Depew, NY Office Spaces for Rent & Lease

$129-$5,356/Mo

(972) 764-8885

NY, Amherst - 251 John James Audubon

Workspaces, services and support to help you work better in NY, Amherst - 251 John James Audubon

251 John James Audubon Pkwy, Unit 1ST, Amherst, NY 14228

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(972) 764-8885

NY, Buffalo - Washington Street

Flexible workspace in FL, Palm Coast - Palm Coast Parkway

369 Washington St, Buffalo, NY 14203

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$25 SF/Yr

3,004 SF

Medical Office Space Available

4893 Transit Road, Lancaster, NY 14043

3,004 SF medical suite for lease on Transit Road.

Excellent location on heavily travelled Transit Road (Rt. 78) with high visibility (33,000+ vehicles/day) in a rapidly growing trade area.
Located in a 20,362 SF medical building with established medical co‑tenants (primary medical group, radiology provider).
3,004 SF former dental suite suitable for medical/professional conversion.
Strong area demographics in one of WNY's rapidly growing communities.
Ample on‑site parking.

Updated: May 14

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$21 SF/Yr

8,000 SF

Class A Office Sublease

4455 Genesee St, Cheektowaga, NY 14225

Class A office space available for sublease in Cheektowaga.

Class A office space with 6 years remaining on the sublease.
Features a large open bull pen area, 15 private offices, and 2 conference rooms (8,000 sq ft).
Includes a showroom area.
660 sq ft storage area with a grade door.
Bright, clean, and well‑maintained space.

Updated: Apr 24

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Medical Building with Development Potential

$650,000 SF/Yr

3,200 SF

Medical Building with Development Potential

Partially leased medical building with developable lot on William Street.

3083 William St, Cheektowaga, NY 14227

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$2.00 SF/Yr

600 SF

Move-In Ready Commercial Space

Updated 600 sq ft commercial space, utilities included.

570 Gould Ave, Lancaster, NY 14043

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$21 SF/Yr

8,000 SF

Class A Office Sublease

Class A office space for sublease with showroom area.

4455 Genesee St, Cheektowaga, NY 14225

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$1,250/Mo

5,600 SF

Walden Avenue Professional Office Space

Well-appointed 2nd-floor office space, ideal for professional use.

3260 Walden Avenue, Depew, NY 14043

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$13 SF/Yr

1,500 SF

Transit Road Retail/Office Space

High-traffic location near supermarket and new apartments.

6338-6348 Transit Rd, Depew, NY

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Lancaster Plaza Retail/Warehouse/Office Space

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15,611 SF

Lancaster Plaza Retail/Warehouse/Office Space

Retail, warehouse, and office space available in Lancaster, NY.

3291 Walden Ave, Lancaster, NY 14043

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Versatile Space in Catalyst Fitness Plaza

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23,000 SF

Versatile Space in Catalyst Fitness Plaza

Medical office, retail, and warehouse spaces available for lease.

5087 Broadway, Depew, NY 14043

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2,000 SF

Prime Location Retail Spaces Available

Retail spaces for lease with high visibility and traffic.

5102 Genesee Street, Depew, NY 14043

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1,500 SF

Transit Road Retail/Office Space

High-traffic retail/office space available on Transit Road.

6348 Transit Road, Cheektowaga, NY 14225

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$12 SF/Yr

2,400 SF

Modern Office Space Available

Well-maintained office space with modern amenities and easy access.

303 Cayuga Rd, Cheektowaga, NY

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1,383 SF

Transit Road Office and Retail

Office and retail spaces available for rent.

4721 Transit Rd, Depew, NY 14043

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$12 SF/Yr

10,847 SF

Office and Flex Space Available

Office and flex space for rent with private entrances.

455 Cayuga Rd, Cheektowaga, NY

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$16 SF/Yr

11,331 SF

Medical Office Space Available

Medical office space available for lease in 2025.

Cheektowaga, NY

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Lancaster Warehouse/Retail/Office Space Available

Versatile space near Transit Rd with high traffic volume.

3283-3291 Walden Ave, Lancaster, NY 14043

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Lancaster Retail/Office Space Available

3,400 SF space suitable for retail or office use.

3297 Walden Ave, Lancaster, NY 14043

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Industrial Space Near Walden Galleria

15,000 SF warehouse/office space available for lease.

51 Anderson Rd, Cheektowaga, NY 14225

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Former Masons' Lodge Stone Building

9,160+/- SF stone building with excellent architecture and parking.

5497 Broadway, Lancaster, NY 14086

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$12 SF/Yr

5,500 SF

Medical Office & Warehouse Space

Medical office and warehouse spaces for lease in Depew.

5087 Broadway, Depew, NY

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Prime Retail/Office Space Available

Highly visible retail/office space in Cheektowaga, near airport.

2521 Walden Avenue, Cheektowaga, NY 14225

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Retail/Office Space Near Downtown Buffalo

Nicely finished retail/office space with quick access to Buffalo.

3807 Harlem Road, Cheektowaga, NY 14215

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Depew, NY Office Spaces Leasing Opportunities Market Analysis

Explore Office Spaces leasing options in Depew, NY with 46 listings featured on our commercial real estate exchange. The current inventory includes 130,045 square feet of properties with an estimated lease value of $650,456.

Estimated lease rates for Office Spaces in Depew, NY begin at $2.00 SF/Yr, with an average of $30,974 and extend to $650,000.