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    Cape Girardeau, MO Office Space for Lease

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    Office Suite in Cape Girardeau
    $5,641 / Mo
    6,770 SF

    Office Suite in Cape Girardeau

    450 Siemers Dr, Cape Girardeau, MO 63701

    Office suite with high visibility and traffic in Cape Girardeau.

    • Turn‑key ready office suite
    • High visibility and high traffic location
    • Highway/Interstate frontage
    • Heating: Forced Air, Natural Gas, Solar
    • Cooling: Central Air, Electric
    Updated: Nov 14, 2025
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    Renovated Commercial Space For Lease
    $2,500 / Mo
    2,937 SF

    Renovated Commercial Space For Lease

    230 N Sprigg St, Cape Girardeau, MO 63701

    Renovated commercial space with high visibility in a prime location.

    • Prime location with high traffic and road frontage on N Sprigg St, offering excellent visibility in the Business District.
    • Almost 3000 sq ft of renovated space suitable for multiple offices or service providers.
    • Completely renovated with brand new A/C, roof, gutters, flooring, fixtures, bathrooms, kitchenette, and siding.
    • Significant rental income potential.
    • Located downtown, in the midst of exciting activities.
    Updated: Jun 30, 2025
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    Based on your search, we've compiled 8 Potential Opportunities for your consideration. Besides 2 Active listings in Cape Girardeau, MO, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 2 Properties for Sales.

    Explore Office space for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Downtown Sikeston Commercial Property
    $4,500 / Mo
    4,273 SF

    Downtown Sikeston Commercial Property

    Versatile commercial space in downtown Sikeston ready for lease.

    202 S Kingshighway St, Sikeston, MO 63801
    View details
    Sikeston Office Suite For Rent
    $3,625 / Mo
    2,000 SF

    Sikeston Office Suite For Rent

    Recently-built office suite with four offices, bathroom, and kitchenette.

    912 S Main St, Sikeston, MO 63801
    View details
    Turnkey Office Space Available
    Contact for pricing

    Turnkey Office Space Available

    Modern office space with private offices, ready for occupancy.

    3415 Office Park Dr, Marion, IL 62959
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    Commercial Suites Available for Lease
    Contact for pricing

    Commercial Suites Available for Lease

    Three commercial suites available for lease near Hwy. 13.

    812 Skyline Dr, Marion, IL 62959
    View details

    Explore Similar Spaces for Sale in Cape Girardeau, MO

    Consider Similar Space for Sale. We found 2 Spaces in Nearby Locations matching your search parameters.

    Versatile Commercial Property in Missouri
    $295,000
    2,920 SF

    Versatile Commercial Property in Missouri

    Adaptable commercial space with retail, office, and warehouse capabilities.

    225 Clark Ave, Cape Girardeau, MO 63701
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    Versatile Commercial Building in Cape
    $225,000
    0.57 Acres

    Versatile Commercial Building in Cape

    Adaptable 1800 sq ft commercial building in thriving Cape Girardeau.

    2357 Rust Ave, Cape Girardeau, MO 63703
    View details

    Cape Girardeau, MO Office space Leasing Opportunities Market Analysis

    Explore Office space leasing options in Cape Girardeau, MO with 4 listings featured on our commercial real estate exchange. The current inventory includes 422,836,920 square feet of properties with an estimated lease value of $20 SF/Yr.

    Estimated lease rates for Office space in Cape Girardeau, MO begin at $10 SF/Yr, with an average of $10 SF/Yr and extend to $10 SF/Yr.
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    Most Searched ZIP Codes in Cape Girardeau, MO

    • 63701

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