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    De Soto, MO
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    De Soto, MO Retail Properties & Spaces for Lease

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    Open-Plan Storefront Space
    Updated: Aug 10
    Open-Plan Storefront Space

    200 S Main Street, De Soto, MO 63020

    $2,695/Mo
    0.14 AC lot
    Approximately 3,000+/- SF of commercial space
    Expansive storefront window line along Main Street
    Open interior layout with 3 half bathrooms
    Triple Net (NNN) lease structure
    Brick building constructed in 1910
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    Retail Space in Downtown DeSoto
    Updated: Jun 24, 2025
    Retail Space in Downtown DeSoto

    De Soto, MO

    Contact for pricing
    5,000 sqft 3.31 AC lot
    Convenient downtown location
    Great visibility
    Roll up doors on end cap
    North Main Street location
    High traffic volume (6,973 VPD)
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    Office Space with High Visibility
    Office Space with High Visibility

    2100 Rock Rd, De Soto, MO 63020

    Contact for pricing
    288 sqft

    Office space with full access along Rock Road and strong passing traffic from Rock Road and Highway 21.

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    Retail Space with High-Traffic Frontage
    Retail Space with High-Traffic Frontage

    2100 Rock Rd, De Soto, MO 63020

    Contact for pricing
    1,550 sqft

    Retail space with full access along Rock Road and strong traffic exposure from Rock Road and Highway 21.

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    Based on your search, we've compiled 10 Potential Opportunities for your consideration. Besides 4 Active listings in De Soto, MO, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 2 Properties for Sales.

    Retail properties & Spaces for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Updated Office Suite
    Updated Office Suite

    130 Main Street, Festus, MO 63028

    $1,795/Mo
    0.14 AC lot

    Single-level commercial suite with private offices, reception space, a kitchen, restroom, and accessible entry.

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    Retail Space in Crystal City
    Retail Space in Crystal City

    203 S Truman Blvd, Crystal City, MO 63019

    Contact for pricing
    3,500 sqft

    Retail space available in a modern, well-maintained building.

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    Regional Shopping Center Space Available
    Regional Shopping Center Space Available

    110-155 Twin City Mall, Crystal City, MO

    Contact for pricing
    5,115 sqft 12.74 AC lot

    Retail space available in regional shopping center with high visibility.

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    Festus Retail, Office, Medical Space
    Festus Retail, Office, Medical Space

    101-109 Borga Bldg, Festus, MO

    Contact for pricing
    2,250 sqft 9.15 AC lot

    Two spaces available in well-maintained Festus center.

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    Similar Spaces for Sale in De Soto, MO

    Consider Similar Space for Sale. We found 2 Spaces matching your search parameters.

    Historic Brick Storefront Building
    Historic Brick Storefront Building

    400 S Main Street, De Soto, MO 63020

    $850,000
    0.14 AC lot

    Two storefront entrances create flexibility for operating one side and leasing the other.

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    Retail Space on Main Street
    Retail Space on Main Street

    400 - 420 North Main Street, De Soto, MO 63020

    Contact for pricing

    Retail space available for lease on North Main Street.

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    De Soto, MO Retail properties & Spaces Lease Rates & Market Statistics

    Browse 4 Retail properties & Spaces for lease in De Soto, MO on Realmo, a commercial real estate marketplace serving the De Soto area. The current inventory totals 6,838 square feet of properties.

    Retail properties & Spaces lease rates in De Soto range from $2,695/Mo at the entry level to $2,695/Mo at the top of the market, averaging $2,695/Mo. Pricing across the market is relatively uniform, which simplifies like-for-like comparison between listings.

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