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    Durham, NC Office Spaces for Lease

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    52 properties
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    Private Office Suite Space
    Updated: Jun 29
    Private Office Suite Space

    3201 Yorktown Avenue, Durham, NC 27713

    $350/Mo
    907 sqft
    Built in 1988
    Private office rooms with shared common area
    24‑hour access
    WiFi and utilities included
    Convenient location near RTP, Downtown, and highways
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    Prime Medical Office Space Available
    Updated: Dec 4, 2024
    Prime Medical Office Space Available

    2609 N Duke Street, Durham, NC 27704

    $18/Mo
    2,312 sqft
    Prime medical/office space in a highly sought‑after location on Durham's North Duke Street corridor.
    Excellent visibility and easy access to major roads and highways.
    Dedicated parking with ample spaces for clients and staff.
    Versatile space ideal for medical, dental, or general office use.
    Includes reception area, private offices, conference rooms, and ADA‑compliant restrooms.
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    Flexible Office Suite on Highway 54
    Flexible Office Suite on Highway 54

    1906 Carolina 54, Durham, NC 27713

    $45,045/Mo
    2,145 sqft

    First-floor office suite with eight private offices, updated interiors, and ample parking on a high-traffic corridor.

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    CG-Zoned Commercial Space
    CG-Zoned Commercial Space

    2810 Hillsborough Road, Durham, NC 27705

    $18 SF/Yr
    2,978 sqft

    High-visibility commercial suite on Hillsborough Road with Commercial General zoning for a broad range of uses.

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    Flex Space with Laydown Yard
    Flex Space with Laydown Yard

    2528 S Alston Avenue, Durham, NC 27713

    $4,500/Mo
    1,233 sqft

    Industrial flex space with a small office setup, offering laydown yard and storage.

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    Office Condo Near I-85
    Office Condo Near I-85

    1816 Front St, Durham, NC 27705

    $18.75 SF/Yr
    3,000 sqft

    Office condo for rent near I-85 in Durham.

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    Roxboro Road Professional Office Space
    Roxboro Road Professional Office Space

    4210 N. Roxboro Street, Suite 140, Durham, NC 27704

    $20.50 SF/Yr
    2,408 sqft

    Office space ideal for professional services and medical offices.

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    NC, Durham - Spaces Mangum Street
    NC, Durham - Spaces Mangum Street

    555 Mangum St, Unit 100, Durham, NC 27701

    $129-$54,775/Mo
    16 spaces available 11-2,612 sqft

    Find fully flexible work and meeting space in NC, Durham - Spaces Mangum Street. Book a tour & get info

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    RTP Imperial
    RTP Imperial

    4819 Emperor Blvd, Unit 400, Durham, NC 27703

    $129-$13,893/Mo
    16 spaces available 11-1,965 sqft

    Flexible workspace in RTP Imperial. Book a tour & get info

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    First Floor Office Unit For Lease
    First Floor Office Unit For Lease

    100-a-1906 E Nc Highway 54, Durham, NC 27713

    $45,045 SF/Yr
    2,145 sqft

    Flexible office unit with ample parking and high traffic count.

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    Retail-Office Suite with Dedicated Parking
    Retail-Office Suite with Dedicated Parking

    600 Foster St, Durham, NC 27701

    Contact for pricing
    2,285 sqft

    Short-term suite with flexible use options, finished concrete floors, high ceilings, natural light, and dedicated parking.

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    Luxury Mixed-Use Development Near Duke
    Luxury Mixed-Use Development Near Duke

    2812 & 2816 Erwin Rd |, Durham, NC 27705

    $25 SF/Yr
    118,000 sqft

    Class A mixed-use development near Duke University and hospitals.

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    Office Space in Durham
    Office Space in Durham

    324 Blackwell Street, Durham, NC 27701

    $29.95 SF/Yr
    9,778 sqft

    Office space available for lease in Durham, North Carolina.

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    Downtown Durham Office Space
    Downtown Durham Office Space

    614 West Main Street, Durham, NC 27701

    $38 SF/Yr
    20,126 sqft

    Office space in the heart of Downtown Durham's West Village.

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    Durham Office Space For Rent
    Durham Office Space For Rent

    2510 Meridian Parkway, Durham, NC 27713

    $27 SF/Yr
    51,566 sqft

    Office space for rent with easy access to nearby amenities.

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    Durham Office Space For Rent
    Durham Office Space For Rent

    2605 Meridian Parkway, Durham, NC 27713

    $28 SF/Yr
    49,387 sqft

    Prime location with easy access to major transportation routes.

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    Durham Office Space For Rent
    Durham Office Space For Rent

    2525 Meridian Parkway, Durham, NC 27713

    $28.50 SF/Yr
    59,039 sqft

    Office space available in a prime Durham location.

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    Office Space Near American Tobacco
    Office Space Near American Tobacco

    302 East Pettigrew Street, Durham, NC 27701

    $36.50 SF/Yr
    15,998 sqft

    Office space for rent adjacent to Durham's historic district.

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    Office Space in Durham
    Office Space in Durham

    700 West Main Street, Durham, NC 27701

    $30 SF/Yr
    7,943 sqft

    7943 SF office space available for lease.

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    Downtown Durham Office Space Available
    Downtown Durham Office Space Available

    433 W. Main Street, Durham, NC 27701

    Contact for pricing
    16,692 sqft

    Office spaces for lease in the heart of downtown Durham.

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    Office Space Available for Rent
    Office Space Available for Rent

    410 Blackwell St, Durham, NC 27701

    Contact for pricing
    10,448 sqft

    Office building with 10,448 square feet available for rent.

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    Durham Lab Space for Lease
    Durham Lab Space for Lease

    4505 Emperor Blvd, Durham, NC 27703

    Contact for pricing
    1,476 sqft

    Lab space available for lease in Durham, North Carolina.

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    Three-Story Multi-Tenant Office Building
    Three-Story Multi-Tenant Office Building

    2828 Croasdaile Drive, Durham, NC 27705

    Contact for pricing
    45,791 sqft

    Second and third floors are available with renovated lobby and balcony space, offering immediate occupancy and I-85 access.

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    Downtown Durham Office Space
    Downtown Durham Office Space

    212 West Main Street, Durham, NC 27701

    Contact for pricing
    41,000 sqft

    Full floor office space in downtown Durham's iconic tower.

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    Durham, NC Office Spaces Market Trends and Statistics

    Explore Office Spaces leasing options in Durham, NC with 52 listings featured on our commercial real estate exchange. The current inventory includes 364,278 square feet of properties with an estimated lease value of $46,083.

    Estimated lease rates for Office Spaces in Durham, NC begin at $4.63 SF/Yr, with an average of $2,425 /Mo and extend to $45,045.
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    Most Searched ZIP Codes in Durham, NC

    • 27701
    • 27713
    • 27703
    • 27705
    • 27707
    • 27704
    • 27215

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