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    Cape Girardeau County, MO Commercial Real Estate for Sale

    88 results
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    Mixed-Use Building in Prime Location
    $895,000
    7,000 SF

    Mixed-Use Building in Prime Location

    246 W Deerwood Drive, Jackson, MO 63755

    Turn-key mixed-use building in a high-traffic Jackson location.

    • Prime location across from baseball fields and the new roundabout.
    • Large commercial zoned building (70x100) suitable for various businesses.
    • High visibility with approximately 183 ft of highway frontage.
    • Turn‑key building with reception area, private offices, 2 bathrooms, and break room.
    • Ample parking space for a minimum of 55 vehicles.
    Updated: Apr 2
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    Unique Mixed-Use Property with Treehouse
    $885,000
    7.44 Acres

    Unique Mixed-Use Property with Treehouse

    4940 County Road 532, Jackson, MO 63755

    Exceptional property with a residence and a remarkable treehouse building.

    • Unique 2,500+ sq. ft. "Treehouse" building with commercial‑style kitchen, bar, and large deck offering significant income‑generating potential.
    • Main house features rustic design elements including wood beams, vaulted pinewood ceilings, and a stone wood‑burning fireplace.
    • Fully finished walk‑out basement with family room, bedroom, bonus rooms, and bathroom.
    • Property includes an existing shop and footings for a 40 x 50 shop.
    • Energy‑efficient wood‑burning stove heats the entire home.
    Updated: Apr 4
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    Updated Office Building For Sale
    $350,000
    4,000 SF

    Updated Office Building For Sale

    Well-maintained office building with high visibility and ample parking.

    824 Independence Street, Cape Girardeau, MO 63703
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    Versatile Riverfront Commercial Property
    $400,000
    4,400 SF

    Versatile Riverfront Commercial Property

    Prime riverfront property suitable for office, restaurant, warehouse, or mixed-use.

    450 N Main Street, Cape Girardeau, MO 63701
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    Versatile Commercial Space in Cape Girardeau
    $825,000
    0.17 Acres

    Versatile Commercial Space in Cape Girardeau

    Well-designed commercial space with banquet, dining, and bar areas.

    20 N Spanish Street, Cape Girardeau, MO 63701
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    Versatile Riverfront Commercial Property
    $475,000
    7,044 SF

    Versatile Riverfront Commercial Property

    Flexible commercial space with riverfront location and development potential.

    308 N Main Street, Cape Girardeau, MO 63701
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    Versatile Commercial Building Near I-55
    $570,000
    3,096 SF

    Versatile Commercial Building Near I-55

    High-traffic location, built in 2017, suitable for diverse businesses.

    5598 Us Highway 61 North, Jackson, MO 63755
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    Mixed-Use Property in Jackson, MO
    $569,000
    2,304 SF

    Mixed-Use Property in Jackson, MO

    Commercial property with shop, office, and storage on 3.3 acres.

    6065 State Highway W, Jackson, MO 63755
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    Furnished Mixed-Use Professional Building
    $299,999
    3,210 SF

    Furnished Mixed-Use Professional Building

    Two-level, fully furnished office building in Jackson, Missouri.

    902 E Jackson Boulevard, Jackson, MO 63755
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    Historic Landmark in Downtown Jackson
    $669,000
    10,000 SF

    Historic Landmark in Downtown Jackson

    Landmark building with potential for various commercial uses.

    101 W Main Street, Jackson, MO 63755
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    Renovated 11-Bedroom Income Property
    $450,000
    4,548 SF

    Renovated 11-Bedroom Income Property

    Versatile, renovated 11-bedroom property in downtown Cape Girardeau.

    224 N Frederick Street, Cape Girardeau, MO 63701
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    Turn-Key Restaurant Business Opportunity
    $200,000
    2,760 SF

    Turn-Key Restaurant Business Opportunity

    Fully operational restaurant, ready for new owner in Oak Ridge.

    4053 State Highway E, Oak Ridge, MO 63769
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    Versatile Commercial Building in Cape
    $225,000
    0.57 Acres

    Versatile Commercial Building in Cape

    Adaptable 1800 sq ft commercial building in thriving Cape Girardeau.

    2357 Rust Avenue, Cape Girardeau, MO 63703
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    Leased Office Building For Sale
    $500,000
    7,140 SF

    Leased Office Building For Sale

    Two-story office building with 21 units and parking.

    2711 Thomas Drive, Cape Girardeau, MO 63701
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    Renovated Commercial Space in Cape Girardeau
    $239,900
    2,937 SF

    Renovated Commercial Space in Cape Girardeau

    Renovated commercial space with high potential in a prime location.

    230 N Sprigg Street, Cape Girardeau, MO 63701
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    Mixed-Use Building in Jackson, MO
    $325,000
    2,665 SF

    Mixed-Use Building in Jackson, MO

    Mixed-use property with income potential in Jackson, Missouri.

    1502 W Jackson Boulevard, Jackson, MO 63755
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    Wedding Venue with Living Quarters
    $629,000
    8.72 Acres

    Wedding Venue with Living Quarters

    Successful wedding venue with living quarters on over 8 acres.

    1082 County Road 349, Jackson, MO 63755
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    Versatile Commercial Property For Sale
    $295,000
    2,920 SF

    Versatile Commercial Property For Sale

    High-visibility commercial property with flexible layout and spacious attached warehouse.

    225 Clark Avenue, Cape Girardeau, MO 63701
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    Industrial Warehouse on 3.9 Acres
    $489,900
    3.90 Acres

    Industrial Warehouse on 3.9 Acres

    Industrial warehouse for sale in Cape Girardeau, Missouri.

    840 S Kingshighway, Cape Girardeau, MO 63703
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    Cape Girardeau Flex Space Building
    $299,900
    5,000 SF

    Cape Girardeau Flex Space Building

    5,000 sq ft building with concrete floors and possibilities.

    3188 Old Route V, Cape Girardeau, MO 63701
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    Downtown Cape Girardeau Commercial Lot
    $450,000
    1.04 Acres

    Downtown Cape Girardeau Commercial Lot

    Prime commercial lot near casino, ideal for development.

    0 N Main Street, Cape Girardeau, MO 63701
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    Cape Girardeau Mixed-Use Investment
    $489,900
    7,282 SF

    Cape Girardeau Mixed-Use Investment

    Leased commercial spaces with residential unit for income growth.

    1606 Independence Street, Cape Girardeau, MO 63703
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    Ambulatory Surgery Center Investment Opportunity
    $8,050,000
    13,650 SF

    Ambulatory Surgery Center Investment Opportunity

    Single-tenant surgery center near St. Francis Medical Center for sale.

    3241 Percy Drive, Cape Girardeau, MO 63701
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    Expansive Farmland Tract For Sale
    $529,500
    35.30 Acres

    Expansive Farmland Tract For Sale

    35.3-acre farmland with development potential in Millersville, Missouri.

    0 Hwy 72, Millersville, MO 63766
    View details

    Cape Girardeau County, MO Commercial Real Estate Investment Opportunities Market Analysis

    Explore 88 commercial real estate for sale in Cape Girardeau County, MO, showcased through 88 active listings on our real estate platform. These investment opportunities span a total of 17,808,112 square feet of properties for sale, with an estimated market value of $50,883,099.

    Sale prices for business properties in Cape Girardeau County, MO start at $35,000, averaging $1,130,735, and reaching up to $22,500,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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