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    Durham County, NC Office Spaces for Lease

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    Found 64 office spaces for lease in Durham County, NC, averaging $36/sq ft/yr. Use lease type data to compare options faster.
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    R&D Lab Suites Available
    R&D Lab Suites Available

    380 East Pettigrew Street, Durham, NC 27701

    Contact for pricing
    203,239 sqft

    R&D lab suites ranging from 4,345 RSF to 7,381 RSF.

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    Flex R&D Space
    Flex R&D Space

    4018 Patriot Dr, Durham, NC 27703

    Contact for pricing

    Flexible commercial space at One Park Center accommodates a range of business requirements.

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    Office Space with Extensive Amenities
    Office Space with Extensive Amenities

    42 Moore Drive, Durham, NC 27703

    Contact for pricing
    298,206 sqft

    Office building featuring on-site cafeteria, fitness center, and health clinic.

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    Durham Office Space For Rent
    Durham Office Space For Rent

    2700 Meridian Parkway, Durham, NC 27713

    Contact for pricing
    25,952 sqft

    Office space for rent with prime location in Durham.

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    Durham Office Space For Rent
    Durham Office Space For Rent

    2520 Meridian Parkway, Durham, NC 27713

    Contact for pricing
    115,283 sqft

    Office space in Durham, convenient location near I-40 and Highway 55.

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    Spacious Campus in Durham, NC
    Spacious Campus in Durham, NC

    2810 Meridian Parkway, Durham, NC 27713

    Contact for pricing
    22,538 sqft

    700,000 SF campus with lake and walking trails.

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    Flex Space with Heavy Power
    Flex Space with Heavy Power

    1101 Hamlin Road, Durham, NC 27704

    Contact for pricing
    34.70 AC lot

    Light Industrial zoning, multiple configurations, and technical infrastructure support manufacturing, R&D, and life science uses.

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    Freestanding Medical Office Space
    Freestanding Medical Office Space

    1823 Chapel Hill Rd., Durham, NC 27701

    Contact for pricing

    Office layout combines exam rooms with open work areas and supports immediate occupancy.

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    Office Space For Rent
    Office Space For Rent

    600 Douglas Street, Durham, NC 27705

    Contact for pricing

    Office spaces available for rent at 600 Douglas Street.

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    Historic Downtown Durham Office Space
    Historic Downtown Durham Office Space

    212 West Main Street, Durham, NC 27701

    Contact for pricing

    Landmark office building in the heart of downtown Durham.

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    Downtown Durham Office Space
    Downtown Durham Office Space

    433 W. Main Street, Durham, NC 27701

    Contact for pricing

    Office space for lease in downtown Durham, NC.

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    Flex Building with Loading Docks
    Flex Building with Loading Docks

    2210 East Pettigrew Street, Durham, NC 27703

    Contact for pricing

    Versatile office and warehouse configuration with kitchen, break area, and convenient regional highway access.

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    Downtown Office Suite in Kress Building
    Downtown Office Suite in Kress Building

    101-103 W Main St, Durham, NC 27701

    Contact for pricing
    5,153 sqft

    Street-level office sublease includes private offices, conference and collaboration space, and original terrazo floors.

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    Office Space in Durham
    Office Space in Durham

    324 Blackwell St, Durham, NC 27701

    Contact for pricing

    Office space available for lease in Durham, North Carolina.

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    Durham Office and Medical Space
    Durham Office and Medical Space

    31 Alexandria Way, Durham, NC 27703

    Contact for pricing
    23,351 sqft

    Office and medical space available for lease in Durham.

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    Based on your search, we've compiled 107 Potential Opportunities for your consideration. Besides 64 Active listings in Durham County, NC, we suggest exploring alternatives. Consider Similar 43 Spaces for Sales.

    Similar Spaces for Sale in Durham County, NC

    Consider Similar Space for Sale. We found 43 Spaces matching your search parameters.

    Ground-Floor Office Unit
    Ground-Floor Office Unit

    3624 Shannon Road, Durham, NC 27707

    $538,650
    2,205 sqft

    Ground-floor office space in an OI-zoned professional office park.

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    Ground-Floor Office Condo
    Ground-Floor Office Condo

    3624 Shannon Road, Suite 101, Durham, NC 27707

    $538,650
    1,920 sqft

    OI zoning accommodates professional, engineering, and institutional office uses.

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    Office Building with Elevator
    Office Building with Elevator

    216-218 Rigsbee Avenue, Durham, NC 27701

    $1,800,000
    10,461 sqft 0.07 AC lot

    Three-story office property with mezzanine amenities and access to Downtown Durham’s retail, dining, arts, and entertainment district.

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    Office Building on Corner Lot
    Office Building on Corner Lot

    1402 Broad Street, Durham, NC 27705

    $849,500
    2,124 sqft 0.47 AC lot

    A brick, two-story-era residence now serves as office space under an attorney lease with a six-month move-out period.

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    Professional Center Office Suite
    Professional Center Office Suite

    4210 N. Roxboro Street, Suite 140, Durham, NC 27704

    $529,000
    2,408 sqft

    Office suite in the Roxboro Road Professional Center, offering space suitable for professional services or medical offices.

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    Craftsman Live-Work Bungalow
    Craftsman Live-Work Bungalow

    1814 Chapel Hill Road, Durham, NC 27707

    $485,000
    1,922 sqft 0.30 AC lot

    This 1938 bungalow combines a residential layout with office-oriented zoning.

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    Craftsman Live-Work Bungalow
    Craftsman Live-Work Bungalow

    1814 Chapel Hill Rd, Durham, NC 27707

    $485,000
    1,922 sqft

    Located in Durham’s Office/Institutional, Urban Tier district with flexible residential and professional-use potential.

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    First-Floor Office Condominium
    First-Floor Office Condominium

    5003 Southpark Drive, Durham, NC 27713

    $389,000
    1,386 sqft

    Leased professional suite with an extended occupancy history and convenient access to major regional transportation routes.

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    Live-Work Craftsman Bungalow
    Live-Work Craftsman Bungalow

    1814 Chapel Hill, Durham, NC 27707

    $485,000
    1,922 sqft

    Craftsman-style home with office-ready interiors, a fireplace front parlor, and flexible outdoor parking behind a detached garage.

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