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    Spartanburg, SC Medical Office Space for Sale

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    Spartanburg Office Building For Sale
    Updated: Nov 26, 2025
    Spartanburg Office Building For Sale

    130 Dillon Drive, Spartanburg, SC 29307

    $1,810,000
    7,200 sqft
    Prime location in Spartanburg, SC with excellent visibility.
    Investment opportunity with a multi‑tenant building.
    ±4,015 SF available, with ±3,185 SF already leased to Ortho Sport & Spine Physicians.
    Close proximity to Spartanburg Medical District and other healthcare providers.
    Ideal for primary care or specialty practices.
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    This listing looks promising.

    Here's a quick look at some key insights for

    130 Dillon Drive, Spartanburg, SC 29307

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    • Est. Cap Rate

      6.3%
      Above avg (5.9%)

    • Est. NOI

      $113K
      Annual

    • Mortgage

      $970K
      Jul 2022

    • Last Sold

      Jul 2022
      $630K

    • Property Type

      Medical Building
      Built 1983
    View Property Analytics
    Medical Office Building with Parking
    Updated: Jul 2
    Medical Office Building with Parking

    1776 Skylyn Dr, Spartanburg, SC 29307

    Contact for pricing
    11,832 sqft
    11,832± SF medical office building built in 1975 with numerous exam, treatment, and procedure rooms
    76 on‑site parking spaces for patients, staff, and visitors
    Located in Spartanburg’s established healthcare corridor, adjacent to the former Spartanburg Regional Mary Black Campus
    Multiple alternative uses supported by flexible layout, including medical/dental, specialty clinics, behavioral health, childcare, and professional office
    Just 3.8 miles from VCOM–Carolinas Campus (Edward Via College of Osteopathic Medicine)
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    Medical/Professional Office Space Available
    Medical/Professional Office Space Available

    125 Dillon Dr, Spartanburg, SC 29307

    Contact for pricing
    10,000 sqft 1.30 AC lot

    10,000 SF property near Mary Black Regional Hospital.

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    NNN Dialysis Center Portfolio
    NNN Dialysis Center Portfolio

    128 Dillon Dr, Spartanburg, SC 29307

    Contact for pricing
    19,182 sqft

    Fee-simple interest in a fully occupied, three-facility Fresenius Medical Care portfolio with NNN lease structures.

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    Turn Any Listing Into an Investment Snapshot Owner equity, real caprate, demand score for every listing. Go To Analytics Center
    Versatile Commercial Building Near Hospital
    Versatile Commercial Building Near Hospital

    200 Dillon Cir, Spartanburg, SC 29307

    Contact for pricing
    11,925 sqft

    Adaptable commercial building suitable for medical, retail, or storage use.

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    Based on your search, we've compiled 80 Potential Opportunities for your consideration. Besides 5 Active listings in Spartanburg, SC, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 67 Off-Market properties to explore as potential leads, plus 4 Land Listings that present a potential for development.

    Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    Downtown Fountain Inn Commercial Space
    Downtown Fountain Inn Commercial Space

    203 S Weston Street, Fountain Inn, SC 29644

    $1,500,000
    4,400 sqft 0.59 AC lot

    Prime location with potential for various business uses.

    View details
    All-Brick Medical Office Building
    All-Brick Medical Office Building

    203 South Weston Street, Unit 201S, Fountain Inn, SC 29644

    $1,500,000
    4,400 sqft

    All-brick, one-level medical office building with adjacent lot providing 30+ parking spaces and an included brick outbuilding.

    View details
    Class A Office Suites Building
    Class A Office Suites Building

    701 & 703 Roper Creek Drive, Greenville, SC 29615

    Contact for pricing
    6,000 sqft

    New Class A office building with two separate suites on lower and upper levels, each accommodating about 3,000 SF.

    View details
    Medical Office Building with Rental Income
    Medical Office Building with Rental Income

    9 Hawthorne Park Court, Greenville, SC 29605

    Contact for pricing

    Medical office building for sale with a current tenant, Brio Internal Medicine, and rental income through September 2021.

    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Cleared Land in Greer, SC
    Cleared Land in Greer, SC

    Aaron Tippin Drive, Greer, SC 29650

    $209,000
    0.87 AC lot

    0.87-acre commercial land parcel in a high-growth area.

    View details
    High-Visibility Commercial Land For Sale
    High-Visibility Commercial Land For Sale

    4108 Old Buncombe Road, Greenville, SC 29617

    $450,000
    0.82 AC lot

    0.82 acre commercial land with high traffic exposure.

    View details
    Prime Land in Greenville, SC
    Prime Land in Greenville, SC

    3900 Highway 153, Greenville, SC 29611

    $1,800,000
    2,500 sqft 10.91 AC lot

    11+/- acre property ideal for development in a growing corridor.

    View details
    Whitmire Redevelopment Opportunity
    Whitmire Redevelopment Opportunity

    6470 Whitmire Highway, Whitmire, SC 29178

    $75,000
    3.43 AC lot

    3.43 acre commercial tract ideal for redevelopment.

    View details

    Off-Market Properties in Spartanburg, SC

    Consider similar Off-Market properties in Spartanburg, SC. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    1770 Skylyn Dr
    MEDICAL BUILDING

    1770 Skylyn Dr, Spartanburg, SC 29307-1045

    $565,000
    Estimated value
    9,594 sqft 1.21 AC lot
    View details
    391 Henry St
    MEDICAL BUILDING

    391 Henry St, Spartanburg, SC 29302-2639

    $800,000
    Estimated value
    5,279 sqft 0.57 AC lot
    View details
    397 Serpentine Dr Ste A
    MEDICAL BUILDING

    397 Serpentine Dr Ste A, Spartanburg, SC 29303-3067

    Value Estimation by Request
    6,807 sqft 0.57 AC lot
    View details
    397 Serpentine Dr Ste B
    MEDICAL BUILDING

    397 Serpentine Dr Ste B, Spartanburg, SC 29303-3067

    Value Estimation by Request
    3,272 sqft 0.26 AC lot
    View details
    735 Main St
    MEDICAL BUILDING

    735 Main St, Spartanburg, SC 29302-1281

    Value Estimation by Request
    3,941 sqft 0.49 AC lot
    View details
    1526 John B White Sr Blvd
    MEDICAL BUILDING

    1526 John B White Sr Blvd, Spartanburg, SC 29301

    Value Estimation by Request
    1,770 sqft 0.10 AC lot
    View details
    1526 John B White Sr Blvd
    MEDICAL BUILDING

    1526 John B White Sr Blvd, Spartanburg, SC 29301

    Value Estimation by Request
    2,363 sqft 0.12 AC lot
    View details
    153 Oakwood Ave
    MEDICAL BUILDING

    153 Oakwood Ave, Spartanburg, SC 29302

    Value Estimation by Request
    8,724 sqft 1.29 AC lot
    View details
    1330 Boiling Spgs Rd Ste, Unit 2800
    MEDICAL BUILDING

    1330 Boiling Spgs Rd Ste, Spartanburg, SC 29303-4216

    Unit 2800
    Value Estimation by Request
    3,530 sqft 0.39 AC lot
    View details
    1250 John B White Sr Blvd
    MEDICAL BUILDING

    1250 John B White Sr Blvd, Spartanburg, SC 29306-3929

    $1,095,000
    Estimated value
    6,875 sqft 0.66 AC lot
    View details
    480 Church St
    MEDICAL BUILDING

    480 Church St, Spartanburg, SC 29303-3638

    Value Estimation by Request
    5,934 sqft 0.82 AC lot
    View details
    233 Blackstock Rd Ste J
    MEDICAL BUILDING

    233 Blackstock Rd Ste J, Spartanburg, SC 29301-2652

    Value Estimation by Request
    1,500 sqft 1.11 AC lot
    View details
    Pearl St
    MEDICAL BUILDING

    Pearl St, Spartanburg, SC 29302

    $3,720,000
    Estimated value
    10,540 sqft 1.13 AC lot
    View details
    295 Pearl St
    MEDICAL BUILDING

    295 Pearl St, Spartanburg, SC 29303-3606

    $3,720,000
    Estimated value
    54,580 sqft 2.55 AC lot
    View details
    250 Grv Medical Park Dr
    MEDICAL BUILDING

    250 Grv Medical Park Dr, Spartanburg, SC 29303-4222

    $3,190,000
    Estimated value
    12,836 sqft 1.62 AC lot
    View details
    120 Dillon Dr
    MEDICAL BUILDING

    120 Dillon Dr, Spartanburg, SC 29307-1018

    $4,510,000
    Estimated value
    17,744 sqft 3.41 AC lot
    View details
    115 Powell Ml Rd
    MEDICAL BUILDING

    115 Powell Ml Rd, Spartanburg, SC 29301-1531

    $975,000
    Estimated value
    3,549 sqft 0.44 AC lot
    View details
    740 Oak Grv Rd
    MEDICAL BUILDING

    740 Oak Grv Rd, Spartanburg, SC 29301-3579

    Value Estimation by Request
    5,511 sqft 0.47 AC lot
    View details
    479 Heywood Ave
    MEDICAL BUILDING

    479 Heywood Ave, Spartanburg, SC 29307-1726

    $1,350,000
    Estimated value
    11,314 sqft 1.42 AC lot
    View details

    Spartanburg, SC Medical Office Space Market Trends and Statistics

    Explore 72 medical office space for sale in Spartanburg, SC, showcased through 5 active listings on our real estate platform. These investment opportunities span a total of 60,139 square feet of properties for sale, with an estimated market value of $1,810,000.

    Sale prices for medical spaces in Spartanburg, SC average $1,810,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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    Top Commercial Asset Segments

    Commercial property segments ranked by active listings on the market

    Office Units 62
    Office buildings 19
    Medical Office Space 10
    Creative space 2

    Demographics Overview

    Population 150K
    Population Growth (5Y) +8.8%
    Median Household Income $59,825
    College Educated 25.6%

    High-Yield Neighborhoods for Investment

    Identify Spartanburg submarkets with the highest inventory density on the market and evaluate the average listing prices of real estate assets

    Neighborhood Average Price
    29307 $1.1M

    Taxes & Financing

    Average Loan-to-Value 65.0%

    Listings Trend

    New vs delisted commercial listings in Spartanburg County

    New Delisted

    Total CRE Inventory on Market (SF)

    Average Property Price per SF

    For-sale pricing trends across core commercial property types in Spartanburg County

    Office

    Residential Income

    Property Size Breakdown

    The majority of commercial real estate listings in Spartanburg fall within the 10,000 to 25,000 square foot range.

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