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    Port Saint Lucie, FL Commercial Real Estate for Lease

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    Miami, FL Orlando, FL Jacksonville, FL
    42 results
    Port St. Lucie Flex Building
    $14 SF/Yr
    48,720 SF

    Port St. Lucie Flex Building

    651 NW Enterprise Dr, Port Saint Lucie, FL 34986

    Industrial flex building with air-conditioned office space for lease.

    • Prime location in Saint Lucie West industrial park with quick access to I‑95 and Florida Turnpike.
    • Excellent condition, newly painted buildings, and resurfaced parking lot.
    • 18’ clear height with 10'x12' roll‑up doors.
    • Air‑conditioned office space in each unit.
    • 3‑phase power, 220 amps.
    Updated: Nov 21, 2025
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    Retail Spaces on US Highway 1
    $1,360/Mo
    11,120 SF

    Retail Spaces on US Highway 1

    10502-10558 S US Highway 1, Port St. Lucie FL 34952, Port Saint Lucie, FL 34952

    Retail spaces available in a busy Port St. Lucie shopping center.

    • High traffic counts: 43,500 AADT on US Highway 1 and 38,000 AADT on Port St Lucie Boulevard.
    • Located near many national tenants, including Walmart, Applebee’s, and Planet Fitness.
    • Available unit sizes: 650 SF and 800 SF.
    • Ample parking available.
    • The 650 SF unit is built out with a retail area and storage/office space.
    Updated: Nov 21, 2025
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    Westport Plaza Retail Space Available
    $29 SF/Yr
    2,124 SF

    Westport Plaza Retail Space Available

    Retail space in Westport Plaza with high traffic and visibility.

    2854-2872 SW Port St Lucie Blvd, Port Saint Lucie, FL
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    Port St. Lucie Retail Space
    $20 SF/Yr
    4,050 SF

    Port St. Lucie Retail Space

    Retail space for lease in Port St. Lucie, Florida.

    7630 S US Hwy 1, Port Saint Lucie, FL
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    Port St. Lucie Office Space
    $27 SF/Yr
    2,500 SF

    Port St. Lucie Office Space

    2,500 SF office space in a thriving commercial corridor.

    155 SW Port St Lucie Blvd, Port Saint Lucie, FL
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    Industrial Space Available For Lease
    $15 SF/Yr
    2,500 SF

    Industrial Space Available For Lease

    2,500 square feet of industrial space for rent.

    574 NW Mercantile Pl, Port Saint Lucie, FL
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    St. Lucie West Flex Space
    $20 SF/Yr
    3,600 SF

    St. Lucie West Flex Space

    Flexible bays near I-95 and Florida’s Turnpike.

    664 NW Enterprise Dr, Port Saint Lucie, FL
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    St. Lucie West Flex Space
    $20 SF/Yr
    5,400 SF

    St. Lucie West Flex Space

    Flex space near I-95 and Florida Turnpike.

    660 NW Enterprise Dr, Port Saint Lucie, FL
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    Industrial Flex Condo For Rent
    $17 SF/Yr
    1,200 SF

    Industrial Flex Condo For Rent

    Versatile 1,200 SF industrial flex condo with offices.

    1547-1561 SE South Niemeyer Cir, Port Saint Lucie, FL
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    St Lucie West Professional Offices
    $25 SF/Yr
    3,076 SF

    St Lucie West Professional Offices

    Medical and professional offices in the heart of St Lucie West.

    525 NW Lake Whitney Pl, Port Saint Lucie, FL
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    Port St. Lucie Warehouse Space
    $18 SF/Yr
    1,500 SF

    Port St. Lucie Warehouse Space

    1500 SF warehouse space for lease in Port St. Lucie.

    1669 SE South Niemeyer Cir, Port Saint Lucie, FL
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    St. Lucie West Office Space
    $23 SF/Yr
    45,416 SF

    St. Lucie West Office Space

    Professional and Medical office space in landmark building for lease.

    1660 SW St. Lucie West Blvd, Port Saint Lucie, FL 34986
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    Port St. Lucie Land Lease
    $5,416/Mo

    Port St. Lucie Land Lease

    Land lease opportunity near Publix and Florida's Turnpike.

    1091 SE Port St Lucie Blvd, Port Saint Lucie, FL
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    Retail Space in Tradition
    Contact for pricing
    2,800 SF

    Retail Space in Tradition

    Retail space available in a master-planned community shopping center.

    10770 SW Village Pkwy, Port Saint Lucie, FL
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    Port Saint Lucie Office Space
    $13 SF/Yr
    13,029 SF

    Port Saint Lucie Office Space

    Office space available for lease in Port Saint Lucie, FL.

    900 E Prima Vista Blvd, Port Saint Lucie, FL
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    Medical Office Space For Rent
    $25 SF/Yr
    1,288 SF

    Medical Office Space For Rent

    Medical office space in Gatlin Kidney Care medical facility.

    1631 SW Gatlin Blvd, Port Saint Lucie, FL
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    Port St. Lucie Warehouse Space
    $15 SF/Yr
    2,000 SF

    Port St. Lucie Warehouse Space

    2,000 SF warehouse with office, roll-up doors, ample parking.

    1593 SE Village Green Dr, Port Saint Lucie, FL
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    Warehouse Units with Easy Access
    $18 SF/Yr
    1,500 SF

    Warehouse Units with Easy Access

    Warehouse units with tall ceilings, roll-up doors, and ample parking.

    792 SW Grove Ave, Port Saint Lucie, FL
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    Port St. Lucie Office Space
    $18 SF/Yr
    3,753 SF

    Port St. Lucie Office Space

    Versatile office space in a high-traffic Port St. Lucie location.

    7664 S US Hwy 1, Port Saint Lucie, FL
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    Retail, Office, Medical Space Available
    $36 SF/Yr
    1,184 SF

    Retail, Office, Medical Space Available

    New retail, office, and medical space for rent.

    1449-1479 SW Gatlin Blvd, Port Saint Lucie, FL
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    Port St. Lucie Warehouse Space
    $12 SF/Yr
    10,000 SF

    Port St. Lucie Warehouse Space

    10,000 SF warehouse space with 3-Phase Power for rent.

    10011 S US Hwy 1, Port Saint Lucie, FL
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    Commercial Land for Lease
    Contact for pricing

    Commercial Land for Lease

    Land available for retail, restaurant, hotel, or commercial development.

    SW Cameo Blvd, Port Saint Lucie, FL
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    Retail Space For Rent
    $25 SF/Yr
    13,086 SF

    Retail Space For Rent

    Retail space available for lease in Port Saint Lucie, FL.

    9197 S US Hwy 1, Port Saint Lucie, FL
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    Port Saint Lucie, FL Commercial real estate Leasing Opportunities Market Analysis

    Explore Commercial real estate leasing options in Port Saint Lucie, FL with 42 listings featured on our commercial real estate exchange. The current inventory includes 199,313 square feet of properties with an estimated lease value of $536 /Mo.

    Estimated lease rates for Commercial real estate in Port Saint Lucie, FL begin at $1.47 SF/Yr, with an average of $19 SF/Yr and extend to $36 SF/Yr.
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