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    Cape Girardeau, MO
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    Cape Girardeau, MO Office Units for Lease

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    Scott City, MO Jackson, MO Anna, IL
    15 properties
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    Office Units with Highway Frontage
    Updated: Nov 14, 2025
    Office Units with Highway Frontage

    450 Siemers Drive, Cape Girardeau, MO 63701

    $5,642/Mo
    6,770 sqft
    6,770 square feet of office space
    Built in 1991
    Business park setting with highway and interstate frontage
    Central air conditioning with electric, natural gas, and forced‑air heating
    Driveway parking available
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    Second-Floor Office Suite
    Updated: Jun 18
    Second-Floor Office Suite

    2027 Broadway Street, Cape Girardeau, MO 63701

    $1,958/Mo
    2.70 AC lot
    Second‑floor office suite in Montgomery Bank’s Broadway location
    Updated suite with new carpet, paint, and LED lighting
    Includes 7 private offices plus a large open space for cubicles, training, or a conference room
    Secure 24/7 access via badge entry; access via elevator or stairs
    Kitchenette includes space for a small refrigerator and microwave
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    Flexible Office Unit
    Flexible Office Unit

    1469 N Kingshighway Street, Cape Girardeau, MO 63701

    $1,128/Mo

    Commercial space with a private bathroom and owner-approved build-to-suit options.

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    Restaurant-Ready Office/Retail Suite
    Restaurant-Ready Office/Retail Suite

    820 N Sprigg St - Suites 3-4, Cape Girardeau, MO 63701

    $18 SF/Yr
    3,000 sqft

    Suite 1 offers an open layout and existing restaurant infrastructure with street visibility across from Towers Hall.

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    Office Unit with Private Offices
    Office Unit with Private Offices

    C-1020 N Kingshighway Street, Cape Girardeau, MO 63701

    $1,200/Mo
    1,050 sqft

    Flexible suite layout includes reception, open workspace, break room, and private restroom.

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    Retail Suite with Pylon Signage
    Retail Suite with Pylon Signage

    3065 William St Unit 202, Cape Girardeau, MO 63703

    $1,285/Mo
    976 sqft

    Flexible commercial suite with on-site signage and access to nearby retail, office, hospitality, and dining uses.

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    Office Suite with Private Offices
    Office Suite with Private Offices

    1020 N. Kingshighway, Suite C, Cape Girardeau, MO 63701

    $1,200/Mo
    1,050 sqft

    Flexible commercial suite with reception, work areas, natural light, parking, and signage options for office or service-oriented use.

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    Flexible Office Units with Private Entrances
    Flexible Office Units with Private Entrances

    106 Farrar Drive, Cape Girardeau, MO 63703

    $2,500/Mo
    2,580 sqft

    Adaptable office suites offer open workspace, private offices, and a dedicated breakroom.

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    Executive Office Suite
    Executive Office Suite

    2a-301 Broadway St, Cape Girardeau, MO 63701

    $5,633/Mo
    2,600 sqft

    Second-floor workspace with private offices, reception, breakroom, and two restrooms.

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    Corner Executive Office Unit
    Corner Executive Office Unit

    301 Broadway St, Cape Girardeau, MO 63701

    $2,708/Mo
    2,600 sqft

    Second-floor corner suite with private offices, reception, breakroom, and two restrooms.

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    Versatile Commercial Space on Kingshighway
    Versatile Commercial Space on Kingshighway

    500 N Kingshighway St, Cape Girardeau, MO 63701

    $3,650/Mo
    3,500 sqft

    3,500 SF commercial property suitable for retail, office, or service.

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    Second-Floor Office Suite
    Second-Floor Office Suite

    2b-301 Broadway St, Cape Girardeau, MO 63701

    $2,600/Mo
    1,250 sqft

    Second-floor office suite with reception, private office, conference space, and an open area for flexible work setups.

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    Office Units with Private Offices
    Office Units with Private Offices

    C-760 S Kingshighway, Cape Girardeau, MO

    $4,995/Mo

    Flexible office layout combines open work areas with enclosed offices and convenient customer parking.

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    Spacious Office Space For Rent
    Spacious Office Space For Rent

    301 South Broadview Street, Cape Girardeau, MO 63703

    Contact for pricing
    15,100 sqft

    15,100 SF office space near dining and shopping.

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    Brand New Office/Retail Center
    Brand New Office/Retail Center

    440 S Mt Auburn Rd, Cape Girardeau, MO 63703

    Contact for pricing

    Brand new office and retail center offering suites starting at 1,088 sf.

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    Based on your search, we've compiled 27 Potential Opportunities for your consideration. Besides 15 Active listings in Cape Girardeau, MO, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 8 Properties for Sales.

    Office Units for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    New Retail/Office Space Available
    New Retail/Office Space Available

    E-600 N Main Street, Sikeston, MO 63801

    $1,950/Mo
    1,300 sqft

    Prime location with high traffic and ample parking.

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    Office Building with Street-Front Space
    Office Building with Street-Front Space

    6 W Sainte Marie Street, Perryville, MO 63775

    $2,000/Mo
    0.09 AC lot

    Street-front space with a public entrance and an upper level featuring six offices, kitchen/break area, and bathroom.

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    Flexible Office Suite
    Flexible Office Suite

    1226 Linn Street Suite C, Sikeston, MO 63801

    $1,500/Mo

    Adaptable layout supports office, studio, or showroom operations.

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    Flex Space with Overhead Door
    Flex Space with Overhead Door

    2015 South Perryville Boulevard, Perryville, MO 63775

    Contact for pricing
    3,000 sqft

    Flexible 60-by-50 suite with white-box finish, multiple entrances, and utilities included for streamlined move-in.

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    Similar Spaces for Sale in Cape Girardeau, MO

    Consider Similar Space for Sale. We found 8 Spaces matching your search parameters.

    Brick Flex Space with Warehouse
    Brick Flex Space with Warehouse

    333 N Main Street, Cape Girardeau, MO 63701

    $425,000
    0.25 AC lot

    Brick commercial property combining warehouse capacity and finished offices in a downtown Cape Girardeau setting.

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    Historic Office Condominium Units
    Historic Office Condominium Units

    937 Broadway Street, Cape Girardeau, MO 63701

    $99,000
    4,300 sqft

    Multiple commercial condominium suites in a brick downtown building with central air, public water, and public sewer.

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    15,100 SF Office Suite
    15,100 SF Office Suite

    301 South Broadview Street, Cape Girardeau, MO 63703

    Contact for pricing
    15,100 sqft

    Two office spaces totaling 15,100 SF offer open areas, private offices, restrooms, and meeting rooms.

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    Cape Girardeau Commercial Space Available
    Cape Girardeau Commercial Space Available

    151 S Mount Auburn Rd, Cape Girardeau, MO 63703

    Contact for pricing
    1,250 sqft

    Flexible commercial space for office, retail, or service businesses.

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    13,875 SF Warehouse For Sale
    13,875 SF Warehouse For Sale

    211 N. Spring Ave., Unit C, Cape Girardeau, MO 63701

    Contact for pricing
    13,875 sqft

    13,875 SF warehouse with office, drive-in doors, and dock.

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    Prime Commercial Space on Mount Auburn
    Prime Commercial Space on Mount Auburn

    326 S. Mount Auburn, Cape Girardeau, MO 63703

    Contact for pricing
    1,660 sqft

    Versatile commercial space with parking and high visibility.

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    Prime Location Office Suites
    Prime Location Office Suites

    440 S. Mount Auburn Road, Cape Girardeau, MO 63703

    Contact for pricing
    1,348 sqft

    Excellent visibility office suites near I-55 and Highway 74.

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    Medical Office Condominiums
    Medical Office Condominiums

    202300305306-937 Broadway St, Cape Girardeau, MO 63701

    $99,000
    4,300 sqft

    Four office condominium units inside a historic medical arts building with established downtown traffic patterns.

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    Cape Girardeau, MO Office Units Lease Rates & Market Statistics

    Browse 15 Office Units for lease in Cape Girardeau, MO on Realmo, a commercial real estate marketplace serving the Cape Girardeau area. The current inventory totals 40,476 square feet of properties — an average of ~2,700 SF per listing.

    Office Units lease rates in Cape Girardeau range from $10 SF/Yr at the entry level to $26 SF/Yr at the top of the market, averaging $16.26 SF/Yr. That's a 3x spread between entry-level and premium space, making side-by-side comparison of asking rents and lease terms essential. The local average of $16.26 SF/Yr is 38% below the Missouri state average of $26.30 SF/Yr.

    Cape Girardeau accounts for 100% of the 15 office units currently available across Cape Girardeau County. Office Units make up 79% of the 19 Office Spaces currently for lease in Cape Girardeau, with asking rates in line with the citywide Office Spaces average.

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    Popular Searches in Cape Girardeau, MO

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    Most Searched ZIP Codes in Cape Girardeau, MO

    • 63701
    • 63703

    Featured Cape Girardeau Real Estate Agencies

    Realmo connects you with licensed Cape Girardeau CRE brokers providing property specifications, local market pricing, and commercial transaction underwriting support.

    Edge Realty
    2511 Independence St, Ste 100 Cape Girardeau, MO 63703
    Phone: 15733358111
    www.capeareahomes.com

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