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    Durham County, NC Commercial Real Estate for Lease

    133 results
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    Versatile Office/Medical Space Available
    $3,000 / Mo
    2,400 SF

    Versatile Office/Medical Space Available

    3925 N Duke St, Durham, NC 27704

    2400 sq ft office/medical suite in prime Durham location.

    • Prime Durham location, minutes from downtown and Duke Regional Hospital.
    • Versatile 2400 sq ft space suitable for office, medical, or service‑based businesses.
    • Five private offices plus open central workspace.
    • Previously configured for dental and salon use.
    • Large reception area ideal for client‑facing businesses.
    Updated: Feb 18
    View details
    Durham Office Condo For Lease
    $1,500 / Mo
    478 SF

    Durham Office Condo For Lease

    3201 Yorktown Ave, Durham, NC 27713

    Recently remodeled office condo with easy access and great location.

    • Recently remodeled with new paint, flooring, ceilings, light fixtures, updated bathroom and kitchenette, and new HVAC system
    • Easy access from parking lot
    • Convenient location: Minutes to Hwy 40 and 885
    • Proximity to Amenities: 2 Miles to Lowes Shopping Plaza, 4 Miles to RTP, 5 Miles to Southpoint Mall and Downtown Durham
    • Includes a brand new refrigerator
    Updated: Feb 10
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    Durham Office Space For Lease
    $45,045
    2,145 SF

    Durham Office Space For Lease

    Flexible office unit with ample parking and recent upgrades.

    1906 A, Durham, NC 27713
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    Office Space Near Universities
    $1,995 / Mo
    1,000 SF

    Office Space Near Universities

    Office space in Durham, close to amenities and universities.

    1804 Martin Luther King Junior Pkwy, Durham, NC 27707
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    Prime Durham Office Space Available
    $29,460
    22,649 SF

    Prime Durham Office Space Available

    12,000 SF office space for lease in Durham, NC.

    5310 S Alston Ave, Durham, NC 27713
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    Retail Space Near RTP
    $3,232 / Mo
    1,168 SF

    Retail Space Near RTP

    Retail space in a vibrant neighborhood center near RTP.

    5125 Nc-55, Durham, NC 27713
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    Prime Medical Office Space Available
    Pending
    $18 SF/Yr
    2,312 SF

    Prime Medical Office Space Available

    Versatile medical/office space in Durham's thriving North Duke corridor.

    2609 N Duke St Unit Bldg 300, Durham, NC 27704
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    Office Suite with Private Offices
    $36,000
    1,760 SF

    Office Suite with Private Offices

    Office suite featuring multiple private office spaces for rent.

    5315 Highgate Dr, Durham, NC 27713
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    Office Condo in Durham's Office Park
    $3,500 / Mo
    2,000 SF

    Office Condo in Durham's Office Park

    Office condominium with private entrance in a convenient location.

    6 Consultant Pl, Durham, NC 27707
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    Auburn Square End Unit
    Contact for pricing

    Auburn Square End Unit

    3BR, 2BTH end unit near Duke, UNC, RTP, Southpoint.

    960 Cinnamon Dr, Durham, NC 27713
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    Durham Duplex Near Duke
    Contact for pricing
    512 SF

    Durham Duplex Near Duke

    One-bedroom duplex unit with included appliances, convenient location in Durham.

    408 N Guthrie Ave, Durham, NC 27703
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    Charming Townhome in Woodcroft
    Contact for pricing

    Charming Townhome in Woodcroft

    3BR/2.5BA end-unit townhome in Durham's desirable Woodcroft neighborhood.

    7 Preakness Dr, Durham, NC 27713
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    Sprawling Townhome in Stellar Durham
    Contact for pricing
    1,890 SF

    Sprawling Townhome in Stellar Durham

    Light-filled townhome with high-end finishes, chef's kitchen, and private backyard.

    118 Brookview St, Durham, NC 27713
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    Sprawling Townhome in Stellar Durham
    Contact for pricing
    1,890 SF

    Sprawling Townhome in Stellar Durham

    Light-filled townhome with high-end finishes, chef's kitchen, and private backyard.

    118 Brookview St, Durham, NC 27713
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    Durham Townhome with Back Deck
    Contact for pricing
    1,501 SF

    Durham Townhome with Back Deck

    Well-maintained townhome in South Durham with modern updates and convenient location.

    11 Edgebrook Cir, Durham, NC 27703
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    Carr Rd Apartments For Rent
    Contact for pricing

    Carr Rd Apartments For Rent

    Apartment building available for rent in Durham, North Carolina.

    3432 Carr Rd, Durham, NC 27703
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    Office/Clinic Space Near Shopping Centers
    $1,995 / Mo

    Office/Clinic Space Near Shopping Centers

    Office or clinic space in a convenient, accessible location.

    1804 Martin Luther King Pkwy, Durham, NC 27707
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    Downtown Durham Retail/Office Space
    Contact for pricing
    8,400 SF

    Downtown Durham Retail/Office Space

    Prime Durham location, two suites available

    706 9Th St, Durham, NC 27705
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    Durham Retail Space: 13,802 SF
    $24 SF/Yr
    13,802 SF

    Durham Retail Space: 13,802 SF

    Sublease opportunity: Prime Research Triangle location.

    4025 Stirrup Creek Dr, Durham, NC 27703
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    2927 Holloway St
    $10 SF/Yr
    8,415 SF

    2927 Holloway St

    Retail properties • 8,415 SF

    2927 Holloway St, Durham, NC 27703
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    Durham Retail Space: Prime Location
    $25 SF/Yr
    6,600 SF

    Durham Retail Space: Prime Location

    6,600 SF Retail; Two Suites Available

    2100 Miami Blvd, Durham, NC 27703
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    Winchester Place Office Space Durham NC
    $29 SF/Yr
    111,689 SF

    Winchester Place Office Space Durham NC

    Durham Office Building: Prime Research Triangle Location

    4309 Emperor Blvd, Durham, NC 27703
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    Westside Bottling: Prime Retail Space
    Contact for pricing
    71,652 SF

    Westside Bottling: Prime Retail Space

    Durham retail center: high-traffic, flexible space.

    3214 Hillsborough Rd, Durham, NC 27705
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    311 Liggett St
    $384 / Mo
    5,729 SF

    311 Liggett St

    Retail properties • 5,729 SF

    311 Liggett St, Durham, NC 27701
    View details

    Durham County, NC Commercial Real Estate Leasing Opportunities Market Analysis

    Explore Commercial Real Estate leasing options in Durham County, NC with 194 listings featured on our commercial real estate exchange. The current inventory includes 120,828,339,720 square feet of properties with an estimated lease value of $40,829.

    Estimated lease rates for Commercial Real Estate in Durham County, NC begin at $3 SF/Yr, with an average of $637 /Mo and extend to $36,000.

    In Durham County, NC, current lease rates show:

    • Office Properties & Spaces positioned at $971
    • Retail properties measuring $171
    • Office space assessed at $1,820
    • Other office properties calculated at $26
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