Sikeston, MO Office buildings for sale

Downtown Sikeston Commercial Office Building

$279,000

4,273 SF

Downtown Sikeston Commercial Office Building

202 S Kingshighway St, Sikeston, MO 63801

Commercial property with endless business opportunities in downtown Sikeston.

Large 7,638 sq ft building suitable for diverse business opportunities.
Prime downtown Sikeston location on a corner lot.
Includes 15 parking spaces with handicap accessibility (2 spaces and ramp).
Functional layout with reception area, open workspace, private offices, conference room, and break room.
Equipped with both stairs and an elevator for basement access.

Updated: Dec 10, 2025

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$979,500

Sikeston Commercial Building Investment Opportunity

808 E Wakefield Ave, Sikeston, MO 63801

High-visibility commercial building with income and upside potential.

High‑visibility location near Missouri Delta Medical Center with strong daily traffic.
Existing cash flow from 2 of 6 currently leased units.
Value‑add opportunity with vacant units needing cosmetic updates.
Versatile space suitable for medical, office, retail, or professional services.
Ample customer parking and easy access.

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Explore Opportunities in Nearby Cities

Here are 4 Similar properties we found in Nearby Locations for your consideration.

$815,000

Two-Level Office Building For Sale

9,857 SF office building with multiple offices and restrooms.

10 Doctors Park, Cape Girardeau, MO 63703

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Contact for pricing

Professional Office Complex For Sale

Professional office complex with parking near I-55, hotels, restaurants.

240-276 S Mount Auburn Rd, Cape Girardeau, MO 63703

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$1,200,000

High-Functioning Office Facility For Sale

Office building in a thriving rural community, Union City, TN.

623 Perkins St, Union City, TN 38261

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$549,900

4,512 SF

Union City Commercial Property For Sale

Income-producing property with storage facility and modern office building.

2720 Section Line Rd, Union City, TN 38261

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Potential Development Sites for Consideration

Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

$144,000

1.01 Acres

Commercial Land on Highway 61

Commercial land on high-traffic route near Sikeston Industrial Park.

103 Grove St, Sikeston, MO 63801

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Explore Off-Market Properties in Sikeston, MO

Consider similar Off-Market properties in Sikeston, MO. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

2863 Malone Ave

OFFICE BUILDING • 2,400 SF

Value Estimation by Request

2863 Malone Ave, Sikeston, MO 63801-8616

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106 Plz Dr

OFFICE BUILDING • 2,780 SF

Value Estimation by Request

106 Plz Dr, Sikeston, MO 63801-5137

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2400 Rose Pkwy

OFFICE BUILDING • 188,562 SF

Value Estimation by Request

2400 Rose Pkwy, Sikeston, MO 63801-7192

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217 Tanner St

OFFICE BUILDING • 1,796 SF

Value Estimation by Request

217 Tanner St, Sikeston, MO 63801-4268

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Tanner St

OFFICE BUILDING • 2,925 SF

Value Estimation by Request

Tanner St, Sikeston, MO 63801

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713 Tanner St

OFFICE BUILDING • 2,782 SF

Value Estimation by Request

713 Tanner St, Sikeston, MO 63801-2160

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Sikeston, MO 63801

OFFICE BUILDING • 2,940 SF

Value Estimation by Request

Sikeston, MO 63801

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Rodgers Ave

OFFICE BUILDING • 1,550 SF

Value Estimation by Request

Rodgers Ave, Sikeston, MO 63801

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300 Wn St

OFFICE BUILDING • 1,232 SF

Value Estimation by Request

300 Wn St, Sikeston, MO 63801-4134

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218 Ctr St

OFFICE BUILDING • 10,604 SF

Value Estimation by Request

218 Ctr St, Sikeston, MO 63801-4229

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602 Compress Rd

OFFICE BUILDING • 6,060 SF

Value Estimation by Request

602 Compress Rd, Sikeston, MO 63801-5403

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615 Greer Ave

OFFICE BUILDING • 1,074 SF

Value Estimation by Request

615 Greer Ave, Sikeston, MO 63801-3233

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501 Interstate Dr

OFFICE BUILDING • 4,500 SF

Value Estimation by Request

501 Interstate Dr, Sikeston, MO 63801-8608

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Interstate N Dr

OFFICE BUILDING • 4,860 SF

Value Estimation by Request

Interstate N Dr, Sikeston, MO 63801

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105 Kathleen St

OFFICE BUILDING • 1,008 SF

Value Estimation by Request

105 Kathleen St, Sikeston, MO 63801-2941

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504 Kendall St

OFFICE BUILDING • 2,400 SF

Value Estimation by Request

504 Kendall St, Sikeston, MO 63801-2742

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240 Kingshighway St

OFFICE BUILDING • 4,060 SF

Value Estimation by Request

240 Kingshighway St, Sikeston, MO 63801-4102

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811 Main St

OFFICE BUILDING • 2,170 SF

Value Estimation by Request

811 Main St, Sikeston, MO 63801-2171

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805 Main St

OFFICE BUILDING • 3,000 SF

Value Estimation by Request

805 Main St, Sikeston, MO 63801-2171

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801 Main St

OFFICE BUILDING • 5,560 SF

Value Estimation by Request

801 Main St, Sikeston, MO 63801-5806

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106 Arthur

OFFICE BUILDING • 25,000 SF

Value Estimation by Request

106 Arthur, Sikeston, MO 63801-5453

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315 Kingshighway St

OFFICE BUILDING • 1,822 SF

Value Estimation by Request

315 Kingshighway St, Sikeston, MO 63801-2947

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Sikeston, MO Office Buildings Investment Opportunities Market Analysis

Explore 134 office buildings for sale in Sikeston, MO, showcased through 3 active listings on our real estate platform. These investment opportunities span a total of 315,647 square feet of properties for sale, with an estimated market value of $3,939,000.

Sale prices for office properties in Sikeston, MO start at $279,000, averaging $562,714, and reaching up to $775,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

Sikeston, MO Office Buildings for Sale

Downtown Sikeston Commercial Office Building

Commercial property with endless business opportunities in downtown Sikeston.

Sikeston Commercial Building Investment Opportunity

High-visibility commercial building with income and upside potential.