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    Seneca, SC Commercial Real Estate for Lease

    13 results
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    Office Space in Seneca, SC
    $2,500 /Mo
    26,136 SF

    Office Space in Seneca, SC

    865 Old Clemson Hwy, Seneca, SC 29678

    Commercial office space available for lease in Seneca, South Carolina.

    • Central heating for those chilly nights.
    • Electric heating available as well.
    • Central air to keep you cool and comfortable.
    • Enjoy electric cooling options.
    • Built in 1997.
    Last Update: Nov 11
    View details
    Seneca Office Space For Lease
    $1,500 /Mo
    26,136 SF

    Seneca Office Space For Lease

    865 Old Clemson Hwy, Seneca, SC 29678

    Two-level office building suitable for various businesses, near Clemson.

    • Suitable for various business types, including medical/dental offices.
    • Two levels with separate entrances and restrooms, offering flexible leasing options (entire building or individual floors).
    • Located in close proximity to Clemson and Seneca.
    • Lower level features 3 offices, conference room, and reception area (Lease: $1,750.00 NNN).
    • Upper level offers 5 offices and a reception area (Lease: $2,900.00 NNN).
    Last Update: Aug 7
    View details
    Professional Office Space in Seneca
    $2,200 /Mo
    30,056 SF

    Professional Office Space in Seneca

    Office space near downtown Seneca with utilities included.
    815 Robin Dr Unit, Seneca, SC 29678
    View details
    Office Space Near Clemson
    $4,000 /Mo
    26,136 SF

    Office Space Near Clemson

    Two-level office building suitable for various businesses, near Clemson.
    865 Old Clemson Hwy, Seneca, SC 29678
    View details
    Downtown Seneca Commercial Space Available
    $2,700 /Mo

    Downtown Seneca Commercial Space Available

    Commercial space for rent in downtown Seneca with street frontage.
    104 North 1St St, Seneca, SC 29678
    View details
    Applewood Shopping Center Opportunity
    Contact for pricing
    244,693 SF

    Applewood Shopping Center Opportunity

    High-traffic retail center near Clemson University
    201 Applewood Center Pl, Seneca, SC 29678
    View details
    Seneca Office Space For Rent
    $15 SF/Yr
    2,900 SF

    Seneca Office Space For Rent

    Office space in the heart of Seneca, ample parking.
    735 N Townville St, Seneca, SC 29678
    View details
    Retail Space Near Clemson University
    $21 SF/Yr
    43,000 SF

    Retail Space Near Clemson University

    End-cap retail space with drive-thru potential near Clemson University.
    1085 Old Clemson Hwy, Seneca, SC 29672
    View details
    Restaurant Space Near Oconee Medical
    Contact for pricing
    16,000 SF

    Restaurant Space Near Oconee Medical

    1,600 SF 2nd Gen Restaurant Space Available For Rent.
    201-273 Applewood Center Pl, Seneca, SC 29678
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    Retail Space Near Oconee Medical
    Contact for pricing
    1,600 SF

    Retail Space Near Oconee Medical

    Retail space available near Oconee Medical Center and Clemson University.
    101 Applewood Center Pl, Seneca, SC 29678
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    Seneca Office/Retail Space Available
    $15 SF/Yr
    4,800 SF

    Seneca Office/Retail Space Available

    Office and retail spaces for lease in Seneca, South Carolina.
    12019 North Radio Station Rd, Seneca, SC 29678
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    Retail Opportunity Near Walmart
    Contact for pricing

    Retail Opportunity Near Walmart

    Retail space available for lease, GL, or build-to-suit.
    1637 Sandifer Blvd, Seneca, SC 29678
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    Retail Opportunity Near Walmart
    Contact for pricing

    Retail Opportunity Near Walmart

    Retail space available for lease near Walmart and hospital.
    Seneca, SC 29678
    View details
    Based on your search, we've compiled 42 Potential Opportunities for your consideration. Besides 13 Active listings in Seneca, SC, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 22 Properties for Sales.

    Explore Commercial Real Estate for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Retail/Restaurant Space Near Clemson University
    Contact for pricing
    3,500 SF

    Retail/Restaurant Space Near Clemson University

    Retail/restaurant space with dedicated parking and lake access.
    894 Tiger Blvd, Clemson, SC 29631
    View details
    Downtown Clemson Retail Space Available
    $2,800 /Mo

    Downtown Clemson Retail Space Available

    Retail space in downtown Clemson, formerly a coffee shop.
    382 College Ave Unit, Clemson, SC 29631
    View details
    Move-in Ready Office Space
    $2,200 /Mo
    15,246 SF

    Move-in Ready Office Space

    Well-maintained office space in established professional park, ready for occupancy.
    111 N Earle St, Walhalla, SC 29691
    View details
    Remodeled Restaurant Space on Main
    $2,000 /Mo
    2,614 SF

    Remodeled Restaurant Space on Main

    Prime restaurant property in a high-traffic, growing tourist area.
    100 W Main St, Walhalla, SC 29691
    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Commercial Land on US Highway
    $72,000
    63,162 SF

    Commercial Land on US Highway

    1.45 acre commercial land for ground lease in Seneca, SC.
    994 Us 123 Hwy, Seneca, SC 29678
    View details
    Land Near Oconee Medical Center
    Contact for pricing

    Land Near Oconee Medical Center

    Commercial land for rent near medical center and Clemson University.
    15516 Wells Hwy, Seneca, SC 29678
    View details
    Hartwell Village Development Opportunity
    Contact for pricing

    Hartwell Village Development Opportunity

    New development opportunity with excellent visibility and easy access.
    13046 Clemson Blvd, Seneca, SC 29678
    View details

    Explore Similar Spaces for Sale in Seneca, SC

    Consider Similar Space for Sale. We found 22 Spaces in Nearby Locations matching your search parameters.

    Seneca Commercial Buildings For Sale
    $450,000
    1.02 Acres

    Seneca Commercial Buildings For Sale

    Two industrial buildings with flexible space and manufacturing potential.
    306 Byp Unit Building B And, Seneca, SC 29678
    View details
    Seneca Commercial Property with Expansion Potential
    $687,500
    3.95 Acres

    Seneca Commercial Property with Expansion Potential

    High-visibility commercial property ideal for storage, sales, or service center.
    298 Worth St, Seneca, SC 29678
    View details
    Two Warehouses Near Clemson
    $490,000
    9,650 SF

    Two Warehouses Near Clemson

    Two warehouse buildings totaling 9,650 SF on one acre.
    306 By Pass 123, Seneca, SC 29678
    View details
    Medical Office NNN Investment
    $2,283,233
    6,227 SF

    Medical Office NNN Investment

    Single tenant medical office building with long-term lease.
    10110 Clemson Blvd, Seneca, SC 29672
    View details
    Affordable Townhome Near Clemson University
    $152,500

    Affordable Townhome Near Clemson University

    Townhome near Clemson University, ideal for rental or affordable living.
    1034 Ridgeview Ln, Seneca, SC 29678
    View details
    Studio Condo Near Clemson Campus
    $270,000

    Studio Condo Near Clemson Campus

    Studio condo near Clemson University with rental management options.
    13500 Clemson Blvd, Seneca, SC 29678
    View details
    Luxury Condo Hotel Near Campus
    $292,110

    Luxury Condo Hotel Near Campus

    Studio condo in luxury hotel with rental management options.
    13500 Clemson Blvd, Seneca, SC 29678
    View details
    Seneca Office Space For Sale
    $599,000
    2,400 SF

    Seneca Office Space For Sale

    Office space conveniently located off Bypass 123 in Seneca, SC.
    631 By Pass 123, Seneca, SC 29678
    View details
    Retail Property on Main Corridor
    $1,000,000
    7,250 SF

    Retail Property on Main Corridor

    Retail property with excellent visibility and heavy traffic.
    1592 Sandifer Blvd, Seneca, SC 29678
    View details
    Seneca Medical Office Building
    $2,283,233
    6,227 SF

    Seneca Medical Office Building

    High-yield, single-tenant medical office
    10110 Clemson Blvd, Seneca, SC 29672
    View details
    Lake Keowee Commercial Land
    $2,250,000
    45.00 Acres

    Lake Keowee Commercial Land

    45 Acres, Seneca, SC - Investment Opportunity
    Unit Keowee I 45+/- Acres Knollwood Dr, Seneca, SC 29678
    View details

    Seneca, SC Commercial Real Estate Leasing Opportunities Market Analysis

    Explore Commercial Real Estate leasing options in Seneca, SC with 35 listings featured on our commercial real estate exchange. The current inventory includes 20,356,738,001 square feet of properties with an estimated lease value of $79,774.

    Estimated lease rates for Commercial Real Estate in Seneca, SC begin at $1.15 SF/Yr, with an average of $8,863 /Mo and extend to $72,000.

    In Seneca, SC, current lease rates show:

    • Office Properties & Spaces positioned at $1,107
    • Office space measuring $1,546
    • Individual retail properties assessed at $19
    • Retail properties calculated at $19
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    Most Searched ZIP Codes in Seneca, SC

    • 29678
    • 29672

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