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    Durham County, NC Commercial Real Estate for Lease

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    Found 122 commercial real estates for lease in Durham County, NC, averaging $34/sq ft/yr. Use lease type data to compare options faster.
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    Office Space in Durham
    Office Space in Durham

    700 West Main Street, Durham, NC 27701

    $30 SF/Yr
    7,943 sqft

    7943 SF office space available for lease.

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    Live-Work Office Sublease Space
    Live-Work Office Sublease Space

    800 Taylor Street, Durham, NC 27701

    Contact for pricing
    20,401 sqft

    Up to 20,401 SF is available for sublease through April 30, with FF&E available at Golden Belt Campus.

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    Professional Office Suite
    Professional Office Suite

    4210 N. Roxboro Street, Suite 140, Durham, NC 27704

    $19 SF/Yr

    Suite 140 supports professional services and medical office users within a maintained commercial center.

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    Industrial Warehouse with Spec Office
    Industrial Warehouse with Spec Office

    1218 Stone Park Ct, Durham, NC 27703

    Contact for pricing
    129,600 sqft

    Available-now warehouse space includes a dedicated spec office and a second planned building.

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    Office Building Near University Hill
    Office Building Near University Hill

    3708 Mayfair Street, Durham, NC 27707

    Contact for pricing
    59,650 sqft

    Three-story office building near mixed-use development available for rent.

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    Retail Space in Luxury Development
    Retail Space in Luxury Development

    441 South Dillard Street, Durham, NC 27701

    Contact for pricing
    6,000 sqft

    Retail space available in a luxury residential development.

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    Graveled Industrial Outdoor Storage Site
    Graveled Industrial Outdoor Storage Site

    5001 Pleasant Green Rd # Ut, Durham, NC 27705

    $3,000/Mo
    1.00 AC lot

    One-acre outdoor storage site with full perimeter fencing, gated access, and integrated above-ground stormwater controls.

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    Freestanding Restaurant Pad
    Freestanding Restaurant Pad

    5419 Durham Chapel Hill Blvd, Durham, NC 27707

    Contact for pricing

    Second-generation restaurant space is offered for lease or ground lease in Durham.

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    Renovated Office Building Near University
    Renovated Office Building Near University

    3710 University Drive, Durham, NC 27707

    Contact for pricing
    58,249 sqft

    Three-story office building near mixed-use development with ongoing renovations.

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    First Floor Office Unit For Lease
    First Floor Office Unit For Lease

    100-a-1906 E Nc Highway 54, Durham, NC 27713

    Contact for pricing
    2,145 sqft

    Flexible office unit with ample parking and high traffic count.

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    Retail Space with Interstate Access
    Retail Space with Interstate Access

    4901 Page Rd, Durham, NC 27703

    Contact for pricing

    Retail space in RTP with direct access from the Page Road interstate ramp and visibility from I-540 and I-40.

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    Flex Space Property
    Flex Space Property

    4900 Prospectus Dr, Durham, NC 27713

    Contact for pricing
    39,816 sqft

    Commercial flex space is available for lease in Durham, North Carolina.

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    Freestanding Office Building
    Freestanding Office Building

    3202 Guess Rd, Durham, NC 27705

    Contact for pricing

    Single-story office property with private offices, reception, kitchen, restroom, and enclosed rear sun porch.

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    Durham Industrial Building Near Duke
    Durham Industrial Building Near Duke

    121 S. LaSalle Street, Durham, NC 27705

    Contact for pricing
    24,000 sqft

    24,000 SF industrial building near Duke University and downtown.

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    Downtown Durham Office Space
    Downtown Durham Office Space

    411 West Chapel Hill Street, Durham, NC 27701

    Contact for pricing
    38,256 sqft

    Centrally located office space in historic Durham tower.

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    Warehouse Space for Lease
    Warehouse Space for Lease

    1951 TW Alexander Drive, Durham, NC 27703

    Contact for pricing
    29,340 sqft

    Warehouse space totaling 29,340 SF is available for lease starting 2/1/27.

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    Mixed-Use Development Retail Space
    Mixed-Use Development Retail Space

    200 Morris Street, Durham, NC 27701

    Contact for pricing
    3,983 sqft

    Retail space available in a large mixed-use development.

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    GeerHouse Ground-Floor Retail
    GeerHouse Ground-Floor Retail

    620 Foster Street, Durham, NC 27701

    Contact for pricing

    Ground-floor retail space with an outdoor dining terrace, structured parking, and signage opportunities.

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    Durham Office Space For Rent
    Durham Office Space For Rent

    2800 Meridian Parkway, Durham, NC 27713

    Contact for pricing
    11,869 sqft

    Office space available in Durham, close to major transport routes.

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    Durham Office Space For Rent
    Durham Office Space For Rent

    2505 Meridian Parkway, Durham, NC 27713

    Contact for pricing
    11,054 sqft

    Office space in prime Durham location with easy access.

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    Retail Space in North Durham
    Retail Space in North Durham

    3500 North Roxboro Street, Durham, NC 27704

    Contact for pricing
    22,425 sqft

    Retail and restaurant spaces available in a busy shopping center.

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    Restored Loft-Style Retail Suites
    Restored Loft-Style Retail Suites

    200 North Mangum Street, Durham, NC 27701

    Contact for pricing

    Two plug-and-play suites support retail or office use.

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    Creative Coworking Office Suite
    Creative Coworking Office Suite

    555 S. Mangum Street, Suite 100, Durham, NC 27701

    Contact for pricing

    Flexible office environment with private offices, meeting rooms, and rooftop terrace views in a well-connected city center.

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    Amenity-Focused Office and Fitness Suite
    Amenity-Focused Office and Fitness Suite

    2500 Meridian Pkwy, Durham, NC 27713

    Contact for pricing

    Suite offers conference rooms plus fitness and tech hub space with garage doors opening to outdoor seating.

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