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    Mesa County, CO Mixed-use Properties for Sale

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    Mixed-Use Office and 4plex Property
    Updated: Nov 19, 2025
    Mixed-Use Office and 4plex Property

    2718 Patterson Road, Grand Junction, CO 81506

    $940,000
    Great potential development opportunity with MU‑1 zoning.
    Located directly off Patterson Rd with high traffic counts.
    Strong investment opportunity with existing income from Commercial Office and 4plex.
    Large lot size of 0.89 Acres.
    Includes both a Commercial Office (Modular at 1440 SF) and a 4plex (3520 SF).
    View details
    Orchard Mesa Commercial Property
    Updated: May 26
    Orchard Mesa Commercial Property

    2706 HWY 50, Grand Junction, CO 81503

    $625,000
    1,440 sqft 0.60 AC lot
    Prime location at the intersection of residential and business areas in Orchard Mesa with direct Highway 50 exit access.
    Highly desirable drive‑thru window suitable for various business types.
    Generous 0.60‑acre lot with MU‑2 zoning offering expansion potential.
    High‑visibility signage to capitalize on heavy traffic.
    Flexible 1,440 sq. ft. interior layout with open office space, 3 service stations, and private offices.
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    Shop with Office and Yard
    Shop with Office and Yard

    1162 Ute Ave, Grand Junction, CO 81501

    $425,000
    1,296 sqft 0.43 AC lot

    Downtown Grand Junction shop with office, yard, and development potential.

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    Fruita Mixed-Use Development Opportunity
    Fruita Mixed-Use Development Opportunity

    551 East Grand Avenue, Fruita, CO 81521

    $500,000
    0.55 AC lot

    Classic bungalow on 0.55 acres with development potential.

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    Fruita Commercial Zoned Bungalow
    Fruita Commercial Zoned Bungalow

    551 E Grand Ave, Fruita, CO 81521

    $425,000
    900 sqft 0.55 AC lot

    1925 bungalow in commercial zone with development potential.

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    Based on your search, we've compiled 40 Potential Opportunities for your consideration. Besides 5 Active listings in Mesa County, CO, we suggest exploring several alternatives: similar 31 Off-Market properties to explore as potential leads, plus 4 Land Listings that present a potential for development.

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Grand Junction Commercial Development Opportunity
    Grand Junction Commercial Development Opportunity

    699 23 1/2 Road, Grand Junction, CO 81505

    $7,000,000
    13.99 AC lot

    13.99 acres in active growth corridor, flexible zoning.

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    Build-Ready Land Site
    Build-Ready Land Site

    2376 G Road, Grand Junction, CO 81505

    $1,699,000
    2.81 AC lot

    Build-ready commercial land site of 2.81 acres, directly across from Community Hospital in Grand Junction, Colorado.

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    Grand Junction Commercial Development Opportunity
    Grand Junction Commercial Development Opportunity

    2385 G Road, Grand Junction, CO 81505

    $5,000,000
    7.81 AC lot

    7.81 acres of mixed-use land near Community Hospital.

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    Multi-Use Commercial Land Parcel
    Multi-Use Commercial Land Parcel

    2350 F 1/2 Road, Grand Junction, CO 81505

    $4,800,000
    16.90 AC lot

    Three-lot commercial parcel totaling 16.9 acres, zoned MU-2, with multiple access points along two busy corridors.

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    Off-Market Properties in Mesa County, CO

    Consider similar Off-Market properties in Mesa County, CO. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    2464 Hwy 6th And 50
    STORE/OFFICE (MIXED USE)

    2464 Hwy 6th And 50, Grand Junction, CO 81505-1138

    $19,030,000
    Estimated value
    206,585 sqft 18.98 AC lot
    View details
    2474 Hwy 6th And 50
    STORE/OFFICE (MIXED USE)

    2474 Hwy 6th And 50, Grand Junction, CO 81505-1145

    $985,000
    Estimated value
    7,389 sqft 1.33 AC lot
    View details
    2478 Hwy 6th And 50
    STORE/OFFICE (MIXED USE)

    2478 Hwy 6th And 50, Grand Junction, CO 81505-1122

    $1,075,000
    Estimated value
    8,194 sqft 1.21 AC lot
    View details
    644 Nn Ave
    STORE/OFFICE (MIXED USE)

    644 Nn Ave, Grand Junction, CO 81501-7544

    $745,000
    Estimated value
    0.76 AC lot
    View details
    2536 Rimrock Ave
    STORE/OFFICE (MIXED USE)

    2536 Rimrock Ave, Grand Junction, CO 81505-8669

    $1,920,000
    Estimated value
    15,300 sqft 1.94 AC lot
    View details
    2504 Hwy 6th And 50
    STORE/OFFICE (MIXED USE)

    2504 Hwy 6th And 50, Grand Junction, CO 81505-7170

    $1,255,000
    Estimated value
    9,801 sqft 4.09 AC lot
    View details
    2502 Hwy 6th And 50
    STORE/OFFICE (MIXED USE)

    2502 Hwy 6th And 50, Grand Junction, CO 81505-4501

    $2,210,000
    Estimated value
    17,544 sqft 2.01 AC lot
    View details
    225 Grand Ave
    STORE/OFFICE (MIXED USE)

    225 Grand Ave, Grand Junction, CO 81501

    Value Estimation by Request
    0.13 AC lot
    View details
    675 23 1/2 Rd
    Multifamily properties

    675 23 1/2 Rd, Grand Junction, CO 81505

    Value Estimation by Request
    60,000 sqft 1.50 AC lot
    View details
    2600 Riverside Pkwy
    Mixed-use properties

    2600 Riverside Pkwy, Grand Junction, CO 81501

    Value Estimation by Request
    1.61 AC lot
    View details
    3526 Front St
    Mixed-use properties

    3526 Front St, Palisade, CO 81526

    Value Estimation by Request
    1,344 sqft 6.87 AC lot
    View details
    2324 Highway 6 And 50
    Mixed-use properties

    2324 Highway 6 And 50, Grand Junction, CO 81505

    Value Estimation by Request
    1,452 sqft 2.89 AC lot
    View details
    1915 I-70Bl
    Distribution properties

    1915 I-70Bl, Grand Junction, CO 81501

    Value Estimation by Request
    9,000 sqft 0.37 AC lot
    View details
    551 Grand Ave
    Multifamily properties

    551 Grand Ave, Fruita, CO 81521

    Value Estimation by Request
    900 sqft 0.55 AC lot
    View details
    1004 High St
    Mixed-use properties

    1004 High St, Collbran, CO 81624

    Value Estimation by Request
    2,439 sqft 0.29 AC lot
    View details
    3164 F Rd
    Churches & religious facilities

    3164 F Rd, Grand Junction, CO 81504

    Value Estimation by Request
    22,536 sqft 4.64 AC lot
    View details
    3281 C Rd
    Farms

    3281 C Rd, Palisade, CO 81526

    Value Estimation by Request
    55,000 sqft 18.06 AC lot
    View details
    3652 G 7/10 Rd
    Farms

    3652 G 7/10 Rd, Palisade, CO 81526

    Value Estimation by Request
    View details
    3245 I-70Bl
    Restaurants

    3245 I-70Bl, Clifton, CO 81520

    Value Estimation by Request
    7,269 sqft 0.90 AC lot
    View details

    Mesa County, CO Mixed-Use Properties Market Trends and Statistics

    Explore 36 mixed-use properties for sale in Mesa County, CO, showcased through 5 active listings on our real estate platform. These investment opportunities span a total of 3,636 square feet of properties for sale, with an estimated market value of $1,475,000.

    Sale prices for multi use buildings in Mesa County, CO start at $425,000, averaging $491,666, and reaching up to $625,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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