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    Port Saint Lucie, FL Office Properties & Spaces for Lease

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    Miami, FL Jacksonville, FL Orlando, FL
    17 results
    Medical Building in Port St. Lucie
    $25 SF/Yr
    10,032 SF

    Medical Building in Port St. Lucie

    1405 SE Goldtree Drive, Port Saint Lucie, FL 34952

    Turnkey medical building near HCA Florida St. Lucie Hospital.

    • Turnkey & Completely Built‑out Medical Building Ready for Immediate Occupancy
    • Located in Prominent Medical Area Adjacent to HCA Florida St. Lucie Hospital
    • Approximately 10,032 sqft Available with Flexible Configuration (Contiguous or 5 Suites)
    • Approximately 50 Parking Spaces
    • NNN Lease at $25/sqft plus CAM $8.43/sqft with 2% Annual Increases
    Updated: Feb 23
    View details
    Versatile Commercial Property in Port St. Lucie
    $1,500,000
    1,242 SF

    Versatile Commercial Property in Port St. Lucie

    1892 SW Biltmore Street, Port Saint Lucie, FL 34984

    Two properties with flexibility for commercial or residential use.

    • High‑visibility location in a rapidly growing commercial corridor of Port St. Lucie.
    • Combined sale of two properties (481 SW Voltaire Ave and 1892 SW Biltmore St) totaling approximately 0.55 acres.
    • Excellent proximity to Florida's Turnpike and I‑95.
    • Oversized parcels with excellent frontage, ample parking, and fully usable fenced outdoor space.
    • Single‑family structures on each site offer flexibility for residential, office, or business use.
    Updated: Mar 5
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    Profitable Office Space with Tenants
    $275,000

    Profitable Office Space with Tenants

    Turnkey office property with long-term tenants and immediate cash flow.

    544 NW University Blvd Boulevard, Port Saint Lucie, FL 34986
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    Port St. Lucie Flex Building
    $14 SF/Yr
    48,720 SF

    Port St. Lucie Flex Building

    Industrial flex building with air-conditioned office space for lease.

    651 NW Enterprise Dr, Port Saint Lucie, FL 34986
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    Port St. Lucie Office Space
    $27 SF/Yr
    2,500 SF

    Port St. Lucie Office Space

    2,500 SF office space in a thriving commercial corridor.

    155 SW Port St Lucie Blvd, Port Saint Lucie, FL
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    St Lucie West Professional Offices
    $25 SF/Yr
    3,076 SF

    St Lucie West Professional Offices

    Medical and professional offices in the heart of St Lucie West.

    525 NW Lake Whitney Pl, Port Saint Lucie, FL
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    St. Lucie West Office Space
    $23 SF/Yr
    45,416 SF

    St. Lucie West Office Space

    Professional and Medical office space in landmark building for lease.

    1660 SW St. Lucie West Blvd, Port Saint Lucie, FL 34986
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    Port Saint Lucie Office Space
    $13 SF/Yr
    13,029 SF

    Port Saint Lucie Office Space

    Office space available for lease in Port Saint Lucie, FL.

    900 E Prima Vista Blvd, Port Saint Lucie, FL
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    Medical Office Space For Rent
    $25 SF/Yr
    1,288 SF

    Medical Office Space For Rent

    Medical office space in Gatlin Kidney Care medical facility.

    1631 SW Gatlin Blvd, Port Saint Lucie, FL
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    Port St. Lucie Office Space
    $18 SF/Yr
    3,753 SF

    Port St. Lucie Office Space

    Versatile office space in a high-traffic Port St. Lucie location.

    7664 S US Hwy 1, Port Saint Lucie, FL
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    Retail, Office, Medical Space Available
    $36 SF/Yr
    1,184 SF

    Retail, Office, Medical Space Available

    New retail, office, and medical space for rent.

    1449-1479 SW Gatlin Blvd, Port Saint Lucie, FL
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    Office Space For Rent
    $22 SF/Yr
    1,629 SF

    Office Space For Rent

    Office space available for lease in Port Saint Lucie, FL.

    1631 NW St Lucie West Blvd, Port Saint Lucie, FL
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    Furnished Office Space Available
    $15 SF/Yr
    5,111 SF

    Furnished Office Space Available

    Professional office space with multiple configurations, fully furnished and equipped.

    526 SW Port St Lucie Blvd, Port Saint Lucie, FL
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    Professional Office Space For Lease
    $900 /Mo
    700 SF

    Professional Office Space For Lease

    Two-story office building with recent renovations and ample parking.

    550 SE Port St Lucie Blvd, Port Saint Lucie, FL
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    Port Saint Lucie Office Space
    $22 SF/Yr
    8,500 SF

    Port Saint Lucie Office Space

    Office space available for lease in Port Saint Lucie.

    584 NW University Blvd, Port Saint Lucie, FL
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    Shared Medical Office Space
    $3,500 /Mo
    1,604 SF

    Shared Medical Office Space

    Shared medical office space available near hospital and major roadways.

    10377 S US Hwy 1, Port Saint Lucie, FL
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    Single-Story Office Building For Rent
    $22 SF/Yr
    4,020 SF

    Single-Story Office Building For Rent

    Single-story office building with immediate availability and hurricane impact glass.

    120-128 SW Chamber Ct, Port Saint Lucie, FL
    View details
    Based on your search, we've compiled 21 Potential Opportunities for your consideration. Besides 17 Active listings in Port Saint Lucie, FL, we suggest exploring alternatives. Similar 4 Properties for Sales.

    Explore Similar Spaces for Sale in Port Saint Lucie, FL

    Consider Similar Space for Sale. We found 4 Spaces matching your search parameters.

    Port Saint Lucie Warehouse Condo
    $375,000
    1,500 SF

    Port Saint Lucie Warehouse Condo

    1,750 SF warehouse condo with office space and mezzanine.

    581 NW Mercantile Place, Port Saint Lucie, FL 34986
    View details
    Port St. Lucie Commercial Condo
    $235,000
    814 SF

    Port St. Lucie Commercial Condo

    Turnkey showroom/office/warehouse space in established Port St. Lucie district.

    1459 SE Village Green Drive, Port Saint Lucie, FL 34952
    View details
    Medical Office For Sale
    $499,000
    2,041 SF

    Medical Office For Sale

    Medical office in excellent condition, well-located near major highways.

    433-481 NW Prima Vista Blvd, Port Saint Lucie, FL
    View details
    Well-Maintained Property For Sale
    $1,290,000
    13,129 SF

    Well-Maintained Property For Sale

    Well-maintained property with long-term occupants and upside potential.

    7430-7448 S Federal Hwy, Port Saint Lucie, FL
    View details

    Port Saint Lucie, FL Office properties & Spaces Leasing Opportunities Market Analysis

    Explore Office properties & Spaces leasing options in Port Saint Lucie, FL with 17 listings featured on our commercial real estate exchange. The current inventory includes 5,087,677,320 square feet of properties with an estimated lease value of $134 SF/Yr.

    Estimated lease rates for Office properties & Spaces in Port Saint Lucie, FL begin at $14 SF/Yr, with an average of $22 SF/Yr and extend to $27 SF/Yr.
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    Browse Office properties & Spaces for Lease Near Port Saint Lucie, FL

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    Most Searched ZIP Codes in Port Saint Lucie, FL

    • 34986
    • 34952
    • 34984

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