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    Rancho Santa Margarita, CA
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    Rancho Santa Margarita, CA Commercial Real Estate for Lease

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    Trabuco Canyon, CA Mission Viejo, CA Lake Forest, CA
    22 listings
    Koll Center
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    Office Building with Mountain Views
    $2 SF/Yr
    18,538 SF
    Office Building with Mountain Views

    22362 Gilberto, Rancho Santa Margarita, CA 92688

    Two-story office building in South Orange County available for rent.
    • Prime South Orange County location
    • Spectacular panoramic Saddleback Mountain views
    • Easy access to the 241 Foothill Transportation Corridor
    • Elevator served office building
    • Corporate headquarters building with formal entry lobby
    Updated: Nov 26, 2025
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    Medical Office Condo For Rent
    $2 SF/Yr
    2,360 SF
    Medical Office Condo For Rent

    30212 Tomas, Rancho Santa Margarita, CA

    Medical office condo featuring private offices, conference room, and balcony.
    • Six private offices ideal for medical practice
    • Conference room for meetings and collaboration
    • Reception area for patient greeting and administration
    • Break room for staff convenience
    • Private balcony offering a relaxing space
    Updated: Sep 23, 2025
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    Industrial Building with Gated Yard
    $1.55 SF/Yr
    20,500 SF
    Industrial Building with Gated Yard

    Freestanding industrial building featuring office space and a gated yard.

    30412 Esperanza, Rancho Santa Margarita, CA 92688

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    High-Image Flex Building For Rent
    $1.45 SF/Yr
    23,849 SF
    High-Image Flex Building For Rent

    R&D/flex building in South Orange County business park.

    30191 Avenida De Las Banderas, Rancho Santa Margarita, CA 92688

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    Rancho Santa Margarita Flex Space
    $1.70 SF/Yr
    5,583 SF
    Rancho Santa Margarita Flex Space

    Flex space with offices, kitchen, fenced yard, and ample power.

    30302 Esperanza, Rancho Santa Margarita, CA 92688

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    Freestanding R&D Building For Lease
    $1.65 SF/Yr
    18,112 SF
    Freestanding R&D Building For Lease

    Two-story R&D building with secured yard in South Orange County.

    22391 Gilberto, Rancho Santa Margarita, CA 92688

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    Freestanding Building with Extensive Glass
    $500/Mo
    5,810 SF
    Freestanding Building with Extensive Glass

    Single-story industrial building with excellent freeway access and retail proximity.

    23142 Arroyo Vista, Rancho Santa Margarita, CA 92688

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    Industrial Warehouse with Fenced Yard
    $1.58 SF/Yr
    10,030 SF
    Industrial Warehouse with Fenced Yard

    Industrial warehouse featuring a fenced yard and major street frontage.

    29720 Avenida de las Banderas, Rancho Santa Margarita, CA 92688

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    Rancho Santa Margarita Retail Center
    Contact for pricing
    275,000 SF
    Rancho Santa Margarita Retail Center

    275,000 SF power center with excellent visibility and access.

    30451-30465 Avenida de las Flores, Rancho Santa Margarita, CA 92688

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    Rancho Santa Margarita Retail Space
    Contact for pricing
    1,104 SF
    Rancho Santa Margarita Retail Space

    Retail space in shopping center with strong anchor tenants.

    30602-30616 Santa Margarita Pky, Rancho Santa Margarita, CA 92688

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    Rancho Santa Margarita Retail Center
    Contact for pricing
    8,500 SF
    Rancho Santa Margarita Retail Center

    Multi-tenant center near 241 Toll Road in Rancho Santa Margarita.

    29821-29941 Aventura, Rancho Santa Margarita, CA 92688

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    Restaurant Spaces in Rancho Santa Margarita
    Contact for pricing
    Restaurant Spaces in Rancho Santa Margarita

    Restaurant spaces for lease in Rancho Santa Margarita shopping center.

    31431-31541 Santa Margarita Parkway, Rancho Santa Margarita, CA 92688

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    Medical Office Space For Rent
    Contact for pricing
    18,400 SF
    Medical Office Space For Rent

    Medical office space in Rancho Santa Margarita available for lease.

    29472 Avenida de las Banderas, Rancho Santa Margarita, CA 92688

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    Medical Office Sublease Opportunity
    Contact for pricing
    2,835 SF
    Medical Office Sublease Opportunity

    Medical office space available for sublease in Rancho Santa Margarita.

    22032 El Paseo, Rancho Santa Margarita, CA 92688

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    Rancho Santa Margarita Office Space
    $22 SF/Yr
    Rancho Santa Margarita Office Space

    Furnished office spaces with mountain views and convenient access.

    30211 Avenida de las Banderas Suite 200, Rancho Santa Margarita, CA 92688

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    Industrial Space Available for Lease
    Contact for pricing
    Industrial Space Available for Lease

    Industrial property available for lease in Rancho Santa Margarita, CA.

    30346 Esperanza, Unit A, Rancho Santa Margarita, CA 92688

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    Office Space Available For Lease
    Contact for pricing
    Office Space Available For Lease

    Office property available for lease in Rancho Santa Margarita, CA.

    30212 Tomas, Rancho Santa Margarita, CA 92688

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    Rancho Santa Margarita Office Building
    Contact for pricing
    8,309 SF
    Rancho Santa Margarita Office Building

    Office building available, early education/school permitted.

    28672 Deerpath, Rancho Santa Margarita, CA

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    Rancho Santa Margarita Retail Space
    Contact for pricing
    Rancho Santa Margarita Retail Space

    Retail space in a premier Rancho Santa Margarita location.

    30612 Santa Margarita Pkwy, Rancho Santa Margarita, CA 92688

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    Industrial Property in Rancho Santa Margarita
    Contact for pricing
    Industrial Property in Rancho Santa Margarita

    100% leased industrial property with no current availability.

    22321 Gilberto, Rancho Santa Margarita, CA

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    Rancho Santa Margarita Industrial Spaces
    Contact for pricing
    1,830 SF
    Rancho Santa Margarita Industrial Spaces

    Industrial spaces available in Rancho Santa Margarita, California.

    23091-23121 Antonio Parkway, Rancho Santa Margarita, CA 92688

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    Based on your search, we've compiled 29 Potential Opportunities for your consideration. Besides 22 Active listings in Rancho Santa Margarita, CA, we suggest exploring alternatives. Similar 7 Properties for Sales.

    Similar Spaces for Sale in Rancho Santa Margarita, CA

    Consider Similar Space for Sale. We found 7 Spaces matching your search parameters.

    Plaza Empresa Commercial Center Portion
    $20,718,000
    35,953 SF
    Plaza Empresa Commercial Center Portion

    NNN leased commercial center portion in Rancho Santa Margarita, CA.

    29911 Aventura, Rancho Santa Margarita, CA 92688

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    Upgraded Office Condo For Sale
    $1,585,500
    3,020 SF
    Upgraded Office Condo For Sale

    Office condo with private offices, conference room, and break room.

    30372 Esperanza, Rancho Santa Margarita, CA 92688

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    Rancho Santa Margarita, CA Commercial real estate Leasing Opportunities Market Analysis

    Explore Commercial real estate leasing options in Rancho Santa Margarita, CA with 22 listings featured on our commercial real estate exchange. The current inventory includes 106,085 square feet of properties with an estimated lease value of $154 SF/Yr.

    Estimated lease rates for Commercial real estate in Rancho Santa Margarita, CA begin at $1.03 SF/Yr, with an average of $17 SF/Yr and extend to $140 SF/Yr.
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    Most Searched ZIP Codes in Rancho Santa Margarita, CA

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