Add Listing
    For Lease
    • For Sale
    • For Lease
    • Recently Sold
    • Property Lookup
    • Brokers
    Space Uses
    • Retail
    • Restaurant
    • Office
    • Coworking
    • Medical Space
    • Automotive
    • Industrial
    • Warehouse
    • Flex
    • Hospitality
    • Sports & Entertainment
    • Specialty
    Rent
    Rent / SF / Yr
    $
    $
    Rent / Mo
    $
    $
    Size
    Property size / sq.ft.

    Meet Realmo: The Largest Hub
    of Commercial Real     Estate in the US

    Over 1 million active listings and over 150 million property profiles

    Rancho Santa Margarita, CA Commercial Real Estate for Lease

    Notify Me
    List
    Map
    Los Angeles, CA San Diego, CA San Francisco, CA
    25 results
    Industrial Warehouse with Fenced Yard
    $1.58 SF/Yr
    10,030 SF

    Industrial Warehouse with Fenced Yard

    29720 Avenida de las Banderas, Rancho Santa Margarita, CA 92688

    Industrial warehouse featuring a fenced yard and major street frontage.

    • Major street frontage offers excellent visibility.
    • Ground level loading via one 12’ x 14’ door.
    • Twenty‑eight (28) car parking spaces available.
    • Features 1,400 square feet of office space.
    • Electrical: 120/208 Volt, 400 AMPS.
    Updated: Nov 26, 2025
    View details
    Office Building with Mountain Views
    $2 SF/Yr
    18,538 SF

    Office Building with Mountain Views

    22362 Gilberto, Rancho Santa Margarita, CA 92688

    Two-story office building in South Orange County available for rent.

    • Prime South Orange County location
    • Spectacular panoramic Saddleback Mountain views
    • Easy access to the 241 Foothill Transportation Corridor
    • Elevator served office building
    • Corporate headquarters building with formal entry lobby
    Updated: Nov 26, 2025
    View details
    Restaurant Spaces in Rancho Santa Margarita
    Contact for pricing

    Restaurant Spaces in Rancho Santa Margarita

    Restaurant spaces for lease in Rancho Santa Margarita shopping center.

    31431-31541 Santa Margarita Parkway, Rancho Santa Margarita, CA 92688
    View details
    Rancho Santa Margarita Flex Space
    $1.70 SF/Yr
    5,583 SF

    Rancho Santa Margarita Flex Space

    Flex space with offices, kitchen, fenced yard, and ample power.

    30302 Esperanza, Rancho Santa Margarita, CA 92688
    View details
    Rancho Santa Margarita Retail Center
    Contact for pricing
    275,000 SF

    Rancho Santa Margarita Retail Center

    275,000 SF power center with excellent visibility and access.

    30451-30465 Avenida de las Flores, Rancho Santa Margarita, CA 92688
    View details
    Freestanding Building with Extensive Glass
    $500/Mo
    5,810 SF

    Freestanding Building with Extensive Glass

    Single-story industrial building with excellent freeway access and retail proximity.

    23142 Arroyo Vista, Rancho Santa Margarita, CA 92688
    View details
    Rancho Santa Margarita Retail Center
    Contact for pricing
    8,500 SF

    Rancho Santa Margarita Retail Center

    Multi-tenant center near 241 Toll Road in Rancho Santa Margarita.

    29821-29941 Aventura, Rancho Santa Margarita, CA 92688
    View details
    Medical Office Condo For Rent
    $2 SF/Yr
    2,360 SF

    Medical Office Condo For Rent

    Medical office condo featuring private offices, conference room, and balcony.

    30212 Tomas, Rancho Santa Margarita, CA
    View details
    Retail Space in South Orange
    $2 SF/Yr
    87,715 SF

    Retail Space in South Orange

    Prime South Orange County retail space available for lease.

    29851 Aventura, Rancho Santa Margarita, CA 92688
    View details
    Industrial Building with Gated Yard
    $1.55 SF/Yr
    20,500 SF

    Industrial Building with Gated Yard

    Freestanding industrial building featuring office space and a gated yard.

    30412 Esperanza, Rancho Santa Margarita, CA 92688
    View details
    High-Image Flex Building For Rent
    $1.45 SF/Yr
    23,849 SF

    High-Image Flex Building For Rent

    R&D/flex building in South Orange County business park.

    30191 Avenida De Las Banderas, Rancho Santa Margarita, CA 92688
    View details
    Rancho Santa Margarita Retail Space
    Contact for pricing
    1,104 SF

    Rancho Santa Margarita Retail Space

    Retail space in shopping center with strong anchor tenants.

    30602-30616 Santa Margarita Pky, Rancho Santa Margarita, CA 92688
    View details
    Freestanding R&D Building For Lease
    $1.65 SF/Yr
    18,112 SF

    Freestanding R&D Building For Lease

    Two-story R&D building with secured yard in South Orange County.

    22391 Gilberto, Rancho Santa Margarita, CA 92688
    View details
    Medical Office Space For Rent
    Contact for pricing
    18,400 SF

    Medical Office Space For Rent

    Medical office space in Rancho Santa Margarita available for lease.

    29472 Avenida de las Banderas, Rancho Santa Margarita, CA 92688
    View details
    Industrial Space Available for Lease
    Contact for pricing

    Industrial Space Available for Lease

    Industrial property available for lease in Rancho Santa Margarita, CA.

    30346 Esperanza, Unit A, Rancho Santa Margarita, CA 92688
    View details
    Office Space Available For Lease
    Contact for pricing

    Office Space Available For Lease

    Office property available for lease in Rancho Santa Margarita, CA.

    30212 Tomas, Rancho Santa Margarita, CA 92688
    View details
    Medical Office Sublease Opportunity
    Contact for pricing
    2,835 SF

    Medical Office Sublease Opportunity

    Medical office space available for sublease in Rancho Santa Margarita.

    22032 El Paseo, Rancho Santa Margarita, CA 92688
    View details
    Rancho Santa Margarita Office Space
    $22 SF/Yr

    Rancho Santa Margarita Office Space

    Furnished office spaces with mountain views and convenient access.

    30211 Avenida de las Banderas Suite 200, Rancho Santa Margarita, CA 92688
    View details
    Rancho Santa Margarita Office Building
    Contact for pricing
    8,309 SF

    Rancho Santa Margarita Office Building

    Office building available, early education/school permitted.

    28672 Deerpath, Rancho Santa Margarita, CA
    View details
    Rancho Santa Margarita Retail Space
    Contact for pricing

    Rancho Santa Margarita Retail Space

    Retail space in a premier Rancho Santa Margarita location.

    30612 Santa Margarita Pkwy, Rancho Santa Margarita, CA 92688
    View details
    Industrial Property in Rancho Santa Margarita
    Contact for pricing

    Industrial Property in Rancho Santa Margarita

    100% leased industrial property with no current availability.

    22321 Gilberto, Rancho Santa Margarita, CA
    View details
    Modern Flex Space Available
    Contact for pricing

    Modern Flex Space Available

    Flex project in prime location with modern units.

    22521 Avenida Empresa, Rancho Santa Margarita, CA 92688
    View details
    Rancho Santa Margarita Industrial Spaces
    Contact for pricing
    1,830 SF

    Rancho Santa Margarita Industrial Spaces

    Industrial spaces available in Rancho Santa Margarita, California.

    23091-23121 Antonio Parkway, Rancho Santa Margarita, CA 92688
    View details

    Rancho Santa Margarita, CA Commercial real estate Leasing Opportunities Market Analysis

    Explore Commercial real estate leasing options in Rancho Santa Margarita, CA with 25 listings featured on our commercial real estate exchange. The current inventory includes 192,497 square feet of properties with an estimated lease value of $15 SF/Yr.

    Estimated lease rates for Commercial real estate in Rancho Santa Margarita, CA begin at $1.03 SF/Yr, with an average of $1.75 SF/Yr and extend to $2 SF/Yr.
    List
    Map

    Browse Commercial real estate for Lease Near Rancho Santa Margarita, CA

    Popular Searches in Rancho Santa Margarita, CA

    Most Searched ZIP Codes in Rancho Santa Margarita, CA

    • 92688

    Select Neighborhood

    Google sign-in failed. Please try again or use another login method.
    Sign Up Successful!
    You now have access to more from Realmo!