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    Cape Girardeau, MO
    Office Units

    Cape Girardeau, MO Office Units for Lease

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    Scott City, MO Jackson, MO Anna, IL
    18 properties
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    Office Units with Highway Frontage
    Updated: Nov 14, 2025
    Office Units with Highway Frontage

    450 Siemers Drive, Cape Girardeau, MO 63701

    $5,642/Mo
    6,770 sqft
    6,770 square feet of office space
    Built in 1991
    Business park setting with highway and interstate frontage
    Central air conditioning with electric, natural gas, and forced‑air heating
    Driveway parking available
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    Office Unit with Garage
    Updated: Oct 2
    Office Unit with Garage

    1000 Kingsway Drive, Cape Girardeau, MO 63701

    $2,348/Mo
    0.63 AC lot
    1,740 finished square feet
    0.632‑acre property
    Two‑car garage and parking lot
    1.5 bathrooms
    Built in 1979
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    Office Unit with Garage
    Office Unit with Garage

    1000 Kingsway Drive, Cape Girardeau, MO 63701

    $1,885/Mo
    0.63 AC lot

    The lease is structured as NNN, with terms to be negotiated.

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    Restaurant-Ready Office/Retail Suite
    Restaurant-Ready Office/Retail Suite

    820 N Sprigg St - Suites 3-4, Cape Girardeau, MO 63701

    $18 SF/Yr
    3,000 sqft

    Suite 1 offers an open layout and existing restaurant infrastructure with street visibility across from Towers Hall.

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    Flexible Office Unit
    Flexible Office Unit

    1469 N Kingshighway Street, Cape Girardeau, MO 63701

    $1,128/Mo

    Adaptable commercial unit with private bathroom and expansion potential for office or service uses.

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    Updated Office Suite
    Updated Office Suite

    2027 Broadway Street, Cape Girardeau, MO 63701

    $1,958/Mo
    2.70 AC lot

    Second-floor workspace offers private offices, open collaboration space, a kitchenette, and secure badge access.

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    Office Unit with Private Offices
    Office Unit with Private Offices

    C-1020 N Kingshighway Street, Cape Girardeau, MO 63701

    $1,200/Mo
    1,050 sqft

    Flexible suite layout includes reception, open workspace, break room, and private restroom.

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    Retail Suite with Pylon Signage
    Retail Suite with Pylon Signage

    3065 William St Unit 202, Cape Girardeau, MO 63703

    $1,285/Mo
    976 sqft

    Flexible commercial suite with on-site signage and access to nearby retail, office, hospitality, and dining uses.

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    Office Suite with Private Offices
    Office Suite with Private Offices

    1020 N. Kingshighway, Suite C, Cape Girardeau, MO 63701

    $1,200/Mo
    1,050 sqft

    Flexible commercial suite with reception, work areas, natural light, parking, and signage options for office or service-oriented use.

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    Executive Office Suite
    Executive Office Suite

    2a-301 Broadway St, Cape Girardeau, MO 63701

    $5,633/Mo
    2,600 sqft

    Second-floor workspace with private offices, reception, breakroom, and two restrooms.

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    Corner Executive Office Unit
    Corner Executive Office Unit

    301 Broadway St, Cape Girardeau, MO 63701

    $2,708/Mo
    2,600 sqft

    Second-floor corner suite with private offices, reception, breakroom, and two restrooms.

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    Versatile Commercial Space on Kingshighway
    Versatile Commercial Space on Kingshighway

    500 N Kingshighway St, Cape Girardeau, MO 63701

    $3,650/Mo
    3,500 sqft

    3,500 SF commercial property suitable for retail, office, or service.

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    Second-Floor Office Suite
    Second-Floor Office Suite

    2b-301 Broadway St, Cape Girardeau, MO 63701

    $2,600/Mo
    1,250 sqft

    Second-floor office suite with reception, private office, conference space, and an open area for flexible work setups.

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    Flex Space With Climate-Controlled Warehouse
    Flex Space With Climate-Controlled Warehouse

    H-760 S Kingshighway, Cape Girardeau, MO

    $4,500/Mo

    Versatile commercial space combines offices, showroom area, and climate-controlled warehouse functionality.

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    Office Units with Private Offices
    Office Units with Private Offices

    C-760 S Kingshighway, Cape Girardeau, MO

    $4,995/Mo

    Flexible office layout combines open work areas with enclosed offices and convenient customer parking.

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    Flexible Office Unit
    Flexible Office Unit

    2905 Independence Street Suite D, Cape Girardeau, MO 63703

    $800/Mo

    Professional suite with reception space, private rooms, a bathroom, and dedicated storage.

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    Brand New Office/Retail Center
    Brand New Office/Retail Center

    440 S Mount Auburn Rd Unit 102, Cape Girardeau, MO 63703

    $2,466/Mo

    Brand new office and retail center offering suites starting at 1,088 sf.

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    Spacious Office Space For Rent
    Spacious Office Space For Rent

    301 South Broadview Street, Cape Girardeau, MO 63703

    Contact for pricing
    15,100 sqft

    15,100 SF office space near dining and shopping.

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    Based on your search, we've compiled 27 Potential Opportunities for your consideration. Besides 18 Active listings in Cape Girardeau, MO, we suggest exploring alternatives. Similar 9 Properties for Sales.

    Similar Spaces for Sale in Cape Girardeau, MO

    Consider Similar Space for Sale. We found 9 Spaces matching your search parameters.

    Brick Flex Space with Warehouse
    Brick Flex Space with Warehouse

    333 N Main Street, Cape Girardeau, MO 63701

    $425,000
    0.25 AC lot

    Brick commercial property combining warehouse capacity and finished offices in a downtown Cape Girardeau setting.

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    Historic Office Condominium Units
    Historic Office Condominium Units

    937 Broadway Street, Cape Girardeau, MO 63701

    $99,000
    4,300 sqft

    Multiple commercial condominium suites in a brick downtown building with central air, public water, and public sewer.

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    15,100 SF Office Suite
    15,100 SF Office Suite

    301 South Broadview Street, Cape Girardeau, MO 63703

    Contact for pricing
    15,100 sqft

    Two office spaces totaling 15,100 SF offer open areas, private offices, restrooms, and meeting rooms.

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    Cape Girardeau Commercial Space Available
    Cape Girardeau Commercial Space Available

    151 S Mount Auburn Rd, Cape Girardeau, MO 63703

    Contact for pricing
    1,250 sqft

    Flexible commercial space for office, retail, or service businesses.

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    13,875 SF Warehouse For Sale
    13,875 SF Warehouse For Sale

    211 N. Spring Ave., Unit C, Cape Girardeau, MO 63701

    Contact for pricing
    13,875 sqft

    13,875 SF warehouse with office, drive-in doors, and dock.

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    Prime Commercial Space on Mount Auburn
    Prime Commercial Space on Mount Auburn

    326 S. Mount Auburn, Cape Girardeau, MO 63703

    Contact for pricing
    1,660 sqft

    Versatile commercial space with parking and high visibility.

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    Cape Girardeau, MO Office Units Lease Rates & Market Statistics

    Browse 18 Office Units for lease in Cape Girardeau, MO on Realmo, a commercial real estate marketplace serving the Cape Girardeau area. The current inventory totals 37,896 square feet of properties — an average of ~2,100 SF per listing.

    Office Units lease rates in Cape Girardeau range from $10 SF/Yr at the entry level to $26 SF/Yr at the top of the market, averaging $16.84 SF/Yr. That's a 3x spread between entry-level and premium space, making side-by-side comparison of asking rents and lease terms essential. The local average of $16.84 SF/Yr is 37% below the Missouri state average of $26.67 SF/Yr.

    Cape Girardeau accounts for 100% of the 18 office units currently available across Cape Girardeau County. Office Units make up 82% of the 22 Office Spaces currently for lease in Cape Girardeau, with asking rates averaging $16.84 SF/Yr — 10% above the citywide Office Spaces average of $15.24 SF/Yr.

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    Popular Searches in Cape Girardeau, MO

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    Most Searched ZIP Codes in Cape Girardeau, MO

    • 63701
    • 63703

    Featured Cape Girardeau Real Estate Agencies

    Realmo connects you with licensed Cape Girardeau CRE brokers providing property specifications, local market pricing, and commercial transaction underwriting support.

    Edge Realty
    2511 Independence St, Ste 100 Cape Girardeau, MO 63703
    Phone: 15733358111
    www.capeareahomes.com
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