South Portland, ME Office buildings for Rent & Lease

$13 SF/Yr

4,646 SF

Class A Office/Medical Building

175 Running Hill Road, South Portland, ME

Class A office/medical building with suites available for lease.

Class A office/medical building with suites available, ranging from 4,646 to 8,542± SF.
Central location with easy access to Maine Turnpike/I‑95 and I‑295.
Conveniently located near Portland International Jetport, hotels, and restaurants.
Professionally managed property situated on 13.09± acres.
Ample paved parking available.

Updated: Jul 29, 2025

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1,323 SF

Class A Office Space Available

778 Main Street, South Portland, ME 4106

Class A office building with ample parking and professional landscaping.

Prime location on Route One, minutes from Portland, Maine Mall, and Portland Jetport.
Easy access to Maine Turnpike and I‑295.
Ample parking and professional landscaping.
Class A office building.
Join esteemed tenants like Boston IVF and Health Markets.

Updated: Jan 27

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$14 SF/Yr

104,752 SF

Class A Office Space Available

Class A office space for lease in South Portland.

2 Gannett Dr, South Portland, ME

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$21 SF/Yr

Class A Office Space

Premier office spaces in South Portland, Maine.

707 Sable Oaks Dr, South Portland, ME 4106

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Based on your search, we've compiled 12 Potential Opportunities for your consideration. Besides 4 Active listings in South Portland, ME, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities

Office buildings for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

$14 SF/Yr

16,000 SF

Westbrook Office Building For Lease

16,000± SF single-story office building in Westbrook's Industrial Park.

501 County Rd, Westbrook, ME

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$16 SF/Yr

24,419 SF

Class A Office Building

Class A office building in Westbrook, Maine for lease.

202 Larrabee Rd, Westbrook, ME 4092

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Freestanding Office Building in Portland

$12 SF/Yr

38,227 SF

Freestanding Office Building in Portland

Professional office building in wooded campus setting for lease.

41 Hutchins Dr, Portland, ME 4102

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$21 SF/Yr

292,322 SF

Class A Office Building ForRent

Premier Class A office building with modern amenities and ample parking.

2211 Congress St, Portland, ME 4102

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Potential Development Sites for Consideration

Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

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Riverfront Development Land

Lease a portion of riverfront land with PD2 and RBV zoning for a range of potential commercial uses.

Riverside Drive, Augusta, ME 04330

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$2,500/Mo

Commercial Land on Montauk Highway

0.55-acre commercial lot on busy Montauk Highway.

1467 Montauk Highway, Mastic, NY 11967

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$10,000/Mo

Prime Retail Corridor Land Lease

20,245 sq ft land for lease in Shirley, NY.

550 William Floyd Pkwy, Shirley, NY 11967

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Prime Land for Ground Lease

20,245 sq ft land in high-traffic retail corridor.

550 William Floyd Parkway, Brookhaven, NY 11967

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South Portland, ME Office buildings Leasing Opportunities Market Analysis

Explore Office buildings leasing options in South Portland, ME with 4 listings featured on our commercial real estate exchange. The current inventory includes 109,398 square feet of properties with an estimated lease value of $28 SF/Yr.

Estimated lease rates for Office buildings in South Portland, ME begin at $13 SF/Yr, with an average of $14 SF/Yr and extend to $14 SF/Yr.