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    Charlotte, NC Greensboro, NC Wilmington, NC

    Durham County, NC Office Units for Lease

    37 results
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    Versatile Office/Medical Space Available
    $3,000 /Mo
    2,400 SF

    Versatile Office/Medical Space Available

    3925 N Duke Street unit: 121, Durham, NC 27704

    2400 sq ft office/medical suite in prime Durham location.

    • Prime Durham location, minutes from downtown and Duke Regional Hospital.
    • Versatile 2400 sq ft space suitable for office, medical, or service‑based businesses.
    • Five private offices plus open central workspace.
    • Previously configured for dental and salon use.
    • Large reception area ideal for client‑facing businesses.
    Updated: Feb 18
    View details
    Durham Office Condo For Lease
    $1,500 /Mo
    478 SF

    Durham Office Condo For Lease

    3201 Yorktown Ave., Durham, NC 27713

    Recently remodeled office condo with easy access and great location.

    • Recently remodeled with new paint, flooring, ceilings, light fixtures, updated bathroom and kitchenette, and new HVAC system
    • Easy access from parking lot
    • Convenient location: Minutes to Hwy 40 and 885
    • Proximity to Amenities: 2 Miles to Lowes Shopping Plaza, 4 Miles to RTP, 5 Miles to Southpoint Mall and Downtown Durham
    • Includes a brand new refrigerator
    Updated: Feb 10
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    Office Suite with Private Offices
    $36,000
    1,760 SF

    Office Suite with Private Offices

    Office suite featuring multiple private office spaces for rent.

    5315 Highgate Drive unit: 103, Durham, NC 27713
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    Durham Office Space For Lease
    $45,045
    2,145 SF

    Durham Office Space For Lease

    Flexible office unit with ample parking and recent upgrades.

    1906 Carolina 54 unit: 100 A, Durham, NC 27713
    View details
    Durham Medical/Office Building for Lease
    $23 SF/Yr
    4,769 SF

    Durham Medical/Office Building for Lease

    Freestanding 4,769 SF building suitable for medical or office use.

    110 E. Carver Street, Durham, NC 27704
    View details
    Professional Office Condos For Lease
    $2,400 /Mo
    5,120 SF

    Professional Office Condos For Lease

    Office condos for lease near Duke University Medical Center.

    2741 Campus Walk Ave, Building 400, Durham, NC 27705
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    Plug and Play Lab Space
    $30 SF/Yr
    94,603 SF

    Plug and Play Lab Space

    Move-in ready lab and office space in Durham, NC.

    4025 Stirrup Creek Drive, Durham, NC 27703
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    Office/Medical Building Near Southpoint Mall
    $26 SF/Yr
    18,395 SF

    Office/Medical Building Near Southpoint Mall

    Single-story office/medical building near Southpoint Mall available for lease.

    5501 Fortunes Ridge Drive, Durham, NC 27713
    View details
    Downtown Durham Office Space Available
    $29 SF/Yr
    32,522 SF

    Downtown Durham Office Space Available

    Move-in ready office space in downtown Durham with modern amenities.

    505 S Duke St, Durham, NC 27701
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    Roxboro Road Professional Office Space
    $20 SF/Yr
    2,408 SF

    Roxboro Road Professional Office Space

    Office space ideal for professional services and medical offices.

    4210 N. Roxboro Street, Suite 140, Durham, NC 27704
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    Luxury Mixed-Use Development Near Duke
    $25 SF/Yr
    118,000 SF

    Luxury Mixed-Use Development Near Duke

    Class A mixed-use development near Duke University and hospitals.

    2812 & 2816 Erwin Rd |, Durham, NC 27705
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    Office Space Near Universities
    $1,995 /Mo
    1,000 SF

    Office Space Near Universities

    Office space in Durham, close to amenities and universities.

    1804 Martin Luther King Junior Parkway unit: 111, Durham, NC 27707
    View details
    Durham Flex Space Available
    $13 SF/Yr
    35,000 SF

    Durham Flex Space Available

    35,000 SF flex space for rent in Durham.

    4808 Chin Page Rd, Durham, NC 27703
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    Downtown Durham Office Space Available
    Contact for pricing
    16,692 SF

    Downtown Durham Office Space Available

    Office spaces for lease in the heart of downtown Durham.

    433 W. Main Street, Durham, NC 27701
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    Downtown Durham Office Space
    Contact for pricing
    41,000 SF

    Downtown Durham Office Space

    Full floor office space in downtown Durham's iconic tower.

    212 West Main Street, Durham, NC 27701
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    Office Space in Durham
    $30 SF/Yr
    7,943 SF

    Office Space in Durham

    7943 SF office space available for lease.

    700 West Main Street, Durham, NC 27701
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    Office Space Near University Hill
    Contact for pricing
    12,500 SF

    Office Space Near University Hill

    Office space with high visibility, convenience, and walkability.

    3917 University Dr, Durham, NC 27707
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    Prime Medical Office Space Available
    $18 SF/Yr
    2,312 SF

    Prime Medical Office Space Available

    Versatile medical/office space in Durham's thriving North Duke corridor.

    2609 N Duke Street unit: Bldg 300, Unit 302, Durham, NC 27704
    View details
    Renovated Historic Building on Ninth
    Contact for pricing
    8,400 SF

    Renovated Historic Building on Ninth

    Fully renovated historic building in Durham's vibrant 9th Street district.

    706 Ninth Street, Durham, NC 27705
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    Modern Office Space Available
    $17 SF/Yr
    7,306 SF

    Modern Office Space Available

    7,306 SF office space, currently leased until 2026.

    101-103 W Main St, Durham, NC
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    Office Condo Near I-85
    Contact for pricing
    3,000 SF

    Office Condo Near I-85

    Office condo for rent near I-85 in Durham.

    1816 Front St, Durham, NC 27705
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    Durham Flex Space For Rent
    $4,500 /Mo
    1,233 SF

    Durham Flex Space For Rent

    Flex space with accessibility to the Greater Triangle Area.

    2528 S Alston Avenue, Durham, NC 27713
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    Versatile Workspace Solutions Available Now
    Contact for pricing

    Versatile Workspace Solutions Available Now

    Flexible office spaces, coworking, meeting rooms, and virtual office options.

    2530 Meridian Pkwy, Suite 300, Durham, NC 27713
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    Move-in Ready Office Suite
    $24 SF/Yr
    1,000 SF

    Move-in Ready Office Suite

    First-floor office suite in a high-demand Durham location.

    1804 Martin Luther King Jr Pkwy, Durham, NC 27707
    View details

    Durham County, NC Office Units Leasing Opportunities Market Analysis

    Explore Office Units leasing options in Durham County, NC with 37 listings featured on our commercial real estate exchange. The current inventory includes 3,366,708,840 square feet of properties with an estimated lease value of $257 SF/Yr.

    Estimated lease rates for Office Units in Durham County, NC begin at $5 SF/Yr, with an average of $23 SF/Yr and extend to $43 SF/Yr.
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