Sign Up Successful!
You now have access to more from Realmo!
    For Lease
    • For Sale
    • For Lease
    • Recently Sold
    • Property Lookup
    • Brokers
    Office
    1
    • Retail
    • Restaurant
    • Office
    • Coworking
    • Medical Space
    • Automotive
    • Industrial
    • Warehouse
    • Flex
    • Hospitality
    • Sports & Entertainment
    • Specialty
    Price
    Price range
    $
    $
    Size
    Property size / sq.ft.
    AI Search

    Sikeston, MO Office Properties & Spaces for Lease

    Notify Me
    List
    Map
    Downtown Sikeston Office Space Available
    $4,500 / Mo
    4,273 SF

    Downtown Sikeston Office Space Available

    202 S Kingshighway St, Sikeston, MO 63801

    Commercial property in downtown Sikeston ready to be leased.

    • Prime downtown Sikeston location on a corner lot.
    • Large 7,638 sq ft building suitable for various business purposes.
    • Handicap accessible with ramp, parking, and restrooms.
    • Includes 15 parking spaces (2 handicap accessible).
    • Flexible layout with reception area, open space, offices, conference room, and break room.
    Updated: Feb 5
    View details
    Sikeston Office Suite For Rent
    $3,625 / Mo
    2,000 SF

    Sikeston Office Suite For Rent

    912 S Main St, Sikeston, MO 63801

    Recently-built office suite with four offices, bathroom, and kitchenette.

    • High visibility location on Sikeston's busiest corridor.
    • Ready for immediate occupancy with 4 finished offices.
    • Two entrances ideal for businesses with public traffic.
    • Includes a bathroom and kitchenette with refrigerator and table/chairs.
    • Located in a recently‑built (2020) strip center.
    Updated: Sep 22, 2025
    View details
    Based on your search, we've compiled 7 Potential Opportunities for your consideration. Besides 2 Active listings in Sikeston, MO, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 1 Properties for Sales.

    Explore Office Properties & Spaces for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Office Suite in Cape Girardeau
    $5,641 / Mo
    6,770 SF

    Office Suite in Cape Girardeau

    Office suite with high visibility and traffic in Cape Girardeau.

    450 Siemers Dr, Cape Girardeau, MO 63701
    View details
    West Park Mall Medical Office Space
    Contact for pricing
    79,122 SF

    West Park Mall Medical Office Space

    Missouri medical office suites for lease

    3049 William St, Cape Girardeau, MO 63703
    View details
    Anna Commercial Flex Space
    $13 SF/Yr
    2,900 SF

    Anna Commercial Flex Space

    Prime Anna location, 2,900 sq ft.

    1000 Leigh Ave, Anna, IL 62906
    View details
    Commercial Office Space in Anna, IL
    Contact for pricing

    Commercial Office Space in Anna, IL

    Office space available in the Wal-Mart Plaza area.

    1000 Leigh Ave, Anna, IL 62906
    View details

    Explore Similar Spaces for Sale in Sikeston, MO

    Consider Similar Space for Sale. We found 1 Spaces in Nearby Locations matching your search parameters.

    Downtown Sikeston Commercial Office Building
    $279,000
    4,273 SF

    Downtown Sikeston Commercial Office Building

    Commercial property with endless business opportunities in downtown Sikeston.

    202 S Kingshighway St, Sikeston, MO 63801
    View details

    Sikeston, MO Office Properties & Spaces Leasing Opportunities Market Analysis

    Explore Office Properties & Spaces leasing options in Sikeston, MO with 3 listings featured on our commercial real estate exchange. The current inventory includes 273,251,880 square feet of properties with an estimated lease value of $34 SF/Yr.

    Estimated lease rates for Office Properties & Spaces in Sikeston, MO begin at $12 SF/Yr, with an average of $17 SF/Yr and extend to $21 SF/Yr.
    List
    Map

    Popular Searches in Sikeston, MO

    Most Searched ZIP Codes in Sikeston, MO

    • 63801

    Select Neighborhood

    Google sign-in failed. Please try again or use another login method.