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    Cape Girardeau County, MO Commercial Real Estate for Sale

    158 results
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    Versatile Riverfront Commercial Property
    Pending
    $400,000
    4,400 SF

    Versatile Riverfront Commercial Property

    450 N Main St, Cape Girardeau, MO 63701

    Prime riverfront property suitable for office, restaurant, warehouse, or mixed-use.

    • Prime riverfront location directly on the Mississippi River.
    • High visibility and ideal location for downtown development and parking.
    • Versatile property suitable for office, restaurant, warehouse, or mixed‑use concepts.
    • Existing warehouse on the property.
    • Metal siding construction.
    Updated: Feb 18
    View details
    Renovated Downtown Commercial Property
    $500,000
    4,548 SF

    Renovated Downtown Commercial Property

    224 N Frederick St, Cape Girardeau, MO 63701

    Versatile 11-bedroom property in downtown Cape Girardeau.

    • Prime downtown location steps from dining, shopping, and campus.
    • Proven income‑producing property as a high‑demand sorority house.
    • Fully renovated in 2020 with 11 bedrooms and over 5,100 square feet.
    • Versatile property suitable for group housing, student rentals, or professional office space.
    • Generous lot with twenty‑five parking spaces.
    Updated: Feb 18
    View details
    Cape Girardeau Mixed-Use Investment
    $489,900
    7,282 SF

    Cape Girardeau Mixed-Use Investment

    Leased commercial spaces with residential unit for income growth.

    1606 Independence St, Cape Girardeau, MO 63703
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    Versatile Riverfront Commercial Property
    $475,000
    7,044 SF

    Versatile Riverfront Commercial Property

    Flexible commercial space with riverfront location and development potential.

    308 N Main St, Cape Girardeau, MO 63701
    View details
    Unique Mixed-Use Property with Treehouse
    $997,000
    2,500 SF

    Unique Mixed-Use Property with Treehouse

    Exceptional property with a residence and a remarkable treehouse building.

    4940 County Road 532, Jackson, MO 63755
    View details
    Versatile Commercial Property For Sale
    $295,000
    2,920 SF

    Versatile Commercial Property For Sale

    High-visibility commercial property with flexible layout and spacious attached warehouse.

    225 Clark Ave, Cape Girardeau, MO 63701
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    Versatile Commercial Space in Missouri
    $900,000
    7,396 SF

    Versatile Commercial Space in Missouri

    7,396 SF commercial building with banquet, dining, and bar areas.

    20 N Spanish St, Cape Girardeau, MO 63701
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    Mixed-Use Building in Prime Location
    $990,000
    7,000 SF

    Mixed-Use Building in Prime Location

    Turn-key mixed-use building with highway frontage and high traffic potential.

    202 W Deerwood Dr, Jackson, MO 63755
    View details
    Turn-Key Restaurant Business Opportunity
    $200,000
    2,760 SF

    Turn-Key Restaurant Business Opportunity

    Fully operational restaurant, ready for new owner in Oak Ridge.

    4053 State Hwy E, Oak Ridge, MO 63769
    View details
    Mixed-Use Property in Jackson, MO
    $569,000
    2,304 SF

    Mixed-Use Property in Jackson, MO

    Commercial property with shop, office, and storage on 3.3 acres.

    6065 State Hwy W, Jackson, MO 63755
    View details
    Furnished Mixed-Use Professional Building
    $299,999
    3,210 SF

    Furnished Mixed-Use Professional Building

    Two-level, fully furnished office building in Jackson, Missouri.

    902 E Jackson Blvd, Jackson, MO 63755
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    Wedding Venue with Living Quarters
    $629,000
    8.72 Acres

    Wedding Venue with Living Quarters

    Successful wedding venue with living quarters on over 8 acres.

    1082 County Road 349, Jackson, MO 63755
    View details
    Broadway Commercial Space with Apartment
    $280,000
    5,100 SF

    Broadway Commercial Space with Apartment

    Versatile investment opportunity with remodeled apartment and commercial space.

    520 Broadway St, Cape Girardeau, MO 63701
    View details
    Leased Office Building For Sale
    $500,000
    7,140 SF

    Leased Office Building For Sale

    Two-story office building with 21 units and parking.

    2711 Thomas Dr, Cape Girardeau, MO 63701
    View details
    Ambulatory Surgery Center Investment Opportunity
    $8,050,000
    13,650 SF

    Ambulatory Surgery Center Investment Opportunity

    Single-tenant surgery center near St. Francis Medical Center for sale.

    3241 Percy Dr, Cape Girardeau, MO 63701
    View details
    Versatile Commercial Building Near I-55
    Pending
    $570,000
    3,096 SF

    Versatile Commercial Building Near I-55

    High-traffic location, built in 2017, suitable for diverse businesses.

    5598 Us Highway 61 North, Jackson, MO 63755
    View details
    Industrial Warehouse in Cape Girardeau
    $499,900
    3.90 Acres

    Industrial Warehouse in Cape Girardeau

    3.9 acres with 7,500 sq ft warehouse near I-55.

    840 S Kings Highway St, Cape Girardeau, MO 63703
    View details
    Cape Girardeau Commercial Property
    Pending
    $825,000
    7,000 SF

    Cape Girardeau Commercial Property

    Well-maintained commercial property with over 7,000 square feet.

    340 S Broadview St, Cape Girardeau, MO 63703
    View details
    Versatile Commercial Building in Cape
    $225,000
    0.57 Acres

    Versatile Commercial Building in Cape

    Adaptable 1800 sq ft commercial building in thriving Cape Girardeau.

    2357 Rust Ave, Cape Girardeau, MO 63703
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    Retail Property in High Visibility Location
    $375,000
    0.67 Acres

    Retail Property in High Visibility Location

    Two-level retail space with 16 parking spots in Jackson, MO.

    1336 Clover Dr, Jackson, MO 63755
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    Renovated Commercial Space in Cape Girardeau
    $239,900
    2,937 SF

    Renovated Commercial Space in Cape Girardeau

    Renovated commercial space with high potential in a prime location.

    230 N Sprigg St, Cape Girardeau, MO 63701
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    Historic Landmark in Downtown Jackson
    $669,000
    10,000 SF

    Historic Landmark in Downtown Jackson

    Landmark building with potential for various commercial uses.

    101 W Main St, Jackson, MO 63755
    View details
    E. Jackson Blvd Retail/Office Building
    Contact for pricing

    E. Jackson Blvd Retail/Office Building

    Creative office or retail building in high-traffic, visible location.

    1204 E Jackson Blvd, Jackson, MO 63755
    View details
    Jackson, MO Commercial Land Opportunity
    $599,000
    4.17 Acres

    Jackson, MO Commercial Land Opportunity

    4.17 Acres, Prime Commercial Location

    Unit, Jackson, MO 63755
    View details

    Cape Girardeau County, MO Commercial Real Estate Investment Opportunities Market Analysis

    Explore 354 commercial real estate investment opportunities in Cape Girardeau County, MO with 158 listings featured on our commercial real estate marketplace. The current inventory includes 48,028,592 square feet of properties with an estimated value of $71,818,104.

    Estimated prices for commercial real estate in Cape Girardeau County, MO begin at $35,000, with an average of $343,627 and extend to $8,050,000.

    In Cape Girardeau County, MO, current investment values show:

    • Land positioned at $244,823
    • Other commercial real estate measuring $403,659
    • Residential land & home lots assessed at $76,466
    • Specialty properties calculated at $257,086
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