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    Jefferson County, MO Commercial Real Estate for Sale

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    Kansas City, MO Louis, MO Springfield, MO
    93 results
    Versatile Flex Office/Warehouse Property
    $875,000
    10,000 SF

    Versatile Flex Office/Warehouse Property

    622 Collins Drive, Festus, MO 63028

    Two-story office/warehouse near I-55, suitable for diverse businesses.

    • Prime Location: Less than a quarter mile from I‑55, providing easy access to the St. Louis metro area.
    • Flexible Office/Warehouse Space: Approximately 10,000 sq. ft. with a 65% office / 35% warehouse split, suitable for various business types.
    • Immediate Income Potential: Currently configured as a multi‑tenant building with an existing tenant occupying 3,455 sq. ft.
    • Ample Parking & Security: 40 paved parking spaces and exterior lighting for enhanced security and accessibility.
    • Robust Infrastructure: Includes one dock‑high bay, one drive‑in bay, 4‑phase 440‑amp electrical service, and high‑speed internet.
    Updated: Apr 13
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    Historic Kimmswick Victorian Commercial Property
    $450,000
    0.19 Acres

    Historic Kimmswick Victorian Commercial Property

    6025 Third Street, Kimmswick, MO 63052

    Victorian property in historic Kimmswick, ideal for various business ventures.

    • Prime location in the heart of historic Kimmswick, a high‑traffic tourist destination.
    • Versatile zoning allows for various business ventures or live‑work space.
    • Updated kitchen with QUARTZ COUNTERTOPS, triple sink, prep sink, planning desk, and generous pantry space.
    • Detached OVERSIZED two‑car garage with workshop and loft provides additional space.
    • Significant recent updates including new roof and siding (2025), newer electrical panels, and PEX plumbing.
    Updated: Apr 23
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    Versatile Commercial Space in Arnold
    $269,900
    4,200 SF

    Versatile Commercial Space in Arnold

    Office/retail space with updated features and ample parking.

    1333 W Outer 21 Road, Arnold, MO 63010
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    Versatile Commercial Building in Crystal City
    $725,900
    9,500 SF

    Versatile Commercial Building in Crystal City

    Well-maintained 9,500 sq ft commercial building on 0.63 acres.

    1222 N Truman Boulevard, Crystal City, MO 63019
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    Imperial, MO Mixed-Use Opportunity
    $775,000
    13.40 Acres

    Imperial, MO Mixed-Use Opportunity

    13.5 acres with road frontage, suitable for various uses.

    4536 Old State Route 21, Imperial, MO 63052
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    Adaptable Mixed-Use Building on Acreage
    $665,000
    8.00 Acres

    Adaptable Mixed-Use Building on Acreage

    12,000 sq ft building on 8 acres in High Ridge.

    3483 High Ridge Boulevard, High Ridge, MO 63049
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    Versatile Commercial Property in Arnold
    $279,900
    1.22 Acres

    Versatile Commercial Property in Arnold

    Three buildings in high-traffic location, ideal for diverse business uses.

    1449 Jeffco Boulevard, Arnold, MO 63010
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    Cedar Hill Industrial Space
    $1,799,000
    22,000 SF

    Cedar Hill Industrial Space

    Industrial space with cranes, office, apartment, and expansion potential.

    6585 Progress Parkway, Cedar Hill, MO 63016
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    Landmark Restaurant NNN Investment Opportunity
    $2,922,566
    7,857 SF

    Landmark Restaurant NNN Investment Opportunity

    NNN leased restaurant on 2.2 acres with future development potential.

    3601 Jeffco Boulevard, Arnold, MO 63010
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    Versatile Retail Property in Arnold
    $279,900
    0.11 Acres

    Versatile Retail Property in Arnold

    Commercial property with three buildings, ideal for diverse business uses.

    1447 Jeffco Boulevard, Arnold, MO 63010
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    High Ridge Multi-Use Investment Property
    $620,000
    0.70 Acres

    High Ridge Multi-Use Investment Property

    Mixed-use property with residential and commercial rental income potential.

    2801 High Ridge Boulevard, High Ridge, MO 63049
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    Mixed-Use Property on High Ridge
    $620,000
    0.70 Acres

    Mixed-Use Property on High Ridge

    Mixed-use property with multiple rental opportunities on 0.7 acres.

    2801 High Ridge Boulevard, High Ridge, MO 63049
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    Hillsboro Land Near City Hall
    $426,900
    2,772 SF

    Hillsboro Land Near City Hall

    Versatile half-acre lot in prime Hillsboro location.

    114 Main Street, Hillsboro, MO 63050
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    Highway Frontage Commercial Land
    $84,900
    0.88 Acres

    Highway Frontage Commercial Land

    Prime commercial land with high visibility and easy access.

    4591 Highway W, House Springs, MO 63051
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    Multi-Use Property with Redevelopment Potential
    $350,000
    0.61 Acres

    Multi-Use Property with Redevelopment Potential

    1.5-acre property with commercial/residential zoning, outbuildings, and redevelopment potential.

    3728 Telegraph Road, Arnold, MO 63010
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    Herculaneum Commercial Property on Highway
    $1,200,000
    3,900 SF

    Herculaneum Commercial Property on Highway

    Commercial property with shop and office space on high-traffic highway.

    888 Commercial Boulevard, Herculaneum, MO 63048
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    Commercial Lot on Highway 30
    $84,900
    1.56 Acres

    Commercial Lot on Highway 30

    1.54 acre commercial lot with highway visibility.

    7095 Old Hwy 30, Cedar Hill, MO 63016
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    Hillsboro Mixed-Use Redevelopment Opportunity
    $450,000
    6,090 SF

    Hillsboro Mixed-Use Redevelopment Opportunity

    Versatile 6-acre property with highway frontage and redevelopment potential.

    9637 Old State Route 21, Hillsboro, MO 63050
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    Hillsboro Church with Conversion Potential
    $1,750,000
    5.00 Acres

    Hillsboro Church with Conversion Potential

    Church building on 5 acres, suitable for office conversion.

    4770 State Road B, Hillsboro, MO 63050
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    Festus Industrial Property Near Hospital
    $365,000
    0.93 Acres

    Festus Industrial Property Near Hospital

    Versatile industrial property near Mercy Jefferson Hospital.

    1045 Airport Road, Festus, MO 63028
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    Pevely Commercial Land and Warehouse
    $750,000
    9.98 Acres

    Pevely Commercial Land and Warehouse

    Large commercial land parcel with warehouse and residential building.

    1545 & 1565 State Hwy Z, Pevely, MO 63070
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    Commercial Lots in Prime Location
    $623,400
    1.79 Acres

    Commercial Lots in Prime Location

    1.79 acres near Highway 30, suitable for various businesses.

    0 Cedric Station, Cedar Hill, MO 63016
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    Festus Church Building For Sale
    $215,000
    0.20 Acres

    Festus Church Building For Sale

    Church building in the heart of Festus with off-street parking.

    410 Moore Street, Festus, MO 63028
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    Underground Warehouse in Crystal City
    $950,000
    2.07 Acres

    Underground Warehouse in Crystal City

    Unique 67,000 SF underground warehouse suitable for storage.

    20 Cave Industrial Drive, Crystal City, MO 63019
    View details

    Jefferson County, MO Commercial Real Estate Investment Opportunities Market Analysis

    Explore 3692 commercial real estate for sale in Jefferson County, MO, showcased through 93 active listings on our real estate platform. These investment opportunities span a total of 240,867 square feet of properties for sale, with an estimated market value of $33,790,339.

    Sale prices for business properties in Jefferson County, MO start at $249,000, averaging $1,469,145, and reaching up to $10,000,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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