, the local average runs 17% below Ohio's state average of $24.73 SF/Yr.

Chillicothe accounts for 67% of the 3 office spaces currently available across Ross County, where a nearby market includes Bainbridge.

How to lease office space in Chillicothe, OH

  1. Right-size for your team and work model. Count full-time, hybrid, and planned hires, then estimate square footage. Start your search 6+ months before you need to move in.
  2. Shortlist buildings by class and commute. Weigh Class A/B/C trade-offs and use Location Intelligence to compare Chillicothe, OH submarkets by transit access, amenities, and workforce reach.
  3. Verify usable vs. rentable square footage. The load factor can inflate advertised space by 20% or more, so confirm how much area your team actually gets before comparing rents.
  4. Decode the lease structure. Full-service gross, modified gross, and NNN leases split costs differently. Two similar asking rents can differ sharply in total five-year cost.
  5. Tour three finalists and compare true costs. Narrowing to three options creates negotiating leverage. Model each deal's occupancy cost and net effective rent with the Lease Calculator.
  6. Negotiate the LOI, then sign. Lock in TI allowance, free rent, escalation caps, and renewal options in the letter of intent, and have an attorney review before executing the lease.
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