Simpsonville, SC Office Units for Rent & Lease

$5,084/Mo

Historic Downtown Simpsonville Office Space

312 S Main Street, Simpsonville, SC 29681

Charming office space in historic downtown Simpsonville with ample parking.

Prime location in Historic Downtown Simpsonville with excellent visibility.
Elegantly finished reception area.
Five potential offices, including one suitable for a conference room.
Full kitchen and full bathroom.
Ample parking with approximately 12‑14 spaces.

Updated: Feb 6

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$18 SF/Yr

2,875 SF

Simpsonville Office Suite for Rent

419 Main St, Simpsonville, SC

Office suite with ample parking and convenient highway access.

Convenient access to I‑385 & downtown Simpsonville
±2,875 SF office suite with 8 spacious offices
±50 parking spaces
Large reception/lobby and kitchenette
Zoned BL City of Simpsonville

Updated: Nov 24, 2025

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$14 SF/Yr

3,150 SF

Simpsonville Office Space For Rent

Office space available for lease in Simpsonville, South Carolina.

1027 South St, Simpsonville, SC

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$19 SF/Yr

12,463 SF

Simpsonville Office Space Available

Office space available for lease in Simpsonville, SC.

100 Allawood Ct, Simpsonville, SC

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24,635 SF

Simpsonville Flex Space For Rent

Flex space featuring warehouses, shops, and office space available for lease.

514 Palmetto Dr, Simpsonville, SC 29681

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$32 SF/Yr

5,904 SF

Simpsonville Office Space For Rent

5,904 SF office space available for lease.

220 Scuffletown Rd, Simpsonville, SC

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$14 SF/Yr

5,000 SF

Commercial Building For Rent

Commercial building for rent with showroom and office space.

926 Fairview Rd, Simpsonville, SC 29680

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0 Bridgeway

±6,197 SF of office space availalble

0 Bridgeway Simpsonville, SC 29681, Simpsonville, SC 29681

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Based on your search, we've compiled 15 Potential Opportunities for your consideration. Besides 8 Active listings in Simpsonville, SC, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 3 Properties for Sales.

Office Units for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

$6 SF/Yr

Creative Office Space Available

Creative office space for lease in Mauldin, South Carolina.

11 Forrester Drive |, Mauldin, SC 29662

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$1,000/Mo

500 SF

Mauldin Office Suite Sublease

Office suite for sublease in growing Mauldin, South Carolina.

505 N Main St, Mauldin, SC

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Downtown Greenville Class A Office

Class A office space available in downtown Greenville.

220 N Main St, Greenville, SC 29601

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$25 SF/Yr

Office Suites Available For Rent

Office suites of various sizes available for rent.

301 N Main St, Greenville, SC 29601

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Similar Spaces for Sale in Simpsonville, SC

Consider Similar Space for Sale. We found 3 Spaces matching your search parameters.

Professional Office Space in Simpsonville

$425,000

1,844 SF

Professional Office Space in Simpsonville

Adaptable 1,844 sq ft office near downtown Simpsonville.

117 Hillcrest Avenue, Simpsonville, SC 29681

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8,082 SF

Historic Mill Office Space Available

Office space in a renovated historic textile mill.

300 S St, Simpsonville, SC

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$750,000

1.42 Acres

Main Street Commercial Opportunity

Property with high visibility and development potential on 1.42 acres.

1306 NE Main St, Simpsonville, SC

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Simpsonville, SC Office Units Leasing Opportunities Market Analysis

Explore Office Units leasing options in Simpsonville, SC with 8 listings featured on our commercial real estate exchange. The current inventory includes 29,392 square feet of properties with an estimated lease value of $97 SF/Yr.

Estimated lease rates for Office Units in Simpsonville, SC begin at $14 SF/Yr, with an average of $19 SF/Yr and extend to $32 SF/Yr.