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    Spartanburg, SC Medical Office Space for Sale

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    Columbia, SC Aiken, SC Greenville, SC
    7 results
    Spartanburg Office Building For Sale
    $1,810,000
    7,200 SF

    Spartanburg Office Building For Sale

    130 Dillon Drive, Spartanburg, SC 29307

    7,200 SF office building near Spartanburg Medical District.

    • Prime location in Spartanburg, SC with excellent visibility.
    • Investment opportunity with a multi‑tenant building.
    • ±4,015 SF available, with ±3,185 SF already leased to Ortho Sport & Spine Physicians.
    • Close proximity to Spartanburg Medical District and other healthcare providers.
    • Ideal for primary care or specialty practices.
    Updated: Nov 26, 2025
    View details
    Medical/Professional Office Space Available
    $775,000
    10,000 SF

    Medical/Professional Office Space Available

    125 Dillon Dr, Spartanburg, SC 29307

    10,000 SF property near Mary Black Regional Hospital.

    • Directly adjacent to Mary Black Regional Hospital
    • Ideal location for medical or professional office use
    • ±10,000 SF on ±1.30 AC
    • Low‑interest owner‑financing terms considered
    • Located in an established office park with excellent accessibility
    Updated: Feb 17
    View details
    Medical Office Space Available
    $430,000
    4,645 SF

    Medical Office Space Available

    4,645 SF medical office space for lease.

    1241 Boiling Springs Rd, Spartanburg, SC
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    Spartanburg Medical/Office Building For Sale
    $825,000
    9,594 SF

    Spartanburg Medical/Office Building For Sale

    9,594 SF medical/office building near downtown Spartanburg.

    1770 Skylyn Dr, Spartanburg, SC
    View details
    Professional Office/Medical Pads For Sale
    $150,000
    3,500 SF

    Professional Office/Medical Pads For Sale

    Two office/medical pads with utilities, parking, and infrastructure included.

    108 Burton St, Spartanburg, SC
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    11,058 SF Office Building For Sale
    Contact for pricing
    11,058 SF

    11,058 SF Office Building For Sale

    11,058 SF fantastic medical investment opportunity

    480 Floyd Rd, Spartanburg, SC 29307
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    Versatile Commercial Building Near Hospital
    $845,000
    11,925 SF

    Versatile Commercial Building Near Hospital

    Adaptable commercial building suitable for medical, retail, or storage use.

    200 Dillon Cir, Spartanburg, SC 29307
    View details
    Based on your search, we've compiled 184 Potential Opportunities for your consideration. Besides 7 Active listings in Spartanburg, SC, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 169 Off-Market properties to explore as potential leads, plus 4 Land Listings that present a potential for development.

    Explore Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    Gaffney Multi-Use High-Visibility Property
    $165,900
    0.33 Acres

    Gaffney Multi-Use High-Visibility Property

    Functional layout suitable for various professional uses or residential conversion.

    403 S Logan Street, Gaffney, SC 29341
    View details
    Gaffney Commercial Site For Sale
    $279,000
    1.89 Acres

    Gaffney Commercial Site For Sale

    Prime commercial location near Floyd Baker Blvd and I-85.

    530,526,524 W Frederick Street, Gaffney, SC 29341
    View details
    Medical Office Building For Sale
    $2,395,000
    7,397 SF

    Medical Office Building For Sale

    Two-story, ±7,397 SF medical office building suited for owner-occupant.

    300 Regent Park Ct, Greenville, SC
    View details
    Freestanding Office Building For Sale
    $1,700,000
    6,046 SF

    Freestanding Office Building For Sale

    Freestanding office building in desirable Eastside office corridor.

    5 Hawthorne Park Ct, Greenville, SC 29615
    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Greer, SC Commercial Site
    $219,000
    0.87 Acres

    Greer, SC Commercial Site

    0.87-acre parcel zoned for office and professional uses.

    00 Aaron Tippin Drive, Greer, SC 29650
    View details
    Mauldin Commercial Site For Sale
    $200,000
    1.00 Acre

    Mauldin Commercial Site For Sale

    1+ acre lot approved for medical offices in growing area.

    Corn and Miller Road, Mauldin, SC 29607
    View details
    Prime Commercial Corner Lot Available
    $200,000
    1.00 Acre

    Prime Commercial Corner Lot Available

    1+ acre corner lot in rapidly growing Mauldin, SC.

    Corn and Miller Road, Mauldin, SC 29607
    View details
    High-Visibility Commercial Land For Sale
    $450,000

    High-Visibility Commercial Land For Sale

    0.82 acre commercial land with high traffic exposure.

    4108 Old Buncombe Road, Greenville, SC 29617
    View details

    Explore Off-Market Properties in Spartanburg, SC

    Consider similar Off-Market properties in Spartanburg, SC. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    1770 Skylyn Dr

    1770 Skylyn Dr

    MEDICAL BUILDING • 9,594 SF
    Value Estimation
    $565,000
    1770 Skylyn Dr, Spartanburg, SC 29307-1045
    View details
    391 Henry St

    391 Henry St

    MEDICAL BUILDING • 5,279 SF
    Value Estimation
    $800,000
    391 Henry St, Spartanburg, SC 29302-2639
    View details
    397 Serpentine Dr Ste A

    397 Serpentine Dr Ste A

    MEDICAL BUILDING • 6,807 SF
    Value Estimation by Request
    397 Serpentine Dr Ste A, Spartanburg, SC 29303-3067
    View details
    397 Serpentine Dr Ste B

    397 Serpentine Dr Ste B

    MEDICAL BUILDING • 3,272 SF
    Value Estimation by Request
    397 Serpentine Dr Ste B, Spartanburg, SC 29303-3067
    View details
    735 Main St

    735 Main St

    MEDICAL BUILDING • 3,941 SF
    Value Estimation by Request
    735 Main St, Spartanburg, SC 29302-1281
    View details
    1526 John B White Sr Blvd

    1526 John B White Sr Blvd

    MEDICAL BUILDING • 1,770 SF
    Value Estimation by Request
    1526 John B White Sr Blvd, Spartanburg, SC 29301
    View details
    1526 John B White Sr Blvd

    1526 John B White Sr Blvd

    MEDICAL BUILDING • 2,363 SF
    Value Estimation by Request
    1526 John B White Sr Blvd, Spartanburg, SC 29301
    View details
    153 Oakwood Ave

    153 Oakwood Ave

    MEDICAL BUILDING • 8,724 SF
    Value Estimation by Request
    153 Oakwood Ave, Spartanburg, SC 29302
    View details
    1330 Boiling Spgs Rd Ste, Unit 2800

    1330 Boiling Spgs Rd Ste, Unit 2800

    MEDICAL BUILDING • 3,530 SF
    Value Estimation by Request
    1330 Boiling Spgs Rd Ste, Spartanburg, SC 29303-4216
    View details
    1250 John B White Sr Blvd

    1250 John B White Sr Blvd

    MEDICAL BUILDING • 6,875 SF
    Value Estimation
    $1,095,000
    1250 John B White Sr Blvd, Spartanburg, SC 29306-3929
    View details
    480 Church St

    480 Church St

    MEDICAL BUILDING • 5,934 SF
    Value Estimation by Request
    480 Church St, Spartanburg, SC 29303-3638
    View details
    233 Blackstock Rd Ste J

    233 Blackstock Rd Ste J

    MEDICAL BUILDING • 1,500 SF
    Value Estimation by Request
    233 Blackstock Rd Ste J, Spartanburg, SC 29301-2652
    View details
    Pearl St

    Pearl St

    MEDICAL BUILDING • 10,540 SF
    Value Estimation
    $3,720,000
    Pearl St, Spartanburg, SC 29302
    View details
    295 Pearl St

    295 Pearl St

    MEDICAL BUILDING • 54,580 SF
    Value Estimation
    $3,720,000
    295 Pearl St, Spartanburg, SC 29303-3606
    View details
    250 Grv Medical Park Dr

    250 Grv Medical Park Dr

    MEDICAL BUILDING • 12,836 SF
    Value Estimation
    $3,190,000
    250 Grv Medical Park Dr, Spartanburg, SC 29303-4222
    View details
    120 Dillon Dr

    120 Dillon Dr

    MEDICAL BUILDING • 17,744 SF
    Value Estimation
    $4,510,000
    120 Dillon Dr, Spartanburg, SC 29307-1018
    View details
    115 Powell Ml Rd

    115 Powell Ml Rd

    MEDICAL BUILDING • 3,549 SF
    Value Estimation
    $975,000
    115 Powell Ml Rd, Spartanburg, SC 29301-1531
    View details

    Spartanburg, SC Medical Office Space Investment Opportunities Market Analysis

    Explore 176 medical office space for sale in Spartanburg, SC, showcased through 7 active listings on our real estate platform. These investment opportunities span a total of 46,864 square feet of properties for sale, with an estimated market value of $4,835,000.

    Sale prices for medical spaces in Spartanburg, SC start at $150,000, averaging $805,833, and reaching up to $1,810,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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