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    Durham County, NC Commercial Real Estate for Lease

    142 results
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    NC, Durham - 3511 Shannon Road
    Contact for pricing

    NC, Durham - 3511 Shannon Road

    Discover many ways to work your way in NC, Durham - 3511 Shannon Road

    3511 Shannon Rd, Durham, NC 27707
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    Versatile Office/Medical Space Available
    $3,000 /Mo
    2,400 SF

    Versatile Office/Medical Space Available

    3925 N Duke Street unit: 121, Durham, NC 27704

    2400 sq ft office/medical suite in prime Durham location.

    • Prime Durham location, minutes from downtown and Duke Regional Hospital.
    • Versatile 2400 sq ft space suitable for office, medical, or service‑based businesses.
    • Five private offices plus open central workspace.
    • Previously configured for dental and salon use.
    • Large reception area ideal for client‑facing businesses.
    Updated: Feb 18
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    Durham Office Condo For Lease
    $1,500 /Mo
    478 SF

    Durham Office Condo For Lease

    3201 Yorktown Ave., Durham, NC 27713

    Recently remodeled office condo with easy access and great location.

    • Recently remodeled with new paint, flooring, ceilings, light fixtures, updated bathroom and kitchenette, and new HVAC system
    • Easy access from parking lot
    • Convenient location: Minutes to Hwy 40 and 885
    • Proximity to Amenities: 2 Miles to Lowes Shopping Plaza, 4 Miles to RTP, 5 Miles to Southpoint Mall and Downtown Durham
    • Includes a brand new refrigerator
    Updated: Feb 10
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    Office Suite with Private Offices
    $36,000
    1,760 SF

    Office Suite with Private Offices

    Office suite featuring multiple private office spaces for rent.

    5315 Highgate Drive unit: 103, Durham, NC 27713
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    Durham Office Space For Lease
    $45,045
    2,145 SF

    Durham Office Space For Lease

    Flexible office unit with ample parking and recent upgrades.

    1906 Carolina 54 unit: 100 A, Durham, NC 27713
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    NC, Durham - Spaces Mangum Street
    Contact for pricing

    NC, Durham - Spaces Mangum Street

    We offer workspace options fully tailored to your needs in NC, Durham - Spaces Mangum Street

    555 Mangum St, Unit 100, Durham, NC 27701
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    RTP Imperial
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    RTP Imperial

    Discover many ways to work your way in RTP Imperial

    4819 Emperor Blvd, Unit 400, Durham, NC 27703
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    Durham Medical/Office Building for Lease
    $23 SF/Yr
    4,769 SF

    Durham Medical/Office Building for Lease

    Freestanding 4,769 SF building suitable for medical or office use.

    110 E. Carver Street, Durham, NC 27704
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    Professional Office Condos For Lease
    $2,400 /Mo
    5,120 SF

    Professional Office Condos For Lease

    Office condos for lease near Duke University Medical Center.

    2741 Campus Walk Ave, Building 400, Durham, NC 27705
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    Plug and Play Lab Space
    $30 SF/Yr
    94,603 SF

    Plug and Play Lab Space

    Move-in ready lab and office space in Durham, NC.

    4025 Stirrup Creek Drive, Durham, NC 27703
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    Class A Office Space
    $23 SF/Yr
    79,440 SF

    Class A Office Space

    Class A office space for lease in North Durham.

    4321 Medical Park Dr, Durham, NC 27704
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    Office/Medical Building Near Southpoint Mall
    $26 SF/Yr
    18,395 SF

    Office/Medical Building Near Southpoint Mall

    Single-story office/medical building near Southpoint Mall available for lease.

    5501 Fortunes Ridge Drive, Durham, NC 27713
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    Downtown Durham Office Space Available
    $29 SF/Yr
    32,522 SF

    Downtown Durham Office Space Available

    Move-in ready office space in downtown Durham with modern amenities.

    505 S Duke St, Durham, NC 27701
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    Roxboro Road Professional Office Space
    $20 SF/Yr
    2,408 SF

    Roxboro Road Professional Office Space

    Office space ideal for professional services and medical offices.

    4210 N. Roxboro Street, Suite 140, Durham, NC 27704
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    Downtown Durham Office Space Available
    $32 SF/Yr
    25,678 SF

    Downtown Durham Office Space Available

    Suites available in historic Art Deco building, downtown Durham.

    331 W Main Street, Durham, NC 27707
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    Luxury Mixed-Use Development Near Duke
    $25 SF/Yr
    118,000 SF

    Luxury Mixed-Use Development Near Duke

    Class A mixed-use development near Duke University and hospitals.

    2812 & 2816 Erwin Rd |, Durham, NC 27705
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    Office Space Near Universities
    $1,995 /Mo
    1,000 SF

    Office Space Near Universities

    Office space in Durham, close to amenities and universities.

    1804 Martin Luther King Junior Parkway unit: 111, Durham, NC 27707
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    Durham Flex Space Available
    $13 SF/Yr
    35,000 SF

    Durham Flex Space Available

    35,000 SF flex space for rent in Durham.

    4808 Chin Page Rd, Durham, NC 27703
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    Downtown Durham Office Space Available
    Contact for pricing
    16,692 SF

    Downtown Durham Office Space Available

    Office spaces for lease in the heart of downtown Durham.

    433 W. Main Street, Durham, NC 27701
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    RTP Meridian
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    RTP Meridian

    Discover many ways to work your way in RTP Meridian

    2530 Floors, Durham, NC 27713
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    North Durham Retail Space Available
    Contact for pricing
    22,425 SF

    North Durham Retail Space Available

    Retail and restaurant spaces available in North Durham power center.

    3500 North Roxboro Street, Durham, NC 27704
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    Retail Space Near RTP
    $3,232 /Mo
    1,168 SF

    Retail Space Near RTP

    Retail space in a vibrant neighborhood center near RTP.

    5125 Nc-55 unit: 103, Durham, NC 27713
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    Renovated Retail Center on Guess
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    Renovated Retail Center on Guess

    Newly renovated retail center with high visibility and accessibility.

    1720 Guess Road, Durham, NC 27705
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    Downtown Durham Retail Space Available
    Contact for pricing
    12,473 SF

    Downtown Durham Retail Space Available

    Prime retail spaces in a vibrant downtown location.

    400 West Main Street, Durham, NC 27701
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    Durham County, NC Commercial real estate Leasing Opportunities Market Analysis

    Explore Commercial real estate leasing options in Durham County, NC with 142 listings featured on our commercial real estate exchange. The current inventory includes 11,957,786,280 square feet of properties with an estimated lease value of $472 /Mo.

    Estimated lease rates for Commercial real estate in Durham County, NC begin at $5 SF/Yr, with an average of $24 SF/Yr and extend to $43 SF/Yr.
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