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Sioux City, IA Office Spaces for Lease

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South Sioux City, NE Dakota Dunes, SD Sergeant Bluff, IA
28 properties
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Medical Office Suite
Updated: Nov 21, 2017
Medical Office Suite

5500 Sergeant Road, Sioux City, IA 51106

$15 SF/Yr
1.91 AC lot
Suite 203 offers approximately 2,216 USF
Vanilla box delivery supports medical or office buildout
Two‑story office center completed in 2017
Existing center tenants include Bruening Eye Care and Children's Medical
Access to the Hwy 75 Bypass and Hwy 20 via I‑29
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Retail or Office Suite
Updated: Jul 26
Retail or Office Suite

2001 Hamilton Blvd, Ste D, Sioux City, IA 51103

$14 SF/Yr
2,420 sqft
2,420 SF retail/office space available in a building built in 1987
Directly on Hamilton Boulevard with approximately 29,000 vehicles per day and excellent frontage/visibility
Glass storefront entry with signage opportunity on Hamilton Blvd
Shell‑ready interior with existing bathrooms for tenant buildout
Abundant natural light throughout the space
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Class A Office Condo with Skywalk Access
Class A Office Condo with Skywalk Access

700 4th, Sioux City, IA 51101

$10 SF/Yr
5,228 sqft

Remodeled Class A office space built in 2012 with direct skywalk access to downtown destinations and parking.

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Turn a Listing Into an Investment Snapshot Cap Rate, Potential NOI, Demand score for every listing. Go To Analytics Center
Downtown Office with Extensive Amenities
Downtown Office with Extensive Amenities

401 Douglas St, Sioux City, IA 51101

$12.48 SF/Yr
12,000 sqft

Updated office space with access to many amenities and services.

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Northbrook Drive Warehouse For Rent
Northbrook Drive Warehouse For Rent

3218 Northbrook Dr, Ste A, Sioux City, IA 51105

$3,375/Mo
4,500 sqft

Flexible warehouse space with dock and drive-in door.

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Renovated Office Space with Kitchenette
Renovated Office Space with Kitchenette

2020 Indian Hills Dr, Sioux City, IA 51104

$7.57 SF/Yr
6,016 sqft

Newly renovated office space featuring an open floor plan and kitchenette.

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Professional Office Suite
Professional Office Suite

600 4th Street, Sioux City, IA 51101

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1,197 sqft

Private offices, a kitchenette, and shared conference facilities support an established workplace setting.

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Professional Office Suites
Professional Office Suites

6101 Whispering Creek Drive, Sioux City, IA 51106

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2,225 sqft

Two modern office suites with front-door parking are available individually or combined in a shared, well-maintained building.

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Downtown Office Suite in Historic Building
Downtown Office Suite in Historic Building

613 Pierce St, Sioux City, IA 51101

$9 SF/Yr

Second-floor office suite with a lobby reception desk, open work area, kitchenette, and attached parking ramp access.

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Corner Retail Space with Showroom
Corner Retail Space with Showroom

1625 Hamilton Boulevard, Sioux City, IA 51103

$17.75 SF/Yr

Well-maintained commercial space with an open showroom, private office, storage room, and two restrooms.

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Professional Office Space Available
Professional Office Space Available

839 Gordon Dr, Sioux City, IA 51101

$12 SF/Yr

Move-in ready office space with drive-through, available August 2026.

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Stylish Office Space For Rent
Stylish Office Space For Rent

1101 4th Street, Sioux City, IA 51101

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1,696 sqft

1,696 SF office space with abundant natural light.

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Prime Commercial Space Available
Prime Commercial Space Available

1380 Hamilton Boulevard, Sioux City, IA 51103

$20 SF/Yr

High-end commercial space with offices, conference room, and more.

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Medical Office Space For Rent
Medical Office Space For Rent

5865 Sunnybrook Drive, Sioux City, IA 51106

$28 SF/Yr

Former dialysis center near Unity Point St. Lukes.

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Sioux City Office Suite For Rent
Sioux City Office Suite For Rent

4700 Gordon Dr, Ste 201, Sioux City, IA 51106

$10 SF/Yr

Office suite with open rooms, private office, restroom, conference room.

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Medical Office Space Available
Medical Office Space Available

2421 Pierce Street, Sioux City, IA 51104

$10 SF/Yr

Medical office space featuring multiple exam rooms and a laboratory.

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Main Floor Office Suite
Main Floor Office Suite

3133 Floyd Boulevard, Suite D, Sioux City, IA 51108

$14 SF/Yr

Main floor office suite with five private offices, open bullpen, and an IT room, plus 40 parking stalls.

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Medical Center With Covered Drop-Off
Medical Center With Covered Drop-Off

Sioux City, IA 51106

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6,030 sqft

Healthcare facility with adaptable clinical space, dedicated arrival coverage, and substantial on-site parking.

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Downtown Office and Retail Space
Downtown Office and Retail Space

600 4th St, Sioux City, IA 51101

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Office and retail space available in downtown Sioux City.

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Professional Office Space Available
Professional Office Space Available

Sioux City, IA 51101

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Highly visible office space with drive-through, available August 2026.

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Premier Office Space in Sioux City
Premier Office Space in Sioux City

600 4th St, Sioux City, IA 51101

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2,308 sqft

Class A office space with city views and skywalk access.

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Bank Space with Drive-Through Potential
Bank Space with Drive-Through Potential

Sioux City, IA 51103

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Fully built-out banking premises with private offices, customer areas, and specialized vault and deposit-box rooms.

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Retail Space with Pylon Signage
Retail Space with Pylon Signage

Sioux City, IA 51105

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Flexible commercial layout includes an open customer area, private work rooms, and a kitchenette.

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Sioux City Office Building
Sioux City Office Building

2800 Gordon Dr, Sioux City, IA 51106

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11,640 sqft

Office building in Sioux City with highway access and parking.

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Sioux City, IA Office Spaces Lease Rates & Market Statistics

Browse 28 Office Spaces for lease in Sioux City, IA on Realmo, a commercial real estate marketplace serving the Sioux City area. The current inventory totals 68,204 square feet of properties — an average of ~2,450 SF per listing.

Office Spaces lease rates in Sioux City range from $7.57 SF/Yr at the entry level to $28 SF/Yr at the top of the market, averaging $13.49 SF/Yr. That's a 4x spread between entry-level and premium space, making side-by-side comparison of asking rents and lease terms essential. At $13.49 SF/Yr, the local average runs 29% below Iowa's state average of $18.92 SF/Yr.

Sioux City accounts for 90% of the 31 office spaces currently available across Woodbury County, where a nearby market includes Sergeant Bluff. By space type, the market includes 22 office units, 4 medical office space listings and 3 office buildings — office buildings typically offer the lowest entry point, while medical office space commands the highest rates.

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