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    Chillicothe, OH Commercial Real Estate for Lease

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    Columbus, OH Cincinnati, OH Cleveland, OH
    9 results
    Renovated Office Space, Downtown Location
    $1,100/Mo
    1,080 SF

    Renovated Office Space, Downtown Location

    Chillicothe, OH 45601

    Newly renovated office space in historic downtown Chillicothe.

    • Prime downtown location in the historic district.
    • Newly renovated, move‑in‑ready office space.
    • Functional layout featuring a lobby, reception area, two private offices, and conference room.
    • Private parking and front/back private entrances.
    • Kitchen includes new appliances.
    Updated: Mar 4
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    Downtown Retail Space Available
    $15 SF/Yr
    2,750 SF

    Downtown Retail Space Available

    23 N Bridge St, Chillicothe, OH

    Prime retail space in downtown Chillicothe with high visibility.

    • Prime Downtown Location on N Bridge Street
    • High Visibility & Foot Traffic
    • Boasting 123’ of Frontage
    • 2,900 SF Retail Space with Flexible Layout
    • Walkable Amenities: Restaurants, Shops, Historic Attractions
    Updated: Sep 11, 2025
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    Industrial Space Along US 23
    $4 SF/Yr
    100,000 SF

    Industrial Space Along US 23

    Industrial property with build-to-suit options and tax abatement.

    1101 River Rd, Chillicothe, OH
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    Retail Power Center Space Available
    Contact for pricing

    Retail Power Center Space Available

    Prime retail space in regional shopping destination with excellent visibility.

    Seney Rd, Chillicothe, OH
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    Retail Space in Chillicothe Hub
    Contact for pricing
    4,354 SF

    Retail Space in Chillicothe Hub

    Retail space available in high-traffic Chillicothe retail hub.

    1334 N Bridge St, Chillicothe, OH 45601
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    Retail, Land, Restaurant
    Contact for pricing

    Retail, Land, Restaurant

    Commercial land

    1251 N Bridge St, Chillicothe, OH 45601
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    Premier Retail Space in Chillicothe
    Contact for pricing

    Premier Retail Space in Chillicothe

    High-visibility retail space on Chillicothe's main retail corridor.

    1080 N Bridge St, Chillicothe, OH 45601
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    Retail Space For Lease
    Contact for pricing

    Retail Space For Lease

    Retail space available for lease on North Bridge Street.

    North Bridge Street (SR 159) at Seney Road, Chillicothe, OH 45601
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    Retail Center Near I-35
    Contact for pricing
    1,500 SF

    Retail Center Near I-35

    154,000 SF retail center near I-35 and Bridge Street.

    2-144 Consumer Center Dr, Chillicothe, OH
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    Based on your search, we've compiled 36 Potential Opportunities for your consideration. Besides 9 Active listings in Chillicothe, OH, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 23 Properties for Sales.

    Explore Commercial real estate for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Circleville Flex Space For Lease
    $4,500/Mo
    4,296 SF

    Circleville Flex Space For Lease

    Flex space with offices, conference room, and drive-in bays.

    1099 US-22, Circleville, OH 43113
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    Rickenbacker Area Warehouse Space
    Contact for pricing
    509,257 SF

    Rickenbacker Area Warehouse Space

    Warehouse space in Rickenbacker area, near major transportation routes.

    3780 TradePort Ct, Ashville, OH
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    Industrial Space in Rickenbacker Park
    Contact for pricing
    1,027,649 SF

    Industrial Space in Rickenbacker Park

    Industrial space available for lease in Groveport, Ohio.

    4229 Raymond Ave, Ashville, OH
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    Office and Warehouse Space Available
    $8 SF/Yr
    20,800 SF

    Office and Warehouse Space Available

    Two-story office and warehouse space for lease.

    1950 Stoneridge Dr, Circleville, OH
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    Explore Similar Spaces for Sale in Chillicothe, OH

    Consider Similar Space for Sale. We found 23 Spaces matching your search parameters.

    Commercial Land in Bustling Corridor
    $525,000
    3.72 Acres

    Commercial Land in Bustling Corridor

    3.72-acre commercial parcel in Chillicothe's heart, primed for development.

    0 Pawnee Road, Chillicothe, OH 45601
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    High-Traffic Commercial Property in Chillicothe
    $169,900
    1,496 SF

    High-Traffic Commercial Property in Chillicothe

    Versatile commercial building on East Main Street with high visibility.

    945 E Main Street, Chillicothe, OH 45601
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    Renovated Commercial Property on Western
    $399,000
    1,848 SF

    Renovated Commercial Property on Western

    Updated commercial property on Western Avenue in Chillicothe, Ohio.

    2111 Western Ave., Chillicothe, OH 45601
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    Mixed-Use Asset in Chillicothe, OH
    $239,000

    Mixed-Use Asset in Chillicothe, OH

    Versatile mixed-use property with income potential and repositioning opportunities.

    83-85 Main Street, Chillicothe, OH 45601
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    Main Street Investment Opportunity
    $550,000
    5,244 SF

    Main Street Investment Opportunity

    High-visibility commercial building with established tenants in a prime location.

    946-954 E Main Street, Chillicothe, OH 45601
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    Prime Retail Ground Lease Opportunity
    Contact for pricing
    1.35 Acres

    Prime Retail Ground Lease Opportunity

    1.35 acre commercial land in high-traffic retail corridor.

    1487 Bridge Street, Chillicothe, OH 45601
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    Commercial Land on US-23
    $325,000
    7.86 Acres

    Commercial Land on US-23

    7.86 acre commercial parcel with high visibility on US-23.

    US-23, Chillicothe, OH 45601
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    Versatile Land in Chillicothe, OH
    $350,000
    20.90 Acres

    Versatile Land in Chillicothe, OH

    Land with commercial, agricultural, and subdivision potential.

    13223 Pleasant Valley Road, Chillicothe, OH 45601
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    Versatile Land in Chillicothe, OH
    $950,000
    40.00 Acres

    Versatile Land in Chillicothe, OH

    Multi-use land with road frontage and utilities in Chillicothe.

    13223 Pleasant Valley Road, Chillicothe, OH 45601
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    Chillicothe Equestrian Estate For Sale
    $574,000
    2,400 SF

    Chillicothe Equestrian Estate For Sale

    11.8-acre mini equestrian estate near Chillicothe, Ohio.

    141 Delano Rd., Chillicothe, OH 45601
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    Retail Space on Bridge Street
    Contact for pricing

    Retail Space on Bridge Street

    NNN lease opportunity in Chillicothe, with high visibility.

    27 Bridge Street, Chillicothe, OH 45601
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    Downtown Chillicothe Mixed-Use Building
    $214,900
    2,200 SF

    Downtown Chillicothe Mixed-Use Building

    Versatile building in historic downtown Chillicothe with retail and residential/office potential.

    13 W 2ND ST, Chillicothe, OH 45602
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    Renovated Mixed-Use Building For Sale
    $650,000
    4,832 SF

    Renovated Mixed-Use Building For Sale

    Renovated mixed-use building with high visibility and ample parking.

    7 Saint Andrews Blvd, Chillicothe, OH 45601
    View details
    Downtown Chillicothe Mixed-Use Investment
    $214,900
    2,200 SF

    Downtown Chillicothe Mixed-Use Investment

    Versatile building in historic Union Block with retail and residential potential.

    11 W 2ND ST, Chillicothe, OH 45601
    View details
    Commercial Land on US Route
    $325,000
    7.86 Acres

    Commercial Land on US Route

    7.86-acre commercial parcel with high visibility on US Route 23.

    US Rt 23, Chillicothe, OH 45601
    View details

    Chillicothe, OH Commercial real estate Leasing Opportunities Market Analysis

    Explore Commercial real estate leasing options in Chillicothe, OH with 9 listings featured on our commercial real estate exchange. The current inventory includes 103,830 square feet of properties with an estimated lease value of $32 SF/Yr.

    Estimated lease rates for Commercial real estate in Chillicothe, OH begin at $4 SF/Yr, with an average of $10 SF/Yr and extend to $15 SF/Yr.
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