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    Cape Girardeau, MO Office Units for Lease

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    Saint Louis, MO Louis, MO Kansas City, MO
    9 results
    Office Suite in Cape Girardeau
    $5,641 /Mo
    6,770 SF

    Office Suite in Cape Girardeau

    450 Siemers Drive, Cape Girardeau, MO 63701

    Office suite with high visibility and traffic in Cape Girardeau.

    • Turn‑key ready office suite
    • High visibility and high traffic location
    • Highway/Interstate frontage
    • Heating: Forced Air, Natural Gas, Solar
    • Cooling: Central Air, Electric
    Updated: Nov 14, 2025
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    Renovated Commercial Space For Lease
    $2,500 /Mo
    2,937 SF

    Renovated Commercial Space For Lease

    230 N Sprigg Street, Cape Girardeau, MO 63701

    Renovated commercial space with high visibility in a prime location.

    • Prime location with high traffic and road frontage on N Sprigg St, offering excellent visibility in the Business District.
    • Almost 3000 sq ft of renovated space suitable for multiple offices or service providers.
    • Completely renovated with brand new A/C, roof, gutters, flooring, fixtures, bathrooms, kitchenette, and siding.
    • Significant rental income potential.
    • Located downtown, in the midst of exciting activities.
    Updated: Jun 30, 2025
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    Historic Art Deco Landmark Space
    $2,900 /Mo

    Historic Art Deco Landmark Space

    Restored historic building in downtown Cape Girardeau's commercial district.

    824 Broadway St, Cape Girardeau, MO 63701
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    Professional Office Building For Rent
    $1,100 /Mo
    1,218 SF

    Professional Office Building For Rent

    1,218 SF professional office building in good location.

    720 Forest Ave, Cape Girardeau, MO 63701
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    600 SF Commercial Storage Space
    $400 /Mo
    600 SF

    600 SF Commercial Storage Space

    Commercial space ideal for off-site storage with drive-in door.

    2222 Kingsway Dr, Suite C, Cape Girardeau, MO 63701
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    Spacious Office Space For Rent
    Contact for pricing
    15,100 SF

    Spacious Office Space For Rent

    15,100 SF office space near dining and shopping.

    301 South Broadview Street, Cape Girardeau, MO 63703
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    Prime Retail/Office Space Available
    Contact for pricing
    2,300 SF

    Prime Retail/Office Space Available

    New 2,300 SF space ideal for retail or office.

    3465 William, Cape Girardeau, MO 63703
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    Retail Storefront with Office Space
    Contact for pricing
    1,275 SF

    Retail Storefront with Office Space

    Downtown retail storefront with office space for rent.

    221 Merriwether Street, Cape Girardeau, MO 63703
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    Commercial Space For Lease
    Contact for pricing

    Commercial Space For Lease

    Commercial space available for lease at 3049 William St.

    3049 William St, Cape Girardeau, MO 63703
    View details
    Based on your search, we've compiled 25 Potential Opportunities for your consideration. Besides 9 Active listings in Cape Girardeau, MO, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 12 Properties for Sales.

    Explore Office Units for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Prime Retail Space in Paducah
    $30 SF/Yr

    Prime Retail Space in Paducah

    Multi-tenant center with customizable spaces in high-growth area.

    5360 Highway 60 West, Paducah, KY 42001
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    Professional Space Near Main Intersection
    $1,000 /Mo

    Professional Space Near Main Intersection

    Prime location, high visibility, and flexible floor plan.

    1226 Linn St, Suite D, Sikeston, MO 63801
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    Sikeston Medical/Office Space Available
    Contact for pricing

    Sikeston Medical/Office Space Available

    Multi-tenant commercial building near Missouri Delta Medical Center.

    808 E Wakefield Ave, Sikeston, MO 63801
    View details
    Corner Space in Olivet Village
    Contact for pricing

    Corner Space in Olivet Village

    Unfinished corner space in the Olivet Village area for rent.

    3201 Olivet Church Rd, Paducah, KY 42001
    View details

    Explore Similar Spaces for Sale in Cape Girardeau, MO

    Consider Similar Space for Sale. We found 12 Spaces matching your search parameters.

    Versatile Riverfront Commercial Property
    $400,000
    4,400 SF

    Versatile Riverfront Commercial Property

    Prime riverfront property suitable for office, restaurant, warehouse, or mixed-use.

    450 N Main Street, Cape Girardeau, MO 63701
    View details
    Versatile Riverfront Commercial Property
    $475,000
    7,044 SF

    Versatile Riverfront Commercial Property

    Flexible commercial space with riverfront location and development potential.

    308 N Main Street, Cape Girardeau, MO 63701
    View details
    Versatile Commercial Property For Sale
    $295,000
    2,920 SF

    Versatile Commercial Property For Sale

    High-visibility commercial property with flexible layout and spacious attached warehouse.

    225 Clark Avenue, Cape Girardeau, MO 63701
    View details
    Historic Bar and Office Space
    $499,900
    4,630 SF

    Historic Bar and Office Space

    Downtown Cape Girardeau property featured in the movie Gone Girl.

    117 Themis Street, Cape Girardeau, MO 63701
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    Downtown Cape Girardeau Office/Flex Space
    Contact for pricing
    5,225 SF

    Downtown Cape Girardeau Office/Flex Space

    5,225 SF office/flex space in downtown Cape Girardeau.

    122 S. Spanish St., Cape Girardeau, MO 63701
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    Cape Girardeau Commercial Space Available
    Contact for pricing
    1,250 SF

    Cape Girardeau Commercial Space Available

    Flexible commercial space for office, retail, or service businesses.

    151 S Mount Auburn Rd, Cape Girardeau, MO 63703
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    Prime Commercial Space on Mount Auburn
    Contact for pricing
    1,660 SF

    Prime Commercial Space on Mount Auburn

    Versatile commercial space with parking and high visibility.

    326 S. Mount Auburn, Cape Girardeau, MO 63703
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    Retail/Office Space Near I-55
    Contact for pricing

    Retail/Office Space Near I-55

    Prime location near I-55 and West Park Mall.

    3065 William, Cape Girardeau, MO 63703
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    Prime Location Office Suites
    Contact for pricing
    1,348 SF

    Prime Location Office Suites

    Excellent visibility office suites near I-55 and Highway 74.

    440 S. Mount Auburn Road, Cape Girardeau, MO 63703
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    Warehouse Space in Central Cape
    Contact for pricing
    50,000 SF

    Warehouse Space in Central Cape

    Up to 50,000 SF available with flexible space sizes.

    334 N. Broadview, Cape Girardeau, MO 63701
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    Commercial Land in Central Location
    Contact for pricing

    Commercial Land in Central Location

    1.2 acres suitable for retail or office development.

    1749 Independence, Cape Girardeau, MO 63701
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    Versatile Commercial Property For Sale
    $295,000

    Versatile Commercial Property For Sale

    Commercial property with retail, office, and warehouse space.

    225 Clark St, Cape Girardeau, MO 63701
    View details

    Cape Girardeau, MO Office Units Leasing Opportunities Market Analysis

    Explore Office Units leasing options in Cape Girardeau, MO with 9 listings featured on our commercial real estate exchange. The current inventory includes 422,836,920 square feet of properties with an estimated lease value of $20 SF/Yr.

    Estimated lease rates for Office Units in Cape Girardeau, MO begin at $10 SF/Yr, with an average of $10 SF/Yr and extend to $10 SF/Yr.
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    Most Searched ZIP Codes in Cape Girardeau, MO

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