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    Spartanburg, SC Office Buildings for Lease

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    Three-Level Professional Office Building
    Updated: Jun 22
    Three-Level Professional Office Building

    291 S. Pine Street, Spartanburg, SC 29301

    Contact for pricing
    6,600 SF professional office building on 3 levels with a versatile layout for professional, medical, or administrative use
    38 on‑site parking spaces in both the front and rear of the property for convenient employee and visitor access
    Main level includes a reception area, reception desk, 3 conference rooms, IT/server room, fully equipped kitchen/break area, and 2 restrooms
    Second floor features five private offices, three large executive offices, multiple open work areas, and 2 restrooms
    Basement level offers 4 private offices, a large conference room, an expansive open work area, and 2 restrooms
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    Mixed-Use Building with Outdoor Area
    Updated: Mar 12, 2025
    Mixed-Use Building with Outdoor Area

    500 W Main St, Spartanburg, SC 29301

    Contact for pricing
    10,992 sqft
    Built in 1916 and renovated in 2023–2024
    Mixed‑use building with retail, restaurant, office, and entertainment space
    Opportunity Zone location
    Ample parking and multiple ingress/egress locations on the building(s)
    Large outdoor area accessible from the rear of the property
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    Renovated Historic Mixed-Use Building
    Renovated Historic Mixed-Use Building

    500 W Main St, Spartanburg, SC 29301

    Contact for pricing
    4,388 sqft

    Historic building renovated 2023–2024 with retail, restaurant, office, and entertainment space plus ample parking.

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    Renovated Office Building with Parking
    Renovated Office Building with Parking

    500 W Main St, Spartanburg, SC 29301

    Contact for pricing
    5,061 sqft

    Office component in a mixed-use building renovated 2023–2024 with ample parking and multiple ingress/egress options.

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    Based on your search, we've compiled 16 Potential Opportunities for your consideration. Besides 4 Active listings in Spartanburg, SC, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 8 Properties for Sales.

    Office buildings for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Turn-Key ADA Accessible Professional Office
    Turn-Key ADA Accessible Professional Office

    106 Memorial Dr, Greer, SC 29650

    $2,200/Mo
    1,442 sqft 0.32 AC lot

    Newly remodeled office with reception, three private offices, lounge, kitchen, and 10 on-site parking spaces.

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    Retail Office Space Near Airport
    Retail Office Space Near Airport

    136 Johns Rd, Greer, SC 29650

    $14.50 SF/Yr

    Commercial space for lease just off Interstate 85 and Highway 14 near GSP and BMW manufacturing.

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    334,000 SF Office Building For Lease
    334,000 SF Office Building For Lease

    300 South St, Simpsonville, SC 29681

    $19 SF/Yr

    334,000 SF Office Building For Lease

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    0 Bridgeway
    0 Bridgeway

    0 Bridgeway Simpsonville, SC 29681, Simpsonville, SC 29681

    Contact for pricing

    ±6,197 SF of office space availalble

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    Similar Spaces for Sale in Spartanburg, SC

    Consider Similar Space for Sale. We found 8 Spaces matching your search parameters.

    Office Building Under Renovation
    Office Building Under Renovation

    180 John B White Sr Boulevard, Spartanburg, SC 29306

    $525,000
    2,664 sqft 0.23 AC lot

    Flexible commercial layout with paved parking, central air, and public water service.

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    Two-Story Office Building
    Two-Story Office Building

    275 E henry Street, Spartanburg, SC 29306

    $365,000
    1,450 sqft 0.23 AC lot

    Leased ground-floor space accompanies an available upper-level office or studio area for owner occupancy or additional leasing.

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    Two-Story Office Building with Income
    Two-Story Office Building with Income

    275 E Henry St, Spartanburg, SC 29306

    $365,000
    1,450 sqft

    Income-producing office building with a leased first floor and vacant second-floor office or studio space.

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    Multi-Office Building
    Multi-Office Building

    858 E Main St, Spartanburg, SC 29302

    $369,000
    2,500 sqft

    Office property in Spartanburg’s business district with on-site parking and a flexible multi-office layout.

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    Spartanburg Office Building For Sale
    Spartanburg Office Building For Sale

    130 Dillon Drive, Spartanburg, SC 29307

    $1,450,000
    7,200 sqft

    7,200 SF office building near Spartanburg Medical District.

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    Limited Office District Office Building
    Limited Office District Office Building

    1423 JOHN B WHITE SR BLVD, Spartanburg, SC 29306

    Contact for pricing
    2,692 sqft 0.61 AC lot

    A 2,692± SF office on 0.61± acres with 200± road frontage, high visibility, and LOD zoning for qualified uses.

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    Office Building with Conversion Potential
    Office Building with Conversion Potential

    225 OAKLAND AVE, Spartanburg, SC 29302

    Contact for pricing
    1,984 sqft 0.20 AC lot

    A 1984± SF house on a 2+/- acre parcel zoned DT4 Downtown General Urban Zone near downtown.

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    Spartanburg Office Building For Sale
    Spartanburg Office Building For Sale

    319 North Pine Street, Spartanburg, SC 29302

    Contact for pricing
    8,000 sqft

    Office building in a growing downtown area with high foot traffic.

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    Spartanburg, SC Office buildings Lease Rates & Market Statistics

    Explore 4 Office buildings for lease in Spartanburg, SC on Realmo, a commercial real estate exchange covering the Spartanburg area. The current inventory totals 20,441 square feet of properties.

    Spartanburg accounts for 67% of the 6 office buildings currently available across Spartanburg County, where nearby markets include Duncan and Moore. Office buildings are one of the more limited space types in Spartanburg, with just 4 listings currently available — a scarcity worth factoring into lease negotiations. Also worth a look for tenants weighing alternatives: Office Units (24 listings) elsewhere in the Spartanburg market.

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    Popular Searches in Spartanburg, SC

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    Most Searched ZIP Codes in Spartanburg, SC

    • 29301

    Featured Spartanburg Real Estate Agencies

    Realmo connects you with licensed Spartanburg CRE brokers providing property specifications, local market pricing, and commercial transaction underwriting support.

    Keller Williams Realty Spartanburg Partners
    1707 John B White Sr Blvd, Suite E Spartanburg, SC 29301
    Phone: (864) 574-6000
    www.kwspartanburg.com
    Better Homes and Gardens Young & Company
    8291 Warren H. Abernathy Highway Spartanburg, SC 29301
    Phone: (970) 660-5323
    bhgyoung.com
    Agent Pros Realty
    2992 Reidville Rd Spartanburg, SC 29301
    Phone: (864) 599-9907
    agentprosrealty.com
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