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    Cape Girardeau County, MO Mixed-use Properties for Sale

    9 results
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    Mixed-Use Building in Prime Location
    $990,000
    7,000 SF

    Mixed-Use Building in Prime Location

    246 W Deerwood Dr, Jackson, MO 63755

    Turn-key mixed-use building with highway frontage and high traffic potential.

    • Prime location across from baseball fields and future roundabout (Fall 2025).
    • 70x100 commercial zoned building suitable for retail and automotive repair.
    • Turn‑key ready with reception area, auto lifts, private offices, 2 bathrooms, and break room.
    • Ample parking with space for 55+ vehicles.
    • Approximately 183 ft of Highway 61 frontage.
    Updated: Mar 4
    View details
    Unique Mixed-Use Property with Treehouse
    $962,000
    2,500 SF

    Unique Mixed-Use Property with Treehouse

    4940 County Road 532, Jackson, MO 63755

    Exceptional property with residence, treehouse venue, and shop potential.

    • Unique 2,500+ sq. ft. 'Treehouse' building with commercial kitchen, bar, and large deck offering significant income potential.
    • Main house features rustic design elements, including wood beams, vaulted ceilings, and a stone fireplace.
    • Finished walk‑out basement with family room, bedroom, bonus rooms, and full bathroom.
    • Recent upgrades include a new roof and freshly stained exterior wood siding (2025).
    • Efficient wood‑burning stove provides primary heating.
    Updated: Feb 27
    View details
    Versatile Riverfront Commercial Property
    Pending
    $400,000
    4,400 SF

    Versatile Riverfront Commercial Property

    Prime riverfront property suitable for office, restaurant, warehouse, or mixed-use.

    450 N Main St, Cape Girardeau, MO 63701
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    Mixed-Use Property in Jackson, MO
    $569,000
    2,304 SF

    Mixed-Use Property in Jackson, MO

    Commercial property with shop, office, and storage on 3.3 acres.

    6065 State Hwy W, Jackson, MO 63755
    View details
    Versatile Commercial Property For Sale
    $295,000
    2,920 SF

    Versatile Commercial Property For Sale

    High-visibility commercial property with flexible layout and spacious attached warehouse.

    225 Clark Ave, Cape Girardeau, MO 63701
    View details
    Furnished Mixed-Use Professional Building
    $299,999
    3,210 SF

    Furnished Mixed-Use Professional Building

    Two-level, fully furnished office building in Jackson, Missouri.

    902 E Jackson Blvd, Jackson, MO 63755
    View details
    Mixed-Use Building in Jackson, MO
    $325,000
    2,665 SF

    Mixed-Use Building in Jackson, MO

    Mixed-use property with income potential in Jackson, Missouri.

    1502 W Jackson Blvd, Jackson, MO 63755
    View details
    Cape Girardeau Mixed-Use Investment
    $489,900
    7,282 SF

    Cape Girardeau Mixed-Use Investment

    Leased commercial spaces with residential unit for income growth.

    1606 Independence St, Cape Girardeau, MO 63703
    View details
    Broadway Commercial Space with Apartment
    $280,000
    5,100 SF

    Broadway Commercial Space with Apartment

    Versatile investment opportunity with remodeled apartment and commercial space.

    520 Broadway St, Cape Girardeau, MO 63701
    View details
    Based on your search, we've compiled 52 Potential Opportunities for your consideration. Besides 9 Active listings in Cape Girardeau County, MO, we suggest exploring several alternatives: similar 43 Off-Market properties to explore as potential leads

    Explore Off-Market Properties in Cape Girardeau County, MO

    Consider similar Off-Market properties in Cape Girardeau County, MO. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    117 Hope St

    117 Hope St

    OFFICE/RESIDENTIAL (MIXED USE) • 1,300 SF
    Value Estimation by Request
    117 Hope St, Jackson, MO 63755-2116
    View details
    716 Broadway St

    716 Broadway St

    OFFICE/RESIDENTIAL (MIXED USE) • 9,817 SF
    Value Estimation by Request
    716 Broadway St, Cape Girardeau, MO 63701-5695
    View details
    437 Broadway St, Unit 439

    437 Broadway St, Unit 439

    OFFICE/RESIDENTIAL (MIXED USE) • 6,506 SF
    Value Estimation by Request
    437 Broadway St, Cape Girardeau, MO 63701-5621
    View details
    108 Main St

    108 Main St

    OFFICE/RESIDENTIAL (MIXED USE) • 6,674 SF
    Value Estimation by Request
    108 Main St, Cape Girardeau, MO 63701-7309
    View details
    2256 Kingsway Dr

    2256 Kingsway Dr

    OFFICE/RESIDENTIAL (MIXED USE) • 2,331 SF
    Value Estimation by Request
    2256 Kingsway Dr, Cape Girardeau, MO 63701-4413
    View details
    403 Broadway St

    403 Broadway St

    OFFICE/RESIDENTIAL (MIXED USE) • 11,261 SF
    Value Estimation
    $1,405,000
    403 Broadway St, Cape Girardeau, MO 63701-5621
    View details
    515 Broadway St

    515 Broadway St

    OFFICE/RESIDENTIAL (MIXED USE) • 1,496 SF
    Value Estimation by Request
    515 Broadway St, Cape Girardeau, MO 63701-5623
    View details
    801 Good Hope St

    801 Good Hope St

    OFFICE/RESIDENTIAL (MIXED USE) • 2,599 SF
    Value Estimation by Request
    801 Good Hope St, Cape Girardeau, MO 63703-6266
    View details
    32 Main St

    32 Main St

    OFFICE/RESIDENTIAL (MIXED USE) • 3,360 SF
    Value Estimation by Request
    32 Main St, Cape Girardeau, MO 63701-7307
    View details
    3189 Old Cpe Rd

    3189 Old Cpe Rd

    OFFICE/RESIDENTIAL (MIXED USE) • 2,400 SF
    Value Estimation by Request
    3189 Old Cpe Rd, Jackson, MO 63755-3725
    View details
    9773 State Hwy 72

    9773 State Hwy 72

    OFFICE/RESIDENTIAL (MIXED USE) • 3,195 SF
    Value Estimation by Request
    9773 State Hwy 72, Millersville, MO 63766
    View details
    Ct St

    Ct St

    OFFICE/RESIDENTIAL (MIXED USE) • 3,162 SF
    Value Estimation by Request
    Ct St, Jackson, MO 63755
    View details
    113 High St

    113 High St

    OFFICE/RESIDENTIAL (MIXED USE) • 5,919 SF
    Value Estimation by Request
    113 High St, Jackson, MO 63755-2041
    View details
    124 Wyandot Ln

    124 Wyandot Ln

    OFFICE/RESIDENTIAL (MIXED USE) • 1,152 SF
    Value Estimation by Request
    124 Wyandot Ln, Cape Girardeau, MO 63701-8969
    View details
    40 Main St

    40 Main St

    OFFICE/RESIDENTIAL (MIXED USE) • 3,608 SF
    Value Estimation by Request
    40 Main St, Cape Girardeau, MO 63701-7307
    View details

    Cape Girardeau County, MO Mixed-Use Properties Investment Opportunities Market Analysis

    Explore 52 mixed-use properties for sale in Cape Girardeau County, MO, showcased through 9 active listings on our real estate platform. These investment opportunities span a total of 1,364,517 square feet of properties for sale, with an estimated market value of $9,170,899.

    Sale prices for multi use buildings in Cape Girardeau County, MO start at $240,000, averaging $366,835, and reaching up to $990,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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