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    South Portland, ME Office Buildings for Lease

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    Portland, ME Bangor, ME Lewiston, ME
    Class A Office/Medical Building
    $13 SF/Yr
    4,646 SF

    Class A Office/Medical Building

    175 Running Hill Road, South Portland, ME

    Class A office/medical building with suites available for lease.

    • Class A office/medical building with suites available, ranging from 4,646 to 8,542± SF.
    • Central location with easy access to Maine Turnpike/I‑95 and I‑295.
    • Conveniently located near Portland International Jetport, hotels, and restaurants.
    • Professionally managed property situated on 13.09± acres.
    • Ample paved parking available.
    Updated: Jul 29, 2025
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    Class A Office Space Available
    Contact for pricing
    1,323 SF

    Class A Office Space Available

    778 Main Street, South Portland, ME 4106

    Class A office building with ample parking and professional landscaping.

    • Prime location on Route One, minutes from Portland, Maine Mall, and Portland Jetport.
    • Easy access to Maine Turnpike and I‑295.
    • Ample parking and professional landscaping.
    • Class A office building.
    • Join esteemed tenants like Boston IVF and Health Markets.
    Updated: Jan 27
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    Class A Office Space Available
    $14 SF/Yr
    104,752 SF

    Class A Office Space Available

    Class A office space for lease in South Portland.

    2 Gannett Dr, South Portland, ME
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    Class A Office Space
    Contact for pricing

    Class A Office Space

    Premier office spaces in South Portland, Maine.

    707 Sable Oaks Dr, South Portland, ME 4106
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    Based on your search, we've compiled 12 Potential Opportunities for your consideration. Besides 4 Active listings in South Portland, ME, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities

    Explore Office buildings for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Class A Office Building
    $15 SF/Yr
    19,405 SF

    Class A Office Building

    Suburban office building with remarkable amenities and on-site parking.

    6 Ashley Dr, Scarborough, ME
    View details
    Freestanding Office Building in Portland
    $12 SF/Yr
    38,227 SF

    Freestanding Office Building in Portland

    Professional office building in wooded campus setting for lease.

    41 Hutchins Dr, Portland, ME 4102
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    Freestanding Office Building in Portland
    Contact for pricing
    52,227 SF

    Freestanding Office Building in Portland

    Professional office building in wooded campus setting for lease.

    41 Hutchins Dr, Portland, ME 4102
    View details
    Class A Office Building
    Contact for pricing

    Class A Office Building

    Class A office space in Scarborough's Roundwood Business Park.

    6 Ashley Dr, Scarborough, ME 4074
    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Commercial Land For Lease Augusta
    Contact for pricing

    Commercial Land For Lease Augusta

    72-acre commercial land available for lease in Augusta, Maine.

    Riverside Drive, Augusta, ME 04330
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    Commercial Land on Montauk Highway
    $2,500/Mo

    Commercial Land on Montauk Highway

    0.55-acre commercial lot on busy Montauk Highway.

    1467 Montauk Highway, Mastic, NY 11967
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    Commercial Land at Major Intersection
    $400,000 SF/Yr

    Commercial Land at Major Intersection

    8 acres of commercial land for ground lease.

    12640 Lord Fairfax Hwy, Boyce, VA 22620
    View details
    Commercial Space on Trent Boulevard
    $1,200/Mo
    1,000 SF

    Commercial Space on Trent Boulevard

    Versatile commercial space ready for customization in a prime location.

    3709 Trent Road, New Bern, NC 28562
    View details

    South Portland, ME Office buildings Leasing Opportunities Market Analysis

    Explore Office buildings leasing options in South Portland, ME with 4 listings featured on our commercial real estate exchange. The current inventory includes 109,398 square feet of properties with an estimated lease value of $28 SF/Yr.

    Estimated lease rates for Office buildings in South Portland, ME begin at $13 SF/Yr, with an average of $14 SF/Yr and extend to $14 SF/Yr.
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    Most Searched ZIP Codes in South Portland, ME

    • 04106

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