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    Lancaster, SC Office Spaces for Sale

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    Fort Lawn, SC Waxhaw, NC Heath Springs, SC Catawba, SC Richburg, SC Edgemoor, SC Great Falls, SC Van Wyck, SC
    11 properties
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    Two-Building Medical Office Property
    Updated: Dec 1, 2025
    Two-Building Medical Office Property

    1201 Colonial Commons Court, Lancaster, SC 29720

    $975,000
    0.82 AC lot
    Two professional buildings on a 0.82‑acre property
    Building 1 includes approximately 14 rooms, reception, waiting, and file areas
    Building 1 has new flooring and a new roof
    Building 2 features three curtained areas and a large open space
    PO Professional Office zoning per the City of Lancaster
    View details
    Historic Mixed-Use Retail/Office Buildings
    Updated: Jun 11
    Historic Mixed-Use Retail/Office Buildings

    209-227 S. Main Street, Lancaster, SC 29720

    Contact for pricing
    29,151 sqft
    1930s‑vintage commercial buildings in downtown Lancaster, SC, historically used for retail or office space
    Currently vacant and in need of renovation—space offers a value‑add rehabilitation opportunity
    Off Highway 521 and about 5 minutes from the Highway 9 intersection
    Within 10 miles: population of over 56,000 grew 10% since 2020, with a forecast to grow an additional 16% by 2029
    More than $641 million in consumer spending during 2024 within 10 miles
    View details
    Downtown Mixed-Use Redevelopment Property
    Downtown Mixed-Use Redevelopment Property

    210 S. White Street, Lancaster, SC 29720

    Contact for pricing
    22,251 sqft

    Vacant 1930s retail/office buildings in downtown Lancaster offer a renovation-ready canvas for mixed-use redevelopment.

    View details
    Turn a Listing Into an Investment Snapshot Cap Rate, Potential NOI, Demand score for every listing. Go To Analytics Center
    1930s Retail/Office Building Portfolio
    1930s Retail/Office Building Portfolio

    116 Arch Street, Lancaster, SC 29720

    Contact for pricing
    29,444 sqft

    Vacant, renovation-needed buildings offering flexible retail or office space in downtown Lancaster with convenient highway access.

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    Office Building
    Office Building

    312 N Main Street N, Lancaster, SC 29720

    Contact for pricing
    2,706 sqft

    Office building with some furnishings staying, and utility split where tenant pays electricity and natural gas.

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    Medical Office Buildings Near MUSC
    Medical Office Buildings Near MUSC

    1201 Colonial Commons Ct, Lancaster, SC 29720

    $975,000

    Two professional buildings suitable for medical or office use.

    View details
    Versatile Commercial Building in Lancaster
    Versatile Commercial Building in Lancaster

    302 N White St, Lancaster, SC 29720

    $325,000

    Two-story commercial building with offices in downtown Lancaster, SC.

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    Office Building with Live-Work Use
    Office Building with Live-Work Use

    36-305 E Arch St, Lancaster, SC 29720

    $250,000

    B-2 zoning supports residential occupancy alongside a business, with parking and accessible entry.

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    Medical Office Building
    Medical Office Building

    1370 W Meeting Street, Lancaster, SC 29720

    Contact for pricing

    Large medical office building with exam rooms, nurses stations, lab space, and ample parking.

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    Glass-Front Retail Space
    Glass-Front Retail Space

    1687 Memorial Park Rd, Lancaster, SC 29720

    Contact for pricing

    Strip-center commercial space with customer parking, two bathrooms, and flexible office or retail configuration.

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    Glass-Front Office Unit
    Glass-Front Office Unit

    1685 Memorial Park Rd, Lancaster, SC 29720

    Contact for pricing

    Flexible unit within a strip center with customer parking, two restrooms, and a separate rear access point.

    View details
    Based on your search, we've compiled 80 Potential Opportunities for your consideration. Besides 11 Active listings in Lancaster, SC, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 61 Off-Market properties to explore as potential leads, plus 4 Land Listings that present a potential for development.

    Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    Corner-Lot Flex Space with Bay Door
    Corner-Lot Flex Space with Bay Door

    215 Dearborn St, Great Falls, SC 29055

    $299,000
    4,800 sqft 0.69 AC lot

    Three separately configured areas combine offices, reception rooms, and workshop space.

    View details
    Two-Building Office Property
    Two-Building Office Property

    320 Dearborn St, Great Falls, SC 29055

    $110,000
    1,449 sqft

    Two separate structures provide reception, office, storage, and support areas for flexible business use.

    View details
    Former Medical Office Space
    Former Medical Office Space

    110 South Cleveland Street, Kershaw, SC 29067

    $150,000
    3,550 sqft

    3,350 SF medical office with 11 parking spaces.

    View details
    Flex Office Space with Storage
    Flex Office Space with Storage

    116 Hampton Street, Kershaw, SC 29067

    Contact for pricing
    3,600 sqft

    Well-maintained flex space with private office, storage back room, and one restroom, plus recent HVAC and roofing updates.

    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Brick Storefront Property
    Brick Storefront Property

    2836 Lynwood Drive, Lancaster, SC 29720

    $149,900
    0.47 AC lot

    Commercial space with central air, electric heat, carpet flooring, and a bathroom.

    View details
    Light Industrial Land For Sale
    Light Industrial Land For Sale

    00 Fork Hill Road, Kershaw, SC 29067

    $90,000

    Land zoned for light industrial use with possible residential rezoning.

    View details
    Commercial Land with Dual Frontage
    Commercial Land with Dual Frontage

    2164 Eden Terrace, Rock Hill, SC 29730

    $350,000
    3.64 AC lot

    GC-zoned development site with public sewer and access from two road frontages.

    View details
    O-I Zoned Commercial Land
    O-I Zoned Commercial Land

    2135 Eden Terrace, Rock Hill, SC 29730

    $450,000
    1.08 AC lot

    The parcel is zoned O-I and has public sewer service for commercial land planning.

    View details

    Off-Market Properties in Lancaster, SC

    Consider similar Off-Market properties in Lancaster, SC. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    979 University Dr
    OFFICE (GENERAL)

    979 University Dr, Lancaster, SC 29720

    $180,000
    Estimated value
    1,584 sqft 130.00 AC lot
    View details
    713 Main St
    OFFICE (GENERAL)

    713 Main St, Lancaster, SC 29720-3644

    $140,000
    Estimated value
    1,128 sqft 234.00 AC lot
    View details
    312 Miller St
    OFFICE (GENERAL)

    312 Miller St, Lancaster, SC 29720

    Value Estimation by Request
    1,467 sqft 4.40 AC lot
    View details
    Hwy 914
    OFFICE (GENERAL)

    Hwy 914, Lancaster, SC 29720

    $345,000
    Estimated value
    2,586 sqft 200.00 AC lot
    View details
    503 Meeting St
    OFFICE (GENERAL)

    503 Meeting St, Lancaster, SC 29720-2323

    $190,000
    Estimated value
    1,210 sqft 75.00 AC lot
    View details
    1320 Hwy 9th W Byp
    MEDICAL BUILDING

    1320 Hwy 9th W Byp, Lancaster, SC 29720-4712

    Value Estimation by Request
    1,320 sqft 70.00 AC lot
    View details
    312 Main St
    OFFICE (GENERAL)

    312 Main St, Lancaster, SC 29720-2132

    $535,000
    Estimated value
    5,644 sqft 130.00 AC lot
    View details
    2583 Kershaw Camden Hwy
    OFFICE (GENERAL)

    2583 Kershaw Camden Hwy, Lancaster, SC 29720-6855

    $340,000
    Estimated value
    8,060 sqft 0.67 AC lot
    View details
    1104 Lockwood Ln
    OFFICE (GENERAL)

    1104 Lockwood Ln, Lancaster, SC 29720-6217

    $110,000
    Estimated value
    2,240 sqft 283.00 AC lot
    View details
    Catawba St
    OFFICE (GENERAL)

    Catawba St, Lancaster, SC 29720

    $415,000
    Estimated value
    3,128 sqft 100.00 AC lot
    View details
    419 Meeting St
    MEDICAL BUILDING

    419 Meeting St, Lancaster, SC 29720-2321

    $750,000
    Estimated value
    4,600 sqft 22.00 AC lot
    View details
    1091 Rebound Rd
    OFFICE (GENERAL)

    1091 Rebound Rd, Lancaster, SC 29720

    $275,000
    Estimated value
    1,994 sqft 22.73 AC lot
    View details
    1629 Springdale Rd
    OFFICE (GENERAL)

    1629 Springdale Rd, Lancaster, SC 29720-2253

    $180,000
    Estimated value
    952 sqft 180.00 AC lot
    View details

    Lancaster, SC Office Spaces Market Trends and Statistics

    Explore 72 office spaces for sale in Lancaster, SC, showcased through 11 active listings on our real estate platform. These investment opportunities span a total of 83,552 square feet of properties for sale, with an estimated market value of $2,525,000.

    Sale prices for office spaces in Lancaster, SC start at $250,000, averaging $631,250, and reaching up to $975,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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    Top Commercial Asset Segments

    Commercial property segments ranked by active listings on the market

    Office buildings 9
    Office Units 4
    Medical Office Space 3

    Demographics Overview

    Population 52K
    Population Growth (5Y) +8.0%
    Median Household Income $59,039
    College Educated 9.5%

    High-Yield Neighborhoods for Investment

    Identify Lancaster submarkets with the highest inventory density on the market and evaluate the average listing prices of real estate assets

    Neighborhood Average Price
    29720 $505K

    Taxes & Financing

    Average Loan-to-Value 65.0%

    Listings Trend

    New vs delisted commercial listings in Lancaster County

    New Delisted

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