Cape Girardeau, MO Office Units for Rent & Lease

Updated: Nov 14, 2025

Turn-Key Office Suite

450 Siemers Drive, Cape Girardeau, MO 63701

$5,642/Mo

6,770 sqft

Office suite with solar heating, forced air heating, and natural gas
Central air and electric cooling
Driveway parking
Year built 1991
Utilities include cable available; served by public water and public sewer

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Updated: Jul 1, 2025

Renovated Office Building with Road Frontage

230 N Sprigg Street, Cape Girardeau, MO 63701

$2,500/Mo

2,937 sqft

Massive building with brick construction and flat roof
Offered for sale or lease with road frontage on N Sprigg St
Almost 3,000 sq ft of renovated space
BRAND NEW A/C, roof, gutters, flooring, fixtures, bathrooms, kitchenette, siding, and newly tuckpointed
Utilities include public water and public sewer; forced air heating

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Flex Warehouse with Office

2285 Sacajawea Lane, Cape Girardeau, MO 63701

$3,250/Mo

4,576 sqft

Flex facility features heated warehouse/shop space, office buildout, mezzanine, and four drive-in overhead doors.

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Versatile Commercial Space on Kingshighway

500 N Kingshighway St, Cape Girardeau, MO 63701

$3,650/Mo

3,500 sqft

3,500 SF commercial property suitable for retail, office, or service.

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Professional Office Building For Rent

720 Forest Ave, Cape Girardeau, MO 63701

$1,100/Mo

1,218 sqft

1,218 SF professional office building in good location.

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Second-Floor Office Suite

2b-301 Broadway St, Cape Girardeau, MO 63701

$2,600/Mo

1,250 sqft

Second-floor office suite with reception, private office, conference space, and an open area for flexible work setups.

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Retail and Office Storefront

211 Merriwether St, Cape Girardeau, MO 63703

$1,000/Mo

1,300 sqft

Flexible 1,300 SF storefront layout with retail frontage and included office spaces, suited for mixed-use operations.

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Office Space for Lease

2027 Broadway Street, Cape Girardeau, MO 63701

$1,958/Mo

Office space available for lease at 2027 Broadway Street in Cape Girardeau.

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Flex Space with Off-Street Parking

213 Clark Street, Cape Girardeau, MO 63701

$1,500/Mo

Flexible 1,172 SF flex space in an M-1 district, suited for day care, office, or professional service use.

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Restaurant-Ready Office/Retail Suite

820 N Sprigg St, Cape Girardeau, MO 63701

Contact for pricing

3,000 sqft

Suite 1 offers an open layout and existing restaurant infrastructure with street visibility across from Towers Hall.

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Warehouse with Drive-In Dock

211 N Spring Avenue C, Cape Girardeau, MO 63701

$6 SF/Yr

13,875 sqft

13,875 SF warehouse with office and drive-in dock.

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Retail Storefront with Office Space

221 Merriwether Street, Cape Girardeau, MO 63703

Contact for pricing

1,275 sqft

Downtown retail storefront with office space for rent.

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Office Space with Reception Area

Cape Girardeau, MO 63701

$1,000/Mo

1,200 sqft

Office space featuring reception, offices, kitchen, and bathroom.

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Based on your search, we've compiled 23 Potential Opportunities for your consideration. Besides 13 Active listings in Cape Girardeau, MO, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 6 Properties for Sales.

Office Units for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

New Retail/Office Space Available

E-600 N Main Street, Sikeston, MO 63801

$1,950/Mo

1,300 sqft

Prime location with high traffic and ample parking.

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Flex Space with Overhead Door

2015 South Perryville Boulevard, Perryville, MO 63775

Contact for pricing

3,000 sqft

Flexible 60-by-50 suite with white-box finish, multiple entrances, and utilities included for streamlined move-in.

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Flexible Downtown Retail-Office Suite

519 N Main St, Perryville, MO 63775

Contact for pricing

4,000 sqft

Commercial space offers a flexible layout with multiple offices, conference rooms, and ADA-accessible restrooms.

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Two-Unit Flex Warehouse Facility

300 Matthews Lane, Sikeston, MO 63801

$5,000/Mo

Two separate warehouse units are available, including a dock-equipped front space and a back unit with offices and shop area.

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Similar Spaces for Sale in Cape Girardeau, MO

Consider Similar Space for Sale. We found 6 Spaces matching your search parameters.

Medical Office Condominiums in Building

937 Broadway Street, Cape Girardeau, MO 63701

$99,000

4,300 sqft

Four commercial condominium units are located inside the historic Cape Girardeau Medical Arts building on Broadway Street.

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15,100 SF Office Suite

301 South Broadview Street, Cape Girardeau, MO 63703

Contact for pricing

15,100 sqft

Two office spaces totaling 15,100 SF offer open areas, private offices, restrooms, and meeting rooms.

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Cape Girardeau Commercial Space Available

151 S Mount Auburn Rd, Cape Girardeau, MO 63703

Contact for pricing

1,250 sqft

Flexible commercial space for office, retail, or service businesses.

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Prime Commercial Space on Mount Auburn

326 S. Mount Auburn, Cape Girardeau, MO 63703

Contact for pricing

1,660 sqft

Versatile commercial space with parking and high visibility.

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Prime Location Office Suites

440 S. Mount Auburn Road, Cape Girardeau, MO 63703

Contact for pricing

1,348 sqft

Excellent visibility office suites near I-55 and Highway 74.

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Medical Office Condominiums

202300305306-937 Broadway St, Cape Girardeau, MO 63701

$99,000

4,300 sqft

Four office condominium units inside a historic medical arts building with established downtown traffic patterns.

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