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    Cape Girardeau, MO Office Units for Lease

    8 results
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    Office Suite in Cape Girardeau
    $5,641 / Mo
    6,770 SF

    Office Suite in Cape Girardeau

    450 Siemers Dr, Cape Girardeau, MO 63701

    Office suite with high visibility and traffic in Cape Girardeau.

    • Turn‑key ready office suite
    • High visibility and high traffic location
    • Highway/Interstate frontage
    • Heating: Forced Air, Natural Gas, Solar
    • Cooling: Central Air, Electric
    Updated: Nov 14, 2025
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    Renovated Commercial Space For Lease
    $2,500 / Mo
    2,937 SF

    Renovated Commercial Space For Lease

    230 N Sprigg St, Cape Girardeau, MO 63701

    Renovated commercial space with high visibility in a prime location.

    • Prime location with high traffic and road frontage on N Sprigg St, offering excellent visibility in the Business District.
    • Almost 3000 sq ft of renovated space suitable for multiple offices or service providers.
    • Completely renovated with brand new A/C, roof, gutters, flooring, fixtures, bathrooms, kitchenette, and siding.
    • Significant rental income potential.
    • Located downtown, in the midst of exciting activities.
    Updated: Jun 30, 2025
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    600 SF Commercial Storage Space
    $400 / Mo

    600 SF Commercial Storage Space

    Commercial space ideal for off-site storage with drive-in door.

    2222 Kings Way Dr, Cape Girardeau, MO 63701
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    Historic Art Deco Landmark Space
    $2,900 / Mo

    Historic Art Deco Landmark Space

    Restored historic building in downtown Cape Girardeau's commercial district.

    824 Broadway St, Cape Girardeau, MO 63701
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    Professional Office Building For Rent
    $1,100 / Mo

    Professional Office Building For Rent

    1,218 SF professional office building in good location.

    720 Forest Ave, Cape Girardeau, MO 63701
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    Prime Retail/Office Space Available
    Contact for pricing

    Prime Retail/Office Space Available

    New 2,300 SF space ideal for retail or office.

    3465 William St, Cape Girardeau, MO 63703
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    Spacious Office Space For Rent
    Contact for pricing

    Spacious Office Space For Rent

    15,100 SF office space near dining and shopping.

    301 South Broadview St, Cape Girardeau, MO 63703
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    Retail Storefront with Office Space
    Contact for pricing

    Retail Storefront with Office Space

    Downtown retail storefront with office space for rent.

    221 Merriwether St, Cape Girardeau, MO 63703
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    Based on your search, we've compiled 26 Potential Opportunities for your consideration. Besides 8 Active listings in Cape Girardeau, MO, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 14 Properties for Sales.

    Explore Office Units for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Sikeston Medical/Office Space Available
    Contact for pricing

    Sikeston Medical/Office Space Available

    Multi-tenant commercial building near Missouri Delta Medical Center.

    808 E Wakefield Ave, Sikeston, MO 63801
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    Professional Space Near Main Intersection
    $1,000 / Mo

    Professional Space Near Main Intersection

    Prime location, high visibility, and flexible floor plan.

    1226 Linn St, Sikeston, MO 63801
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    Turnkey Office Space Available
    Contact for pricing

    Turnkey Office Space Available

    Modern office space with private offices, ready for occupancy.

    3415 Office Park Dr, Marion, IL 62959
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    Commercial Suites Available for Lease
    Contact for pricing

    Commercial Suites Available for Lease

    Three commercial suites available for lease near Hwy. 13.

    812 Skyline Dr, Marion, IL 62959
    View details

    Explore Similar Spaces for Sale in Cape Girardeau, MO

    Consider Similar Space for Sale. We found 14 Spaces in Nearby Locations matching your search parameters.

    Versatile Riverfront Commercial Property
    Pending
    $400,000
    4,400 SF

    Versatile Riverfront Commercial Property

    Prime riverfront property suitable for office, restaurant, warehouse, or mixed-use.

    450 N Main St, Cape Girardeau, MO 63701
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    Versatile Commercial Property For Sale
    $295,000
    2,920 SF

    Versatile Commercial Property For Sale

    High-visibility commercial property with flexible layout and spacious attached warehouse.

    225 Clark Ave, Cape Girardeau, MO 63701
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    Versatile Commercial Building in Cape
    $225,000
    0.57 Acres

    Versatile Commercial Building in Cape

    Adaptable 1800 sq ft commercial building in thriving Cape Girardeau.

    2357 Rust Ave, Cape Girardeau, MO 63703
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    Cape Girardeau Mixed-Use Investment
    $489,900
    7,282 SF

    Cape Girardeau Mixed-Use Investment

    Leased commercial spaces with residential unit for income growth.

    1606 Independence St, Cape Girardeau, MO 63703
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    Downtown Cape Girardeau Office/Flex Space
    Contact for pricing

    Downtown Cape Girardeau Office/Flex Space

    5,225 SF office/flex space in downtown Cape Girardeau.

    122 S Spanish St, Cape Girardeau, MO 63701
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    Cape Girardeau Industrial Building For Sale
    Contact for pricing

    Cape Girardeau Industrial Building For Sale

    10,000 SF industrial building with office and warehouse space.

    2109 Rust Ave, Cape Girardeau, MO 63703
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    Prime Location Office Suites
    Contact for pricing

    Prime Location Office Suites

    Excellent visibility office suites near I-55 and Highway 74.

    440 S Mount Auburn Rd, Cape Girardeau, MO 63703
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    Retail/Office Space Near I-55
    Contact for pricing

    Retail/Office Space Near I-55

    Prime location near I-55 and West Park Mall.

    3065 William St, Cape Girardeau, MO 63703
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    Cape Girardeau Commercial Space Available
    Contact for pricing

    Cape Girardeau Commercial Space Available

    Flexible commercial space for office, retail, or service businesses.

    151 S Mount Auburn Rd, Cape Girardeau, MO 63703
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    Warehouse Space in Central Cape
    Contact for pricing

    Warehouse Space in Central Cape

    Up to 50,000 SF available with flexible space sizes.

    334 N Broadview St, Cape Girardeau, MO 63701
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    13,875 SF Warehouse For Sale
    Contact for pricing

    13,875 SF Warehouse For Sale

    13,875 SF warehouse with office, drive-in doors, and dock.

    211 N Spring Ave, Cape Girardeau, MO 63701
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    Prime Commercial Space on Mount Auburn
    Contact for pricing

    Prime Commercial Space on Mount Auburn

    Versatile commercial space with parking and high visibility.

    326 Mount Auburn Rd S, Cape Girardeau, MO 63703
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    Commercial Land in Central Location
    Contact for pricing

    Commercial Land in Central Location

    1.2 acres suitable for retail or office development.

    1749 Independence St, Cape Girardeau, MO 63701
    View details
    Versatile Riverfront Commercial Property
    Pending
    $475,000
    7,044 SF

    Versatile Riverfront Commercial Property

    Flexible commercial space with riverfront location and development potential.

    308 N Main St, Cape Girardeau, MO 63701
    View details

    Cape Girardeau, MO Office Units Leasing Opportunities Market Analysis

    Explore Office Units leasing options in Cape Girardeau, MO with 22 listings featured on our commercial real estate exchange. The current inventory includes 422,836,920 square feet of properties with an estimated lease value of $20 SF/Yr.

    Estimated lease rates for Office Units in Cape Girardeau, MO begin at $10 SF/Yr, with an average of $10 SF/Yr and extend to $10 SF/Yr.
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    Popular Searches in Cape Girardeau, MO

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    Most Searched ZIP Codes in Cape Girardeau, MO

    • 63701
    • 63703

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