Spartanburg, SC Medical Office Space for Sale

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Updated: Jun 23

Medical Office Building

1250 John B White Sr Boulevard, Spartanburg, SC 29306

$1,295,000

6,875 sqft

6,875‑square‑foot medical office property
Located at 1250 John B White Sr Boulevard
Spartanburg, SC 29306 address

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Updated: Nov 26, 2025

Spartanburg Office Building For Sale

130 Dillon Drive, Spartanburg, SC 29307

$1,450,000

7,200 sqft

Prime location in Spartanburg, SC with excellent visibility.
Investment opportunity with a multi‑tenant building.
±4,015 SF available**, with ±3,185 SF already leased to Ortho Sport & Spine Physicians.
Close proximity to Spartanburg Medical District and other healthcare providers.
Ideal for primary care or specialty practices.

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Medical Office Building with Parking

1776 Skylyn Dr, Spartanburg, SC 29307

Contact for pricing

11,832 sqft

Medical office building with numerous exam, treatment, and procedure rooms and ample on-site parking.

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See what stands out in Spartanburg County

We check every for-sale listing in the county against comparable properties across the country. Most price about where you would expect. A few are worth a second look.

We check every listing here. A few are worth a second look.

Cap Rate available after sign in

NOI available after sign in

Local Demand available after sign in

Medical/Professional Office Space Available

125 Dillon Dr, Spartanburg, SC 29307

Contact for pricing

10,000 sqft 1.30 AC lot

10,000 SF property near Mary Black Regional Hospital.

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Based on your search, we've compiled 77 Potential Opportunities for your consideration. Besides 4 Active listings in Spartanburg, SC, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 68 Off-Market properties to explore as potential leads, plus 1 Land Listings that present a potential for development.

Opportunities in Nearby Cities

Here are 4 Similar properties we found in Nearby Locations for your consideration.

Absolute NNN Dental Office

1173 Ashmore Bridge Rd, Greenville, SC 29605

Contact for pricing

4,200 sqft

Newly delivered dental office offered on an Absolute NNN basis with a long-term lease and corporate guarantee.

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Medical Office with Basement

202 Memorial Drive, Greer, SC 29650

Contact for pricing

1,144 sqft 0.34 AC lot

The property includes on-site parking and additional basement area for potential office conversion.

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Medical Office with Parking

21 Memorial Medical Dr, Greenville, SC 29605

Contact for pricing

3,400 sqft 0.50 AC lot

Former dermatology practice with dedicated parking near I-85 and Faris Road.

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All-Brick Medical Office Building

3115 Brushy Creek Rd, Greer, SC 29650

Contact for pricing

6,244 sqft

All-brick medical office building in a professional office park with a 10-year leaseback.

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Potential Development Sites for Consideration

Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

Cleared Commercial Land

4 Aaron Tippin Drive, Greer, SC 29650

$194,000

0.87 AC lot

Level OP-zoned site with public water and sewer available for office, medical, and professional development.

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Off-Market Properties in Spartanburg, SC

Consider similar Off-Market properties in Spartanburg, SC. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

MEDICAL BUILDING

1770 Skylyn Dr, Spartanburg, SC 29307-1045

Estimated value:

$565,000

9,594 sqft 1.21 AC lot

View details

MEDICAL BUILDING

391 Henry St, Spartanburg, SC 29302-2639

Estimated value:

$545,000

5,279 sqft 0.57 AC lot

View details

MEDICAL BUILDING

397 Serpentine Dr Ste A, Spartanburg, SC 29303-3067

Estimated value:

$415,000

6,807 sqft 0.57 AC lot

View details

MEDICAL BUILDING

397 Serpentine Dr Ste B, Spartanburg, SC 29303-3067

Estimated value:

$415,000

3,272 sqft 0.26 AC lot

View details

MEDICAL BUILDING

735 Main St, Spartanburg, SC 29302-1281

Estimated value:

$425,000

3,941 sqft 0.49 AC lot

View details

MEDICAL BUILDING

1526 John B White Sr Blvd, Spartanburg, SC 29301

Estimated value:

$385,000

1,770 sqft 0.10 AC lot

View details

MEDICAL BUILDING

1526 John B White Sr Blvd, Spartanburg, SC 29301

Estimated value:

$385,000

2,363 sqft 0.12 AC lot

View details

MEDICAL BUILDING

153 Oakwood Ave, Spartanburg, SC 29302

Estimated value:

$370,000

8,724 sqft 1.29 AC lot

View details

MEDICAL BUILDING

1330 Boiling Spgs Rd Ste, Spartanburg, SC 29303-4216

Unit 2800

Estimated value:

$485,000

3,530 sqft 0.39 AC lot

View details

MEDICAL BUILDING

1250 John B White Sr Blvd, Spartanburg, SC 29306-3929

Estimated value:

$1,095,000

6,875 sqft 0.66 AC lot

View details

MEDICAL BUILDING

480 Church St, Spartanburg, SC 29303-3638

Estimated value:

by Request

5,934 sqft 0.82 AC lot

View details

MEDICAL BUILDING

233 Blackstock Rd Ste J, Spartanburg, SC 29301-2652

Estimated value:

$150,000

1,500 sqft 1.11 AC lot

View details

MEDICAL BUILDING

Pearl St, Spartanburg, SC 29302

Estimated value:

$3,720,000

10,540 sqft 1.13 AC lot

View details

MEDICAL BUILDING

295 Pearl St, Spartanburg, SC 29303-3606

Estimated value:

$3,720,000

54,580 sqft 2.55 AC lot

View details

MEDICAL BUILDING

250 Grv Medical Park Dr, Spartanburg, SC 29303-4222

Estimated value:

$230,000

12,836 sqft 1.62 AC lot

View details

MEDICAL BUILDING

120 Dillon Dr, Spartanburg, SC 29307-1018

Estimated value:

$4,510,000

17,744 sqft 3.41 AC lot

View details

MEDICAL BUILDING

115 Powell Ml Rd, Spartanburg, SC 29301-1531

Estimated value:

$975,000

3,549 sqft 0.44 AC lot

View details

MEDICAL BUILDING

740 Oak Grv Rd, Spartanburg, SC 29301-3579

Estimated value:

$310,000

5,511 sqft 0.47 AC lot

View details

MEDICAL BUILDING

479 Heywood Ave, Spartanburg, SC 29307-1726

Estimated value:

$1,350,000

11,314 sqft 1.42 AC lot

View details

MEDICAL BUILDING

151 Dillon Dr, Spartanburg, SC 29307-1017

Estimated value:

$375,000

2,280 sqft 1.03 AC lot

View details

Spartanburg, SC Medical Office Space Market Trends and Statistics

Explore 72 medical office space for sale in Spartanburg, SC, showcased through 4 active listings on our real estate platform. These investment opportunities span a total of 35,907 square feet of properties for sale, with an estimated market value of $2,745,000.

Sale prices for medical spaces in Spartanburg, SC start at $1,295,000, averaging $1,372,500, and reaching up to $1,450,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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Top Commercial Asset Segments

Commercial property segments ranked by active listings on the market

Demographics Overview

Population 150K

Population Growth (5Y) +8.8%

Median Household Income $59,825

College Educated 25.6%

High-Yield Neighborhoods for Investment

Identify Spartanburg submarkets with the highest inventory density on the market and evaluate the average listing prices of real estate assets

Neighborhood	Average Price
29306	$1.3M
29307	$1.5M

Taxes & Financing

Average Loan-to-Value 65.0%

Listings Trend

New vs delisted commercial listings in Spartanburg County

New Delisted

Total CRE Inventory on Market (SF)

Average Property Price per SF

For-sale pricing trends across core commercial property types in Spartanburg County

Office

Property Size Breakdown

The majority of commercial real estate listings in Spartanburg fall within the 10,000 to 25,000 square foot range.

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Spartanburg, SC Medical Office Space for Sale

1250 John B White Sr Boulevard, Spartanburg, SC 29306

130 Dillon Drive, Spartanburg, SC 29307

1776 Skylyn Dr, Spartanburg, SC 29307

125 Dillon Dr, Spartanburg, SC 29307

Opportunities in Nearby Cities

1173 Ashmore Bridge Rd, Greenville, SC 29605

202 Memorial Drive, Greer, SC 29650

21 Memorial Medical Dr, Greenville, SC 29605

3115 Brushy Creek Rd, Greer, SC 29650

Potential Development Sites for Consideration

4 Aaron Tippin Drive, Greer, SC 29650

Off-Market Properties in Spartanburg, SC

1770 Skylyn Dr, Spartanburg, SC 29307-1045

391 Henry St, Spartanburg, SC 29302-2639

397 Serpentine Dr Ste A, Spartanburg, SC 29303-3067

397 Serpentine Dr Ste B, Spartanburg, SC 29303-3067

735 Main St, Spartanburg, SC 29302-1281

1526 John B White Sr Blvd, Spartanburg, SC 29301

1526 John B White Sr Blvd, Spartanburg, SC 29301

153 Oakwood Ave, Spartanburg, SC 29302

1330 Boiling Spgs Rd Ste, Spartanburg, SC 29303-4216

1250 John B White Sr Blvd, Spartanburg, SC 29306-3929

480 Church St, Spartanburg, SC 29303-3638

233 Blackstock Rd Ste J, Spartanburg, SC 29301-2652

Pearl St, Spartanburg, SC 29302

295 Pearl St, Spartanburg, SC 29303-3606

250 Grv Medical Park Dr, Spartanburg, SC 29303-4222

120 Dillon Dr, Spartanburg, SC 29307-1018

115 Powell Ml Rd, Spartanburg, SC 29301-1531

740 Oak Grv Rd, Spartanburg, SC 29301-3579

479 Heywood Ave, Spartanburg, SC 29307-1726

151 Dillon Dr, Spartanburg, SC 29307-1017

Spartanburg, SC Medical Office Space Market Trends and Statistics

Top Commercial Asset Segments

Demographics Overview

High-Yield Neighborhoods for Investment

Taxes & Financing

Listings Trend

Total CRE Inventory on Market (SF)

Average Property Price per SF

Office

Property Size Breakdown

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