Advertise
    Chillicothe, OH
    For Lease
    • For Sale
    • For Lease
    • Recently Sold
    • Property Lookup
    • Brokers
    Space Uses
    • Retail
    • Restaurant
    • Office
    • Coworking
    • Medical Space
    • Automotive
    • Industrial
    • Warehouse
    • Flex
    • Hospitality
    • Sports & Entertainment
    • Specialty
    Rent
    Rent
    $
    $
    Size
    Property Size / SF

    Chillicothe, OH Commercial Real Estate for Lease

    Notify Me
    List
    Map
    Waverly, OH Circleville, OH Piketon, OH
    9 listings
    Newly Renovated Office Suite
    $1,100/Mo
    1,080 SF
    Newly Renovated Office Suite

    Chillicothe, OH 45601

    Move-in-ready suite with private offices, conference space, kitchen, and convenient entrances for a downtown professional setting.
    • Prime downtown location in the historic district.
    • Newly renovated, move‑in‑ready office space.
    • Functional layout featuring a lobby, reception area, two private offices, and conference room.
    • Private parking and front/back private entrances.
    • Kitchen includes new appliances.
    Updated: Mar 4
    View details
    Downtown Retail Space Available
    $15 SF/Yr
    2,750 SF
    Downtown Retail Space Available

    23 N Bridge St, Chillicothe, OH

    Prime retail space in downtown Chillicothe with high visibility.
    • Prime Downtown Location on N Bridge Street
    • High Visibility & Foot Traffic
    • Boasting 123’ of Frontage
    • 2,900 SF Retail Space with Flexible Layout
    • Walkable Amenities: Restaurants, Shops, Historic Attractions
    Updated: Sep 11, 2025
    View details
    Industrial Space Along US 23
    $4 SF/Yr
    100,000 SF
    Industrial Space Along US 23

    Industrial property with build-to-suit options and tax abatement.

    1101 River Rd, Chillicothe, OH

    View details
    Retail Power Center Space Available
    Contact for pricing
    Retail Power Center Space Available

    Prime retail space in regional shopping destination with excellent visibility.

    Seney Rd, Chillicothe, OH

    View details
    Retail Space in Chillicothe Hub
    Contact for pricing
    4,354 SF
    Retail Space in Chillicothe Hub

    Retail space available in high-traffic Chillicothe retail hub.

    1334 N Bridge St, Chillicothe, OH 45601

    View details
    Retail, Land, Restaurant
    Contact for pricing
    Retail, Land, Restaurant

    Commercial land

    1251 N Bridge St, Chillicothe, OH 45601

    View details
    Premier Retail Space in Chillicothe
    Contact for pricing
    Premier Retail Space in Chillicothe

    High-visibility retail space on Chillicothe's main retail corridor.

    1080 N Bridge St, Chillicothe, OH 45601

    View details
    Retail Space For Lease
    Contact for pricing
    Retail Space For Lease

    Retail space available for lease on North Bridge Street.

    North Bridge Street (SR 159) at Seney Road, Chillicothe, OH 45601

    View details
    Retail Center Near I-35
    Contact for pricing
    1,500 SF
    Retail Center Near I-35

    154,000 SF retail center near I-35 and Bridge Street.

    2-144 Consumer Center Dr, Chillicothe, OH

    View details
    Based on your search, we've compiled 35 Potential Opportunities for your consideration. Besides 9 Active listings in Chillicothe, OH, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 22 Properties for Sales.

    Commercial real estate for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Remodeled Flex Space with Drive-In Bays
    $4,500/Mo
    4,296 SF
    Remodeled Flex Space with Drive-In Bays

    Almost 7,000 sq ft flex layout with three drive-in bays, remodeled offices, and ample parking.

    1099 US-22, Circleville, OH 43113

    View details
    Rickenbacker Area Warehouse Space
    Contact for pricing
    509,257 SF
    Rickenbacker Area Warehouse Space

    Warehouse space in Rickenbacker area, near major transportation routes.

    3780 TradePort Ct, Ashville, OH

    View details
    Industrial Space in Rickenbacker Park
    Contact for pricing
    1,027,649 SF
    Industrial Space in Rickenbacker Park

    Industrial space available for lease in Groveport, Ohio.

    4229 Raymond Ave, Ashville, OH

    View details
    Office and Warehouse Space Available
    $8 SF/Yr
    20,800 SF
    Office and Warehouse Space Available

    Two-story office and warehouse space for lease.

    1950 Stoneridge Dr, Circleville, OH

    View details

    Similar Spaces for Sale in Chillicothe, OH

    Consider Similar Space for Sale. We found 22 Spaces matching your search parameters.

    High-Traffic Commercial Property on Main
    $159,900
    1,496 SF
    High-Traffic Commercial Property on Main

    Versatile commercial building in Chillicothe with high visibility.

    945 E Main Street, Chillicothe, OH 45601

    View details
    Flat Undeveloped Commercial Land
    $525,000
    3.72 Acres
    Flat Undeveloped Commercial Land

    A 3.72-acre flat parcel with dual access points, offering a flexible site for commercial development in Chillicothe.

    Pawnee Road, Chillicothe, OH 45601

    View details
    Renovated Commercial Property on Western
    $399,000
    1,848 SF
    Renovated Commercial Property on Western

    Updated commercial property on Western Avenue in Chillicothe, Ohio.

    2111 Western Ave., Chillicothe, OH 45601

    View details
    Main Street Investment Opportunity
    $550,000
    5,244 SF
    Main Street Investment Opportunity

    High-visibility commercial building with established tenants in a prime location.

    946-954 E Main Street, Chillicothe, OH 45601

    View details
    Downtown Chillicothe Mixed-Use Building
    $214,900
    2,200 SF
    Downtown Chillicothe Mixed-Use Building

    Versatile building in historic downtown Chillicothe with retail and residential/office potential.

    13 W 2ND ST, Chillicothe, OH 45602

    View details
    Renovated Mixed-Use Building For Sale
    $650,000
    4,832 SF
    Renovated Mixed-Use Building For Sale

    Renovated mixed-use building with high visibility and ample parking.

    7 Saint Andrews Blvd, Chillicothe, OH 45601

    View details
    Downtown Chillicothe Mixed-Use Investment
    $214,900
    2,200 SF
    Downtown Chillicothe Mixed-Use Investment

    Versatile building in historic Union Block with retail and residential potential.

    11 W 2ND ST, Chillicothe, OH 45601

    View details
    Tim Hortons | White Castle Lease
    $2,020,000
    5,424 SF
    Tim Hortons | White Castle Lease

    Ground lease investment with long-term tenants in prime location.

    1000-1020 N Bridge St, Chillicothe, OH 45601

    View details
    Prime Retail Ground Lease Opportunity
    Contact for pricing
    1.35 Acres
    Prime Retail Ground Lease Opportunity

    1.35 acre commercial land in high-traffic retail corridor.

    1487 Bridge Street, Chillicothe, OH 45601

    View details
    Multi-Use Development Land
    $950,000
    40.00 Acres
    Multi-Use Development Land

    Versatile land parcel with road frontage and utilities in place, suitable for a range of development or agricultural uses.

    13223 Pleasant Valley Road, Chillicothe, OH 45601

    View details
    Established Tire Business For Sale
    $369,000
    2,020 SF
    Established Tire Business For Sale

    Well-respected tire business on a highly visible corner lot.

    394 N High St, Chillicothe, OH 45601

    View details
    Commercial Land on US Route
    $325,000
    7.86 Acres
    Commercial Land on US Route

    7.86-acre commercial parcel with high visibility on US Route 23.

    US Rt 23, Chillicothe, OH 45601

    View details
    Retail Space on Bridge Street
    Contact for pricing
    Retail Space on Bridge Street

    NNN lease opportunity in Chillicothe, with high visibility.

    27 Bridge Street, Chillicothe, OH 45601

    View details
    Commercial and Agricultural Land Parcel
    $350,000
    20.90 Acres
    Commercial and Agricultural Land Parcel

    Flexible land offering road frontage and existing utilities, suitable for commercial or agricultural planning uses.

    13223 Pleasant Valley Road, Chillicothe, OH 45601

    View details
    Prime Retail Site on Western
    $439,000
    0.71 Acres
    Prime Retail Site on Western

    0.71-acre retail site with high traffic and visibility.

    1318 Western Ave, Chillicothe, OH 45601

    View details

    Chillicothe, OH Commercial real estate Leasing Opportunities Market Analysis

    Explore Commercial real estate leasing options in Chillicothe, OH with 9 listings featured on our commercial real estate exchange. The current inventory includes 103,830 square feet of properties with an estimated lease value of $32 SF/Yr.

    Estimated lease rates for Commercial real estate in Chillicothe, OH begin at $4 SF/Yr, with an average of $10 SF/Yr and extend to $15 SF/Yr.
    List
    Map

    Popular Searches in Chillicothe, OH

    Popular Categories

    Most Searched ZIP Codes in Chillicothe, OH

    • 45601

    Select Neighborhood

    Google sign-in failed. Please try again or use another login method.
    Sign Up Successful!
    You now have access to more from Realmo!