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    Lexington County, SC Office Spaces for Lease

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    Greenville, SC Columbia, SC Charleston, SC
    257 results
    Main Street
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    Turnkey Medical Office Suites
    $20 SF/Yr
    3,742 SF
    Turnkey Medical Office Suites

    4100 N. Main Street, Columbia, SC 29203

    Turnkey suites with exam rooms and plumbing, recently renovated common areas, designed for efficient medical operations.
    • 1987‑built medical office with turnkey suites featuring exam rooms with plumbing
    • Suite 101: ±2,484 SF available 8/1/26
    • Suite 200: ±1,226 SF with reception, 3 exam rooms (with plumbing), 1 private office, and restroom
    • Suite 201: ±2,516 SF with large reception/waiting area, 6 exam rooms (with plumbing), 2 private offices, IT/storage rooms, and restroom
    • Major renovations in 2019 included new roof, building façade, and common area upgrades
    Updated: Jun 2
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    Freestanding Flex Building
    $11 SF/Yr
    6,000 SF
    Freestanding Flex Building

    175 Foster Brothers Dr # 179, West Columbia, SC 29172

    Freestanding flex building with office, warehouse space, dock and drive-in doors, and room for yard storage or parking.
    • 6,000 SF freestanding flex building for lease, built in 2003
    • Building includes 2,000 SF office space and 4,000 SF warehouse space
    • Warehouse has two (2) dock level doors plus one (1) drive‑in door
    • Clear height includes 16' eave height and 22' center height
    • Small yard area that could be used for parking or storage
    Updated: Jun 2
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    SC, Columbia - Stoneridge Drive
    $129-$7,236/Mo
    SC, Columbia - Stoneridge Drive

    Workspaces, services and support to help you work better in SC, Columbia - Stoneridge Drive

    140 Columbia Ave, Columbia, SC 29210

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    SC, Columbia - 1501 Main St
    $129-$4,896/Mo
    SC, Columbia - 1501 Main St

    Discover many ways to work your way in SC, Columbia - 1501 Main St

    1501 Main St, Unit 501, Columbia, SC 29201

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    Reimagined Class-A Office Space
    $25 SF/Yr
    7,521 SF
    Reimagined Class-A Office Space

    Newly renovated office space in prime downtown location.

    1710 Gervais St., Columbia, SC 29201

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    Columbia Flex Space For Lease
    $12 SF/Yr
    12,550 SF
    Columbia Flex Space For Lease

    Flex space available for lease in Columbia, South Carolina.

    901 Brookwood Drive, Columbia, SC 29201

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    Two-Story Office Building For Rent
    $16 SF/Yr
    3,960 SF
    Two-Story Office Building For Rent

    Two-story office building with flexible layout in central Columbia.

    123 Lawand Dr, Columbia, SC 29210

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    Office Space in Vista District
    $23 SF/Yr
    6,782 SF
    Office Space in Vista District

    Office spaces for lease in Columbia's popular Vista district.

    500 Taylor Street, Columbia, SC 29201

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    Premier Office Tower with Capitol Views
    $40 SF/Yr
    2,289 SF
    Premier Office Tower with Capitol Views

    Office space in Columbia's premier tower with integrated parking.

    1221 Main Street, Columbia, SC 29201

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    Mixed-Use Property in Cayce, SC
    $825/Mo
    7,541 SF
    Mixed-Use Property in Cayce, SC

    Mixed-use property suitable for redevelopment, retail, or office use.

    528-532 Knox Abbott Dr, Cayce, SC 29033

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    West Columbia Office/Medical Suite
    $18 SF/Yr
    12,000 SF
    West Columbia Office/Medical Suite

    Office/medical suite for lease near Lexington Medical Hospital.

    3618 Sunset Blvd., West Columbia, SC 29169

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    Office Space For Rent
    $20 SF/Yr
    15,000 SF
    Office Space For Rent

    Office suites available in Columbia, between Downtown and Forest Acres.

    3321 Forest Drive, Columbia, SC 29204

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    New Lexington County Office Space
    $23 SF/Yr
    6,500 SF
    New Lexington County Office Space

    Office space for lease in a growing Lexington County location.

    120 Brookside Parkway, Lexington, SC 29072

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    Office Suite in West Columbia
    $15 SF/Yr
    9,890 SF
    Office Suite in West Columbia

    Office suite for lease near downtown Columbia and Lexington Medical Center.

    1523 Sunset Blvd., West Columbia, SC 29169

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    Medical Office Space For Lease
    $20 SF/Yr
    7,659 SF
    Medical Office Space For Lease

    Medical office space in prime healthcare corridor location.

    161 Medical Circle, West Columbia, SC 29169

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    Flex Space Near Interstate I-26
    $15 SF/Yr
    2,520 SF
    Flex Space Near Interstate I-26

    Professional flex and light manufacturing space with easy interstate access.

    104 Corporate Boulevard, West Columbia, SC 29169

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    Flex Space Near Interstate Access
    $15 SF/Yr
    1,575 SF
    Flex Space Near Interstate Access

    Professional flex and light manufacturing space with convenient interstate access.

    101 Corporate Boulevard, West Columbia, SC 29169

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    New Lexington Office Space Available
    $21 SF/Yr
    1,380 SF
    New Lexington Office Space Available

    Newly constructed Class A office space for lease in Lexington.

    322 W. Main Street, Lexington, SC 29072

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    Office Property Near Downtown Columbia
    $17 SF/Yr
    8,181 SF
    Office Property Near Downtown Columbia

    Office and flex spaces available near I-20 and I-26.

    720 Gracern Rd, Columbia, SC

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    Prime Office Space on Devine
    $23 SF/Yr
    12,200 SF
    Prime Office Space on Devine

    Office space for lease in the Devine Street District.

    2422 Devine Street, Columbia, SC 29205

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    Warehouse with Secured Yard
    $12 SF/Yr
    5,000 SF
    Warehouse with Secured Yard

    5,000 SF warehouse with office and secured yard.

    125 North Shorecrest Drive, Columbia, SC 29209

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    Downtown Columbia Office Space Available
    $21 SF/Yr
    17,594 SF
    Downtown Columbia Office Space Available

    Prime office space for rent in downtown Columbia.

    1333 Main Street, Columbia, SC 29201

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    Columbia Office Building For Lease
    $14 SF/Yr
    16,966 SF
    Columbia Office Building For Lease

    Class B office space with interstate visibility and modern amenities.

    1628 Browning Road, Columbia, SC 29210

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    Lexington County, SC Office Spaces Leasing Opportunities Market Analysis

    Explore Office Spaces leasing options in Lexington County, SC with 257 listings featured on our commercial real estate exchange. The current inventory includes 3,010,336 square feet of properties with an estimated lease value of $3,437 /Mo.

    Estimated lease rates for Office Spaces in Lexington County, SC begin at $1.31 SF/Yr, with an average of $21 SF/Yr and extend to $140 SF/Yr.
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